PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2167134-0 1990 [Tetrodotoxin--a sensitive component of the depolarizing response to GABA administration to the pyramidal neuron dendrites of the CA1 field of the hippocampus]. gamma-Aminobutyric Acid 69-73 carbonic anhydrase 1 Mus musculus 130-133 2259043-0 1990 Distribution of GABA concentrations and GAD activities in the parietal cortex and the hippocampal CA1 in an El mouse. gamma-Aminobutyric Acid 16-20 carbonic anhydrase 1 Mus musculus 98-101 2167134-1 1990 The intracellular recording of CA1 neurons in mouse hippocampal slice preparation was used to study the properties of depolarizing responses to iontophoretically applied GABA to their apical dendrites. gamma-Aminobutyric Acid 170-174 carbonic anhydrase 1 Mus musculus 31-34 35167940-3 2022 We now investigated whether impairing this type of feed-back inhibition by selectively inhibiting GABA release from SST expressing interneurons in hippocampal sector CA1 and subiculum may be sufficient to induce spontaneous recurrent seizures. gamma-Aminobutyric Acid 98-102 carbonic anhydrase 1 Mus musculus 166-169 34648750-4 2021 Bidirectional intervention experiments in head-restrained mice performing a random foraging task revealed that AACs inhibit CA1 pyramidal cells, indicating that the effect of GABA on the initial segments in the hippocampus is inhibitory in vivo. gamma-Aminobutyric Acid 175-179 carbonic anhydrase 1 Mus musculus 124-127 31607482-0 2019 GABA releases from parvalbumin-expressing and unspecific GABAergic neurons onto CA1 pyramidal cells are differentially modulated by presynaptic GABAB receptors in mouse hippocampus. gamma-Aminobutyric Acid 0-4 carbonic anhydrase 1 Mus musculus 80-83 31833596-3 2020 Here, we report that pharmacological or genetic intervention of the GABA-permeable Bestrophin-1 (Best1) channel prevented the generation of tonic GABA inhibition, disinhibiting CA1 pyramidal neuronal firing and augmenting seizure susceptibility in kainic acid (KA)-induced epileptic mice. gamma-Aminobutyric Acid 68-72 carbonic anhydrase 1 Mus musculus 177-180 32041202-7 2020 We demonstrate using in vitro whole-cell patch-clamping an increased inhibitory GABAergic tonic conductance mediated by extrasynaptic type A GABA receptors (GABAARs), recorded in the CA1 region of the mouse hippocampus following Abeta1-42 micro injection. gamma-Aminobutyric Acid 80-84 carbonic anhydrase 1 Mus musculus 183-186 31607482-1 2019 Hippocampus CA1 pyramidal cells receive gamma-aminobutyric acid (GABA) release from multiple GABAergic interneurons. gamma-Aminobutyric Acid 40-63 carbonic anhydrase 1 Mus musculus 12-15 31607482-1 2019 Hippocampus CA1 pyramidal cells receive gamma-aminobutyric acid (GABA) release from multiple GABAergic interneurons. gamma-Aminobutyric Acid 65-69 carbonic anhydrase 1 Mus musculus 12-15 31607482-5 2019 The data strengthen the proposal that diverse GABA neurons play different roles in modulating CA1 pyramidal cell excitability. gamma-Aminobutyric Acid 46-50 carbonic anhydrase 1 Mus musculus 94-97 30022867-6 2018 Strikingly, a stab wound brain injury lead to hypertrophy of astrocytes accompanied by increased GABA expression and tonic GABA release in mouse CA1 hippocampus. gamma-Aminobutyric Acid 123-127 carbonic anhydrase 1 Mus musculus 145-148 30377105-3 2018 GABA currents in CA1 and CA3 pyramidal neurons were induced with the selective GABAA-R agonist muscimol and recorded using perforated patch-clamp recording technique. gamma-Aminobutyric Acid 0-4 carbonic anhydrase 1 Mus musculus 17-20 30377105-4 2018 The GABA currents of CA1 and CA3 pyramidal neurons were tested for their equilibrium potentials (EMuss) and kinetic parameters and were compared with the measurements in wild-type mice (WT group). gamma-Aminobutyric Acid 4-8 carbonic anhydrase 1 Mus musculus 21-24 31555354-0 2019 Upregulation of GABA receptor promotes long-term potentiation and depotentiation in the hippocampal CA1 region of mice with type 2 diabetes mellitus. gamma-Aminobutyric Acid 16-20 carbonic anhydrase 1 Mus musculus 100-103 31555354-3 2019 The current study therefore aimed to assess the effect of the GABA receptor (GABA-R) on the long-term potentiation (LTP) and depotentiation of the hippocampal CA1 region in mice with T2DM. gamma-Aminobutyric Acid 62-66 carbonic anhydrase 1 Mus musculus 159-162 31555354-3 2019 The current study therefore aimed to assess the effect of the GABA receptor (GABA-R) on the long-term potentiation (LTP) and depotentiation of the hippocampal CA1 region in mice with T2DM. gamma-Aminobutyric Acid 77-81 carbonic anhydrase 1 Mus musculus 159-162 31555354-10 2019 The results of the current study support the theory that the upregulation of GABA-R protects the neuronal ultrastructure and promotes LTP and depotentiation in the hippocampal CA1 region by inhibiting the accumulation of OH- in T2DM mice. gamma-Aminobutyric Acid 77-81 carbonic anhydrase 1 Mus musculus 176-179 30315127-10 2018 Collectively, our data reveal mechanisms by which distinctly composed macromolecular complexes modulate the activity of key ion channels that mediate the inhibitory effects of GABA on hippocampal CA1 pyramidal neurons.SIGNIFICANCE STATEMENT This study identifies the contributions of distinct macromolecular complexes containing a major G-protein regulator to controlling key ion channel function in hippocampal neurons with implications for understanding molecular mechanisms underlying synaptic plasticity, learning, and memory. gamma-Aminobutyric Acid 176-180 carbonic anhydrase 1 Mus musculus 196-199 28864826-5 2017 Deleting IgSF21 in mice impairs inhibitory presynaptic organization, especially in the hippocampal CA1 stratum radiatum, and also diminishes GABA-mediated synaptic transmission in hippocampal CA1 neurons without affecting their excitatory synapses. gamma-Aminobutyric Acid 141-145 carbonic anhydrase 1 Mus musculus 192-195 28733354-13 2017 The present experiments demonstrate that specific and sustained inhibition of GABA release from parvalbumin-expressing interneurons (mostly basket cells) in sector CA1/subiculum is sufficient to induce hyperexcitability and spontaneous recurrent seizures in mice. gamma-Aminobutyric Acid 78-82 carbonic anhydrase 1 Mus musculus 164-167 28390894-13 2017 Finally, in mouse hippocampal CA1 pyramidal neurons, MB inhibited GABA-activated currents as well as GABAergic IPSCs. gamma-Aminobutyric Acid 66-70 carbonic anhydrase 1 Mus musculus 30-33 23732644-4 2013 Here, we analysed the Cl- dynamics of neurons and astrocytes in CA1 hippocampal GABAergic tripartite synapses, using Cl- imaging during GABA application, and whole cell recordings from interneuron-astrocyte pairs in the stratum lacunosum-moleculare. gamma-Aminobutyric Acid 80-84 carbonic anhydrase 1 Mus musculus 64-67 28189613-0 2017 alpha4betadelta GABAA receptors reduce dendritic spine density in CA1 hippocampus and impair relearning ability of adolescent female mice: Effects of a GABA agonist and a stress steroid. gamma-Aminobutyric Acid 16-20 carbonic anhydrase 1 Mus musculus 66-69 23732644-6 2013 Although GABA application evoked bidirectional Cl- flux via GABAA receptors and mouse GABA transporter 4 (mGAT4) in CA1 astrocytes, a train of interneuron firing induced only GABAA receptor-mediated inward currents in an adjacent astrocyte. gamma-Aminobutyric Acid 9-13 carbonic anhydrase 1 Mus musculus 116-119 23231965-7 2013 On the other hand, intra-CA1 injection of the higher doses of muscimol (GABA(A) receptor agonist) at 0.25, 0.5 and 1 mug/mouse, not only impaired the spatial change detection on its own, but also affected the reaction to non-spatial novelty. gamma-Aminobutyric Acid 72-76 carbonic anhydrase 1 Mus musculus 25-28 23494150-3 2013 Here we show that the transport system regulating ambient GABA responsible for tonic GABAA conductances in hippocampal CA1 interneurons depends on its source. gamma-Aminobutyric Acid 58-62 carbonic anhydrase 1 Mus musculus 119-122 22368083-7 2013 Interestingly, a lower tonic GABA(A) current due to the impaired GABA release is responsible for the more depolarized resting potential found in TKO CA1 neurons, which makes them more susceptible to fire. gamma-Aminobutyric Acid 29-33 carbonic anhydrase 1 Mus musculus 149-152 22368083-7 2013 Interestingly, a lower tonic GABA(A) current due to the impaired GABA release is responsible for the more depolarized resting potential found in TKO CA1 neurons, which makes them more susceptible to fire. gamma-Aminobutyric Acid 65-69 carbonic anhydrase 1 Mus musculus 149-152 23400282-5 2013 The monitoring of L-glutamate release in the CA1 region of mouse hippocampal slices under chemical stimulation with gamma-aminobutyric acid (GABA) and potassium chloride (KCl) was demonstrated. gamma-Aminobutyric Acid 116-139 carbonic anhydrase 1 Mus musculus 45-48 23400282-5 2013 The monitoring of L-glutamate release in the CA1 region of mouse hippocampal slices under chemical stimulation with gamma-aminobutyric acid (GABA) and potassium chloride (KCl) was demonstrated. gamma-Aminobutyric Acid 141-145 carbonic anhydrase 1 Mus musculus 45-48 20357123-5 2010 There were region-specific changes of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD), with increased GAD-67-immunopositive interneurons in the stratum oriens of the CA1 region of the hippocampus, accompanied by nonsignificant reduction of GAD-67 synapses in the CA3 region. gamma-Aminobutyric Acid 42-46 carbonic anhydrase 1 Mus musculus 181-184 21471392-7 2011 Our results from pharmacological tests suggest that the nitric oxide signaling pathway is mobilized by NMDAR activation in CA1 pyramidal neurons, which in turn retrogradely facilitates GABA release from the presynaptic terminals. gamma-Aminobutyric Acid 185-189 carbonic anhydrase 1 Mus musculus 123-126 20392949-3 2010 We studied the regulation of synaptic plasticity by alpha5 subunit-containing GABA(A)Rs (alpha5GABA(A)Rs), which generate a tonic inhibitory conductance in CA1 pyramidal neurons using electrophysiological recordings of field and whole-cell potentials in hippocampal slices from both wild-type and null mutant mice for the alpha5 subunit of the GABA(A)R (Gabra5(-/-) mice). gamma-Aminobutyric Acid 78-82 carbonic anhydrase 1 Mus musculus 156-159 22178330-3 2012 After confirming that GABA(B)/GIRK current density is significantly elevated in Ts65Dn CA1 pyramidal neurons, we compared monosynaptic inhibitory inputs in CA1 pyramidal neurons in response to proximal (stratum radiatum; SR) and distal (stratum lacunosum moleculare; SLM) stimulation of diploid and Ts65Dn acute hippocampal slices. gamma-Aminobutyric Acid 22-26 carbonic anhydrase 1 Mus musculus 87-90 22178330-6 2012 These results indicate that GIRK overexpression in Ts65Dn has functional consequences which affect the balance between GABA(B) and GABA(A) inhibition of CA1 pyramidal neurons, most likely in a pathway specific manner, and may contribute to cognitive deficits reported in these mice. gamma-Aminobutyric Acid 131-135 carbonic anhydrase 1 Mus musculus 153-156 21082021-8 2010 Furthermore, IPSC decay times in both CA1 and CA3 pyramidal cells were faster in mouse strains with higher oscillation frequencies than in mouse strains with lower oscillation frequency, suggesting that differences in GABA(A)-receptor subunit composition exist between these strains. gamma-Aminobutyric Acid 218-222 carbonic anhydrase 1 Mus musculus 38-41 17409173-6 2007 Blocking the postsynaptic effects of GABA(B) and A1 receptor activation on CA1 pyramidal cell excitability with an inhibitor of G-protein-activated inwardly rectifying potassium channels had no effect on either paired-pulse depression or LFS-induced depression. gamma-Aminobutyric Acid 37-41 carbonic anhydrase 1 Mus musculus 75-78 19846622-2 2009 In hippocampal area CA1, GABA(A,fast) is generally believed to underlie gamma oscillations, whereas the contribution of GABA(A,slow) to hippocampal rhythms has been speculative. gamma-Aminobutyric Acid 25-29 carbonic anhydrase 1 Mus musculus 20-23 20089897-7 2010 Thus, in hippocampal slices obtained from 6-month-old AD11 (but not wild-type) mice, the GABA(A) agonist isoguvacine significantly increased the firing of CA1 principal cells and, at the network level, the frequency of multiunit activity recorded with extracellular electrodes. gamma-Aminobutyric Acid 89-93 carbonic anhydrase 1 Mus musculus 155-158 18794205-7 2009 We suggest that increased inhibitory synapse density reflects tenuous compensation of altered clustering of alpha2 subunit-containing GABA(A)-Rs in CA1 dendrites, whereas increased PSD length in perforated synapses suggests secondary alterations in excitatory synapse organization associated with enhanced synaptic excitation. gamma-Aminobutyric Acid 134-138 carbonic anhydrase 1 Mus musculus 148-151 15634771-3 2005 Using whole-cell recording and fluorescence imaging, we studied action potential-evoked Ca(i) transients in axons of GABA-releasing interneurons from mouse cerebellum. gamma-Aminobutyric Acid 117-121 carbonic anhydrase 1 Mus musculus 88-93 16835366-8 2006 In the CA1 area, but not in the subiculum, perisynaptic alpha5-GABA(A)Rs contributed to slow phasic currents. gamma-Aminobutyric Acid 63-67 carbonic anhydrase 1 Mus musculus 7-10 16835366-9 2006 In the CA1 area, the diazepam-sensitive component of tonic inhibition also involved activation of alpha5-GABA(A)Rs and slow phasic and tonic signals shared overlapping pools of receptors. gamma-Aminobutyric Acid 105-109 carbonic anhydrase 1 Mus musculus 7-10 17131399-2 2007 Here, we show that a transgenic mouse line overexpressing cerebellum-restricted gamma-aminobutyric acid type A (GABA(A)) receptor alpha6 subunit in the hippocampal CA1 pyramidal cells (Thy1alpha6 mouse line) exhibits about a 20% increase in the electroshock current intensity inducing tonic hindlimb extension convulsion in 50% of the mice compared with that of their wild-type controls. gamma-Aminobutyric Acid 80-103 carbonic anhydrase 1 Mus musculus 164-167 17131399-2 2007 Here, we show that a transgenic mouse line overexpressing cerebellum-restricted gamma-aminobutyric acid type A (GABA(A)) receptor alpha6 subunit in the hippocampal CA1 pyramidal cells (Thy1alpha6 mouse line) exhibits about a 20% increase in the electroshock current intensity inducing tonic hindlimb extension convulsion in 50% of the mice compared with that of their wild-type controls. gamma-Aminobutyric Acid 112-116 carbonic anhydrase 1 Mus musculus 164-167 12532406-2 2003 Our previous electrophysiologic study of mice deficient in the extracellular matrix glycoprotein tenascin-R (TN-R) showed an impaired gamma-aminobutyric acid release at perisomatic inhibitory synapses in the CA1 pyramidal cell layer of the hippocampus. gamma-Aminobutyric Acid 134-157 carbonic anhydrase 1 Mus musculus 208-211 15450096-4 2004 Here we demonstrate that isolated CA1 neurons of these mice showed furosemide-sensitivity of GABA-evoked currents, confirming the functional expression of alpha6 subunit. gamma-Aminobutyric Acid 93-97 carbonic anhydrase 1 Mus musculus 34-37 14993607-2 2004 Here we describe a nonsynaptic, tonic form of inhibition in mouse CA1 pyramidal neurons that is generated by a distinct subpopulation of GABA type A receptors (GABA(A)Rs). gamma-Aminobutyric Acid 137-141 carbonic anhydrase 1 Mus musculus 66-69 11516401-2 2001 Endocannabinoids are thought to mediate the suppression of GABA release that follows depolarization of a hippocampal CA1 pyramidal neuron-termed "depolarization-induced suppression of inhibition" (DSI). gamma-Aminobutyric Acid 59-63 carbonic anhydrase 1 Mus musculus 117-120 12495621-1 2002 GABA and glutamate receptors are expressed in immature "silent" CA1 pyramidal neurons prior to synapse formation, but their function is unknown. gamma-Aminobutyric Acid 0-4 carbonic anhydrase 1 Mus musculus 64-67 8985682-0 1996 Analysis of the kinetics of synaptic inhibition points to a reduction in GABA release in area CA1 of the genetically epileptic mouse, El. gamma-Aminobutyric Acid 73-77 carbonic anhydrase 1 Mus musculus 94-97 8985682-9 1996 It is concluded that the synaptic release of GABA in area CA1 of the El mouse is decreased compared to that of the ddY mouse. gamma-Aminobutyric Acid 45-49 carbonic anhydrase 1 Mus musculus 58-61 8604050-5 1996 Most remarkably, t-PA-deficient mice exhibit a different form of long-lasting potentiation that is characterized by an NMDA receptor-dependent modification of GABA transmission in the CA1 region. gamma-Aminobutyric Acid 159-163 carbonic anhydrase 1 Mus musculus 184-187