PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18662706-3	2008	Here we demonstrate that there are two binding sites for AP2 in the gamma2-subunit: a Yxxvarphi type motif specific to gamma2-subunits and a basic patch AP2 binding motif, that is also found in GABA(A) receptor beta-subunits.	gamma-Aminobutyric Acid	194-198	transcription factor AP-2 alpha	Homo sapiens	57-60	
18662706-3	2008	Here we demonstrate that there are two binding sites for AP2 in the gamma2-subunit: a Yxxvarphi type motif specific to gamma2-subunits and a basic patch AP2 binding motif, that is also found in GABA(A) receptor beta-subunits.	gamma-Aminobutyric Acid	194-198	transcription factor AP-2 alpha	Homo sapiens	153-156	
18305175-4	2008	Blocking GABA(A)R-AP2 interactions via this motif increases synaptic responses within minutes.	gamma-Aminobutyric Acid	9-13	transcription factor AP-2 alpha	Homo sapiens	18-21	
18305175-6	2008	In addition, the crystal structure provides an explanation for the high affinity of this motif for AP2 and suggests that gamma2-subunit-containing heteromeric GABA(A)Rs may be internalized as dimers or multimers.	gamma-Aminobutyric Acid	159-163	transcription factor AP-2 alpha	Homo sapiens	99-102	
17254016-2	2007	Clathrin and adaptor protein 2 (AP2) complex-mediated endocytosis is known to play a fundamental role in regulating cell surface GABA(A) receptor numbers.	gamma-Aminobutyric Acid	129-133	transcription factor AP-2 alpha	Homo sapiens	13-30	
17254016-2	2007	Clathrin and adaptor protein 2 (AP2) complex-mediated endocytosis is known to play a fundamental role in regulating cell surface GABA(A) receptor numbers.	gamma-Aminobutyric Acid	129-133	transcription factor AP-2 alpha	Homo sapiens	32-35	
18184780-4	2008	Dephosphorylation of S408/9 unmasks a basic patch-binding motif for the clathrin adaptor AP2, enhancing the endocytosis of selected GABA(A)R subtypes from the plasma membrane during SE.	gamma-Aminobutyric Acid	132-136	transcription factor AP-2 alpha	Homo sapiens	89-92	
18184780-5	2008	In agreement with this, enhancing S408/9 phosphorylation or selectively blocking the binding of the beta3 subunit to AP2 increased GABA(A)R cell surface expression levels and restored the efficacy of synaptic inhibition in SE.	gamma-Aminobutyric Acid	131-135	transcription factor AP-2 alpha	Homo sapiens	117-120	
16192353-2	2005	The clathrin adaptor protein 2 (AP2) complex is a critical regulator of GABA(A)R endocytosis and, hence, surface receptor number.	gamma-Aminobutyric Acid	72-76	transcription factor AP-2 alpha	Homo sapiens	13-30	
16192353-2	2005	The clathrin adaptor protein 2 (AP2) complex is a critical regulator of GABA(A)R endocytosis and, hence, surface receptor number.	gamma-Aminobutyric Acid	72-76	transcription factor AP-2 alpha	Homo sapiens	32-35	
16192353-3	2005	Here, we identify a previously uncharacterized atypical AP2 binding motif conserved within the intracellular domains of all GABA(A)R beta subunit isoforms.	gamma-Aminobutyric Acid	124-128	transcription factor AP-2 alpha	Homo sapiens	56-59	
16192353-5	2005	Furthermore, by using surface plasmon resonance, we establish that a peptide (pepbeta3) corresponding to the AP2 binding motif in the GABA(A)R beta3 subunit binds to AP2 with high affinity only when dephosphorylated.	gamma-Aminobutyric Acid	134-138	transcription factor AP-2 alpha	Homo sapiens	109-112	
16192353-5	2005	Furthermore, by using surface plasmon resonance, we establish that a peptide (pepbeta3) corresponding to the AP2 binding motif in the GABA(A)R beta3 subunit binds to AP2 with high affinity only when dephosphorylated.	gamma-Aminobutyric Acid	134-138	transcription factor AP-2 alpha	Homo sapiens	166-169	
16192353-8	2005	Therefore phospho-dependent regulation of AP2 binding to GABA(A)Rs provides a mechanism to specify receptor cell surface number and the efficacy of inhibitory synaptic transmission.	gamma-Aminobutyric Acid	57-61	transcription factor AP-2 alpha	Homo sapiens	42-45