PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25577709-4 2015 In this context, aiming at further exploring the mechanisms of action of our newly synthesized antioxidant compounds (AK1 and AK2) in a skeletal muscle experimental setting, we initially investigated their scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and subsequently assessed their effect on the viability of C2 skeletal myoblasts in the presence of two pro-oxidants: H2O2 and curcumin (MTT assay). Curcumin 391-399 adenylate kinase 2 Homo sapiens 126-129 25577709-5 2015 Interestingly, while both compounds reversed the detrimental effect of H2O2, only AK2 was cytoprotective in curcumin-treated C2 cells. Curcumin 108-116 adenylate kinase 2 Homo sapiens 82-85 25577709-7 2015 In correlation with the aforementioned results, only AK2 blocked the curcumin-induced activation of JNKs pathway. Curcumin 69-77 adenylate kinase 2 Homo sapiens 53-56