PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26535644-10 2015 The GABA group rats had higher levels of tissue TNF-alpha and IL-6 than in ALI rats and control rats. gamma-Aminobutyric Acid 4-8 interleukin 6 Rattus norvegicus 62-66 28456544-6 2017 GABA pretreatment could not only remarkably restrain oxidative stress by increasing activities of superoxide dismutase and catalase as well as decreasing content of malondialdehyde both in gastric tissue and cells, but also significantly reduced pro-inflammatory factors (interleukin-6 and tumor necrosis factor alpha) levels in gastric tissue. gamma-Aminobutyric Acid 0-4 interleukin 6 Rattus norvegicus 272-285 18679050-0 2008 Gamma-aminobutyric acid inhibits synergistic interleukin-6 release but not transcriptional activation in astrocytoma cells. gamma-Aminobutyric Acid 0-23 interleukin 6 Rattus norvegicus 45-58 24098073-0 2013 Upregulation of genes related to bone formation by gamma-amino butyric acid and gamma-oryzanol in germinated brown rice is via the activation of GABAB-receptors and reduction of serum IL-6 in rats. gamma-Aminobutyric Acid 51-75 interleukin 6 Rattus norvegicus 184-188 18679050-2 2008 We investigated the GABA-mediated suppression of the synergistic release of interleukin (IL)-6 due to interleukin 1-beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha). gamma-Aminobutyric Acid 20-24 interleukin 6 Rattus norvegicus 76-94 18679050-7 2008 Additionally, GABA suppressed IL-6 release but did not alter cytokine-driven synergistic increases in IL-6 gene expression. gamma-Aminobutyric Acid 14-18 interleukin 6 Rattus norvegicus 30-34 18679050-8 2008 Western blot analysis revealed that co-treatments with IL-1 beta and TNF-alpha resulted in an increase in intracellular IL-6 that was prevented by GABA. gamma-Aminobutyric Acid 147-151 interleukin 6 Rattus norvegicus 120-124 18679050-9 2008 CONCLUSION: GABA-induced inhibition of IL-6 release appears to coincide with a reduction in cellular IL-6. gamma-Aminobutyric Acid 12-16 interleukin 6 Rattus norvegicus 39-43 18679050-9 2008 CONCLUSION: GABA-induced inhibition of IL-6 release appears to coincide with a reduction in cellular IL-6. gamma-Aminobutyric Acid 12-16 interleukin 6 Rattus norvegicus 101-105 18679050-10 2008 The GABA-induced suppression of IL-6 release may include inhibition of IL-6 gene translation. gamma-Aminobutyric Acid 4-8 interleukin 6 Rattus norvegicus 32-36 18679050-10 2008 The GABA-induced suppression of IL-6 release may include inhibition of IL-6 gene translation. gamma-Aminobutyric Acid 4-8 interleukin 6 Rattus norvegicus 71-75 16357100-0 2006 Prenatal exposure to interleukin-6 results in inflammatory neurodegeneration in hippocampus with NMDA/GABA(A) dysregulation and impaired spatial learning. gamma-Aminobutyric Acid 102-106 interleukin 6 Rattus norvegicus 21-34 16201258-5 2005 Compared with the controls, the immunoreaction of Glu was significantly increased, while GABA was obviously decreased in IL-1beta group and IL-6 group after 120 min. gamma-Aminobutyric Acid 89-93 interleukin 6 Rattus norvegicus 140-144 15316244-0 2004 Somatostatin and gamma-aminobutyric acid inhibit interleukin-1 beta-stimulated release of interleukin-6 from rat C6 glioma cells. gamma-Aminobutyric Acid 17-40 interleukin 6 Rattus norvegicus 90-103 15316244-6 2004 GABA also prevented IL-1 beta-driven IL-6 release (ED(50) = 100 microM). gamma-Aminobutyric Acid 0-4 interleukin 6 Rattus norvegicus 37-41 15316244-7 2004 IL-1 beta and LPC synergistically enhanced release of IL-6 in the presence of the beta-adrenergic receptor agonist isoproterenol (ISO); these effects were largely reversed by SRIF or GABA. gamma-Aminobutyric Acid 183-187 interleukin 6 Rattus norvegicus 54-58 15316244-9 2004 CONCLUSIONS: The effects of IL-1 beta and LPC on IL-6 release from glioma cells are effectively antagonized by the inhibitory neurotransmitters SRIF and GABA. gamma-Aminobutyric Acid 153-157 interleukin 6 Rattus norvegicus 49-53 15316244-10 2004 On the basis of correlative studies, we propose that the ability of inhibitory transmitters such as SRIF and GABA to counter the induction of IL-6 release may entail suppression of p38 activity. gamma-Aminobutyric Acid 109-113 interleukin 6 Rattus norvegicus 142-146 10686516-0 2000 Effect of interleukin-6 and tumor necrosis factor-alpha on GABA release from mediobasal hypothalamus and posterior pituitary. gamma-Aminobutyric Acid 59-63 interleukin 6 Rattus norvegicus 10-23 10686516-2 2000 We examined the effect of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) on release of gamma-aminobutyric acid (GABA) from mediobasal hypothalamic (MBH) explants and posterior pituitaries (PP) of male rats. gamma-Aminobutyric Acid 130-134 interleukin 6 Rattus norvegicus 26-39 10686516-3 2000 IL-6 (10 ng/ml) did not modify basal GABA release from MBH and PP, but significantly increased GABA release under depolarizing conditions (40 mM K(+)). gamma-Aminobutyric Acid 95-99 interleukin 6 Rattus norvegicus 0-4 10686516-4 2000 This effect was abolished by incubation of the tissue with indomethacin, an inhibitor of cyclooxygenase activity, indicating that prostaglandins could mediate the stimulation of GABA release induced by IL-6. gamma-Aminobutyric Acid 178-182 interleukin 6 Rattus norvegicus 202-206 10686516-8 2000 The current results indicate that IL-6 stimulates GABA release from both hypothalamus and posterior pituitary by a mechanism mediated by prostaglandins. gamma-Aminobutyric Acid 50-54 interleukin 6 Rattus norvegicus 34-38 9641526-6 1997 Astrocytes which became reactive after producing an artificial scar or after addition of certain compounds such as dibutyryl cyclic AMP, interleukin-6, basic fibroblast growth factor and kainic acid, also revealed GABA(A)-receptor immunoreactivity. gamma-Aminobutyric Acid 214-218 interleukin 6 Rattus norvegicus 137-150 32024466-11 2020 After injection of MI rat PVNs with the anti-IL-6 antibody or glycoprotein 130 inhibitor (SC144), glutamate levels increased and gamma-aminobutyric acid (GABA) levels decreased in the PVN. gamma-Aminobutyric Acid 129-152 interleukin 6 Rattus norvegicus 45-49 32024466-11 2020 After injection of MI rat PVNs with the anti-IL-6 antibody or glycoprotein 130 inhibitor (SC144), glutamate levels increased and gamma-aminobutyric acid (GABA) levels decreased in the PVN. gamma-Aminobutyric Acid 154-158 interleukin 6 Rattus norvegicus 45-49