PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2567554-4 1989 The release of ACTH is controlled by two stimulating hormones, the ACTH releasing factor and vasopressin, the effects of neurotransmitters are less marked, with the involvement of noradrenaline, serotonin, acetylcholine, gamma aminobutyric acid and other agents. gamma-Aminobutyric Acid 221-244 proopiomelanocortin Homo sapiens 15-19 2577268-4 1989 MetENK has both direct synaptic input onto GC and indirect action possibly via a GABA inhibitory interneuron. gamma-Aminobutyric Acid 81-85 proopiomelanocortin Homo sapiens 0-6 2898899-3 1988 These ACTH fragments also inhibited GABA-stimulated [3H] FNP binding. gamma-Aminobutyric Acid 36-40 proopiomelanocortin Homo sapiens 6-10 2562233-1 1989 Sodium valproate, a gamma-aminobutyric acid (GABA) agonist, was found to decrease plasma ACTH concentration in some cases of Cushing"s disease and Nelson"s syndrome. gamma-Aminobutyric Acid 20-43 proopiomelanocortin Homo sapiens 89-93 2562233-1 1989 Sodium valproate, a gamma-aminobutyric acid (GABA) agonist, was found to decrease plasma ACTH concentration in some cases of Cushing"s disease and Nelson"s syndrome. gamma-Aminobutyric Acid 45-49 proopiomelanocortin Homo sapiens 89-93 2562233-5 1989 The fall in plasma ACTH level in the same patients at 10 p.m., after the next two doses of this drug, suggests that single dose may be insufficient for introducing GABA-dependent reduction in ACTH release. gamma-Aminobutyric Acid 164-168 proopiomelanocortin Homo sapiens 19-23 2562233-5 1989 The fall in plasma ACTH level in the same patients at 10 p.m., after the next two doses of this drug, suggests that single dose may be insufficient for introducing GABA-dependent reduction in ACTH release. gamma-Aminobutyric Acid 164-168 proopiomelanocortin Homo sapiens 192-196 2552350-0 1989 Central-type benzodiazepines and the octadecaneuropeptide modulate the effects of GABA on the release of alpha-melanocyte-stimulating hormone from frog neurointermediate lobe in vitro. gamma-Aminobutyric Acid 82-86 proopiomelanocortin Homo sapiens 105-141 2552350-2 1989 The GABAA agonist 3-amino-1 propane sulfonic acid mimicked the biphasic effect of GABA on alpha-melanocyte-stimulating hormone secretion: a brief stimulation followed by an inhibition of melanotropin secretion. gamma-Aminobutyric Acid 4-8 proopiomelanocortin Homo sapiens 90-126 2552350-3 1989 The GABAA antagonist SR 95531 (10(-4) M) inhibited both stimulation and inhibition of alpha-melanocyte-stimulating hormone release induced by GABA (10(-4) M). gamma-Aminobutyric Acid 4-8 proopiomelanocortin Homo sapiens 86-122 2552350-5 1989 GABA-induced stimulation of alpha-melanocyte-stimulating hormone release was inhibited by tetrodotoxin (10(-5) M), an Na+ -channel blocker, or nifedipine (10(-5) M), a voltage-dependent Ca2+ -channel blocker, suggesting that Na+ and Ca2+ ions are involved in the stimulatory phase of GABA action. gamma-Aminobutyric Acid 0-4 proopiomelanocortin Homo sapiens 28-64 2552350-5 1989 GABA-induced stimulation of alpha-melanocyte-stimulating hormone release was inhibited by tetrodotoxin (10(-5) M), an Na+ -channel blocker, or nifedipine (10(-5) M), a voltage-dependent Ca2+ -channel blocker, suggesting that Na+ and Ca2+ ions are involved in the stimulatory phase of GABA action. gamma-Aminobutyric Acid 284-288 proopiomelanocortin Homo sapiens 28-64 2839946-10 1988 They also indicate that chronic administration of sodium valproate, hence activation of central gamma-aminobutyric acid system, results in a blunting of the stimulated GH and ACTH secretion. gamma-Aminobutyric Acid 96-119 proopiomelanocortin Homo sapiens 175-179 2571183-5 1989 The stimulatory influence of norepinephrine, serotonin, and acetylcholine on the secretion of corticotropin (ACTH) in rodents and man will be discussed, whereas GABA exerts an inhibitory effect on the secretion of ACTH in both man and rodents. gamma-Aminobutyric Acid 161-165 proopiomelanocortin Homo sapiens 214-218 2952856-4 1987 In addition, dopamine, GABA and NPY, three neuroendocrine factors which inhibit alpha-MSH secretion totally suppressed the action of ANF on alpha-MSH production. gamma-Aminobutyric Acid 23-27 proopiomelanocortin Homo sapiens 140-149 3026578-0 1986 GABA-ergic control of alpha-melanocyte-stimulating hormone (alpha-MSH) release by frog neurointermediate lobe in vitro. gamma-Aminobutyric Acid 0-4 proopiomelanocortin Homo sapiens 22-58 3614001-4 1987 Brennan et al (Life Sciences 27: 1097-1101, 1980) reported a greater percent inhibition of potassium-stimulated GABA release with increasing concentrations of met-enkephalin. gamma-Aminobutyric Acid 112-116 proopiomelanocortin Homo sapiens 159-173 3033417-0 1987 The benzodiazepine agonist clonazepam potentiates the effects of gamma-aminobutyric acid on alpha-MSH release from neurointermediate lobes in vitro. gamma-Aminobutyric Acid 65-88 proopiomelanocortin Homo sapiens 92-101 3033417-3 1987 High doses of GABA (10(-5) and 10(-4) M) induced a biphasic effect on pars intermedia cells: a brief stimulation followed by a sustained inhibition of alpha-MSH secretion. gamma-Aminobutyric Acid 14-18 proopiomelanocortin Homo sapiens 151-160 3033417-4 1987 Administration of clonazepam (10(-5) M) in the presence of various concentrations of GABA (10(-6) to 10(-4) M) led to a potentiation of both stimulatory and inhibitory phases of alpha-MSH secretion induced by GABA. gamma-Aminobutyric Acid 85-89 proopiomelanocortin Homo sapiens 178-187 3033417-4 1987 Administration of clonazepam (10(-5) M) in the presence of various concentrations of GABA (10(-6) to 10(-4) M) led to a potentiation of both stimulatory and inhibitory phases of alpha-MSH secretion induced by GABA. gamma-Aminobutyric Acid 209-213 proopiomelanocortin Homo sapiens 178-187 3033417-6 1987 Thus our results indicate that endogenous benzodiazepine receptors may modulate the effects of GABA on alpha-MSH secretion. gamma-Aminobutyric Acid 95-99 proopiomelanocortin Homo sapiens 103-112 3026578-0 1986 GABA-ergic control of alpha-melanocyte-stimulating hormone (alpha-MSH) release by frog neurointermediate lobe in vitro. gamma-Aminobutyric Acid 0-4 proopiomelanocortin Homo sapiens 60-69 3026578-5 1986 Administration of GABA (10(-6) to 10(-4) M), to perifused neurointermediate lobes caused a brief stimulation of alpha-melanocyte stimulating hormone (alpha-MSH) release followed by an inhibition. gamma-Aminobutyric Acid 18-22 proopiomelanocortin Homo sapiens 112-148 3026578-5 1986 Administration of GABA (10(-6) to 10(-4) M), to perifused neurointermediate lobes caused a brief stimulation of alpha-melanocyte stimulating hormone (alpha-MSH) release followed by an inhibition. gamma-Aminobutyric Acid 18-22 proopiomelanocortin Homo sapiens 150-159 3026578-8 1986 The GABAA agonist muscimol (10(-7) to 10(-4) M) mimicked the biphasic effect of GABA on alpha-MSH release. gamma-Aminobutyric Acid 4-8 proopiomelanocortin Homo sapiens 88-97 6300181-11 1983 We suggest that it reduces the hypersecretion of ACTH by enhancing gamma-aminobutyric acid function in the hypothalamus, thereby inhibiting the release of corticotropin-releasing factor. gamma-Aminobutyric Acid 67-90 proopiomelanocortin Homo sapiens 49-53 3027601-5 1986 The present data show that sodium valproate and diazepam inhibit stress-induced beta-EP, beta-LPH and cortisol secretion in humans, suggesting that endogenous GABA and benzodiazepine receptors participate in physiological mechanisms regulating the activity of the HPA axis. gamma-Aminobutyric Acid 159-163 proopiomelanocortin Homo sapiens 80-87 3027601-5 1986 The present data show that sodium valproate and diazepam inhibit stress-induced beta-EP, beta-LPH and cortisol secretion in humans, suggesting that endogenous GABA and benzodiazepine receptors participate in physiological mechanisms regulating the activity of the HPA axis. gamma-Aminobutyric Acid 159-163 proopiomelanocortin Homo sapiens 89-97 2868517-3 1985 At the pituitary level, alpha-MSH secretion is under multifactorial control: it is inhibited by dopamine and GABA and stimulated by corticoliberin (CRF), thyroliberin (TRH), beta-adrenergic agonists and (or) serotonin. gamma-Aminobutyric Acid 109-113 proopiomelanocortin Homo sapiens 24-33 6147872-0 1984 Clinical and experimental studies on the role of GABA in the regulation of ACTH secretion: a review. gamma-Aminobutyric Acid 49-53 proopiomelanocortin Homo sapiens 75-79 6294679-5 1982 Results indicated that, for an equivalent degree of catalepsy, the profile of beta-endorphin was similar to that of opiates, except for changes in body temperature; beta-endorphin"s profile differed markedly from that of haloperidol, arecoline and GABA. gamma-Aminobutyric Acid 248-252 proopiomelanocortin Homo sapiens 165-179 205622-2 1978 It is postulated that dexamethasone may, at least in part, inhibit the secretion of ACTH via the induction of GAD, thereby raising the level of gamma-aminobutyric acid in the central nervous system. gamma-Aminobutyric Acid 144-167 proopiomelanocortin Homo sapiens 84-88 7139278-0 1982 In vivo modulations by GABA-related drugs of met-enkephalin release in basal ganglia of the cat brain. gamma-Aminobutyric Acid 23-27 proopiomelanocortin Homo sapiens 45-59 7139278-1 1982 The influence of the intrapallidal application of GABA-related compounds on the release of Met-enkephalin in the globus pallidus and the caudate nucleus in the two hemispheres was investigated in vivo in the cat. gamma-Aminobutyric Acid 50-54 proopiomelanocortin Homo sapiens 91-105 7139278-3 1982 GABA (10-500 microM) reduced the local release of Met-enkephalin during its application but once the amino acid was removed from the superfusing fluid, an increase in the peptide release was observed. gamma-Aminobutyric Acid 0-4 proopiomelanocortin Homo sapiens 50-64 6174697-0 1982 Serotonin and gamma-aminobutyric acid turnover after injection into the median raphe of substance P and D-ala-met-enkephalin amide. gamma-Aminobutyric Acid 14-37 proopiomelanocortin Homo sapiens 110-124 7139278-5 1982 Opposite changes in Met-enkephalin release were also seen with the GABA antagonists, bicuculline methiodide (1 microM) and picrotoxin (10 microM), suggesting that the local regulation of Met-enkephalin release by GABA related compounds may be mediated by at least two types of GABA receptors. gamma-Aminobutyric Acid 67-71 proopiomelanocortin Homo sapiens 20-34 7139278-5 1982 Opposite changes in Met-enkephalin release were also seen with the GABA antagonists, bicuculline methiodide (1 microM) and picrotoxin (10 microM), suggesting that the local regulation of Met-enkephalin release by GABA related compounds may be mediated by at least two types of GABA receptors. gamma-Aminobutyric Acid 67-71 proopiomelanocortin Homo sapiens 187-201 7139278-5 1982 Opposite changes in Met-enkephalin release were also seen with the GABA antagonists, bicuculline methiodide (1 microM) and picrotoxin (10 microM), suggesting that the local regulation of Met-enkephalin release by GABA related compounds may be mediated by at least two types of GABA receptors. gamma-Aminobutyric Acid 213-217 proopiomelanocortin Homo sapiens 20-34 7139278-5 1982 Opposite changes in Met-enkephalin release were also seen with the GABA antagonists, bicuculline methiodide (1 microM) and picrotoxin (10 microM), suggesting that the local regulation of Met-enkephalin release by GABA related compounds may be mediated by at least two types of GABA receptors. gamma-Aminobutyric Acid 213-217 proopiomelanocortin Homo sapiens 187-201 7139278-6 1982 In several cases, the unilateral pallidal application of GABA agonists and antagonists induced significant changes in Met-enkephalin release at distant structures. gamma-Aminobutyric Acid 57-61 proopiomelanocortin Homo sapiens 118-132 6273025-4 1981 Secretion of ACTH may thus be influenced by both opiate peptide and by gamma aminobutyric acid, as well as by the cortisol concentration, these agents may act at different sites to inhibit ACTH release by the tumour. gamma-Aminobutyric Acid 71-94 proopiomelanocortin Homo sapiens 13-17 25808323-3 2015 Here we show that leptin"s action on GABA release to POMC neurons is influenced by glucose levels. gamma-Aminobutyric Acid 37-41 proopiomelanocortin Homo sapiens 53-57 25808323-6 2015 However, postsynaptic TRPC channel opening by the PI3K-PLC signalling pathway in POMC neurons enhances spontaneous GABA release via activation of presynaptic MC3/4 and mGlu receptors at 2.5 mM glucose. gamma-Aminobutyric Acid 115-119 proopiomelanocortin Homo sapiens 81-85 23318874-10 2013 Dynorphin attenuated glutamate and GABA neurotransmission to POMC neurons. gamma-Aminobutyric Acid 35-39 proopiomelanocortin Homo sapiens 61-65 22522889-5 2012 Despite the reports of GABA release from POMC neurons, vGat was not detected in POMC neurons, although Gad65 and Gad67 were present in ~40% of POMC neurons. gamma-Aminobutyric Acid 23-27 proopiomelanocortin Homo sapiens 41-45 23384353-3 2013 Adrenocorticotropic hormone concentration in serum was highest for chicks fed the GABA-deficient water and was significantly decreased by the supplement of GABA at days 1, 3 and 5 after beak trimming (P < 0.05). gamma-Aminobutyric Acid 82-86 proopiomelanocortin Homo sapiens 0-27 23384353-3 2013 Adrenocorticotropic hormone concentration in serum was highest for chicks fed the GABA-deficient water and was significantly decreased by the supplement of GABA at days 1, 3 and 5 after beak trimming (P < 0.05). gamma-Aminobutyric Acid 156-160 proopiomelanocortin Homo sapiens 0-27 23440036-5 2013 Are GABA and glutamate or neuropeptides released from POMC neurons more crucial for modulating feeding and metabolism? gamma-Aminobutyric Acid 4-8 proopiomelanocortin Homo sapiens 54-58 22522889-2 2012 Recent work shows that POMC neurons can also release the amino acid transmitters gamma-aminobutyric acid (GABA) and glutamate, although studying GABAergic and glutamatergic populations of POMC neurons has been hindered by the difficulty in reliably identifying amino acid (AA) transmitter phenotypes. gamma-Aminobutyric Acid 81-104 proopiomelanocortin Homo sapiens 23-27 22522889-2 2012 Recent work shows that POMC neurons can also release the amino acid transmitters gamma-aminobutyric acid (GABA) and glutamate, although studying GABAergic and glutamatergic populations of POMC neurons has been hindered by the difficulty in reliably identifying amino acid (AA) transmitter phenotypes. gamma-Aminobutyric Acid 106-110 proopiomelanocortin Homo sapiens 23-27 11596866-4 2001 These results suggest, that GABA may suppress GnRH release directly by GABA(A) receptor mechanism on the axon terminal of GnRH neurons or indirectly by GABA(A) receptor processes activating beta-endorphin-ergic and dopaminergic neurons in the VEN/NI. gamma-Aminobutyric Acid 28-32 proopiomelanocortin Homo sapiens 190-204 17360821-4 2007 Previous studies using whole cell recordings from identified neurons in brain slices have shown that cannabinoids reduce GABA release from inhibitory synapses onto the POMC cells. gamma-Aminobutyric Acid 121-125 proopiomelanocortin Homo sapiens 168-172 16237178-3 2005 The basal endocannabinoid release selectively inhibited GABA release onto POMC neurons, although exogenous administration of cannabinoid agonists also inhibited glutamate release. gamma-Aminobutyric Acid 56-60 proopiomelanocortin Homo sapiens 74-78 14973227-0 2004 GABA release from proopiomelanocortin neurons. gamma-Aminobutyric Acid 0-4 proopiomelanocortin Homo sapiens 18-37 14973227-3 2004 In addition to orexigenic peptides, NPY neurons also release the inhibitory neurotransmitter GABA, which can act in a local circuit to inhibit POMC neuron activity. gamma-Aminobutyric Acid 93-97 proopiomelanocortin Homo sapiens 143-147 14973227-8 2004 Double-label in situ RNA hybridization for POMC and glutamic acid decarboxylase, the GABA synthetic enzyme, revealed colocalization of mRNAs in approximately one-third of POMC neurons in vivo. gamma-Aminobutyric Acid 85-89 proopiomelanocortin Homo sapiens 43-47 14973227-10 2004 However, this rapid inhibition may not play a major role within local hypothalamic circuits, but rather is likely to be important in more distant projection areas as indicated by the colocalization of vesicular GABA transporter immunoreactivity predominantly in extrahypothalamic POMC terminals. gamma-Aminobutyric Acid 211-215 proopiomelanocortin Homo sapiens 280-284 12899671-7 2003 GABA increased the basal release of vasopressin and alpha-melanocyte stimulating hormone from the posterior and intermediate pituitary lobe, respectively, an effect that could be blocked by picrotoxinin. gamma-Aminobutyric Acid 0-4 proopiomelanocortin Homo sapiens 52-88 1688992-3 1990 Dopaminergic and gamma-aminobutyric acid-containing neuronal systems inhibit POMC-derived peptide release from the hypothalamus through D2-dopamine and GABAA receptors, respectively. gamma-Aminobutyric Acid 17-40 proopiomelanocortin Homo sapiens 77-81 11373681-7 2001 Leptin increases the frequency of action potentials in the anorexigenic POMC neurons by two mechanisms: depolarization through a nonspecific cation channel; and reduced inhibition by local orexigenic neuropeptide-Y/GABA (gamma-aminobutyric acid) neurons. gamma-Aminobutyric Acid 221-244 proopiomelanocortin Homo sapiens 72-76 7911815-4 1994 Chronic treatment with ACTH in infantile spasms reduces cerebrospinal fluid GABA, beta-endorphin, and somatostatin, increases norepinephrine and tyrosine, and has variable or no effect on homovanillic acid, 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid, histamine, and tryptophan. gamma-Aminobutyric Acid 76-80 proopiomelanocortin Homo sapiens 23-27 2165430-1 1990 The neurotransmitter GABA exerts a biphasic effect on alpha-melanocyte-stimulating hormone (alpha-MSH) secretion from pars intermedia cells: GABA induces a rapid and transient stimulation followed by a sustained inhibition of alpha-MSH release. gamma-Aminobutyric Acid 21-25 proopiomelanocortin Homo sapiens 54-90 2165430-1 1990 The neurotransmitter GABA exerts a biphasic effect on alpha-melanocyte-stimulating hormone (alpha-MSH) secretion from pars intermedia cells: GABA induces a rapid and transient stimulation followed by a sustained inhibition of alpha-MSH release. gamma-Aminobutyric Acid 21-25 proopiomelanocortin Homo sapiens 92-101 2165430-1 1990 The neurotransmitter GABA exerts a biphasic effect on alpha-melanocyte-stimulating hormone (alpha-MSH) secretion from pars intermedia cells: GABA induces a rapid and transient stimulation followed by a sustained inhibition of alpha-MSH release. gamma-Aminobutyric Acid 21-25 proopiomelanocortin Homo sapiens 226-235 2165430-1 1990 The neurotransmitter GABA exerts a biphasic effect on alpha-melanocyte-stimulating hormone (alpha-MSH) secretion from pars intermedia cells: GABA induces a rapid and transient stimulation followed by a sustained inhibition of alpha-MSH release. gamma-Aminobutyric Acid 141-145 proopiomelanocortin Homo sapiens 54-90 2165430-1 1990 The neurotransmitter GABA exerts a biphasic effect on alpha-melanocyte-stimulating hormone (alpha-MSH) secretion from pars intermedia cells: GABA induces a rapid and transient stimulation followed by a sustained inhibition of alpha-MSH release. gamma-Aminobutyric Acid 141-145 proopiomelanocortin Homo sapiens 92-101 2165430-1 1990 The neurotransmitter GABA exerts a biphasic effect on alpha-melanocyte-stimulating hormone (alpha-MSH) secretion from pars intermedia cells: GABA induces a rapid and transient stimulation followed by a sustained inhibition of alpha-MSH release. gamma-Aminobutyric Acid 141-145 proopiomelanocortin Homo sapiens 226-235 2165430-9 1990 Taken together, our results indicate that the rapid and transient stimulation of alpha-MSH release induced by GABA can be accounted for by activation of a chloride conductance which causes membrane depolarization. gamma-Aminobutyric Acid 110-114 proopiomelanocortin Homo sapiens 81-90 2165430-10 1990 These data support the notion that the transient stimulation of alpha-MSH secretion induced by GABA can be accounted for by membrane depolarization which provokes activation of voltage-operated calcium channels. gamma-Aminobutyric Acid 95-99 proopiomelanocortin Homo sapiens 64-73 2165430-11 1990 Since no evidence was found for GABA-induced hyperpolarization, the intracellular mechanisms leading to the strong inhibitory effect of GABA on alpha-MSH secretion remain to be elucidated. gamma-Aminobutyric Acid 136-140 proopiomelanocortin Homo sapiens 144-153 7772233-6 1995 Both GABA and 3APS (100 microM each) induced a biphasic effect on alpha-MSH release from perifused frog neurointermediate lobes, i.e. a transient stimulation followed by an inhibition of alpha-MSH secretion. gamma-Aminobutyric Acid 5-9 proopiomelanocortin Homo sapiens 66-75 7772233-6 1995 Both GABA and 3APS (100 microM each) induced a biphasic effect on alpha-MSH release from perifused frog neurointermediate lobes, i.e. a transient stimulation followed by an inhibition of alpha-MSH secretion. gamma-Aminobutyric Acid 5-9 proopiomelanocortin Homo sapiens 187-196 2143059-11 1990 Finally, beta-endorphin, but not cholecystokinin, increases both in rat and human lymphocytes after treatment with the GABA agonist sodium valproate. gamma-Aminobutyric Acid 119-123 proopiomelanocortin Homo sapiens 9-23