PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21504136-5 2010 The addition of selective COX2 inhibitors Celebrex and curcumin to the culture medium resulted in a significant and comparable inhibition of PGE2 release, but did not inhibit Abeta42 secretion, and even significantly increased Abeta42 production in this cell system. Curcumin 55-63 mitochondrially encoded cytochrome c oxidase II Homo sapiens 26-30 20200402-2 2010 The PGN-induced COX-2 expression was attenuated by the DNs of ASK1, JNK1, JNK2, a JNK inhibitor (SP600125), and an AP-1 inhibitor (curcumin). Curcumin 131-139 mitochondrially encoded cytochrome c oxidase II Homo sapiens 16-21 19682434-9 2010 Curcumin abolished the constitutive activation of NF-kappaB in the tumor tissue; induced apoptosis, and decreased cyclin D1, VEGF, COX-2, c-myc and Bcl-2 expression in the bladder cancer tissue. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 131-136 19076306-7 2009 In most of the regions examined, histone H3 acetylation peaked 24 h after UVR and then returned to baseline levels by 72 h. The induction of ATF3, COX2 and MKP1 was blocked in the presence of curcumin at doses that decrease in vivo histone H3 acetylation but not at lower doses that do not affect acetylation levels. Curcumin 192-200 mitochondrially encoded cytochrome c oxidase II Homo sapiens 147-151 19191010-7 2009 Curcumin acts as an anti-inflammatory and anti-proliferative agent by causing down regulation of COX-2, iNOS and cyclin D1 in all the three cell lines but to different extent. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 97-102 19623659-0 2009 Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 88-93 19671757-3 2009 Curcumin, a polyphenolic beta-diketone from tumeric with anti-carcinogenic and anti-inflammatory activities, was shown to suppress PGE(2) formation and to block the expression of COX-2 and of microsomal PGE(2) synthase-1. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 179-184 19093868-0 2009 Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 140-145 19250217-6 2009 Furthermore, curcumin or, more potently, the isoxazole analogue, produced early reductions in the amounts of relevant gene transcripts that were diverse (i.e., they were relative to Bcl-2 and Bcl-X(L) in MCF-7 and the inhibitory of apoptosis proteins and COX-2 in MCF-7R) in the two cell lines. Curcumin 13-21 mitochondrially encoded cytochrome c oxidase II Homo sapiens 255-260 19093868-4 2009 Stimulation of AMPK by curcumin resulted in the down-regulation of PPAR (peroxisome proliferator-activated receptor)-gamma in 3T3-L1 adipocytes and the decrease in COX-2 in MCF-7 cells. Curcumin 23-31 mitochondrially encoded cytochrome c oxidase II Homo sapiens 164-169 19093868-7 2009 Regulation of AMPK and its downstream targets such as PPAR-gamma, Mapkinases, and COX-2 by curcumin appears to be important in controlling adipocytes and cancerous cells. Curcumin 91-99 mitochondrially encoded cytochrome c oxidase II Homo sapiens 82-87 17671742-6 2007 Furthermore, curcumin decreased the expression levels of the cyclooxygenase (COX)-2 mRNA and protein without causing significant changes in the COX-1 levels, which was correlated with the inhibition of prostaglandin E(2) synthesis. Curcumin 13-21 mitochondrially encoded cytochrome c oxidase II Homo sapiens 61-83 19519446-13 2009 The inhibitory effects of curcumin on major inflammatory mechanisms like COX-2, LOX, TNF-alpha, IFN-gamma, NF-kappaB and its unrivalled safety profile suggest that it has bright prospects in the treatment of IBD. Curcumin 26-34 mitochondrially encoded cytochrome c oxidase II Homo sapiens 73-78 18549505-13 2008 Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression (IC50 = 2 muM) and a reduction of secreted IL-6 and PGE2 (IC50 ~ 20 muM). Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 128-133 18289124-4 2008 We discovered that the addition of curcumin, a natural COX-2 inhibitor, to celecoxib synergistically (up to 1000%) augments the growth inhibitory effects of celecoxib in in-vitro and in-vivo models of arthritis and cancer, thus rendering effective action of the drug at up to tenfold lower dose. Curcumin 35-43 mitochondrially encoded cytochrome c oxidase II Homo sapiens 55-60 17671737-5 2007 RT-PCR evaluations performed in MCF-7 and MCF-7R showed that curcumin or MR 39 produced early modifications in the amounts of relevant gene transcripts, which, however, were mostly diverse (i.e. represented by decreases in IAPs and COX-2 in MCF-7R versus reductions in Bcl-2 and Bcl-XL as well as increases in the Bcl-XS/Bcl-XL ratio in MCF-7) in the two cell lines. Curcumin 61-69 mitochondrially encoded cytochrome c oxidase II Homo sapiens 232-237 16526022-12 2006 Curcumin also down regulated the expression of COX-2, a gene regulated by NFkappaB. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 47-52 17640567-5 2007 The reducing agent also counteracted the inhibitory effects of curcumin on TNF-induced NF-kappaB-regulated antiapoptotic (Bcl-2, Bcl-xL, IAP1), proliferative (cyclin D1), and proinflammatory (COX-2, iNOS, and MMP-9) gene products. Curcumin 63-71 mitochondrially encoded cytochrome c oxidase II Homo sapiens 192-197 16685393-2 2006 The IFN-alpha-induced COX-2 expression and STAT1 activation were markedly inhibited by the addition of curcumin to the IFN-alpha-pretreated cells. Curcumin 103-111 mitochondrially encoded cytochrome c oxidase II Homo sapiens 22-27 16340194-2 2006 Curcumin, a major yellow pigment in turmeric which is used widely all over the world, inhibits the growth of human colon cancer cell line HT-29 significantly and specifically inhibits the expression of COX-2 protein. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 202-207 16596191-5 2006 Furthermore, curcumin decreased the levels of COX-2 mRNA and protein expression without significant changes in the levels of COX-1, which correlated with a decrease in prostaglandin E2 (PGE2) synthesis. Curcumin 13-21 mitochondrially encoded cytochrome c oxidase II Homo sapiens 46-51 16000872-10 2005 These results collectively suggest that curcumin may inhibit COX- 2 expression by suppressing p38 MAPK and JNK activities in UVB-irradiated HaCaT cells. Curcumin 40-48 mitochondrially encoded cytochrome c oxidase II Homo sapiens 61-67 16005433-0 2005 Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human A549 non-small cell lung cancer cells. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 57-62 16005433-4 2005 Curcumin also inhibited IFN-alpha-induced COX-2 expression in A549 cells. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 42-47 16005433-6 2005 Taken together, IFN-alpha-induced activations of NF-kappaB and COX-2 were inhibited by the addition of curcumin in A549 cells. Curcumin 103-111 mitochondrially encoded cytochrome c oxidase II Homo sapiens 63-68 15911101-7 2005 Curcumin determined early changes in COX-2 and c-myc mRNAs, which were down-regulated, and in livin mRNA, which was up-regulated. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 37-42 15073046-7 2004 Curcumin (20 micro M) significantly inhibited LPS-induced COX-2 expression; this effect, rather than the catalytic inhibition of COX, may contribute to the decreased PGE(2) formation. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 58-63 15073046-8 2004 Without LPS-stimulation, however, curcumin increased the COX-2 level in the macrophage cells. Curcumin 34-42 mitochondrially encoded cytochrome c oxidase II Homo sapiens 57-62 15073046-11 2004 The results suggest that curcumin affects arachidonic acid metabolism by blocking the phosphorylation of cPLA(2), decreasing the expression of COX-2 and inhibiting the catalytic activities of 5-LOX. Curcumin 25-33 mitochondrially encoded cytochrome c oxidase II Homo sapiens 143-148 11751448-2 2001 Curcumin, a polyphenol derived from Curcuma spp., has shown wide-ranging chemopreventive activity in preclinical carcinogenic models, in which it inhibits cyclooxygenase (COX)-2 at the transcriptional level. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 155-177 12807725-0 2003 Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1. Curcumin 10-27 mitochondrially encoded cytochrome c oxidase II Homo sapiens 195-200 14739610-8 2003 To determine that the higher levels of apoptosis in HT29 cells with SC236 >75 microM were related to decreased Cox-2 protein levels, we decreased Cox-2 protein expression in HT29 cells with curcumin (diferuloylmethane) and studied its effect on SC236-induced apoptosis. Curcumin 193-201 mitochondrially encoded cytochrome c oxidase II Homo sapiens 149-154 12807725-0 2003 Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 195-200 11751448-5 2001 When 1 microM curcumin was added in vitro to blood from healthy volunteers, LPS-induced COX-2 protein levels and concomitant PGE(2) production were reduced by 24% and 41%, respectively (P < 0.05 by ANOVA). Curcumin 14-22 mitochondrially encoded cytochrome c oxidase II Homo sapiens 88-93 34355287-5 2021 METHODS: The effect of curcumin and BDMC-A on transcription factors (NF-kappaB, p65, c-Jun, c-Fos, STAT3, 5, PPAR-gamma, beta-catenin, COX-2, MMP-9, VEGF, TIMP-2) involved in signal transduction cascade, invasion, and angiogenesis in Hep-2 cells were quantified using Western blotting and RT-PCR technique. Curcumin 23-31 mitochondrially encoded cytochrome c oxidase II Homo sapiens 135-140 34694468-0 2021 Correction to: Co(II) complexes of curcumin and a ferrocene-based curcuminoid: a study on photo-induced antitumor activity. Curcumin 35-43 mitochondrially encoded cytochrome c oxidase II Homo sapiens 15-21 32328199-0 2020 Synergistic Effects of Curcumin and 5-Fluorouracil on the Hepatocellular Carcinoma In vivo and vitro through regulating the expression of COX-2 and NF-kappaB. Curcumin 23-31 mitochondrially encoded cytochrome c oxidase II Homo sapiens 138-143 32899726-9 2020 Curcumin and CGA together reduced the mRNA expression of pro-inflammatory cytokines [TNF-alpha (~88%) and IL-6 (~99%)], and COX-2 (~92%), possibly by suppression of NF-kappaB (~78%), IkappaB-beta-kinase (~60%) and TLR-4 receptor (~72%) at the mRNA level. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 124-129 33025506-15 2020 Concentration dependent alleviation of chemoresistance development by curcumin was confirmed and was found to reduce gene level expression of P-glycoprotein and Cox-2. Curcumin 70-78 mitochondrially encoded cytochrome c oxidase II Homo sapiens 161-166 32124251-4 2020 Curcumin treatment inhibited the expression of the inflammation mediators IL-6, iNOS, and COX-2 and of the matrix-degrading proteinases MMP-1, MMP-3, MMP-9, MMP-13, ADAMTS-4, and ADAMTS-5 and upregulated the mRNA levels of the cartilage anabolic factors COL2A1 and ACAN after IL-1beta treatment. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 90-95 29961171-7 2018 Overall, curcumin alleviates the airway inflammation and airway remolding, which is closely related to inhibit the BEAS-2B cells proliferation and suppress the activation of NF-kappaB and COX-2 expression. Curcumin 9-17 mitochondrially encoded cytochrome c oxidase II Homo sapiens 188-193 31486959-0 2019 Curcumin and capsaicin modulates LPS induced expression of COX-2, IL-6 and TGF-beta in human peripheral blood mononuclear cells. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 59-64 31486959-2 2019 RT-PCR analysis has shown that the curcumin and capsaicin significantly reduced LPS induced over expression of COX-2, IL-6 and TGF-beta in PBMCs. Curcumin 35-43 mitochondrially encoded cytochrome c oxidase II Homo sapiens 111-116 31486959-4 2019 Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively. Curcumin 24-32 mitochondrially encoded cytochrome c oxidase II Homo sapiens 72-77 31486959-4 2019 Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively. Curcumin 161-169 mitochondrially encoded cytochrome c oxidase II Homo sapiens 72-77 30623450-10 2019 Furthermore, curcumin has a potent inhibitory effect on the activity of NF-kappaB and COX-2, which are involved in the overexpression of antiapoptosis genes such as Bcl-2. Curcumin 13-21 mitochondrially encoded cytochrome c oxidase II Homo sapiens 86-91 31551208-6 2019 The expression levels of COX-2 and MMP-9 were both down-regulated by curcumin. Curcumin 69-77 mitochondrially encoded cytochrome c oxidase II Homo sapiens 25-30 30599890-10 2019 Further investigation of the mechanism of action of curcumin and quercetin in melanoma cells, A375, suggested that inhibition of cell proliferation occurred through down-regulation of Wnt/beta-catenin signaling pathway proteins, DVL2, beta-catenin, cyclin D1, Cox2, and Axin2. Curcumin 52-60 mitochondrially encoded cytochrome c oxidase II Homo sapiens 260-264 32002054-0 2019 Curcumin"s Effect on COX-2 and IL-10 Serum in Preeclampsia"s Patient Undergo Sectio Caesarea with Spinal Anesthesia. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 21-26 32002054-2 2019 Curcumin affects several biological markers that are thought to play a role in the pathogenesis of preeclampsia such as IL-10 and COX-2, resulting in an improvement in pregnant women with preeclampsia. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 130-135 32002054-3 2019 AIM: To see the effect of perioperative curcumin administration on IL-10 and COX-2 in preeclamptic patients undergoing caesarean section under spinal anaesthesia. Curcumin 40-48 mitochondrially encoded cytochrome c oxidase II Homo sapiens 77-82 30760195-4 2019 Omega- 3 fatty acids and curcumin, an active polyphenol of turmeric, have anti-inflammatory and neuroprotective effects through several mechanisms, including the suppression of COX-2 and iNOS gene expression, as well as their serum levels. Curcumin 25-33 mitochondrially encoded cytochrome c oxidase II Homo sapiens 177-182 30760195-9 2019 RESULTS: The results of the present trial showed that omega-3 fatty acids and nano-curcumin can reinforce each other"s effects in the downregulation of COX-2/iNOS mRNA, as well as reduce their serum levels. Curcumin 83-91 mitochondrially encoded cytochrome c oxidase II Homo sapiens 152-157 29225427-0 2017 Molecular docking analysis of curcumin analogues with COX-2. Curcumin 30-38 mitochondrially encoded cytochrome c oxidase II Homo sapiens 54-59 30037344-10 2018 Quantitative real-time PCR analysis revealed that curcumin, but not rapamycin, reduced the levels of inflammatory markers IL-6 and COX-2 in cultured astrocytes that were challenged with IL-1beta. Curcumin 50-58 mitochondrially encoded cytochrome c oxidase II Homo sapiens 131-136 29316620-6 2018 Other phytochemicals such as curcumin, resveratrol, and anthocyanins also inhibit COX2. Curcumin 29-37 mitochondrially encoded cytochrome c oxidase II Homo sapiens 82-86 29866021-8 2018 Activation of NF-kappaB, expression of COX2, HIF-1alpha and cMyc, as well as expression and activity of LDH-A were significantly reduced by curcumin. Curcumin 140-148 mitochondrially encoded cytochrome c oxidase II Homo sapiens 39-43 29225427-1 2017 Curcumin analogues were evaluated for COX-2 inhibitory as anti-inflammatory activities. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 38-43 29225427-5 2017 Molecular docking study revealed the binding orientations of curcumin analogues in the active sites of COX-2 towards the design of potent inhibitors. Curcumin 61-69 mitochondrially encoded cytochrome c oxidase II Homo sapiens 103-108 27010501-0 2016 Evaluation of the anti-inflammatory action of curcumin analog (DM1): Effect on iNOS and COX-2 gene expression and autophagy pathways. Curcumin 46-54 mitochondrially encoded cytochrome c oxidase II Homo sapiens 88-93 27667581-4 2017 The stability of the complexes of COX-1, COX-2, Topo I, Topo IIbeta and aromatase with the most potent inhibitor curcumin and those of the respective drugs, namely ibuprofen, aspirin, topotecan, etoposide, and exemestane were also analyzed through MD simulation analyses which revealed better stability of curcumin complexes than those of respective drugs. Curcumin 113-121 mitochondrially encoded cytochrome c oxidase II Homo sapiens 41-46 27267893-2 2016 We investigated the effectiveness of curcumin, a potent inhibitor of NF-kappaB/COX-2, molecules perturbed in oral carcinogenesis, to treat leukoplakia. Curcumin 37-45 mitochondrially encoded cytochrome c oxidase II Homo sapiens 79-84 29180881-0 2017 Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-kappaB/COX-2 signaling pathways. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 122-127 29180881-7 2017 Further, curcumin and ACNU acted synergistically in their antitumor effects by targeting N-cadherin/MMP2/9, PI3K/AKT, and NF-kappaB/COX-2 signaling. Curcumin 9-17 mitochondrially encoded cytochrome c oxidase II Homo sapiens 132-137 29151957-0 2017 Curcumin Enhances the Anticancer Effect Of 5-fluorouracil against Gastric Cancer through Down-Regulation of COX-2 and NF- kappaB Signaling Pathways. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 108-113 29151957-11 2017 Furthermore, the protein expressions of COX-2 and NF-kappaB in MKN45 cells were decreased by 44.79% and 37.67%, 47.17% and 48.21%, 60.21% and 62.44%, respectively, after treatment of curcumin (25 mumol/l) and 5-FU (50 mumol/l) alone or in combination for 48 h. Curcumin also enhanced the anticancer activity of 5-FU without increasing toxicity in nude mice bearing MKN45 tumor xenografts in vivo. Curcumin 183-191 mitochondrially encoded cytochrome c oxidase II Homo sapiens 40-45 29151957-11 2017 Furthermore, the protein expressions of COX-2 and NF-kappaB in MKN45 cells were decreased by 44.79% and 37.67%, 47.17% and 48.21%, 60.21% and 62.44%, respectively, after treatment of curcumin (25 mumol/l) and 5-FU (50 mumol/l) alone or in combination for 48 h. Curcumin also enhanced the anticancer activity of 5-FU without increasing toxicity in nude mice bearing MKN45 tumor xenografts in vivo. Curcumin 261-269 mitochondrially encoded cytochrome c oxidase II Homo sapiens 40-45 28810535-8 2017 In addition, curcumin enhanced radiosensitivity was through markedly inhibiting IR-induced NF-kappaB signaling by modulating the related protein expressions including NF-kappaBP65, I-kappaB, VEGF, COX2, and Bcl-2 in ACHN cells, which was further strengthened by NF-kappaB inhibitor PDTC treatment. Curcumin 13-21 mitochondrially encoded cytochrome c oxidase II Homo sapiens 197-201 28849163-0 2017 Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKbeta/NF-kappaB/COX-2 signaling pathway. Curcumin 46-54 mitochondrially encoded cytochrome c oxidase II Homo sapiens 87-92 28676971-6 2017 Elevated ROS also increased the expression of COX-2 and APE1 enzymes and pretreatment of Curcumin and Quercetin decreased COX-2 expression and increased APE1 expression in the oxidatively stressed U-87 MG cells. Curcumin 89-97 mitochondrially encoded cytochrome c oxidase II Homo sapiens 122-127 28199187-8 2017 Interestingly, the combined treatment with curcumin and docetaxel modulates the expression of RTKs, PI3K, phospho-AKT, NF-kappa B, p53, and COX-2. Curcumin 43-51 mitochondrially encoded cytochrome c oxidase II Homo sapiens 140-145 27677346-8 2017 In addition, curcumin and IFN-beta/RA combination inhibited the expression of COX-2 and up-regulated GADD153. Curcumin 13-21 mitochondrially encoded cytochrome c oxidase II Homo sapiens 78-83 27128654-6 2017 Curcumin and its analogues significantly inhibited VEGF-A synthesis and secretion in both cell lines in association with loss of HIF-1alpha, COX-2, and p-STAT-3 expression. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 141-146 26691217-9 2016 Induction of CUGBP2 expression by curcumin resulted in the downregulation of HO-1 and COX-2 and strongly sensitized tumor cells to GEM treatment. Curcumin 34-42 mitochondrially encoded cytochrome c oxidase II Homo sapiens 86-91 24058438-9 2013 Treatment with salubrinal, MG132 and COX2 inhibitor, like curcumin, prevented the replication of RSV and the epithelial responses, and treatment with salubrinal and MG132 enhanced the upregulation of tight junction molecules induced by infection with RSV. Curcumin 58-66 mitochondrially encoded cytochrome c oxidase II Homo sapiens 37-41 25497868-6 2015 Significant inhibition of VEGF, angiopoietin 1, angiopoietin 2, platelet derived growth factor, COX-2, and TGFbeta secretion was observed in PC cell lines treated with UBS109, EF31 or curcumin. Curcumin 184-192 mitochondrially encoded cytochrome c oxidase II Homo sapiens 96-101 25497868-9 2015 Finally, we demonstrate for the first time that curcumin analogues EF31 and UBS109 induce the downregulation of HIF-1alpha, Hsp90, COX-2 and VEGF in tumor samples from xenograft models compared to untreated xenografts. Curcumin 48-56 mitochondrially encoded cytochrome c oxidase II Homo sapiens 131-136 24058438-7 2013 Curcumin also has wide pharmacokinetic effects as an inhibitor of NF-kappaB, eIF-2alpha dephosphorylation, proteasome and COX2. Curcumin 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 122-126 24910117-5 2014 Western blot assay data demonstrated that curcumin inhibited phosphorylation of PI3K and Akt signaling pathways and subsequently attenuated MMP1/7 and COX-2 protein expressions in FTC133. Curcumin 42-50 mitochondrially encoded cytochrome c oxidase II Homo sapiens 151-156 23042094-8 2012 Treatment of the cells with curcumin and siRNA-based knockdown of CXCL1 and -2 induce apoptosis, inhibit proliferation and downregulate several important metastasis-promoting factors like COX2, SPARC and EFEMP. Curcumin 28-36 mitochondrially encoded cytochrome c oxidase II Homo sapiens 188-192 22483553-3 2012 Several pathways and specific targets including NF-kappaB, STAT3, COX-2, Akt and multidrug resistant protein have been identified to facilitate curcumin as a chemosensitizer. Curcumin 144-152 mitochondrially encoded cytochrome c oxidase II Homo sapiens 66-71 20883815-7 2011 Up-regulation of Cyclin-D1, Cox-2, XIAP and cIAP1 and phosphorylation of MAPKs, were completely inhibited on inactivation of NF-kappaB assigning a key regulatory role to NF-kappaB in the synergistic effect of paclitaxel and curcumin. Curcumin 224-232 mitochondrially encoded cytochrome c oxidase II Homo sapiens 28-33