PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19800021-6 2010 The IL-1-mediated induction of C/EBPdelta expression was attenuated in the presence of pharmacological inhibitors against c-Jun N-terminal kinase (JNK) (curcumin and SP600125), casein kinase 2 (CK2) (apigenin) and nuclear factor-kappaB (NF-kappaB) (NF-kappaB activation inhibitor). Curcumin 153-161 mitogen-activated protein kinase 8 Homo sapiens 122-151 20358476-5 2010 Curcumin-treated PC3 cells showed apoptosis-inducing cellular ceramide accumulation and activation of p38 mitogen-activated protein kinase (MAPK) and c-jun N-terminal kinase (JNK). Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 150-173 20358476-5 2010 Curcumin-treated PC3 cells showed apoptosis-inducing cellular ceramide accumulation and activation of p38 mitogen-activated protein kinase (MAPK) and c-jun N-terminal kinase (JNK). Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 175-178 19246153-2 2009 Here we show that the natural compound curcumin induces nuclear translocation of the heat shock transcription factor (HSF)-1, its binding to a heat shock regulatory element (HSE), and the subsequent activation of the hsp70 promoter through the extracellular regulated kinase (ERK)/mitogen activated protein (MAP) ERK (MEK) and c-jun N-terminal kinase (JNK) pathways, but not through p38. Curcumin 39-47 mitogen-activated protein kinase 8 Homo sapiens 327-350 19246153-2 2009 Here we show that the natural compound curcumin induces nuclear translocation of the heat shock transcription factor (HSF)-1, its binding to a heat shock regulatory element (HSE), and the subsequent activation of the hsp70 promoter through the extracellular regulated kinase (ERK)/mitogen activated protein (MAP) ERK (MEK) and c-jun N-terminal kinase (JNK) pathways, but not through p38. Curcumin 39-47 mitogen-activated protein kinase 8 Homo sapiens 352-355 19393026-9 2009 Inhibition of AP-1 with curcumin also inhibited 14-3-3gamma up-regulation indicating that ischemia-induced up-regulation of 14-3-3gamma in astrocyte involves activation of the JNK/p-c-Jun/AP-1 pathway. Curcumin 24-32 mitogen-activated protein kinase 8 Homo sapiens 176-179 19771847-3 2009 RESULTS: The suppressive effect of curcumin was shown as a dose dependent and a time dependent manner,and the IC50 was 22.48 micromol/L 40 micromol/L curcumin inhibited the expression of p-ERK, p-NF-kappaB and p-p38, but not p-JNK. Curcumin 35-43 mitogen-activated protein kinase 8 Homo sapiens 227-230 19771847-3 2009 RESULTS: The suppressive effect of curcumin was shown as a dose dependent and a time dependent manner,and the IC50 was 22.48 micromol/L 40 micromol/L curcumin inhibited the expression of p-ERK, p-NF-kappaB and p-p38, but not p-JNK. Curcumin 150-158 mitogen-activated protein kinase 8 Homo sapiens 227-230 18794131-8 2008 Curcumin was able to induce c-Jun NH(2)-kinase (JNK) phosphorylation, whereas the JNK inhibitor (SP-600125) could attenuate curcumin-induced JunD and HLJ1 expression. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 28-46 18794131-8 2008 Curcumin was able to induce c-Jun NH(2)-kinase (JNK) phosphorylation, whereas the JNK inhibitor (SP-600125) could attenuate curcumin-induced JunD and HLJ1 expression. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 48-51 18794131-8 2008 Curcumin was able to induce c-Jun NH(2)-kinase (JNK) phosphorylation, whereas the JNK inhibitor (SP-600125) could attenuate curcumin-induced JunD and HLJ1 expression. Curcumin 124-132 mitogen-activated protein kinase 8 Homo sapiens 82-85 18794131-10 2008 Our results show that curcumin induces HLJ1, through activation of the JNK/JunD pathway, and inhibits lung cancer cell invasion and metastasis by modulating E-cadherin expression. Curcumin 22-30 mitogen-activated protein kinase 8 Homo sapiens 71-74 18638545-0 2008 Curcumin protects cardiac cells against ischemia-reperfusion injury: effects on oxidative stress, NF-kappaB, and JNK pathways. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 113-116 18638545-5 2008 This confirms that the protective effect of curcumin is not related simply to its antioxidant properties but involves other mechanisms, notably interactions in the NF-kappaB and JNK pathways. Curcumin 44-52 mitogen-activated protein kinase 8 Homo sapiens 178-181 18332871-8 2008 In addition, curcumin reduced the phosphorylation levels of PDGF-betaR and EGFR, as well as their downstream signaling cascades, including ERK1/2 and JNK1/2. Curcumin 13-21 mitogen-activated protein kinase 8 Homo sapiens 150-156 18316600-6 2008 Egr-1 expression is induced by curcumin through extracellular signal-regulated kinase (ERK) and c-Jun NH(2)-terminal kinase (JNK), but not the p38, mitogen-activated protein kinase (MAPK) pathways, which mediate the transactivation of Elk-1. Curcumin 31-39 mitogen-activated protein kinase 8 Homo sapiens 96-123 18316600-6 2008 Egr-1 expression is induced by curcumin through extracellular signal-regulated kinase (ERK) and c-Jun NH(2)-terminal kinase (JNK), but not the p38, mitogen-activated protein kinase (MAPK) pathways, which mediate the transactivation of Elk-1. Curcumin 31-39 mitogen-activated protein kinase 8 Homo sapiens 125-128 18316600-9 2008 Our results indicate that ERK and JNK MAPK/Elk-1/Egr-1 signal cascade is required for p53-independent transcriptional activation of p21(Waf1/Cip1) in response to curcumin in U-87MG human glioblastoma cells. Curcumin 162-170 mitogen-activated protein kinase 8 Homo sapiens 34-37 18082042-10 2007 Curcumin pretreatment decreased significantly ROS and JNK/SAPK levels as well as the apoptosis rate when compared with the CuSO4-treated alone group (P < 0.01). Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 54-62 18082042-13 2007 Curcumin produced protections on copper-injured BRL cells possibly by anti-oxidation and inhibition of p-JNK expression. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 105-108 17666914-5 2007 Curcumin also reduced the intracellular reactive oxygen species (ROS), monocyte adhesion, phosphorylation of c-Jun N-terminal kinase (JNK), p38, and signal transducer and activator of transcription (STAT)-3 in TNF-alpha-stimulated HUVECs. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 109-132 17666914-5 2007 Curcumin also reduced the intracellular reactive oxygen species (ROS), monocyte adhesion, phosphorylation of c-Jun N-terminal kinase (JNK), p38, and signal transducer and activator of transcription (STAT)-3 in TNF-alpha-stimulated HUVECs. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 134-137 17666914-8 2007 We suggest that curcumin could contribute to protection against the adverse vascular effect of the proinflammatory response through the modulation of p38 and STAT-3 in addition to NF-kappaB and JNK in endothelial cells. Curcumin 16-24 mitogen-activated protein kinase 8 Homo sapiens 194-197 17596214-6 2007 Curcumin reduced cell survival in a p53- and caspase-independent manner, an effect correlated with the inhibition of AP-1 and NFkappaB signaling pathways via prevention of constitutive JNK and Akt activation. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 185-188 17273796-7 2007 In addition, curcumin inhibited the activation of MAPKs (JNK, p38 MAPK, and ERK) and NF-kappaB in TNF-alpha-treated HaCaT cells. Curcumin 13-21 mitogen-activated protein kinase 8 Homo sapiens 57-60 16624471-3 2006 Here, we demonstrate that curcumin can induce apoptotic changes, including JNK activation, caspase-3 activation, and cleavage of PARP and PAK2, at treatment concentrations lower than 25 microM in human osteoblast cells. Curcumin 26-34 mitogen-activated protein kinase 8 Homo sapiens 75-78 16819191-0 2006 Curcumin decreases binding of Shiga-like toxin-1B on human intestinal epithelial cell line HT29 stimulated with TNF-alpha and IL-1beta: suppression of p38, JNK and NF-kappaB p65 as potential targets. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 156-159 16819191-6 2006 Additionally, curcumin was able to inhibit mitogen-activated protein kinases (MAPKs), such as p38 and JNK, but not ERK1/2, degradation of IkappaB or translocation of NF-kappaB p65. Curcumin 14-22 mitogen-activated protein kinase 8 Homo sapiens 102-105 16497702-4 2006 We have shown previously that curcumin inhibits NFkappaB, activates JNK and promotes apoptosis in HCT116 colorectal cancer cells. Curcumin 30-38 mitogen-activated protein kinase 8 Homo sapiens 68-71 16497702-9 2006 Taken together, these results show that curcumin-mediated activation of JNK or induction of apoptosis does not require inhibition of p65. Curcumin 40-48 mitogen-activated protein kinase 8 Homo sapiens 72-75 16081677-10 2005 Curcumin suppressed cytokine-induced mPGES-1 by inhibiting phosphorylation of Jun N-terminal kinase (JNK)1/2. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 78-108 16081677-12 2005 These results indicate that curcumin inhibits IL-1beta-induced PGE(2) formation by inhibiting the expression of mPGES-1 that is mediated by suppression of EGR-1 expression as well as NF-kappaB and JNK1/2. Curcumin 28-36 mitogen-activated protein kinase 8 Homo sapiens 197-203 16102725-6 2005 Furthermore, curcumin strongly repressed the PMA-induced phosphorylation of ERK, JNK, and p38 MAP kinase, which were dependent on the PKC pathway. Curcumin 13-21 mitogen-activated protein kinase 8 Homo sapiens 81-84 15982617-9 2005 Curcumin, a specific inhibitor of JNK, also concentration-dependently reduced IL-17--induced IL-8 production, with a maximal decrease of 82+/-4% (n=8, p<0.01). Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 34-37 16000872-0 2005 Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 141-144 16000872-8 2005 Notably, there was effective inhibition by curcumin on UVB-induced activations of p38 MAPK and JNK in HaCaT cells. Curcumin 43-51 mitogen-activated protein kinase 8 Homo sapiens 95-98 16000872-10 2005 These results collectively suggest that curcumin may inhibit COX- 2 expression by suppressing p38 MAPK and JNK activities in UVB-irradiated HaCaT cells. Curcumin 40-48 mitogen-activated protein kinase 8 Homo sapiens 107-110 15640282-11 2005 Signal transduction pathway inhibitors (SB203580, curcumin, and PD98059) implicated p38 and JNK, but not ERK, in 8-iso-PGF2alpha-induced suppression of monocyte adhesion. Curcumin 50-58 mitogen-activated protein kinase 8 Homo sapiens 92-95 15491342-15 2004 Our data also shows that EGF-stimulated uPA production involves the activation of the extracellular signal-regulated kinases 1/2 and JNK signaling pathways and might be modulated by the natural phytoestrogens curcumin and genistein. Curcumin 209-217 mitogen-activated protein kinase 8 Homo sapiens 86-136 15256484-0 2004 Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 17-40 15256484-5 2004 Here we report that curcumin time- and dose-dependent induction of apoptosis were accompanied by sustained phosphorylation and activation of c-jun N-terminal kinase (JNK) and p38 MAPK as well as inhibition of constitutive NFkappaB transcriptional activity. Curcumin 20-28 mitogen-activated protein kinase 8 Homo sapiens 141-164 15256484-5 2004 Here we report that curcumin time- and dose-dependent induction of apoptosis were accompanied by sustained phosphorylation and activation of c-jun N-terminal kinase (JNK) and p38 MAPK as well as inhibition of constitutive NFkappaB transcriptional activity. Curcumin 20-28 mitogen-activated protein kinase 8 Homo sapiens 166-169 15256484-6 2004 Curcumin treatment also induced JNK-dependent sustained phosphorylation of c-jun and stimulation of AP-1 transcriptional activity. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 32-35 15256484-7 2004 Curcumin-mediated c-jun phosphorylation and apoptosis were reduced by treatment with the JNK-specific inhibitor SP600125. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 89-92 15256484-10 2004 Taken together, our data show for the first time that JNK, but not p38 or ERK signalling, plays an important role in curcumin-mediated apoptosis in human colon cancer cells that may underlie its chemopreventive effects. Curcumin 117-125 mitogen-activated protein kinase 8 Homo sapiens 54-57 15352173-6 2004 Curcumin, an anti-oxidant and JNK inhibitor, inhibited PF-induced apoptosis, suggesting the possible involvement of curcumin-sensitive JNK or other redox-sensitive elements in PF-induced apoptosis. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 30-33 15352173-6 2004 Curcumin, an anti-oxidant and JNK inhibitor, inhibited PF-induced apoptosis, suggesting the possible involvement of curcumin-sensitive JNK or other redox-sensitive elements in PF-induced apoptosis. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 135-138 15352173-6 2004 Curcumin, an anti-oxidant and JNK inhibitor, inhibited PF-induced apoptosis, suggesting the possible involvement of curcumin-sensitive JNK or other redox-sensitive elements in PF-induced apoptosis. Curcumin 116-124 mitogen-activated protein kinase 8 Homo sapiens 135-138 15118344-5 2004 Pretreatment of curcumin, an inhibitor of c-jun N-terminal kinase (JNK), dose-dependently suppressed the induction of Mn-SOD mRNA by YS 51, but not by 2"-amino-3"-methoxyflavone (PD98059) and 4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)imidazol (SB203580), inhibitors of mitogen-activated protein kinase. Curcumin 16-24 mitogen-activated protein kinase 8 Homo sapiens 42-65 15118344-5 2004 Pretreatment of curcumin, an inhibitor of c-jun N-terminal kinase (JNK), dose-dependently suppressed the induction of Mn-SOD mRNA by YS 51, but not by 2"-amino-3"-methoxyflavone (PD98059) and 4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)imidazol (SB203580), inhibitors of mitogen-activated protein kinase. Curcumin 16-24 mitogen-activated protein kinase 8 Homo sapiens 67-70 15095415-5 2004 We report that curcumin prevented PDT-induced JNK activation, mitochondrial release of cytochrome c, caspase-3 activation, and cleavage of PAK2. Curcumin 15-23 mitogen-activated protein kinase 8 Homo sapiens 46-49 15095415-9 2004 Collectively, these results demonstrate that singlet oxygen triggers JNK activation, cytochrome c release, caspase activation and subsequent apoptotic biochemical changes during PDT and show that curcumin is a potent inhibitor for this process. Curcumin 196-204 mitogen-activated protein kinase 8 Homo sapiens 69-72 14724571-8 2004 JNK activation and PARP cleavage induced by 30 nM Taxotere at 48 h were reversed by curcumin, PD169316 and SP600125, JNK inhibitors in order of progressive specificity. Curcumin 84-92 mitogen-activated protein kinase 8 Homo sapiens 0-3 14724571-8 2004 JNK activation and PARP cleavage induced by 30 nM Taxotere at 48 h were reversed by curcumin, PD169316 and SP600125, JNK inhibitors in order of progressive specificity. Curcumin 84-92 mitogen-activated protein kinase 8 Homo sapiens 117-120 14674708-8 2003 Although curcumin was ineffective in preventing UV-induced p44/42 MAP kinase phosphorylation, the JNK (1 and 2) and AP-1 activation were efficiently blocked by curcumin in HeLa cells. Curcumin 160-168 mitogen-activated protein kinase 8 Homo sapiens 98-110 14505349-3 2003 In this study we demonstrate that curcumin (Cur), the yellow pigment of Curcuma longa with known anti-oxidant and anti-inflammatory properties, can prevent UV irradiation-induced apoptotic changes, including c-Jun N-terminal kinase (JNK) activation, loss of mitochondrial membrane potential (MMP), mitochondrial release of cytochrome C, caspase-3 activation, and cleavage/activation of PAK2 in A431 cells. Curcumin 34-42 mitogen-activated protein kinase 8 Homo sapiens 233-236 12859962-10 2003 Both 5-lipoxygenase inhibition-induced activation of JNK and induction of apoptosis are prevented by curcumin, an inhibitor of JNK-signaling pathway. Curcumin 101-109 mitogen-activated protein kinase 8 Homo sapiens 53-56 12859962-10 2003 Both 5-lipoxygenase inhibition-induced activation of JNK and induction of apoptosis are prevented by curcumin, an inhibitor of JNK-signaling pathway. Curcumin 101-109 mitogen-activated protein kinase 8 Homo sapiens 127-130 12806293-9 2003 Treatment of oxidative-stressed cultures with either curcumin, a MAPKKK pathway inhibitor, or PD-098059, a MEK1 inhibitor, blocked loss of neurons via the JNK/c-Jun apoptotic pathway. Curcumin 53-61 mitogen-activated protein kinase 8 Homo sapiens 155-158 12795836-6 2003 Curcumin, a JNK blocker, blocked the apoptosis and the growth inhibition induced by ATRA. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 12-15 12105223-7 2002 Curcumin, but not PD98059 or SB203580, inhibited IL-1 beta-mediated suppression of nuclear RXR:RAR binding activity, which correlated with inhibition of JNK phosphorylation and phospho-JNK-mediated phosphorylation of RXR. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 153-156 12105223-7 2002 Curcumin, but not PD98059 or SB203580, inhibited IL-1 beta-mediated suppression of nuclear RXR:RAR binding activity, which correlated with inhibition of JNK phosphorylation and phospho-JNK-mediated phosphorylation of RXR. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 185-188 12105223-8 2002 Taken together, these data provide evidence supporting a novel player (JNK), as well as its inhibitor (curcumin), in inflammation-mediated regulation of hepatobiliary transporters and correlate JNK-dependent RXR phosphorylation with reduced RXR-dependent hepatic gene expression. Curcumin 103-111 mitogen-activated protein kinase 8 Homo sapiens 194-197 12097302-2 2002 However, this agent also inhibits the generation of reactive oxygen species (ROS) and the c-Jun NH(2)-terminal kinase (JNK) pathway, and because many chemotherapeutic drugs generate ROS and activate JNK in the course of inducing apoptosis, we considered the possibility that curcumin might antagonize their antitumor efficacy. Curcumin 275-283 mitogen-activated protein kinase 8 Homo sapiens 119-122 12097302-2 2002 However, this agent also inhibits the generation of reactive oxygen species (ROS) and the c-Jun NH(2)-terminal kinase (JNK) pathway, and because many chemotherapeutic drugs generate ROS and activate JNK in the course of inducing apoptosis, we considered the possibility that curcumin might antagonize their antitumor efficacy. Curcumin 275-283 mitogen-activated protein kinase 8 Homo sapiens 199-202 12097302-5 2002 Under these conditions, curcumin exhibited antioxidant properties and inhibited both JNK activation and mitochondrial release of cytochrome c in a concentration-dependent manner. Curcumin 24-32 mitogen-activated protein kinase 8 Homo sapiens 85-88 12097302-8 2002 These findings support the hypothesis that dietary curcumin can inhibit chemotherapy-induced apoptosis through inhibition of ROS generation and blockade of JNK function, and suggest that additional studies are needed to determine whether breast cancer patients undergoing chemotherapy should avoid curcumin supplementation, and possibly even limit their exposure to curcumin-containing foods. Curcumin 51-59 mitogen-activated protein kinase 8 Homo sapiens 156-159 12149148-7 2002 The essential role of JNK in the induction of SCLC apoptosis with CDDP and anti-GD2 mAb was confirmed by experiments with a JNK inhibitor, curcumin. Curcumin 139-147 mitogen-activated protein kinase 8 Homo sapiens 22-25 12149148-7 2002 The essential role of JNK in the induction of SCLC apoptosis with CDDP and anti-GD2 mAb was confirmed by experiments with a JNK inhibitor, curcumin. Curcumin 139-147 mitogen-activated protein kinase 8 Homo sapiens 124-127 12009331-7 2002 Inhibitor of JNK, AP-1 and NF-kappa B, curcumin, achieved 48-99% suppression of MMP-3 and 45-97% of MMP-13 in human and 8-100% (MMP-3) and 32-100% (MMP-13) in bovine chondrocytes. Curcumin 39-47 mitogen-activated protein kinase 8 Homo sapiens 13-16 11795492-6 2001 Pretreatment of JNK specific inhibitors, curcumin and all trans-retinoic acid, decreased the basal motility of DAR-ECV cells in a dose-dependent manner. Curcumin 41-49 mitogen-activated protein kinase 8 Homo sapiens 16-19 11053056-6 2000 Furthermore, treatment with either PD098059, SB203580, or the JNK-AP-1 inhibitor curcumin diminished the expression of MCP-1 and stromelysin. Curcumin 81-89 mitogen-activated protein kinase 8 Homo sapiens 62-65 10972672-8 2000 Pretreatment with MAP kinase kinase inhibitor PD098059 or JNK-c-Jun/AP-1 inhibitor curcumin attenuated the H2O2-induced apoptosis. Curcumin 83-91 mitogen-activated protein kinase 8 Homo sapiens 58-61 10723098-5 2000 Inhibition of JNK activity by a JNK inhibitor, curcumin, remarkably reduced MG-induced caspase-3 activation, PARP cleavage, and apoptosis. Curcumin 47-55 mitogen-activated protein kinase 8 Homo sapiens 14-17 10723098-5 2000 Inhibition of JNK activity by a JNK inhibitor, curcumin, remarkably reduced MG-induced caspase-3 activation, PARP cleavage, and apoptosis. Curcumin 47-55 mitogen-activated protein kinase 8 Homo sapiens 32-35 10570055-9 1999 4-HPR-induced apoptosis in LNCaP cells was suppressed by curcumin, which inhibits JNK activation. Curcumin 57-65 mitogen-activated protein kinase 8 Homo sapiens 82-85 10363643-8 1999 Since curcumin is known as an inhibitor of the c-Jun N-terminal kinase (JNK) signaling pathway acting upstream of the MAP kinase kinase kinase level, one site of action of the COP9 signalosome might be proximal to regulators on that level. Curcumin 6-14 mitogen-activated protein kinase 8 Homo sapiens 47-70 10363643-8 1999 Since curcumin is known as an inhibitor of the c-Jun N-terminal kinase (JNK) signaling pathway acting upstream of the MAP kinase kinase kinase level, one site of action of the COP9 signalosome might be proximal to regulators on that level. Curcumin 6-14 mitogen-activated protein kinase 8 Homo sapiens 72-75 9674701-0 1998 Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin. Curcumin 69-77 mitogen-activated protein kinase 8 Homo sapiens 18-41 9674701-0 1998 Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin. Curcumin 69-77 mitogen-activated protein kinase 8 Homo sapiens 43-46 9674701-3 1998 In this report, we show that curcumin inhibits JNK activation by various agonists including PMA plus ionomycin, anisomycin, UV-C, gamma radiation, TNF-alpha, and sodium orthovanadate. Curcumin 29-37 mitogen-activated protein kinase 8 Homo sapiens 47-50 9674701-4 1998 Although both JNK and ERK activation by phorbol 12-myristate 13-acetate (PMA) plus ionomycin were suppressed by curcumin, the JNK pathway was more sensitive. Curcumin 112-120 mitogen-activated protein kinase 8 Homo sapiens 14-17 9674701-5 1998 The IC50 (50% inhibition concentration) of curcumin was between 5-10 microM for JNK activation and was 20 microM for ERK activation. Curcumin 43-51 mitogen-activated protein kinase 8 Homo sapiens 80-83 9674701-6 1998 In transfection assays, curcumin moderately suppressed MEKK1-induced JNK activation; however, it effectively blocked JNK activation caused by co-transfection of TAK1, GCK, or HPK1. Curcumin 24-32 mitogen-activated protein kinase 8 Homo sapiens 69-72 9674701-6 1998 In transfection assays, curcumin moderately suppressed MEKK1-induced JNK activation; however, it effectively blocked JNK activation caused by co-transfection of TAK1, GCK, or HPK1. Curcumin 24-32 mitogen-activated protein kinase 8 Homo sapiens 117-120 9674701-9 1998 Our data suggest that curcumin may affect the JNK pathway by interfering with the signaling molecule(s) at the same level or proximally upstream of the MAPKKK level. Curcumin 22-30 mitogen-activated protein kinase 8 Homo sapiens 46-49 9674701-10 1998 Taken together, the inhibition of the MEKK1-JNK pathway reveals a possible mechanism of suppression of AP-1 and NF-kappaB signaling by curcumin, and may explain the potent anti-inflammatory and anti-carcinogenic effects of this chemical. Curcumin 135-143 mitogen-activated protein kinase 8 Homo sapiens 44-47 34407450-7 2022 Interestingly, while not contributing to changes in Smad-mediated TGFbeta signaling, curcumin caused early activation of MAPK signaling in all cell lines, including JNK, an effect possibly involving interactions with TGFbetaR2 within lipid rafts. Curcumin 85-93 mitogen-activated protein kinase 8 Homo sapiens 165-168 34073773-0 2021 GO-Y078, a Curcumin Analog, Induces Both Apoptotic Pathways in Human Osteosarcoma Cells via Activation of JNK and p38 Signaling. Curcumin 11-19 mitogen-activated protein kinase 8 Homo sapiens 106-109 34148046-0 2021 Curcumin Affects Leptin-Induced Expression of Methionine Adenosyltransferase 2A in Hepatic Stellate Cells by Inhibition of JNK Signaling. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 123-126 34148046-10 2021 JNK signaling contributed to leptin-induced increase in MAT2A level, which could be interrupted by curcumin treatment. Curcumin 99-107 mitogen-activated protein kinase 8 Homo sapiens 0-3 35630552-0 2022 Curcumin Derivative C66 Suppresses Pancreatic Cancer Progression through the Inhibition of JNK-Mediated Inflammation. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 91-94 35015114-7 2022 In retinal ischemia reperfusion injury, curcumin downregulates IL-17, IL-23, NFKB, STAT-3, MCP-1 and JNK. Curcumin 40-48 mitogen-activated protein kinase 8 Homo sapiens 101-104 35229255-0 2022 Curcumin alleviates lipopolysaccharides-induced inflammation and apoptosis in vascular smooth muscle cells via inhibition of the NF-kappaB and JNK signaling pathways. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 143-146 35229255-9 2022 Mechanistically, we found that curcumin attenuated LPS-induced cell damage in VSMCs via inhibition of NF-kappaB and the JNK signal pathway. Curcumin 31-39 mitogen-activated protein kinase 8 Homo sapiens 120-123 35229255-10 2022 Curcumin can protect VSMCs from LPS induced inflammatory damage, which may be related to the blocking of NF-kappaB and the JNK signaling pathway. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 123-126 35191177-0 2022 Curcumin analog HO-3867 triggers apoptotic pathways through activating JNK1/2 signalling in human oral squamous cell carcinoma cells. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 71-77 35182412-0 2022 Curcumin Mitigates TNFalpha-Induced Caco-2 Cell Monolayer Permeabilization Through modulation of NF-kappaB, ERK1/2 and JNK Pathways. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 119-122 35182412-6 2022 CONCLUSION: The inhibition of NF-kappaB, ERK1/2 and JNK activation could be in part involved in the capacity of curcumin to mitigate intestinal inflammation, oxidant production, activation of redox-sensitive pathways, and prevention of monolayer permeabilization. Curcumin 112-120 mitogen-activated protein kinase 8 Homo sapiens 52-55 35082487-0 2022 Erratum: Inhibition of JNK Phosphorylation by Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury (Corrigendum). Curcumin 46-54 mitogen-activated protein kinase 8 Homo sapiens 23-26 33907586-13 2021 Subsequent in vivo and in vitro results demonstrated that the JNK, p38 MAPK and ER stress pathways were activated in curcumin-treated ACC cells, and that C/EBP homologous protein induction was responsible for curcumin-induced apoptosis of ACC cells. Curcumin 117-125 mitogen-activated protein kinase 8 Homo sapiens 62-65 33907586-14 2021 In summary, curcumin induced ACC cell apoptosis and inhibited tumour growth by activating the JNK, p38 MAPK and ER stress pathways. Curcumin 12-20 mitogen-activated protein kinase 8 Homo sapiens 94-97 31854220-7 2020 The results of western blotting showed that curcumin treatment inhibited NF-kappaB and ERK signalling while activating p38 and JNK. Curcumin 44-52 mitogen-activated protein kinase 8 Homo sapiens 127-130 33247374-6 2022 In addition, we showed that the phosphorylation levels of ERK1/2, JNK, and P38 were upregulated in apoptotic hUC-MSCs, while curcumin increased the phosphorylation of ERK1/2 but did not activate JNK or P38, and these effects were reversed by the p42/44 antagonist U0126. Curcumin 125-133 mitogen-activated protein kinase 8 Homo sapiens 195-198 32934683-7 2020 Additionally, curcumin and rAd-p53 were demonstrated to regulate the activation of mitogen-activated protein kinases (MAPKs) ERK1/2, p38 MAPK and JNK. Curcumin 14-22 mitogen-activated protein kinase 8 Homo sapiens 146-149 32502496-0 2020 The pivotal role of SUMO-1-JNK-Tau axis in an in vitro model of oxidative stress counteracted by the protective effect of curcumin. Curcumin 122-130 mitogen-activated protein kinase 8 Homo sapiens 27-30 32502496-5 2020 Curcumin, a natural compound with anti-oxidant and anti-inflammatory effects, demonstrated to tackle oxidative stress re-equilibrating SUMO-1, JNK and Tau functions. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 143-146 32502496-8 2020 These results highlight the SUMO-1-JNK-Tau axis key role in oxidative stress and the protective effect of curcumin against this pathological event, focusing on the importance of SUMO/deSUMOylation balance to regulate essential cellular processes. Curcumin 106-114 mitogen-activated protein kinase 8 Homo sapiens 35-38 32370057-0 2020 Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 98-101 31958483-0 2020 The curcumin analogue WZ35 affects glycolysis inhibition of gastric cancer cells through ROS-YAP-JNK pathway. Curcumin 4-12 mitogen-activated protein kinase 8 Homo sapiens 97-100 32107363-13 2020 Moreover, curcumin pre-treatment significantly decreased expression levels of Wnt5a, IL6, TNFalpha, and phosphorylation level of JNK1, as well as the nuclear translocation level of NF-kappaB in H/R-exposed neurons, in a concentration-dependent manner. Curcumin 10-18 mitogen-activated protein kinase 8 Homo sapiens 129-133 32107363-14 2020 CONCLUSIONS Curcumin exerted neuro-protective effects against H/R-induced neuron apoptosis and inflammation by inhibiting activation of the Wnt/JNK1 signaling pathway. Curcumin 12-20 mitogen-activated protein kinase 8 Homo sapiens 144-148 33329788-8 2020 Results: Curcumin attenuated expression of TNF-alpha, IL-6, and IL-8 and the phosphorylation levels of p38 and JNK, but not ERK1/2, in LPS-stimulated neutrophils. Curcumin 9-17 mitogen-activated protein kinase 8 Homo sapiens 111-114 31703744-0 2019 Curcumin derivative WZ35 inhibits tumor cell growth via ROS-YAP-JNK signaling pathway in breast cancer. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 64-67 31172987-6 2019 WZ35, a novel curcumin derivative, exhibits potential anti-tumor activity in gastric cancer cells by regulating ROS dependent JNK activation and ER stress. Curcumin 14-22 mitogen-activated protein kinase 8 Homo sapiens 126-129 31143210-17 2019 Conclusions: Our results demonstrate that curcumin showed an obvious protective effect on PDS-induced EMT of HMrSV5 cells and suggest implication of the TAK1, p38 and JNK pathway in mediating the effects of curcumin in EMT of MCs. Curcumin 42-50 mitogen-activated protein kinase 8 Homo sapiens 167-170 31143210-17 2019 Conclusions: Our results demonstrate that curcumin showed an obvious protective effect on PDS-induced EMT of HMrSV5 cells and suggest implication of the TAK1, p38 and JNK pathway in mediating the effects of curcumin in EMT of MCs. Curcumin 207-215 mitogen-activated protein kinase 8 Homo sapiens 167-170 33168498-5 2018 Western blotting showed that treatment of the siRNA-transfected SHI-1 cells with 0-25 mumol/L curcumin or with 0-2.0 mumol/L Ara-C further increased the cell inhibition rate and obviously enhanced the expressions of p-P38 MAPK and p-JNK without significantly affecting p-ERK expression. Curcumin 94-102 mitogen-activated protein kinase 8 Homo sapiens 233-236 29766185-0 2018 The curcumin derivative WZ35 activates ROS-dependent JNK to suppress hepatocellular carcinoma metastasis. Curcumin 4-12 mitogen-activated protein kinase 8 Homo sapiens 53-56 29485738-0 2018 Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 54-57 29485738-9 2018 Curcumin inhibited JNK pathway and repressed H3K4me3 in LNCaP cells. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 19-22 29485738-11 2018 In conclusion, curcumin inhibits JNK pathway and plays a role in epigenetic regulation of prostate cancer cells by repressing H3K4me3. Curcumin 15-23 mitogen-activated protein kinase 8 Homo sapiens 33-36 29793316-0 2018 Curcumin suppresses JNK pathway to attenuate BPA-induced insulin resistance in LO2 cells. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 20-23 29793316-6 2018 Furthermore, curcumin downregulated the activation of p38, JNK, and NF-kappaB pathways upon stimulation with BPA. Curcumin 13-21 mitogen-activated protein kinase 8 Homo sapiens 59-62 29793316-8 2018 CONCLUSION: Curcumin inhibits BPA-induced insulin resistance by suppressing JNK pathway. Curcumin 12-20 mitogen-activated protein kinase 8 Homo sapiens 76-79 28684236-9 2017 Curcumin protected adipocytes from hypoxia induced inflammation and insulin resistance via reducing inflammatory adipokine, nuclear factor-kappaB (NF-kappaB)/c-jun N-terminal kinase (JNK) and serine phosphorylation of IRS-1 receptors and improving adiponectin secretion. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 183-186 28684422-0 2017 WITHDRAWN: Curcumin shifts RAS-induced pro-proliferative MEK/ERK-signaling toward pro-apoptotic p38MAPK/JNK1-signaling, triggering p53 activation and apoptosis. Curcumin 11-19 mitogen-activated protein kinase 8 Homo sapiens 104-108 28672972-0 2017 JNK pathway mediates curcumin-induced apoptosis and autophagy in osteosarcoma MG63 cells. Curcumin 21-29 mitogen-activated protein kinase 8 Homo sapiens 0-3 28672972-5 2017 Notably, inhibition of apoptosis enhanced curcumin-induced autophagy due to upregulation of the c-Jun N-terminal kinase (JNK) signaling pathway. Curcumin 42-50 mitogen-activated protein kinase 8 Homo sapiens 96-119 28672972-5 2017 Notably, inhibition of apoptosis enhanced curcumin-induced autophagy due to upregulation of the c-Jun N-terminal kinase (JNK) signaling pathway. Curcumin 42-50 mitogen-activated protein kinase 8 Homo sapiens 121-124 28300666-0 2017 Curcumin attenuates BPA-induced insulin resistance in HepG2 cells through suppression of JNK/p38 pathways. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 89-92 28300666-7 2017 Moreover, we revealed that curcumin effectively attenuated the spectrum of effects of BPA-triggered insulin resistance, whereas pretreatment with JNK and p38 agonist anisomycin could significantly compensate the effects caused by curcumin. Curcumin 230-238 mitogen-activated protein kinase 8 Homo sapiens 146-149 28377722-10 2017 Atg5-knockdown also abolished the beneficial effects of curcumin on palmitate-induced ER stress, JNK/IRS-1 pathway as well as insulin signaling. Curcumin 56-64 mitogen-activated protein kinase 8 Homo sapiens 97-100 28377722-11 2017 Our results reveal that curcumin-activated autophagy could maintain proteostasis in ER leading to attenuation of ER stress and subsequent inhibition of JNK/IRS-1 pathway and improvement of insulin resistance. Curcumin 24-32 mitogen-activated protein kinase 8 Homo sapiens 152-155 27580989-0 2016 Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 131-134 27580989-9 2016 The ERK1/2 and SAPK/JNK and their downstream molecules including P90RSK and c-Jun, respectively, were activated by curcumin. Curcumin 115-123 mitogen-activated protein kinase 8 Homo sapiens 20-23 27580989-10 2016 Moreover, pharmacological inhibitors of ERK1/2 (U0126) and SAPK/JNK (SP600125) suppressed ERK1/2 and SAPK/JNK activation respectively, and blockage of P38 MAPK by its inhibitor (SB203580) had a synergistic effect with curcumin. Curcumin 218-226 mitogen-activated protein kinase 8 Homo sapiens 64-67 27580989-11 2016 These results indicate that curcumin acts as a novel chemotherapeutic agent on human placental choriocarcinoma cells via activation of ERK1/2 and SAPK/JNK signal transduction cascades. Curcumin 28-36 mitogen-activated protein kinase 8 Homo sapiens 151-154 27432244-0 2016 Curcumin exerts antitumor effects in retinoblastoma cells by regulating the JNK and p38 MAPK pathways. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 76-79 27432244-8 2016 We also found that curcumin induced the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK). Curcumin 19-27 mitogen-activated protein kinase 8 Homo sapiens 59-82 27432244-8 2016 We also found that curcumin induced the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK). Curcumin 19-27 mitogen-activated protein kinase 8 Homo sapiens 84-87 27432244-9 2016 JNK and p38 MAPK inhibitors significantly suppressed curcumin-induced activation of caspases-9/-3 and inhibited the apoptosis of Y79 cells. Curcumin 53-61 mitogen-activated protein kinase 8 Homo sapiens 0-3 27432244-10 2016 Taken together, our results suggest that curcumin induced the apoptosis of Y79 cells through the activation of JNK and p38 MAPK pathways. Curcumin 41-49 mitogen-activated protein kinase 8 Homo sapiens 111-114 26134921-7 2016 The results of PCR and Western blotting showed that curcumin increased the FasL mRNA level; inhibited Bcl-2, NF-kappaB, and ERK expression; and activated P38 MAPK, JNK, and caspase-3. Curcumin 52-60 mitogen-activated protein kinase 8 Homo sapiens 164-167 26134921-9 2016 DISCUSSION AND CONCLUSION: This study demonstrates that curcumin not only induces SHI-1 cell apoptosis, possibly via both intrinsic and extrinsic pathways triggered by JNK, P38 MAPK and ERK signaling, but also partially suppresses SHI-1 cell invasion, likely by reducing the levels of transcription and secretion of MMP-2 and MMP-9. Curcumin 56-64 mitogen-activated protein kinase 8 Homo sapiens 168-171 26945822-8 2016 In conclusion, this curcumin derivative attenuates liver fibrosis likely involving a CB/JNK/NF-kappaB-mediated pathway. Curcumin 20-28 mitogen-activated protein kinase 8 Homo sapiens 88-91 27106025-0 2016 c-Jun N-terminal kinase-dependent apoptotic photocytotoxicity of solvent exchange-prepared curcumin nanoparticles. Curcumin 91-99 mitogen-activated protein kinase 8 Homo sapiens 0-23 26833194-9 2016 Moreover, inhibition of Abl through ST571 treatment and its downstream effector JNK through SP600125 treatment blocked GADD45alpha upregulation and cell death triggered by curcumin. Curcumin 172-180 mitogen-activated protein kinase 8 Homo sapiens 80-83 26833194-10 2016 Collective results lead us to conclude that GADD45alpha modulates curcumin sensitivity through activation of c-Abl > JNK signaling in a mismatch repair-dependent manner. Curcumin 66-74 mitogen-activated protein kinase 8 Homo sapiens 120-123 26707143-0 2016 Curcumin enhances the antitumor effect of ABT-737 via activation of the ROS-ASK1-JNK pathway in hepatocellular carcinoma cells. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 81-84 26261481-0 2015 Curcumin inhibits cell proliferation and promotes apoptosis in human osteoclastoma cell through MMP-9, NF-kappaB and JNK signaling pathways. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 117-120 26261481-7 2015 Firstly, MMP-9, NF-kappaB and JNK inhibitors were added into GCT cells and which was researched the mechanism of curcumin on human GCT cells. Curcumin 113-121 mitogen-activated protein kinase 8 Homo sapiens 30-33 26261481-9 2015 Furthermore, curcumin inhibited the MMP-9 gene expression quantity and NF-kappaB activity, and activated JNK protein expression in GCT cells. Curcumin 13-21 mitogen-activated protein kinase 8 Homo sapiens 105-108 26261481-11 2015 Interesting, down-regulation of JNK protein expression could also reversed the anti-cancer effect of curcumin on cell viability of GCT cells. Curcumin 101-109 mitogen-activated protein kinase 8 Homo sapiens 32-35 26261481-12 2015 Taken together, our results suggest that curcumin inhibits cell proliferation and promotes apoptosis in osteoclastoma cell through suppression of MMP-9 and NF-kappaB, and activation JNK signaling pathways. Curcumin 41-49 mitogen-activated protein kinase 8 Homo sapiens 182-185 25792385-11 2015 Furthermore, we observed that curcumin increased DUSP-2 protein expression and decreased the phosphorylation of ERK and JNK. Curcumin 30-38 mitogen-activated protein kinase 8 Homo sapiens 120-123 25792385-12 2015 CONCLUSION: Our results suggest that low-dose curcumin may enhance the radiosensitivity of human glioma U87 cells in vitro by inducing G2/M cell cycle arrest through up-regulation of DUSP-2 expression and inhibition of ERK and JNK phosphorylation. Curcumin 46-54 mitogen-activated protein kinase 8 Homo sapiens 227-230 25998190-11 2015 Furthermore, curcumin significantly inhibited the phosphorylation of ERK, JNK, p38, and nuclear factor (NF)-kappaB. Curcumin 13-21 mitogen-activated protein kinase 8 Homo sapiens 74-77 25998190-12 2015 In contrast, SiTLR4 in combination with p-JNK, p-ERK, and p-p38 inhibition reduced the effect of curcumin on polarization. Curcumin 97-105 mitogen-activated protein kinase 8 Homo sapiens 42-45 25310360-8 2014 Curcumin also decreased the phosphorylation of JNK and p38 that were induced by P19. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 47-50 25310360-10 2014 These data suggest that curcumin may protect macrophages from P19-induced cell apoptosis via a TLR2-mediated JNK-dependent pathway. Curcumin 24-32 mitogen-activated protein kinase 8 Homo sapiens 109-112 25064633-0 2014 Curcumin inhibits monocyte chemoattractant protein-1 expression and enhances cholesterol efflux by suppressing the c-Jun N-terminal kinase pathway in macrophage. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 115-138 25064633-8 2014 Curcumin suppressed the phosphorylation of JNK and activation of NF-kappaB. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 43-46 25064633-11 2014 CONCLUSION: Curcumin suppresses MCP-1 production induced by ox-LDL via the JNK pathway and NK-kappaB pathway, while enhances cholesterol efflux in macrophage via suppressing the JNK pathway and activating the LXR-ABCA1/SR-BI pathway, which indicate that the vascular protective effect of curcumin is related to anti-inflammation and anti-atherosclerosis. Curcumin 12-20 mitogen-activated protein kinase 8 Homo sapiens 75-78 25064633-11 2014 CONCLUSION: Curcumin suppresses MCP-1 production induced by ox-LDL via the JNK pathway and NK-kappaB pathway, while enhances cholesterol efflux in macrophage via suppressing the JNK pathway and activating the LXR-ABCA1/SR-BI pathway, which indicate that the vascular protective effect of curcumin is related to anti-inflammation and anti-atherosclerosis. Curcumin 12-20 mitogen-activated protein kinase 8 Homo sapiens 178-181 25198898-0 2014 Curcumin induced human gastric cancer BGC-823 cells apoptosis by ROS-mediated ASK1-MKK4-JNK stress signaling pathway. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 88-91 25198898-5 2014 Notably, we observed that curcumin activated ASK1, a MAPKKK that is oxidative stress sensitive and responsible to phosphorylation of JNK via triggering cascades, up-regulated an upstream effector of the JNK, MKK4, and phosphorylated JNK protein expression in BGC-823 cells. Curcumin 26-34 mitogen-activated protein kinase 8 Homo sapiens 133-136 25198898-5 2014 Notably, we observed that curcumin activated ASK1, a MAPKKK that is oxidative stress sensitive and responsible to phosphorylation of JNK via triggering cascades, up-regulated an upstream effector of the JNK, MKK4, and phosphorylated JNK protein expression in BGC-823 cells. Curcumin 26-34 mitogen-activated protein kinase 8 Homo sapiens 203-206 25198898-5 2014 Notably, we observed that curcumin activated ASK1, a MAPKKK that is oxidative stress sensitive and responsible to phosphorylation of JNK via triggering cascades, up-regulated an upstream effector of the JNK, MKK4, and phosphorylated JNK protein expression in BGC-823 cells. Curcumin 26-34 mitogen-activated protein kinase 8 Homo sapiens 203-206 25198898-6 2014 However, curcumin induced ASK1-MKK4-JNK signaling was attenuated by NAC. Curcumin 9-17 mitogen-activated protein kinase 8 Homo sapiens 36-39 25198898-7 2014 All the findings confirm the possibility that oxidative stress-activated ASK1-MKK4-JNK signaling cascade promotes the apoptotic response in curcumin-treated BGC-823 cells. Curcumin 140-148 mitogen-activated protein kinase 8 Homo sapiens 83-86 24382451-9 2014 Curcumin, a compound with both anti-oxidant and JNK inhibitory properties, specifically protects axons, but not neuronal cell bodies, from NO-mediated degeneration. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 48-51 24052408-3 2014 Here we report that two ROS generating phytochemicals, hydroxychavicol and curcumin synergize in leukemic cells in inducing enhanced apoptosis by independently activating both mitogen activated protein kinase (MAPK) (JNK and P(38)) and mTOR pathways. Curcumin 75-83 mitogen-activated protein kinase 8 Homo sapiens 217-220 24369247-5 2013 Treatment of Jurkat cells with 25, 50, and 75 micromol/L curcumin resulted in a concentration-dependent increase of JNK and p-JNK expressions (P<0.01) without significantly affecting the expressions of ERK1/2 and P38 MAPK or the activity of MMP-2 and MMP-9. Curcumin 57-65 mitogen-activated protein kinase 8 Homo sapiens 116-119 24369247-5 2013 Treatment of Jurkat cells with 25, 50, and 75 micromol/L curcumin resulted in a concentration-dependent increase of JNK and p-JNK expressions (P<0.01) without significantly affecting the expressions of ERK1/2 and P38 MAPK or the activity of MMP-2 and MMP-9. Curcumin 57-65 mitogen-activated protein kinase 8 Homo sapiens 126-129 24369247-6 2013 CONCLUSION: Curcumin within the concentration range of 6.25-25.00 micromol/L can induce apoptosis and cell cycle arrest of Jurkat cells, the mechanism of which might involve the activation of JNK pathway but not the MMPs. Curcumin 12-20 mitogen-activated protein kinase 8 Homo sapiens 192-195 24134840-0 2013 MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells. Curcumin 19-27 mitogen-activated protein kinase 8 Homo sapiens 37-40 24134840-5 2013 c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation. Curcumin 52-60 mitogen-activated protein kinase 8 Homo sapiens 0-31 24134840-5 2013 c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation. Curcumin 52-60 mitogen-activated protein kinase 8 Homo sapiens 33-36 24134840-5 2013 c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation. Curcumin 52-60 mitogen-activated protein kinase 8 Homo sapiens 156-159 24134840-5 2013 c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation. Curcumin 139-147 mitogen-activated protein kinase 8 Homo sapiens 0-31 24134840-5 2013 c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation. Curcumin 139-147 mitogen-activated protein kinase 8 Homo sapiens 33-36 24134840-5 2013 c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation. Curcumin 139-147 mitogen-activated protein kinase 8 Homo sapiens 156-159 24134840-7 2013 In conclusion, we suggested that MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells. Curcumin 52-60 mitogen-activated protein kinase 8 Homo sapiens 70-73 23881281-4 2013 Meanwhile, curcumin induced endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells. Curcumin 11-19 mitogen-activated protein kinase 8 Homo sapiens 202-205 23881281-5 2013 Overexpression of bax, total JNK, phospho-FADD and total FADD were also observed in curcumin-treated HT-29 cells. Curcumin 84-92 mitogen-activated protein kinase 8 Homo sapiens 29-32 23609161-0 2013 Curcumin inhibits TGFbeta1-induced CCN2 via Src, JNK, and Smad3 in gingiva. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 49-52 23609161-8 2013 We further found that curcumin significantly abrogated the TGFbeta1-induced CCN2 in HGFs by inhibiting the phosphorylations of Src, JNK, and Smad3. Curcumin 22-30 mitogen-activated protein kinase 8 Homo sapiens 132-135 23353183-2 2013 At higher concentrations, curcumin induced ROS production leading to JNK and p38 phosphorylation in DU-145 prostate cancer cells. Curcumin 26-34 mitogen-activated protein kinase 8 Homo sapiens 69-72 23353183-3 2013 Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt, while significant amounts of ROS production in later periods stimulated cell death with caspase degradation. Curcumin 70-78 mitogen-activated protein kinase 8 Homo sapiens 31-34 23353183-3 2013 Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt, while significant amounts of ROS production in later periods stimulated cell death with caspase degradation. Curcumin 115-123 mitogen-activated protein kinase 8 Homo sapiens 31-34 23614750-0 2013 Curcumin inhibits UVB-induced matrix metalloproteinase-1/3 expression by suppressing the MAPK-p38/JNK pathways in human dermal fibroblasts. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 98-101 22324466-0 2012 Curcumin inhibits thrombin-stimulated connective tissue growth factor (CTGF/CCN2) production through c-Jun NH2-terminal kinase suppression in human gingival fibroblasts. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 101-126 22324466-10 2012 Curcumin dose dependently inhibited thrombin-induced CCN2 expression through JNK suppression in HGFs. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 77-80 22324466-12 2012 Curcumin could effectively inhibit CCN2 expression through JNK suppression. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 59-62 22921746-6 2012 Also, curcumin strongly repressed the TPA-induced phosphorylation of p38 and JNK and inhibited TPA-induced translocation of PKCalpha from the cytosol to the membrane, but did not affect the translocation of PKCdelta. Curcumin 6-14 mitogen-activated protein kinase 8 Homo sapiens 77-80 22909087-0 2012 Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity. Curcumin 26-34 mitogen-activated protein kinase 8 Homo sapiens 170-173 22909087-8 2012 Pathway analysis indicated that curcumin did not show involvement of NF-kappaB, but down-regulated TLR2 expression and inhibited the MAP kinase JNK while activating p38 and ERK. Curcumin 32-40 mitogen-activated protein kinase 8 Homo sapiens 144-147 22298641-4 2012 Curcumin rapidly induced activation of the mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase 1/2 (Erk1/2) and c-Jun N-terminal kinase (JNK). Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 150-173 22298641-4 2012 Curcumin rapidly induced activation of the mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase 1/2 (Erk1/2) and c-Jun N-terminal kinase (JNK). Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 175-178 22298641-5 2012 Inhibition of JNK (with SP600125) or Erk1/2 (with U0126) partially prevented curcumin-induced cell death in the cells. Curcumin 77-85 mitogen-activated protein kinase 8 Homo sapiens 14-17 22298641-9 2012 Overexpression of PP2A or PP5 partially prevented curcumin-induced activation of JNK and Erk1/2 phosphorylation as well as cell death. Curcumin 50-58 mitogen-activated protein kinase 8 Homo sapiens 81-84 22443687-9 2012 Inhibitor of JNK and ERK reduced the pro-apoptotic effect of curcumin on THP-1 cells as evidenced by caspase activity and the activation of ERK/JNK/Jun cascades. Curcumin 61-69 mitogen-activated protein kinase 8 Homo sapiens 13-16 22443687-0 2012 Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK pathways. Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 93-96 22443687-8 2012 Curcumin significantly increased the phosphorylation of ERK, JNK and their downstream molecules (c-Jun and Jun B). Curcumin 0-8 mitogen-activated protein kinase 8 Homo sapiens 61-64 22443687-9 2012 Inhibitor of JNK and ERK reduced the pro-apoptotic effect of curcumin on THP-1 cells as evidenced by caspase activity and the activation of ERK/JNK/Jun cascades. Curcumin 61-69 mitogen-activated protein kinase 8 Homo sapiens 144-147 22443687-11 2012 CONCLUSIONS: This study demonstrates that curcumin can induce the THP-1 cell apoptosis through the activation of JNK/ERK/AP1 pathways. Curcumin 42-50 mitogen-activated protein kinase 8 Homo sapiens 113-116 21959977-0 2012 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) facilitates curcumin-induced melanoma cell apoptosis by enhancing ceramide accumulation, JNK activation, and inhibiting PI3K/AKT activation. Curcumin 68-76 mitogen-activated protein kinase 8 Homo sapiens 145-148 22606012-6 2012 These results suggested that curcumin might enhance the cytotoxicity of PS-341 by interacting with NF-kappaB, at least in part, through JNK mechanism. Curcumin 29-37 mitogen-activated protein kinase 8 Homo sapiens 136-139 20385124-5 2010 Further investigation revealed that curcumin-induced down-regulation of EZH2 through stimulation of three major members of the mitogen-activated protein kinase (MAPK) pathway: c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 kinase. Curcumin 36-44 mitogen-activated protein kinase 8 Homo sapiens 176-201 20385124-5 2010 Further investigation revealed that curcumin-induced down-regulation of EZH2 through stimulation of three major members of the mitogen-activated protein kinase (MAPK) pathway: c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 kinase. Curcumin 36-44 mitogen-activated protein kinase 8 Homo sapiens 203-206 20036734-5 2010 ERK2 and JNK activation were positively associated with curcumin-induced cell death. Curcumin 56-64 mitogen-activated protein kinase 8 Homo sapiens 9-12 20230279-3 2010 In this study, we investigated whether curcumin protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP) or 1-methyl-4-phenylpyridnium ion- (MPP(+)) induced dopaminergic neurotoxicity in C57BL/6N mice or SH-SY5Y cells by inhibiting JNK pathways both in vivo and in vitro. Curcumin 39-47 mitogen-activated protein kinase 8 Homo sapiens 245-248 21364631-5 2010 The pivotal role of the JNK/c-Jun/AP-1 pathway for gal-1-induced apoptosis was documented by reduction of DNA fragmentation after inhibition JNK by SP600125 (20 muM) or inhibition of AP-1 activation by curcumin (2 muM). Curcumin 202-210 mitogen-activated protein kinase 8 Homo sapiens 24-27