PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12611844-1 2003 OBJECTIVE: Reduced gamma-aminobutyric acid (GABA) concentrations have been reported in the plasma, CSF, and cortex of depressed subjects. gamma-Aminobutyric Acid 19-42 colony stimulating factor 2 Homo sapiens 99-102 12611844-1 2003 OBJECTIVE: Reduced gamma-aminobutyric acid (GABA) concentrations have been reported in the plasma, CSF, and cortex of depressed subjects. gamma-Aminobutyric Acid 44-48 colony stimulating factor 2 Homo sapiens 99-102 1283505-4 1992 The CSF GABA level was highest in the IS children with normal CT, cryptogenic cause and no antiepileptic treatment, and lowest in those with abnormal CT, symptomatic cause and antiepileptic treatment. gamma-Aminobutyric Acid 8-12 colony stimulating factor 2 Homo sapiens 4-7 9638660-10 1998 One indication for specialized CSF analyses including biogenic monoamines and GABA is severe neonatal/infantile epileptic encephalopathy. gamma-Aminobutyric Acid 78-82 colony stimulating factor 2 Homo sapiens 31-34 11552003-4 2001 The intrathecal synthesis of anti-GAD(65) IgG was calculated, and the functional significance of the antibodies was examined by measuring the GABA levels in the CSF. gamma-Aminobutyric Acid 142-146 colony stimulating factor 2 Homo sapiens 161-164 11552003-8 2001 The mean level of GABA in the CSF was lower in patients with SPS than in controls. gamma-Aminobutyric Acid 18-22 colony stimulating factor 2 Homo sapiens 30-33 10785255-2 2000 Recently, we found that an anti-GAD autoantibody in the CSF of an ataxic patient selectively suppressed GABA-mediated transmission on cerebellar Purkinje cells without affecting glutamate-mediated transmission. gamma-Aminobutyric Acid 104-108 colony stimulating factor 2 Homo sapiens 56-59 10785255-4 2000 The present results indicate that CSF immunoglobulins prepared from an ataxic patient acted on the presynaptic terminals of GABAergic interneurons and decreased GABA release onto Purkinje cells. gamma-Aminobutyric Acid 124-128 colony stimulating factor 2 Homo sapiens 34-37 9483201-10 1997 GM-CSF inhibits LHRH release by acting on its receptors on gamma-aminobutyric acid (GABA)ergic neurons to stimulate GABA release. gamma-Aminobutyric Acid 59-82 colony stimulating factor 2 Homo sapiens 0-6 9483201-10 1997 GM-CSF inhibits LHRH release by acting on its receptors on gamma-aminobutyric acid (GABA)ergic neurons to stimulate GABA release. gamma-Aminobutyric Acid 84-88 colony stimulating factor 2 Homo sapiens 0-6 9483201-10 1997 GM-CSF inhibits LHRH release by acting on its receptors on gamma-aminobutyric acid (GABA)ergic neurons to stimulate GABA release. gamma-Aminobutyric Acid 116-120 colony stimulating factor 2 Homo sapiens 0-6 1454145-1 1992 In an infant with typical pyridoxine-dependent seizures, CSF GABA level, was determined before treatment with pyridoxine. gamma-Aminobutyric Acid 61-65 colony stimulating factor 2 Homo sapiens 57-60 1454145-2 1992 Before onset of treatment, level of GABA in CSF was highly lowered (16 pmol/ml), pyridoxine level in serum was within normal range. gamma-Aminobutyric Acid 36-40 colony stimulating factor 2 Homo sapiens 44-47 2166773-0 1990 Detection of several novel gamma-aminobutyric acid-containing compounds in human CSF. gamma-Aminobutyric Acid 27-50 colony stimulating factor 2 Homo sapiens 81-84 2166773-1 1990 gamma-Aminobutyric acid (GABA) concentrations in human CSF are known to increase significantly after hydrolysis; however, the source of this increase has been unknown. gamma-Aminobutyric Acid 0-23 colony stimulating factor 2 Homo sapiens 55-58 2166773-1 1990 gamma-Aminobutyric acid (GABA) concentrations in human CSF are known to increase significantly after hydrolysis; however, the source of this increase has been unknown. gamma-Aminobutyric Acid 25-29 colony stimulating factor 2 Homo sapiens 55-58 3850849-0 1985 Alterations in plasma and CSF levels of GABA, 5-HT and amino acids in fulminant hepatic failure. gamma-Aminobutyric Acid 40-44 colony stimulating factor 2 Homo sapiens 26-29 2079831-2 1990 Hereditary disorders of the GABA metabolism presenting in childhood are discussed with particular emphasis on the recently identified succinic semialdehyde dehydrogenase deficiency and GABA-transaminase deficiency, and on diseases associated with low CSF GABA which await further unravelling. gamma-Aminobutyric Acid 28-32 colony stimulating factor 2 Homo sapiens 251-254 2079831-3 1990 Low CSF GABA concentrations are not always associated with convulsions. gamma-Aminobutyric Acid 8-12 colony stimulating factor 2 Homo sapiens 4-7 3504408-0 1987 GABA and amino acid concentrations in lumbar CSF in patients with treated and untreated epilepsy. gamma-Aminobutyric Acid 0-4 colony stimulating factor 2 Homo sapiens 45-48 4037136-1 1985 Ethanol intoxication has been noted to cause marked changes in brain and CSF levels of gamma-aminobutyric acid (GABA). gamma-Aminobutyric Acid 87-110 colony stimulating factor 2 Homo sapiens 73-76 4037136-1 1985 Ethanol intoxication has been noted to cause marked changes in brain and CSF levels of gamma-aminobutyric acid (GABA). gamma-Aminobutyric Acid 112-116 colony stimulating factor 2 Homo sapiens 73-76 2104526-6 1990 Sequential analysis of CSF for GABA and dopamine during illness revealed reciprocal changes each other with normal recovery. gamma-Aminobutyric Acid 31-35 colony stimulating factor 2 Homo sapiens 23-26 3028028-3 1986 Free and conjugated CSF GABA was significantly decreased in prolonged HC with advanced disease states and was suggested practicable as an additional diagnostic tool. gamma-Aminobutyric Acid 24-28 colony stimulating factor 2 Homo sapiens 20-23 3028028-5 1986 An age-dependent decrease of conjugated CSF GABA was observed in patients and controls. gamma-Aminobutyric Acid 44-48 colony stimulating factor 2 Homo sapiens 40-43 4027591-7 1985 In general, ratios of conjugated to free AAs were relatively low, however for the neurotransmitter AAs aspartate, glutamate, glycine and GABA as well as for beta-alanine hydrolysis produced marked increases indicating that these compounds are present predominantly in bound form in CSF. gamma-Aminobutyric Acid 137-141 colony stimulating factor 2 Homo sapiens 282-285 4006890-1 1985 The mean gamma-aminobutyric acid (GABA) level in lumbar CSF of 31 children with epilepsy was not significantly different from that of 41 age-matched controls. gamma-Aminobutyric Acid 9-32 colony stimulating factor 2 Homo sapiens 56-59 4006890-1 1985 The mean gamma-aminobutyric acid (GABA) level in lumbar CSF of 31 children with epilepsy was not significantly different from that of 41 age-matched controls. gamma-Aminobutyric Acid 34-38 colony stimulating factor 2 Homo sapiens 56-59 4006890-2 1985 However, when the epileptic children were subdivided into untreated patients and patients treated with antiepileptic drugs, the medication-free subgroup had a significantly lower mean CSF GABA level than nonepileptic children. gamma-Aminobutyric Acid 188-192 colony stimulating factor 2 Homo sapiens 184-187 4006890-3 1985 Patients controlled by anticonvulsant therapy had significantly higher CSF GABA levels than untreated epileptic patients. gamma-Aminobutyric Acid 75-79 colony stimulating factor 2 Homo sapiens 71-74 4006890-4 1985 A more detailed analysis of the children taking antiepileptic medication indicated that the only drug that significantly increased GABA in CSF was valproic acid. gamma-Aminobutyric Acid 131-135 colony stimulating factor 2 Homo sapiens 139-142 4006890-5 1985 Analysis of CSF data with respect to the seizure type of the patients showed that, compared with controls, significantly reduced average GABA levels were present in children with infantile spasms (mostly untreated) and unmedicated generalized tonic-clonic seizures, whereas treated children with generalized tonic-clonic seizures and patients with partial epilepsy (mostly treated) did not significantly differ from controls. gamma-Aminobutyric Acid 137-141 colony stimulating factor 2 Homo sapiens 12-15 6470627-1 1984 A rapid and simple procedure is described for the determination of 4-aminobutyric acid in human CSF. gamma-Aminobutyric Acid 67-86 colony stimulating factor 2 Homo sapiens 96-99 4010335-0 1985 A specific and sensitive determination of gamma aminobutyric acid in CSF and brain tissue by gas chromatography-mass spectrometry. gamma-Aminobutyric Acid 42-65 colony stimulating factor 2 Homo sapiens 69-72 6470627-6 1984 By first using ultrafiltration and by minimizing the time between lumbar puncture and analysis, it was shown that protein precipitation with a concentration of sulphosalicylic acid as low as 5 g/l gives 4-aminobutyric acid values in CSF that are essentially correct. gamma-Aminobutyric Acid 203-222 colony stimulating factor 2 Homo sapiens 233-236 6682197-0 1983 Syndrome of continuous muscle-fiber activity: increased CSF GABA and effect of dantrolene. gamma-Aminobutyric Acid 60-64 colony stimulating factor 2 Homo sapiens 56-59 6412668-0 1983 Concentrations of gamma-aminobutyric acid and adenosine in the CSF in progressive myoclonus epilepsy without Lafora"s bodies. gamma-Aminobutyric Acid 18-41 colony stimulating factor 2 Homo sapiens 63-66 6412668-3 1983 Concentrations of gamma-aminobutyric acid in the CSF averaged 89 +/- 10 pmole/mL (mean +/- SE) in eight patients with PME, compared with 135 +/- 18 pmole/mL in ten control patients. gamma-Aminobutyric Acid 18-41 colony stimulating factor 2 Homo sapiens 49-52 6682197-3 1983 GABA (gamma-aminobutyric acid) content in CSF was remarkably increased. gamma-Aminobutyric Acid 0-4 colony stimulating factor 2 Homo sapiens 42-45 6682197-3 1983 GABA (gamma-aminobutyric acid) content in CSF was remarkably increased. gamma-Aminobutyric Acid 6-29 colony stimulating factor 2 Homo sapiens 42-45 6806442-0 1982 EDTA inhibits in vitro increases in the GABA content of human CSF. gamma-Aminobutyric Acid 40-44 colony stimulating factor 2 Homo sapiens 62-65 7150885-0 1982 Plasma and CSF GABA in affective illness. gamma-Aminobutyric Acid 15-19 colony stimulating factor 2 Homo sapiens 11-14 6806442-2 1982 The determination of gamma-aminobutyric acid (GABA) levels in CSF by a radioreceptor assay showed a progressive increase in GABA content with time, which could be counteracted by addition of EDTA (5 mM). gamma-Aminobutyric Acid 21-44 colony stimulating factor 2 Homo sapiens 62-65 6806442-2 1982 The determination of gamma-aminobutyric acid (GABA) levels in CSF by a radioreceptor assay showed a progressive increase in GABA content with time, which could be counteracted by addition of EDTA (5 mM). gamma-Aminobutyric Acid 46-50 colony stimulating factor 2 Homo sapiens 62-65 6806442-2 1982 The determination of gamma-aminobutyric acid (GABA) levels in CSF by a radioreceptor assay showed a progressive increase in GABA content with time, which could be counteracted by addition of EDTA (5 mM). gamma-Aminobutyric Acid 124-128 colony stimulating factor 2 Homo sapiens 62-65 6806442-4 1982 The in vitro increases in GABA levels of untreated CSF might relate to the action of a metal-enzyme which is inhibited by metal-trapping substances such as EDTA. gamma-Aminobutyric Acid 26-30 colony stimulating factor 2 Homo sapiens 51-54 6460947-5 1982 GABA concentrations were markedly increased in CSF during INH therapy. gamma-Aminobutyric Acid 0-4 colony stimulating factor 2 Homo sapiens 47-50 7073535-2 1982 Central nervous system gamma-aminobutyric acid (GABA) activity was demonstrated to be an age- and sex-dependent phenomenon through the study of GABA concentration in lumbar CSF obtained from 87 drug-free normal individuals. gamma-Aminobutyric Acid 23-46 colony stimulating factor 2 Homo sapiens 173-176 7073535-2 1982 Central nervous system gamma-aminobutyric acid (GABA) activity was demonstrated to be an age- and sex-dependent phenomenon through the study of GABA concentration in lumbar CSF obtained from 87 drug-free normal individuals. gamma-Aminobutyric Acid 48-52 colony stimulating factor 2 Homo sapiens 173-176 7073535-2 1982 Central nervous system gamma-aminobutyric acid (GABA) activity was demonstrated to be an age- and sex-dependent phenomenon through the study of GABA concentration in lumbar CSF obtained from 87 drug-free normal individuals. gamma-Aminobutyric Acid 144-148 colony stimulating factor 2 Homo sapiens 173-176 7073535-3 1982 Evaluation of the data from homogeneous subgroups of this population disclosed that both the propensity of lumbar CSF GABA levels to decrease with age and the magnitude of the rostrocaudal GABA concentration gradient are more pronounced in females, suggesting possible neuroendocrine involvement. gamma-Aminobutyric Acid 118-122 colony stimulating factor 2 Homo sapiens 114-117 7073535-5 1982 Patient populations included in clinical investigations must be age- and sex-matched to avoid invalid conclusions biased by these physiologic variations in CSF GABA concentrations. gamma-Aminobutyric Acid 160-164 colony stimulating factor 2 Homo sapiens 156-159 7094868-9 1982 CSF levels of HVA and GABA rose from day 0 to day 7 but were back to the initial values on day 28 in 2 patients and were decreased from day 0 to day 28 in one patient. gamma-Aminobutyric Acid 22-26 colony stimulating factor 2 Homo sapiens 0-3 7086446-1 1982 CSF gamma-aminobutyric acid (GABA) levels were reduced in patients with idiopathic Parkinson"s disease when compared with age matched controls, but the difference was not significant. gamma-Aminobutyric Acid 4-27 colony stimulating factor 2 Homo sapiens 0-3 7086446-1 1982 CSF gamma-aminobutyric acid (GABA) levels were reduced in patients with idiopathic Parkinson"s disease when compared with age matched controls, but the difference was not significant. gamma-Aminobutyric Acid 29-33 colony stimulating factor 2 Homo sapiens 0-3 7055411-0 1982 CSF levels of gamma-aminobutyric acid in schizophrenia. gamma-Aminobutyric Acid 14-37 colony stimulating factor 2 Homo sapiens 0-3 7055411-2 1982 gamma-Aminobutyric acid (GABA) levels in CSF were not significantly different in 30 drug-free schizophrenic patients and in 39 normal control subjects, because the control subjects were significantly older. gamma-Aminobutyric Acid 0-23 colony stimulating factor 2 Homo sapiens 41-44 7055411-2 1982 gamma-Aminobutyric acid (GABA) levels in CSF were not significantly different in 30 drug-free schizophrenic patients and in 39 normal control subjects, because the control subjects were significantly older. gamma-Aminobutyric Acid 25-29 colony stimulating factor 2 Homo sapiens 41-44 7065833-8 1982 The CSF levels of HVA and GABA increased to day 7 but returned to initial values on day 28 in two patients; they were decreased to day 28 in one patient. gamma-Aminobutyric Acid 26-30 colony stimulating factor 2 Homo sapiens 4-7 7108533-2 1982 Low CSF GABA levels have been reported in epilepsy and also febrile convulsions of children. gamma-Aminobutyric Acid 8-12 colony stimulating factor 2 Homo sapiens 4-7 7108533-4 1982 A highly significant positive correlation was found between seizure excitability and CSF GABA level, but not between CSF and plasma GABA concentrations. gamma-Aminobutyric Acid 89-93 colony stimulating factor 2 Homo sapiens 85-88 7094868-10 1982 For the 3 patients a close correlation was observed between changes in CSF HVA and GABA levels. gamma-Aminobutyric Acid 83-87 colony stimulating factor 2 Homo sapiens 71-74 7247786-0 1981 Clinical implications of enzyme-mediated alterations of gamma-aminobutyric acid content in human CSF. gamma-Aminobutyric Acid 56-79 colony stimulating factor 2 Homo sapiens 97-100 7220676-0 1980 Preliminary studies on CSF gamma-aminobutyric acid levels in psychiatric patients before and during treatment with different psychotropic drugs. gamma-Aminobutyric Acid 27-50 colony stimulating factor 2 Homo sapiens 23-26 6107437-0 1980 Increased CSF gamma-aminobutyric acid after treatment with gamma-vinyl GABA. gamma-Aminobutyric Acid 14-37 colony stimulating factor 2 Homo sapiens 10-13 1003229-0 1976 Is GABA detectable in human CSF? gamma-Aminobutyric Acid 3-7 colony stimulating factor 2 Homo sapiens 28-31 623945-0 1978 Gamma-aminobutyric acid (GABA) in the CSF of schizophrenic patients before and after neuroleptic treatment. gamma-Aminobutyric Acid 0-23 colony stimulating factor 2 Homo sapiens 38-41 623945-0 1978 Gamma-aminobutyric acid (GABA) in the CSF of schizophrenic patients before and after neuroleptic treatment. gamma-Aminobutyric Acid 25-29 colony stimulating factor 2 Homo sapiens 38-41 623945-1 1978 Gamma-aminobutyric acid (GABA) levels in the CSF were measured in 9 normal individuals, 17 drug-free schizophrenic patients and 10 of these same schizophrenic patients after neuroleptic treatment. gamma-Aminobutyric Acid 0-23 colony stimulating factor 2 Homo sapiens 45-48 623945-1 1978 Gamma-aminobutyric acid (GABA) levels in the CSF were measured in 9 normal individuals, 17 drug-free schizophrenic patients and 10 of these same schizophrenic patients after neuroleptic treatment. gamma-Aminobutyric Acid 25-29 colony stimulating factor 2 Homo sapiens 45-48 623945-3 1978 There was a significant decline of 12 per cent in mean GABA levels in the CSF after a mean of two months of neuroleptic treatment. gamma-Aminobutyric Acid 55-59 colony stimulating factor 2 Homo sapiens 74-77 166315-0 1975 Letter: Gamma-aminobutyric acid in CSF in schizophrenia. gamma-Aminobutyric Acid 8-31 colony stimulating factor 2 Homo sapiens 35-38 235093-0 1975 Letter: Low GABA levels in CSF in Huntington"s chorea. gamma-Aminobutyric Acid 12-16 colony stimulating factor 2 Homo sapiens 27-30 18534624-5 2008 Our results provide evidence that GAD-Abs in the CSF elicited physiopathological effects on cerebellar GABA synapses in vitro and that such synaptic impairment was reversible. gamma-Aminobutyric Acid 103-107 colony stimulating factor 2 Homo sapiens 49-52