PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35296664-3 2022 Here, using conditional gamma-aminobutyric acid receptor B1- deficient mice we identify a gamma-aminobutyric acid/tumor necrosis factor superfamily member 12-mediated bidirectional communication pathway between parvalbumin-positive fast spiking interneurons and oligodendrocyte precursor cells that determines the density and function of interneurons in the developing medial prefrontal cortex. gamma-Aminobutyric Acid 90-113 parvalbumin Mus musculus 211-222 35406741-4 2022 Here, we found that induction of ischemia resulted in loss of parvalbumin (PV) gamma-aminobutyric acid (GABAergic) neurons more than Ca2+/calmodulin-kinase II (CaMKII) glutamatergic neurons in the mouse cortex. gamma-Aminobutyric Acid 79-102 parvalbumin Mus musculus 62-73 35001871-1 2022 Parvalbumin-positive (PV+) gamma-aminobutyric acid (GABA) interneurons are critically involved in producing rapid network oscillations and cortical microcircuit computations but the significance of PV+ axon myelination to the temporal features of inhibition remains elusive. gamma-Aminobutyric Acid 27-50 parvalbumin Mus musculus 0-11 35001871-1 2022 Parvalbumin-positive (PV+) gamma-aminobutyric acid (GABA) interneurons are critically involved in producing rapid network oscillations and cortical microcircuit computations but the significance of PV+ axon myelination to the temporal features of inhibition remains elusive. gamma-Aminobutyric Acid 52-56 parvalbumin Mus musculus 0-11 33859158-2 2021 Parvalbumin-positive interneurons (PV+ interneurons), a main subtype of GABA neurons, were shown to be decreased in the brain during the depression. gamma-Aminobutyric Acid 72-76 parvalbumin Mus musculus 0-11 33872635-2 2021 Gene-targeted disruption of the voltage-dependent potassium channel Kv3.1 broadens action potentials and reduces net inhibitory function of parvalbumin (PV)-positive GABA subtypes within the neocortex. gamma-Aminobutyric Acid 166-170 parvalbumin Mus musculus 140-151 33841107-2 2021 Disruptions in GABA transmission, in particular, that from parvalbumin-expressing interneurons (PVI), has been highlighted as a likely mechanism by which this imbalance arises, as they regulate excitation and synchronization of principle output neurons. gamma-Aminobutyric Acid 15-19 parvalbumin Mus musculus 59-70 33837272-9 2021 We found that functional GABAergic transmission was reduced in C4-OE mice, in line with diminished GABA release probability from parvalbumin interneurons, lower GAD67 expression, and decreased intrinsic excitability in parvalbumin interneurons. gamma-Aminobutyric Acid 25-29 parvalbumin Mus musculus 129-140 33837272-9 2021 We found that functional GABAergic transmission was reduced in C4-OE mice, in line with diminished GABA release probability from parvalbumin interneurons, lower GAD67 expression, and decreased intrinsic excitability in parvalbumin interneurons. gamma-Aminobutyric Acid 25-29 parvalbumin Mus musculus 219-230 31607482-0 2019 GABA releases from parvalbumin-expressing and unspecific GABAergic neurons onto CA1 pyramidal cells are differentially modulated by presynaptic GABAB receptors in mouse hippocampus. gamma-Aminobutyric Acid 0-4 parvalbumin Mus musculus 19-30 32012273-0 2020 Cation-chloride cotransporters and the polarity of GABA signalling in mouse hippocampal parvalbumin interneurons. gamma-Aminobutyric Acid 51-55 parvalbumin Mus musculus 88-99 32423230-3 2020 In this study, calretinin- (CR) and parvalbumin- (PV) positive gamma-aminobutyric acid-producing (GABAergic) interneurons were quantified in different hippocampal subfields of 12-month-old wild-type mice, as well as in the transgenic AD mouse models 5XFAD and Tg4-42. gamma-Aminobutyric Acid 63-86 parvalbumin Mus musculus 36-47 30541023-5 2019 From our electrophysiological analyses in the CA1 of the hippocampus, we conclude that the disruption in parvalbumin-positive neurons impairs the release of GABA-loaded vesicles, but increases the size of GABA quanta. gamma-Aminobutyric Acid 157-161 parvalbumin Mus musculus 105-116 30541023-5 2019 From our electrophysiological analyses in the CA1 of the hippocampus, we conclude that the disruption in parvalbumin-positive neurons impairs the release of GABA-loaded vesicles, but increases the size of GABA quanta. gamma-Aminobutyric Acid 205-209 parvalbumin Mus musculus 105-116 29120948-0 2017 Parvalbumin-containing GABA cells and schizophrenia: experimental model based on targeted gene delivery through adeno-associated viruses. gamma-Aminobutyric Acid 23-27 parvalbumin Mus musculus 0-11 31139063-1 2019 Parvalbumin (PV) expressing GABAergic interneurons provide large source of GABA to spiny projection neurons (SPNs) in the striatum. gamma-Aminobutyric Acid 28-32 parvalbumin Mus musculus 0-11 30837664-7 2019 For the first time we demonstrate that spindle density is markedly reduced by (i) optogenetic stimulation of a major GABA/PV inhibitory input to TRN arising from basal forebrain parvalbumin neurons (BF-PV) and; (ii) localized pharmacological inhibition of low-threshold calcium channels, implicated as a genetic risk factor for schizophrenia. gamma-Aminobutyric Acid 117-121 parvalbumin Mus musculus 178-189 30837664-7 2019 For the first time we demonstrate that spindle density is markedly reduced by (i) optogenetic stimulation of a major GABA/PV inhibitory input to TRN arising from basal forebrain parvalbumin neurons (BF-PV) and; (ii) localized pharmacological inhibition of low-threshold calcium channels, implicated as a genetic risk factor for schizophrenia. gamma-Aminobutyric Acid 117-121 parvalbumin Mus musculus 202-204 30233323-1 2018 Exposure to prenatal stress (PS) and mutations in Gad1, which encodes GABA synthesizing enzyme glutamate decarboxylase (GAD) 67, are the primary risk factors for psychiatric disorders associated with abnormalities in parvalbumin (PV)-positive GABAergic interneurons in the medial prefrontal cortex (mPFC). gamma-Aminobutyric Acid 70-74 parvalbumin Mus musculus 217-228 30072881-1 2018 The calcium-binding protein parvalbumin (PV) is a recognized marker of short-axon GABA-ergic neurons in the cortex and the hippocampus. gamma-Aminobutyric Acid 82-86 parvalbumin Mus musculus 28-39 30072881-1 2018 The calcium-binding protein parvalbumin (PV) is a recognized marker of short-axon GABA-ergic neurons in the cortex and the hippocampus. gamma-Aminobutyric Acid 82-86 parvalbumin Mus musculus 41-43 29042322-8 2017 They were specifically inhibited by GABA, which is released from local axonal endings of PV neurons. gamma-Aminobutyric Acid 36-40 parvalbumin Mus musculus 89-91 29345055-2 2018 This balance is largely established during early postnatal and adolescent developmental periods by maturation of the gamma-aminobutyric acid (GABA) system, including increased density of parvalbumin (PV) cells and perineuronal nets (PNNs). gamma-Aminobutyric Acid 117-140 parvalbumin Mus musculus 187-198 29345055-2 2018 This balance is largely established during early postnatal and adolescent developmental periods by maturation of the gamma-aminobutyric acid (GABA) system, including increased density of parvalbumin (PV) cells and perineuronal nets (PNNs). gamma-Aminobutyric Acid 142-146 parvalbumin Mus musculus 187-198 28733354-13 2017 The present experiments demonstrate that specific and sustained inhibition of GABA release from parvalbumin-expressing interneurons (mostly basket cells) in sector CA1/subiculum is sufficient to induce hyperexcitability and spontaneous recurrent seizures in mice. gamma-Aminobutyric Acid 78-82 parvalbumin Mus musculus 96-107 26980143-1 2016 In the cortex of subjects with schizophrenia, expression of glutamic acid decarboxylase 67 (GAD67), the enzyme primarily responsible for cortical GABA synthesis, is reduced in the subset of GABA neurons that express parvalbumin (PV). gamma-Aminobutyric Acid 146-150 parvalbumin Mus musculus 216-227 26980143-1 2016 In the cortex of subjects with schizophrenia, expression of glutamic acid decarboxylase 67 (GAD67), the enzyme primarily responsible for cortical GABA synthesis, is reduced in the subset of GABA neurons that express parvalbumin (PV). gamma-Aminobutyric Acid 190-194 parvalbumin Mus musculus 216-227 26980143-1 2016 In the cortex of subjects with schizophrenia, expression of glutamic acid decarboxylase 67 (GAD67), the enzyme primarily responsible for cortical GABA synthesis, is reduced in the subset of GABA neurons that express parvalbumin (PV). gamma-Aminobutyric Acid 190-194 parvalbumin Mus musculus 229-231 26980143-4 2016 We tested the hypothesis that this pattern of GABA-associated transcript levels is secondary to the GAD67 deficit in PV neurons by analyzing cortical levels of these GABA-associated mRNAs in mice with a PV neuron-specific GAD67 knockout. gamma-Aminobutyric Acid 46-50 parvalbumin Mus musculus 203-205 26980143-4 2016 We tested the hypothesis that this pattern of GABA-associated transcript levels is secondary to the GAD67 deficit in PV neurons by analyzing cortical levels of these GABA-associated mRNAs in mice with a PV neuron-specific GAD67 knockout. gamma-Aminobutyric Acid 166-170 parvalbumin Mus musculus 203-205 20080551-4 2010 Ablation of the NRG1 receptor ErbB4 in parvalbumin (PV)-positive interneurons prevented NRG1 from stimulating GABA release and from inhibiting pyramidal neurons. gamma-Aminobutyric Acid 110-114 parvalbumin Mus musculus 39-50 27251614-5 2016 The potentiation of GABAergic transmission arises from both an increased number of inhibitory synapses and an enhancement of presynaptic GABA release from parvalbumin- and somatostatin-expressing interneurons. gamma-Aminobutyric Acid 20-24 parvalbumin Mus musculus 155-166 26261347-3 2015 The maturation of cortical GABA inhibitory circuitry, the parvalbumin(+) (PV(+)) fast-spiking interneurons in particular, is a key component that regulates the initiation and termination of the critical period. gamma-Aminobutyric Acid 27-31 parvalbumin Mus musculus 58-69 26261347-5 2015 The functional maturation of parvalbumin interneurons was accelerated upon vision onset, as indicated by elevated GABA synthetic enzymes, vesicular GABA transporter, perineuronal nets, and enhanced GABA transmission among PV interneurons. gamma-Aminobutyric Acid 114-118 parvalbumin Mus musculus 29-40 26261347-5 2015 The functional maturation of parvalbumin interneurons was accelerated upon vision onset, as indicated by elevated GABA synthetic enzymes, vesicular GABA transporter, perineuronal nets, and enhanced GABA transmission among PV interneurons. gamma-Aminobutyric Acid 148-152 parvalbumin Mus musculus 29-40 25698507-2 2015 Reduction of parvalbumin (Pvalb)(+) gamma-aminobutyric acid (GABA)-ergic interneurons in the hilus of the dentate gyrus along with promoter region hypermethylation are thought to be responsible for this aberrant neurogenesis. gamma-Aminobutyric Acid 36-59 parvalbumin Mus musculus 13-24 25698507-2 2015 Reduction of parvalbumin (Pvalb)(+) gamma-aminobutyric acid (GABA)-ergic interneurons in the hilus of the dentate gyrus along with promoter region hypermethylation are thought to be responsible for this aberrant neurogenesis. gamma-Aminobutyric Acid 36-59 parvalbumin Mus musculus 26-31 25698507-2 2015 Reduction of parvalbumin (Pvalb)(+) gamma-aminobutyric acid (GABA)-ergic interneurons in the hilus of the dentate gyrus along with promoter region hypermethylation are thought to be responsible for this aberrant neurogenesis. gamma-Aminobutyric Acid 61-65 parvalbumin Mus musculus 13-24 25698507-2 2015 Reduction of parvalbumin (Pvalb)(+) gamma-aminobutyric acid (GABA)-ergic interneurons in the hilus of the dentate gyrus along with promoter region hypermethylation are thought to be responsible for this aberrant neurogenesis. gamma-Aminobutyric Acid 61-65 parvalbumin Mus musculus 26-31 23077066-0 2012 Target-specific suppression of GABA release from parvalbumin interneurons in the basolateral amygdala by dopamine. gamma-Aminobutyric Acid 31-35 parvalbumin Mus musculus 49-60 19874871-2 2010 Previously it was hypothesized that GABA and calcium-binding proteins including parvalbumin are not only colocalized in the same neuron subpopulation, but that GABA synthesis and parvalbumin expression could be also genetically regulated by a common mechanism. gamma-Aminobutyric Acid 36-40 parvalbumin Mus musculus 80-91 19874871-2 2010 Previously it was hypothesized that GABA and calcium-binding proteins including parvalbumin are not only colocalized in the same neuron subpopulation, but that GABA synthesis and parvalbumin expression could be also genetically regulated by a common mechanism. gamma-Aminobutyric Acid 36-40 parvalbumin Mus musculus 179-190 19874871-2 2010 Previously it was hypothesized that GABA and calcium-binding proteins including parvalbumin are not only colocalized in the same neuron subpopulation, but that GABA synthesis and parvalbumin expression could be also genetically regulated by a common mechanism. gamma-Aminobutyric Acid 160-164 parvalbumin Mus musculus 80-91 19874871-3 2010 Moreover, parvalbumin expression levels could influence GABA synthesis. gamma-Aminobutyric Acid 56-60 parvalbumin Mus musculus 10-21 19874871-4 2010 For this, we analyzed GABA immunoreactivity in RTN gigantic calyciform presynaptic terminals of parvalbumin-deficient (PV-/-) mice. gamma-Aminobutyric Acid 22-26 parvalbumin Mus musculus 96-107 21094213-1 2011 Reduction in cortical presynaptic markers, notably parvalbumin (PV), for the chandelier subtype of inhibitory gamma-amino-butyric acid (GABA) interneurons is a highly replicated post-mortem finding in schizophrenia. gamma-Aminobutyric Acid 110-134 parvalbumin Mus musculus 51-62 21094213-1 2011 Reduction in cortical presynaptic markers, notably parvalbumin (PV), for the chandelier subtype of inhibitory gamma-amino-butyric acid (GABA) interneurons is a highly replicated post-mortem finding in schizophrenia. gamma-Aminobutyric Acid 110-134 parvalbumin Mus musculus 64-66 21094213-1 2011 Reduction in cortical presynaptic markers, notably parvalbumin (PV), for the chandelier subtype of inhibitory gamma-amino-butyric acid (GABA) interneurons is a highly replicated post-mortem finding in schizophrenia. gamma-Aminobutyric Acid 136-140 parvalbumin Mus musculus 51-62 21094213-1 2011 Reduction in cortical presynaptic markers, notably parvalbumin (PV), for the chandelier subtype of inhibitory gamma-amino-butyric acid (GABA) interneurons is a highly replicated post-mortem finding in schizophrenia. gamma-Aminobutyric Acid 136-140 parvalbumin Mus musculus 64-66 12626620-2 2003 PV in GABAergic synaptic terminals was proposed to limit repetitive GABA release by buffering of "residual calcium." gamma-Aminobutyric Acid 6-10 parvalbumin Mus musculus 0-2 18985736-4 2009 Whereas the total number of neurons and astrocytes in these brain regions remain unaltered, pointing to a non- gliotic neurodegeneration (as seen in schizophrenia), the subgroup of parvalbumin-positive inhibitory GABAergic interneurons is increased bilaterally in the hippocampus, as is the expression of the GABA-synthesizing enzyme GAD67. gamma-Aminobutyric Acid 213-217 parvalbumin Mus musculus 181-192 18344910-2 2008 Because synaptic plasticity depends on an intact perineuronal net (PN), a specialized extracellular matrix that surrounds parvalbumin (PV)-positive GABAergic (gamma-aminobutyric acid [GABA]) inhibitory interneurons, we investigated the temporal relationships between microglial activation and loss of PN and PV-positive neurons in ME7 murine prion disease. gamma-Aminobutyric Acid 159-182 parvalbumin Mus musculus 122-133 18344910-2 2008 Because synaptic plasticity depends on an intact perineuronal net (PN), a specialized extracellular matrix that surrounds parvalbumin (PV)-positive GABAergic (gamma-aminobutyric acid [GABA]) inhibitory interneurons, we investigated the temporal relationships between microglial activation and loss of PN and PV-positive neurons in ME7 murine prion disease. gamma-Aminobutyric Acid 148-152 parvalbumin Mus musculus 122-133 15080894-8 2004 Through an increase in inhibition, the absence of PV facilitates synchronous activity in the cortex and facilitates hypersynchrony through the depolarizing action of GABA in the hippocampus. gamma-Aminobutyric Acid 166-170 parvalbumin Mus musculus 50-52 12626620-12 2003 These observations suggest that PV deficiency, due to an increased short-term facilitation of GABA release, enhances inhibition by high-frequency burst-firing PV-expressing interneurons and may affect the higher cognitive functions associated with gamma oscillations. gamma-Aminobutyric Acid 94-98 parvalbumin Mus musculus 32-34 11069288-1 2000 GABAergic (GABA = gamma-aminobutyric acid) neurons from different brain regions contain high levels of parvalbumin, both in their soma and in their neurites. gamma-Aminobutyric Acid 0-4 parvalbumin Mus musculus 103-114 11069288-1 2000 GABAergic (GABA = gamma-aminobutyric acid) neurons from different brain regions contain high levels of parvalbumin, both in their soma and in their neurites. gamma-Aminobutyric Acid 18-41 parvalbumin Mus musculus 103-114 34562597-2 2022 Fast-spiking parvalbumin-positive interneurons (PVIs), a subpopulation of GABAergic interneurons (GABA, g-aminobutyric acid), exhibit a widespread distribution throughout the hippocampus, and has been reported to play an important role in a variety of mental disorders. gamma-Aminobutyric Acid 98-102 parvalbumin Mus musculus 13-24 10509736-6 1999 The cultures treated for 24 h with antisense oligos (CaB+PV) showed a significant decrease in [3H]-GABA uptake as compared with the cultures treated with lipofectin alone or with lipofectin + mismatched antisense oligos to CaB and PV mRNA. gamma-Aminobutyric Acid 99-103 parvalbumin Mus musculus 57-59 33764684-2 2021 Two subtypes of BF gamma-aminobutyric acid (GABA) neurons, including somatostatin-expressing (GABASOM ) and parvalbumin-positive (GABAParv ) neurons, function differently in mediating the natural sleep-wake cycle. gamma-Aminobutyric Acid 19-42 parvalbumin Mus musculus 108-119 33764684-2 2021 Two subtypes of BF gamma-aminobutyric acid (GABA) neurons, including somatostatin-expressing (GABASOM ) and parvalbumin-positive (GABAParv ) neurons, function differently in mediating the natural sleep-wake cycle. gamma-Aminobutyric Acid 44-48 parvalbumin Mus musculus 108-119 34562597-2 2022 Fast-spiking parvalbumin-positive interneurons (PVIs), a subpopulation of GABAergic interneurons (GABA, g-aminobutyric acid), exhibit a widespread distribution throughout the hippocampus, and has been reported to play an important role in a variety of mental disorders. gamma-Aminobutyric Acid 104-123 parvalbumin Mus musculus 13-24