PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24823815-3 2014 RDL undergoes alternative splicing and RNA editing, which influence the potency of GABA. gamma-Aminobutyric Acid 83-87 Resistant to dieldrin Drosophila melanogaster 0-3 26554339-5 2016 Rdl(MD-RR)Drosophila are naturally occurring mutants that express an aberrant form of the GABAA receptor, which has a lower affinity for PTX, but not GABA itself. gamma-Aminobutyric Acid 90-94 Resistant to dieldrin Drosophila melanogaster 0-3 26124278-1 2015 Breakdown of the major sleep-promoting neurotransmitter, gamma-aminobutyric acid (GABA), in the GABA shunt generates catabolites that may enter the tricarboxylic acid cycle, but it is unknown whether catabolic by-products of the GABA shunt actually support metabolic homeostasis. gamma-Aminobutyric Acid 57-80 Resistant to dieldrin Drosophila melanogaster 82-86 26124278-1 2015 Breakdown of the major sleep-promoting neurotransmitter, gamma-aminobutyric acid (GABA), in the GABA shunt generates catabolites that may enter the tricarboxylic acid cycle, but it is unknown whether catabolic by-products of the GABA shunt actually support metabolic homeostasis. gamma-Aminobutyric Acid 57-80 Resistant to dieldrin Drosophila melanogaster 96-100 26124278-1 2015 Breakdown of the major sleep-promoting neurotransmitter, gamma-aminobutyric acid (GABA), in the GABA shunt generates catabolites that may enter the tricarboxylic acid cycle, but it is unknown whether catabolic by-products of the GABA shunt actually support metabolic homeostasis. gamma-Aminobutyric Acid 57-80 Resistant to dieldrin Drosophila melanogaster 96-100 24365472-6 2014 Comparative studies showed that R. microplus RDL is 52-fold more sensitive than R. microplus GluCl to fluralaner inhibition, confirming that the GABA-gated chloride channel is the primary target of this new parasiticide. gamma-Aminobutyric Acid 145-149 Resistant to dieldrin Drosophila melanogaster 45-48 22940478-4 2012 The sensitivity of the Hco-LGC-38 channel to GABA is similar to reported values for the Drosophila RDL receptor whereas its lower sensitivity to muscimol is similar to nematode GABA receptors. gamma-Aminobutyric Acid 45-49 Resistant to dieldrin Drosophila melanogaster 99-102 23707718-3 2013 The inhibitory gamma-aminobutyric acid (GABA) system is important for regulating information processing in MBs, but its specific role in the sparse coding of odors is unclear. gamma-Aminobutyric Acid 15-38 Resistant to dieldrin Drosophila melanogaster 40-44 19038223-2 2008 Drosophila sleep has recently been shown to be controlled by GABA, which acts on unknown cells expressing the Rdl GABAA receptor. gamma-Aminobutyric Acid 61-65 Resistant to dieldrin Drosophila melanogaster 110-113 20200125-6 2010 The pharmacological profile of the L. migratoria GABACl fitted neither the vertebrate GABA(A) nor GABA(C) receptor and was similar to the properties of the cloned Drosophila melanogaster GABA receptor subunit (Rdl). gamma-Aminobutyric Acid 49-53 Resistant to dieldrin Drosophila melanogaster 210-213 19906878-5 2010 Molecular analysis of the GABA-responding cells revealed that both subunits RDL and LCCH3 were expressed out of the three orthologs of Drosophila melanogaster GABA-receptor subunits encoded within the honeybee genome (RDL, resistant to dieldrin; GRD, GABA/glycine-like receptor of Drosophila; LCCH3, ligand-gated chloride channel homologue 3), opening the door to possible homo- and/or heteromeric associations. gamma-Aminobutyric Acid 26-30 Resistant to dieldrin Drosophila melanogaster 76-79 19339622-2 2009 Using RDL, a Drosophila melanogaster GABA-gated ion channel, we examined the functional impact of RNA editing at several sites along with alternative splicing of more than one exon. gamma-Aminobutyric Acid 37-41 Resistant to dieldrin Drosophila melanogaster 6-9 18520997-2 2008 In Drosophila, the resistance to dieldrin (RDL) gamma-aminobutyric acid (GABA) receptor subunit displays an editing site (R122) that is close to the putative GABA-binding site. gamma-Aminobutyric Acid 73-77 Resistant to dieldrin Drosophila melanogaster 19-41 18520997-2 2008 In Drosophila, the resistance to dieldrin (RDL) gamma-aminobutyric acid (GABA) receptor subunit displays an editing site (R122) that is close to the putative GABA-binding site. gamma-Aminobutyric Acid 73-77 Resistant to dieldrin Drosophila melanogaster 43-46 11226707-7 2001 Thus, using expression in Xenopus oocytes, we have demonstrated differences in agonist potency for the neurotransmitter GABA (and four analogues) between splice variant products of the Drosophila melanogaster Rdl gene encoding homomer-forming GABA receptor subunits. gamma-Aminobutyric Acid 120-124 Resistant to dieldrin Drosophila melanogaster 209-212 16027231-2 2005 A GABA-gated chloride channel subunit from Drosophila melanogaster [Resistant to Dieldrin (RDL)] has been cloned, functionally expressed, and found to exhibit many aspects of the pharmacology of native, bicuculline-insensitive insect GABA receptors. gamma-Aminobutyric Acid 2-6 Resistant to dieldrin Drosophila melanogaster 91-94 11226707-5 2001 The EC(so) values for GABA and its analogues isoguvacine, muscimol, isonipecotic acid and 3-amino sulphonic acid on the RDL(ad) homomeric receptor differed from those previously described for RDL(ac) and DRC17-1-2 receptors. gamma-Aminobutyric Acid 22-26 Resistant to dieldrin Drosophila melanogaster 120-123 11226707-5 2001 The EC(so) values for GABA and its analogues isoguvacine, muscimol, isonipecotic acid and 3-amino sulphonic acid on the RDL(ad) homomeric receptor differed from those previously described for RDL(ac) and DRC17-1-2 receptors. gamma-Aminobutyric Acid 22-26 Resistant to dieldrin Drosophila melanogaster 192-195 17729251-0 2007 gamma-Aminobutyric acid (GABA) signaling components in Drosophila: immunocytochemical localization of GABA(B) receptors in relation to the GABA(A) receptor subunit RDL and a vesicular GABA transporter. gamma-Aminobutyric Acid 0-23 Resistant to dieldrin Drosophila melanogaster 139-155 17729251-0 2007 gamma-Aminobutyric acid (GABA) signaling components in Drosophila: immunocytochemical localization of GABA(B) receptors in relation to the GABA(A) receptor subunit RDL and a vesicular GABA transporter. gamma-Aminobutyric Acid 0-23 Resistant to dieldrin Drosophila melanogaster 164-167 17729251-0 2007 gamma-Aminobutyric acid (GABA) signaling components in Drosophila: immunocytochemical localization of GABA(B) receptors in relation to the GABA(A) receptor subunit RDL and a vesicular GABA transporter. gamma-Aminobutyric Acid 25-29 Resistant to dieldrin Drosophila melanogaster 139-155 17729251-2 2007 GABA acts on ion channel receptors (GABA(A)R) for fast inhibitory transmission and on G-protein-coupled ones (GABA(B)R) for slow and modulatory action. gamma-Aminobutyric Acid 0-4 Resistant to dieldrin Drosophila melanogaster 36-44 12770577-4 2003 The closest homologue of the predicted gene product of RdlDv is the RDL protein encoded by the GABA-gated chloride channel gene Drosophila Rdl (Resistance to Dieldrin), with which it shares 64% amino acid identity. gamma-Aminobutyric Acid 95-99 Resistant to dieldrin Drosophila melanogaster 68-71 12770577-4 2003 The closest homologue of the predicted gene product of RdlDv is the RDL protein encoded by the GABA-gated chloride channel gene Drosophila Rdl (Resistance to Dieldrin), with which it shares 64% amino acid identity. gamma-Aminobutyric Acid 95-99 Resistant to dieldrin Drosophila melanogaster 55-58 12770577-4 2003 The closest homologue of the predicted gene product of RdlDv is the RDL protein encoded by the GABA-gated chloride channel gene Drosophila Rdl (Resistance to Dieldrin), with which it shares 64% amino acid identity. gamma-Aminobutyric Acid 95-99 Resistant to dieldrin Drosophila melanogaster 144-166 12770577-5 2003 When expressed in Xenopus oocytes, RdlDv produces GABA-activated currents blocked by the known insecticides and RDL antagonists fipronil and picrotoxinin. gamma-Aminobutyric Acid 50-54 Resistant to dieldrin Drosophila melanogaster 112-115 12009920-0 2002 Ivermectin and nodulisporic acid receptors in Drosophila melanogaster contain both gamma-aminobutyric acid-gated Rdl and glutamate-gated GluCl alpha chloride channel subunits. gamma-Aminobutyric Acid 83-106 Resistant to dieldrin Drosophila melanogaster 113-116 11226707-7 2001 Thus, using expression in Xenopus oocytes, we have demonstrated differences in agonist potency for the neurotransmitter GABA (and four analogues) between splice variant products of the Drosophila melanogaster Rdl gene encoding homomer-forming GABA receptor subunits. gamma-Aminobutyric Acid 120-124 Resistant to dieldrin Drosophila melanogaster 243-256 10679793-4 2000 The sequences were most similar to the Drosophila RDL (resistance to dieldrin) GABA subunit with 54% identity, and 30-35% identity with vertebrate ionotropic GABA receptor subunits. gamma-Aminobutyric Acid 79-83 Resistant to dieldrin Drosophila melanogaster 50-53 10952672-1 2000 Single channel recordings were obtained from a Drosophila S2 cell line stably expressing the wild-type RDL(ac) Drosophila melanogaster homomer-forming ionotropic GABA receptor subunit, a product of the resistance to dieldrin gene, RDL: GABA (50 microM) was applied by pressure ejection to outside-out patches from S2-RDL cells at a holding potential of -60 mV. gamma-Aminobutyric Acid 162-166 Resistant to dieldrin Drosophila melanogaster 103-106 10679793-4 2000 The sequences were most similar to the Drosophila RDL (resistance to dieldrin) GABA subunit with 54% identity, and 30-35% identity with vertebrate ionotropic GABA receptor subunits. gamma-Aminobutyric Acid 79-83 Resistant to dieldrin Drosophila melanogaster 55-77 10679793-4 2000 The sequences were most similar to the Drosophila RDL (resistance to dieldrin) GABA subunit with 54% identity, and 30-35% identity with vertebrate ionotropic GABA receptor subunits. gamma-Aminobutyric Acid 79-83 Resistant to dieldrin Drosophila melanogaster 158-171 7898754-4 1994 Response of the expressed Drosophila Rdl receptor to GABA was reduced by t-butylbicyclophosphorothionate (TBPS), 4-n-propyl-4"-ethynylbicycloorthobenzoate (EBOB), picrotoxinin and the novel insecticide, fipronil (all at 1.0 x 10(-5) M). gamma-Aminobutyric Acid 53-57 Resistant to dieldrin Drosophila melanogaster 37-40 9740020-1 1998 The Resistance to dieldrin (Rdl) gene encodes a novel subunit of a gamma-aminobutyric acid (GABA)-gated chloride ion channel in Drosophila. gamma-Aminobutyric Acid 67-90 Resistant to dieldrin Drosophila melanogaster 4-26 9740020-1 1998 The Resistance to dieldrin (Rdl) gene encodes a novel subunit of a gamma-aminobutyric acid (GABA)-gated chloride ion channel in Drosophila. gamma-Aminobutyric Acid 67-90 Resistant to dieldrin Drosophila melanogaster 28-31 9740020-1 1998 The Resistance to dieldrin (Rdl) gene encodes a novel subunit of a gamma-aminobutyric acid (GABA)-gated chloride ion channel in Drosophila. gamma-Aminobutyric Acid 92-96 Resistant to dieldrin Drosophila melanogaster 4-26 9740020-1 1998 The Resistance to dieldrin (Rdl) gene encodes a novel subunit of a gamma-aminobutyric acid (GABA)-gated chloride ion channel in Drosophila. gamma-Aminobutyric Acid 92-96 Resistant to dieldrin Drosophila melanogaster 28-31 8882620-2 1996 Functional GABA-gated chloride channels are formed when cRNA encoding the Drosophila melanogaster GABA receptor subunit RDL is injected into the cytoplasm of Xenopus oocytes. gamma-Aminobutyric Acid 11-15 Resistant to dieldrin Drosophila melanogaster 120-123 8882620-3 1996 Two-electrode voltage-clamp was used to investigate allosteric modulation of GABA-induced currents recorded from the expressed, bicuculline-insensitive, RDL homo-oligomers. gamma-Aminobutyric Acid 77-81 Resistant to dieldrin Drosophila melanogaster 153-156 8882620-17 1996 delta-Hexachlorocyclohexane (0.1 microM to 30 microM) was a potent enhancer of submaximal responses to GABA of RDL. gamma-Aminobutyric Acid 103-107 Resistant to dieldrin Drosophila melanogaster 111-114 8601436-4 1996 Here we report the production of stable mosquito cell lines carrying high copy numbers of Rdl genes from both Drosophila and Aedes aegypti mosquitoes and the subsequent high efficiency expression of functional GABA gated chlorine ion channels. gamma-Aminobutyric Acid 210-214 Resistant to dieldrin Drosophila melanogaster 90-93 9014156-4 1996 Using these stable lines, a striking reduction in sensitivity to both picrotoxinin and dieldrin was observed for responses to GABA of S2-RDLA302S compared to S2-RDL. gamma-Aminobutyric Acid 126-130 Resistant to dieldrin Drosophila melanogaster 137-140 10455279-2 1999 Sensitivity to the block by KN244 of the response to 30 microM GABA (IC50=41.6 nM, wild-type RDLac) was reduced abut 100 fold (IC50=4.5 microM) in the dieldrin-resistant (RDLacA302S) form of RDL. gamma-Aminobutyric Acid 63-67 Resistant to dieldrin Drosophila melanogaster 93-96 7476913-8 1995 Putative Rdl plus beta channels also show reduced GABA sensitivity, slow desensitization, rapid bursting, and shorter mean open time. gamma-Aminobutyric Acid 50-54 Resistant to dieldrin Drosophila melanogaster 9-12 7533909-4 1994 Rapid and pronounced rundown of responses to GABA during whole-cell patch clamp recordings was overcome by the inclusion of EGTA in the pipette solution, indicating a possible role for calcium-dependent processes in the functional regulation of this GABA receptor. gamma-Aminobutyric Acid 45-49 Resistant to dieldrin Drosophila melanogaster 250-263 34234379-0 2021 Agonist and antagonist properties of an insect GABA-gated chloride channel (RDL) are influenced by heterologous expression conditions. gamma-Aminobutyric Acid 47-51 Resistant to dieldrin Drosophila melanogaster 76-79 8025556-4 1994 Rdl codes for a subunit of a novel class of GABA gated chloride ion channels and resistance is correlated with replacement of the same amino acid residue in a wide range of species from different insect orders. gamma-Aminobutyric Acid 44-48 Resistant to dieldrin Drosophila melanogaster 0-3 1651498-2 1991 Resistance is due to insensitivity of the cyclodiene/picrotoxinin binding site on the gamma-aminobutyric acid subtype A (GABAA) receptor-chloride ionophore complex. gamma-Aminobutyric Acid 86-109 Resistant to dieldrin Drosophila melanogaster 121-126 34234379-2 2021 One of the best characterised insect GABA-gated chloride channels is RDL, an abbreviation of "resistance to dieldrin", that was originally identified by genetic screening in Drosophila melanogaster. gamma-Aminobutyric Acid 37-41 Resistant to dieldrin Drosophila melanogaster 69-72 33002317-2 2021 To design a novel insecticide, studies on the structures of homologous pentameric ligand-gated ion channels provide information about important amino acids that are necessary for the function of insect Rdl GABA receptors. gamma-Aminobutyric Acid 206-210 Resistant to dieldrin Drosophila melanogaster 202-205 32980057-1 2020 The resistance to dieldrin gene (Rdl) encodes a subunit of the insect gamma-amino butyric acid (GABA) receptor, and the encoded Rdl subunit is a major target site for cyclodiene and phenylpyrazole insecticides. gamma-Aminobutyric Acid 70-94 Resistant to dieldrin Drosophila melanogaster 33-36 32980057-1 2020 The resistance to dieldrin gene (Rdl) encodes a subunit of the insect gamma-amino butyric acid (GABA) receptor, and the encoded Rdl subunit is a major target site for cyclodiene and phenylpyrazole insecticides. gamma-Aminobutyric Acid 70-94 Resistant to dieldrin Drosophila melanogaster 128-131 32980057-1 2020 The resistance to dieldrin gene (Rdl) encodes a subunit of the insect gamma-amino butyric acid (GABA) receptor, and the encoded Rdl subunit is a major target site for cyclodiene and phenylpyrazole insecticides. gamma-Aminobutyric Acid 96-100 Resistant to dieldrin Drosophila melanogaster 33-36 32980057-1 2020 The resistance to dieldrin gene (Rdl) encodes a subunit of the insect gamma-amino butyric acid (GABA) receptor, and the encoded Rdl subunit is a major target site for cyclodiene and phenylpyrazole insecticides. gamma-Aminobutyric Acid 96-100 Resistant to dieldrin Drosophila melanogaster 128-131 29555017-6 2018 We examined the molecular and cellular determinants of this social acoustic learning and found that GABA signaling acting on the GABAA receptor Rdl in the pC1 neurons, the integration node for courtship stimuli, regulated auditory tuning and sexual behavior. gamma-Aminobutyric Acid 100-104 Resistant to dieldrin Drosophila melanogaster 144-147 30058603-2 2018 In neurodegenerative study, the direct spatial information of neurotransmitters such as gamma-aminobutyric acid (GABA) in the brain of Drosophila melanogaster is important to understand the role of GABA. gamma-Aminobutyric Acid 88-111 Resistant to dieldrin Drosophila melanogaster 113-117 30058603-2 2018 In neurodegenerative study, the direct spatial information of neurotransmitters such as gamma-aminobutyric acid (GABA) in the brain of Drosophila melanogaster is important to understand the role of GABA. gamma-Aminobutyric Acid 88-111 Resistant to dieldrin Drosophila melanogaster 198-202