PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22003072-1 2011 SAR3419 is a novel anti-CD19 humanized monoclonal antibody conjugated to a maytansine derivate through a cleavable linker for the treatment of B-cell malignancies. Maytansine 75-85 CD19 molecule Homo sapiens 24-28 25856201-1 2015 Coltuximab ravtansine (SAR3419) is an antibody-drug conjugate (ADC) targeting CD19 created by conjugating a derivative of the potent microtubule-acting cytotoxic agent, maytansine, to a version of the anti-CD19 antibody, anti-B4, that was humanized as an IgG1 by variable domain resurfacing. Maytansine 169-179 CD19 molecule Homo sapiens 78-82 25856201-1 2015 Coltuximab ravtansine (SAR3419) is an antibody-drug conjugate (ADC) targeting CD19 created by conjugating a derivative of the potent microtubule-acting cytotoxic agent, maytansine, to a version of the anti-CD19 antibody, anti-B4, that was humanized as an IgG1 by variable domain resurfacing. Maytansine 169-179 CD19 molecule Homo sapiens 206-210 24023523-9 2013 SAR3419 (huB4-DM4) is a novel antibody-drug conjugate that is composed of a humanized monoclonal IgG1 anti-CD19 antibody (huB4) attached to the potent cytotoxic drug, a maytansine derivative (DM4), through a cleavable disulfide cross-linking agent N-Succinimidyl-4-2-pyridyldithio butanoic acid (SPDB). Maytansine 14-17 CD19 molecule Homo sapiens 107-111 24023523-10 2013 The preclinical efficacy of maytansine derivative-anti-CD19 conjugate was demonstrated in our laboratory, and SAR3419 was found to be more effective than CHOP in a xenograft model. Maytansine 28-38 CD19 molecule Homo sapiens 55-59