PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26357462-6 2015 The presence of an ester linkage between the phenolic rings in (-)-epigallocatechin-3-gallate (EGCG) and the alkyl chain in curcumin allows them to orient in the active site of the HMGR and bind to the catalytic residues. Curcumin 124-132 high mobility group AT-hook 1 Homo sapiens 181-185 26357462-7 2015 EGCG and curcumin showed binding to the active site residues with a low GRID score, which may be a potential inhibitor of HMGR. Curcumin 9-17 high mobility group AT-hook 1 Homo sapiens 122-126 26170618-8 2015 The results indicated that curcumin and salvianolic acid C can effectively inhibit hHMGR, with IC50 (half maximal inhibitory concentration) values of 4.3 microM and 8 microM, respectively. Curcumin 27-35 high mobility group AT-hook 1 Homo sapiens 83-88