PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30173398-7 2018 Our results indicate that the formate substrate does not coordinate directly to Mo when it enters the oxidised active site of the FDH, but instead resides in the second coordination sphere. formic acid 30-37 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 130-133 30010323-5 2018 Formate was found in in vitro assays using the purified Hdr complex to act directly as the electron donor for FBEB via the associated Fdh. formic acid 0-7 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 134-137 28072510-1 2017 In this study, we demonstrated the conversion of CO2 to formic acid under ambient conditions in a photoreduction nanoporous reactor using a photosensitizer, methyl viologen (MV2+), and formate dehydrogenase (FDH). formic acid 56-67 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 185-206 28303650-1 2017 The enzymatic electrosynthesis of formic acid from the reduction of carbon dioxide (CO2 ) by using formate dehydrogenase (FDH) as a catalyst at the cathode in both its free and immobilized forms was studied in detail in a bioelectrochemical system (BES). formic acid 34-45 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 122-125 28228507-0 2017 Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells. formic acid 39-46 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 0-23 28228507-2 2017 Folate-independent pathways are mediated by cytosolic alcohol dehydrogenase 5 (ADH5) and mitochondrial aldehyde dehydrogenase 2 (ALDH2), which generate formate by oxidizing formaldehyde. formic acid 152-159 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 54-77 28228507-2 2017 Folate-independent pathways are mediated by cytosolic alcohol dehydrogenase 5 (ADH5) and mitochondrial aldehyde dehydrogenase 2 (ALDH2), which generate formate by oxidizing formaldehyde. formic acid 152-159 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 79-83 28228507-3 2017 Formate is a potential biomarker of B-vitamin-dependent one-carbon metabolism.Objective: This study investigated the contributions of ADH5 and ALDH2 to formate production and folate-dependent de novo purine and dTMP synthesis in HepG2 cells.Methods:ADH5 knockout and ALDH2 knockdown HepG2 cells were cultured in folate-deficient [0 nM (6S) 5-formyltetrahydrofolate] or folate-sufficient [25 nM (6S) 5-formyltetrahydrofolate] medium. formic acid 0-7 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 249-253 29182696-1 2018 The effect of the functional ionic group of 4,4"-bipyridinium salt derivatives (4,4"-BPs) as the electron carrier on the visible-light driven conversion of CO2 to formic acid with the system consisting of water-soluble zinc tetraphenylporphyrin tetrasulfonate (ZnTPPS) and formate dehydrogenase (FDH) in the presence of triethanolamine (TEOA) as an electron donor was investigated. formic acid 163-174 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 296-299 29182696-3 2018 Irradiation of a CO2 saturated buffer solution containing TEOA, ZnTPPS, 4,4"-BP and FDH with visible light irradiation resulted in the production of formic acid. formic acid 149-160 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 84-87 28072510-1 2017 In this study, we demonstrated the conversion of CO2 to formic acid under ambient conditions in a photoreduction nanoporous reactor using a photosensitizer, methyl viologen (MV2+), and formate dehydrogenase (FDH). formic acid 56-67 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 208-211 24220877-5 2014 Expression of dehydrogenase (formaldehyde dehydrogenase (FDH)) in the formaldehyde (10.40) and methanol (10.60) groups increased significantly compared with the control (1), while it was similar to the control in formic acid (0.90) and acetaldehyde (1.10) groups. formic acid 213-224 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 29-55 26509703-6 2015 In spite of these similarities, they catalyze very different reactions: Nap abstracts an oxygen atom from nitrate releasing nitrite, whereas FdH catalyzes a hydrogen atom transfer from formate and releases carbon dioxide. formic acid 185-192 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 141-144 25476858-3 2015 To fulfil these varied physiological roles, different types of formate dehydrogenase (FDH) enzymes have evolved to catalyse the reversible 2-electron oxidation of formate to carbon dioxide. formic acid 63-70 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 86-89 25476858-4 2015 This review will highlight our present knowledge about the diverse physiological roles of FDH in prokaryotes, their modular structural organisation and active site structures and the mechanistic strategies followed to accomplish the formate oxidation. formic acid 233-240 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 90-93 24999994-7 2014 Electrodes modified with NG and NG/gold nanoparticals/formate dehydrogenase (NG/AuNPs/FDH) showed excellent analytical performance for the detection of NADH and formate. formic acid 54-61 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 86-89 24220877-5 2014 Expression of dehydrogenase (formaldehyde dehydrogenase (FDH)) in the formaldehyde (10.40) and methanol (10.60) groups increased significantly compared with the control (1), while it was similar to the control in formic acid (0.90) and acetaldehyde (1.10) groups. formic acid 213-224 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 57-60 26605631-1 2012 Formate dehydrogenase (FDH) catalyzes the oxidation of formic acid to carbon dioxide using nicotinamide adenine dinucleotide (NAD(+)) as a cofactor. formic acid 55-66 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 0-21 23557458-1 2013 OBJECTIVE: The dual actions of S-nitrosoglutathione reductase comprise reduction of S-nitrosoglutathione, a potent endogenous airway smooth muscle relaxant that is depleted in asthmatics, and detoxification of formaldehyde to formate. formic acid 226-233 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 31-61 23557458-6 2013 Formate concentrations doubled 1 h post-challenge in asthmatics with dual-airway response but essentially unchanged in patients with an isolated early reaction, CONCLUSIONS: Dual-airway response to allergen in atopic asthmatics could be associated with increased activity of S-nitrosoglutathione reductase as suggested by greater concentrations of formate in exhaled breath condensate. formic acid 0-7 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 275-305 23557458-7 2013 Measurement of formate in exhaled breath condensate could serve as a noninvasive biomarker of S-nitrosoglutathione reductase activity in vivo. formic acid 15-22 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 94-124 26605631-1 2012 Formate dehydrogenase (FDH) catalyzes the oxidation of formic acid to carbon dioxide using nicotinamide adenine dinucleotide (NAD(+)) as a cofactor. formic acid 55-66 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 23-26 22800191-2 2012 Actually, the energetics associated with the transfer from formate to all H (proton or hydride) acceptors that are present within the FDH active site have been sampled. formic acid 59-66 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 134-137 11340000-3 2001 The formic acid biosensor based on the combination of formate dehydrogenase (FDH)-modified membrane with 3,4-DHB-coated glassy carbon electrode is one to two orders more sensitive (LOD, 5.0x10(-5) M) than previously reported electrochemical biosensors. formic acid 4-15 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 54-75 11340000-3 2001 The formic acid biosensor based on the combination of formate dehydrogenase (FDH)-modified membrane with 3,4-DHB-coated glassy carbon electrode is one to two orders more sensitive (LOD, 5.0x10(-5) M) than previously reported electrochemical biosensors. formic acid 4-15 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 77-80 10978156-2 2000 It is inactivated by oxidative metabolism to formate in humans by glutathione-dependent formaldehyde dehydrogenase. formic acid 45-52 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 66-114 33418141-8 2021 In mammals, the toxicity of formaldehyde is limited by a metabolic route centred on the enzyme alcohol dehydrogenase 5 (ADH5/GSNOR), which oxidizes formaldehyde conjugated to GSH, lastly generating formate. formic acid 198-205 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 120-124 29274566-0 2018 Immobilization of formaldehyde dehydrogenase in tailored siliceous mesostructured cellular foams and evaluation of its activity for conversion of formate to formaldehyde. formic acid 146-153 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 18-44 29274566-1 2018 Formaldehyde dehydrogenase (FaldDH) is used as a catalyst to reduce formate to formaldehyde in a cascade reaction to convert CO2 to methanol. formic acid 68-75 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 0-26 29274566-1 2018 Formaldehyde dehydrogenase (FaldDH) is used as a catalyst to reduce formate to formaldehyde in a cascade reaction to convert CO2 to methanol. formic acid 68-75 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 28-34 6705187-2 1984 The measurement is accomplished by transforming creatine to formic acid in a reaction catalyzed by creatinase (creatine amidinohydrolase), sarcosine oxidase and formaldehyde dehydrogenase (see Figure 1). formic acid 60-71 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 161-187 33418141-8 2021 In mammals, the toxicity of formaldehyde is limited by a metabolic route centred on the enzyme alcohol dehydrogenase 5 (ADH5/GSNOR), which oxidizes formaldehyde conjugated to GSH, lastly generating formate. formic acid 198-205 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 125-130 31317382-6 2020 When water-soluble zinc porphyrin is coupled with FDH, visible light drives CO2 to produce formic acid. formic acid 91-102 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 50-53 31200015-1 2019 The reversible interconversion of formate (HCOO-) and carbon dioxide (CO2) is catalyzed by formate dehydrogenase (FDH, EC 1.17.1.9). formic acid 34-41 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 114-117