PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34806141-0 2022 Curcumin induces apoptosis through caspase dependent pathway in human colon carcinoma cells. Curcumin 0-8 caspase 8 Homo sapiens 35-42 33000266-12 2020 Additionally, the mRNA and protein levels of apoptosis-associated proteins (Fas, FADD, caspase-8 and caspase-3) and E-cadherin in HCT-116 cells were upregulated following treatment with curcumin in a dose-dependent manner. Curcumin 186-194 caspase 8 Homo sapiens 87-96 35431006-5 2022 In addition, HN5 cells were also treated with curcumin to evaluate its effect on the caspase-8, -9, Bcl-2, Bax, and Stat3 genes expression. Curcumin 46-54 caspase 8 Homo sapiens 85-98 31074052-4 2019 In the present study, we examined the effect of curcumin on the gene expression of caspase-8, caspase-10, and anti-apoptotic protein c-FLIP, in HAM/TSP patients. Curcumin 48-56 caspase 8 Homo sapiens 83-92 31569380-9 2019 Results showed the viability of preadipocytes was significantly decreased by treatment with 30 microM curcumin, a concentration that caused apoptosis in preadipocytes, as assessed by the TUNEL assay, and caused activation of caspases 8, 9, and 3. Curcumin 102-110 caspase 8 Homo sapiens 225-245 31602860-7 2019 Moreover,curcumin could inhibit the migration and invasion of MKN45 cells,downregulate the expression of N-cadherin,snail1,Wnt3 a,p-beta-catenin,p-LRP6 and Bcl-2,and upregulate the expression of E-cadherin and Bax,it could increase the activity of caspase-3,caspase-8,caspase-9 and induce apoptosis as well. Curcumin 9-17 caspase 8 Homo sapiens 258-267 31275848-7 2019 Curcumin induces apoptosis in B-Pre-ALL cell lines via activation of caspase-8 and truncation of BID. Curcumin 0-8 caspase 8 Homo sapiens 69-78 27779649-11 2016 Curcumin alone and combined with paclitaxel increased p53, Bid, caspase-3, caspase-8 and Bax gene expression in MDA-MB-231, whereas Bcl-xL decreased such expression in MDA-MB-231 cells. Curcumin 0-8 caspase 8 Homo sapiens 75-84 28927092-7 2017 The rate of apoptosis, caspase-3/caspase-8 activity and the expression of Bax were significantly increased, whereas Bcl-2 expression was significantly reduced following treatment with curcumin and/or FP, compared with the untreated control group. Curcumin 184-192 caspase 8 Homo sapiens 33-42 28927092-9 2017 Therefore, curcumin may enhance the anticancer effects of FP chemotherapy in MGC-803 cells through the promotion of apoptosis via the caspase-3/caspase-8, Bcl-2 and Bax signaling pathways. Curcumin 11-19 caspase 8 Homo sapiens 144-153 28056970-6 2017 In vitro experiments demonstrated that curcumin treatment could reverse the up-regulation of active forms of caspase-3 and caspase-8, and down-regulation of bcl-2 induced by alcohol treatment. Curcumin 39-47 caspase 8 Homo sapiens 123-132 25262359-0 2015 Curcumin induces apoptosis through mitochondrial pathway and caspases activation in human melanoma cells. Curcumin 0-8 caspase 8 Homo sapiens 61-69 27082017-7 2016 Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB. Curcumin 23-31 caspase 8 Homo sapiens 278-287 26802648-8 2016 In conclusion, curcumin may act synergistically with the chemotherapeutic regimen FOLFOX in gastric cancer in vitro and in vivo by inducing apoptosis via Bcl/Bax-caspase 8,9-caspase 3 pathway. Curcumin 15-23 caspase 8 Homo sapiens 162-171 26232616-0 2015 Ceramide generation during curcumin-induced apoptosis is controlled by crosstalk among Bcl-2, Bcl-xL, caspases and glutathione. Curcumin 27-35 caspase 8 Homo sapiens 102-110 26232616-5 2015 These data place nSMase activation downstream of caspase-8 and Bcl-xL and indicate a mutual regulation between nSMase and caspase-3 activity on one hand, and Bcl-2 level on the other hand in curcumin-treated cells. Curcumin 191-199 caspase 8 Homo sapiens 49-58 26299580-5 2015 Mechanistic studies showed that anticancer activity of curcumin is associated with decrease in migration of HNSCC and associated angiogenesis through activating of intrinsic apoptotic pathway (caspase-9) and extrinsic apoptotic pathway (caspase-8). Curcumin 55-63 caspase 8 Homo sapiens 237-246 25262359-10 2015 During curcumin treatment, caspase-8 and Caspase-3 were cleaved in time and dose-dependent manners. Curcumin 7-15 caspase 8 Homo sapiens 27-36 24604218-9 2014 The curcumin- or EF-24-induced apoptosis in the Saos2 cells was mediated by the expression of Fas and activation of caspase-8, caspase-3 and poly(ADP-ribose) polymerase. Curcumin 4-12 caspase 8 Homo sapiens 116-125 22101335-4 2011 Knockdown experiments and knockout cells excluded a role of caspase-8 in curcumin-induced caspase-3 activation. Curcumin 73-81 caspase 8 Homo sapiens 60-69 23451189-9 2013 Curcumin potentiated 5-FU-induced expression or cleavage of pro-apoptotic proteins (caspase-8, -9, -3, PARP and Bax), and down-regulated anti-apoptotic (Bcl-xL) and proliferative (cyclin D1) proteins. Curcumin 0-8 caspase 8 Homo sapiens 84-101 24966519-8 2014 Out of all the selected compounds, rosmarinic acid and curcumin proved to be the most potent inhibitors of Caspase-8 with binding energy (DeltaG) of -7.10 Kcal/mol and -7.08 Kcal/mol, respectively. Curcumin 55-63 caspase 8 Homo sapiens 107-116 24716979-0 2014 Curcumin inhibits MHCC97H liver cancer cells by activating ROS/TLR-4/caspase signaling pathway. Curcumin 0-8 caspase 8 Homo sapiens 69-76 23794119-13 2013 Curcumin effect was mediated through activation of TNFR, CASP 8, CASP3, BID, BAX, and down-regulation of NFkappaB, NDRG 1, and BCL2L10 genes. Curcumin 0-8 caspase 8 Homo sapiens 57-63 22653966-3 2012 Curcumin induces the activation of caspase-8, -2, and -9, alteration of mitochondrial membrane potential, release of cytochrome c, and activation of caspase-3 and concomitant PARP cleavage, but the addition of caspase inhibitors only partially blocked the curcumin-mediated apoptosis. Curcumin 0-8 caspase 8 Homo sapiens 35-56 21282356-5 2011 Curcumin-mediated ER stress via inhibiting the activity of SERCA2 caused increasing expressions of CHOP and its transcription target death receptor 5 (TRAIL-R2), leading to a caspase-3 and caspase-8 cascade-dependent apoptosis in SW872 cells in vitro and in vivo. Curcumin 0-8 caspase 8 Homo sapiens 189-198 21616659-8 2011 MMC and curcumin together synergistically enhanced apoptosis in MCF-7 cells and the apoptosis most likely resulted from both the activation of caspases and modulation of bcl-2/bax expression. Curcumin 8-16 caspase 8 Homo sapiens 143-151 21347788-7 2011 Finally, we found that knocking down GRP78 causes resistance to curcumin treatment through the suppression of caspase-3 and caspase-8 expression levels. Curcumin 64-72 caspase 8 Homo sapiens 124-133 20958191-8 2010 Curcumin inhibited RPE cell increase exclusively by inducing caspase 3/7-dependent but caspase 8-independent cell death and necrosis. Curcumin 0-8 caspase 8 Homo sapiens 87-96 20661831-5 2010 Early stage of curcumin/carnosic acid-induced apoptosis was associated with cleavage (activation) of caspase-8, caspase-9, and caspase-3 and the proapoptotic protein Bid, but not with oxidative stress or altered levels of other Bcl-2 family proteins (Bcl-2, Bcl-xl, Mcl-1, Bax, and Bak). Curcumin 15-23 caspase 8 Homo sapiens 101-110 20651361-9 2010 Curcumin-induced apoptosis was also stimulated through the FAS/caspase-8 (extrinsic) pathway and ER stress proteins, growth arrest- and DNA damage-inducible gene 153 (GADD153) and glucose-regulated protein 78 (GRP78) were activated in the NCI-H460 cells. Curcumin 0-8 caspase 8 Homo sapiens 63-72 20651361-10 2010 Apoptotic cell death induced by curcumin was significantly reversed by pretreatment with ROS scavenger or caspase-8 inhibitor. Curcumin 32-40 caspase 8 Homo sapiens 106-115 20358476-6 2010 Caspase-3, caspase-8, and caspase-9 were activated, and cytochrome c and apoptosis-inducing factor (AIF) were released from mitochondria following curcumin treatment. Curcumin 147-155 caspase 8 Homo sapiens 11-20 20661831-7 2010 Caspase-8 inhibition abrogated Bid cleavage and strongly reduced caspase-9 activation, suggesting that the cross-talk mechanism mediated by caspase-8-dependent Bid cleavage can contribute to the activation of the intrinsic apoptotic pathway by curcumin + carnosic acid. Curcumin 244-252 caspase 8 Homo sapiens 0-9 20661831-7 2010 Caspase-8 inhibition abrogated Bid cleavage and strongly reduced caspase-9 activation, suggesting that the cross-talk mechanism mediated by caspase-8-dependent Bid cleavage can contribute to the activation of the intrinsic apoptotic pathway by curcumin + carnosic acid. Curcumin 244-252 caspase 8 Homo sapiens 140-149 11396178-6 2001 Curcumin also stimulated the activity of caspase-8, which initiates Fas signalling pathway of apoptosis. Curcumin 0-8 caspase 8 Homo sapiens 41-50 17273730-0 2007 Photosensitizer effect of curcumin on UVB-irradiated HaCaT cells through activation of caspase pathways. Curcumin 26-34 caspase 8 Homo sapiens 87-94 17273730-6 2007 Furthermore, combination of UVB irradiation with curcumin synergistically induces apoptotic cell death in HaCaT cells through activation of caspase-8, and -3 as well as caspase-9 activation followed by release of cytochrome c. Curcumin 49-57 caspase 8 Homo sapiens 140-157 16173963-7 2005 BAY 11-7082- and curcumin-induced cell death was associated with downregulation of Bcl-xL, cyclin D1, XIAP and c-FLIP, followed by caspase-8, poly(ADP-ribose) polymerase cleavage and activation. Curcumin 17-25 caspase 8 Homo sapiens 131-140 11756235-0 2002 Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl. Curcumin 0-8 caspase 8 Homo sapiens 69-78 11756235-0 2002 Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl. Curcumin 10-27 caspase 8 Homo sapiens 69-78 11756235-6 2002 Curcumin activated caspase-8 and caspase-3 in HL-60 neo cells but not in Bcl-2 and Bcl-xl-transfected cells. Curcumin 0-8 caspase 8 Homo sapiens 19-28 11756235-10 2002 Because DN-FLICE blocked curcumin-induced apoptosis, caspase-8 must play a critical role. Curcumin 25-33 caspase 8 Homo sapiens 11-16 11756235-11 2002 Overall, our results indicate that curcumin induces apoptosis through mitochondrial pathway involving caspase-8, BID cleavage, cytochrome c release, and caspase-3 activation. Curcumin 35-43 caspase 8 Homo sapiens 102-111 11716543-0 2001 Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53. Curcumin 0-8 caspase 8 Homo sapiens 74-83 16129047-0 2005 [Effect of curcumin on caspase 8- and caspase 9- induced apoptosis of lymphoma Raji cell]. Curcumin 11-19 caspase 8 Homo sapiens 23-32 16129047-6 2005 The expressions of caspase 8 and caspase 9 in Raji cells after treatment with curcumin at 25 micromol/L (IC(50)) and for 24 hours were detected by Western blot. Curcumin 78-86 caspase 8 Homo sapiens 19-28 16129047-10 2005 It is concluded that the expression of caspase 8 and caspase 9 plays an important role in the proliferation and apoptosis of Raji cells, so that curcumin showed inhibitive effect on Raji cells at various concentrations. Curcumin 145-153 caspase 8 Homo sapiens 39-48 15205359-8 2004 Curcumin-induced activation of caspase 8 was blocked by Ku70 but not by Bcl-XL. Curcumin 0-8 caspase 8 Homo sapiens 31-40 15205359-9 2004 However, caspase 8 activation by curcumin was accelerated in both AsBcl-XL and AsKu70 cells suggesting a possible feedback activation of caspase 8 by caspase 3. Curcumin 33-41 caspase 8 Homo sapiens 9-18 15205359-9 2004 However, caspase 8 activation by curcumin was accelerated in both AsBcl-XL and AsKu70 cells suggesting a possible feedback activation of caspase 8 by caspase 3. Curcumin 33-41 caspase 8 Homo sapiens 137-146 11716543-6 2001 Both a caspase-8 and broad-based caspase inhibitor, but not a caspase-9 specific inhibitor, suppressed curcumin-induced cell death. Curcumin 103-111 caspase 8 Homo sapiens 7-16