PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17013930-5	2006	Using HEK293 cells stably transfected with the alpha1beta2gamma2 form of the GABAA receptor, we found that UO126 reduced basal ERK phosphorylation and resulted in an enhancement of GABA-induced peak current amplitudes.	gamma-Aminobutyric Acid	77-81	mitogen-activated protein kinase 1	Homo sapiens	127-130	
17942900-7	2007	Furthermore, GABA treatment in GABRP-positive cells increased intracellular Ca2+ levels and activated the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) cascade.	gamma-Aminobutyric Acid	13-17	mitogen-activated protein kinase 1	Homo sapiens	178-182	
17942900-7	2007	Furthermore, GABA treatment in GABRP-positive cells increased intracellular Ca2+ levels and activated the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) cascade.	gamma-Aminobutyric Acid	13-17	mitogen-activated protein kinase 1	Homo sapiens	183-186	
17582742-8	2007	Furthermore, by using LY294002, a PI-3 kinase inhibitor, and a C-term of GRK-2 that has been reported to sequester Gbetagamma subunits, we demonstrate the role of Gbetagamma in GABA(B) receptor-mediated-ERK(1/2) phosphorylation.	gamma-Aminobutyric Acid	177-181	mitogen-activated protein kinase 1	Homo sapiens	203-210	
17013930-7	2006	Finally, mutation of the ERK phosphorylation site (T375-->A) prevented the UO126-induced enhancement of GABA-gated currents.	gamma-Aminobutyric Acid	107-111	mitogen-activated protein kinase 1	Homo sapiens	25-28	
18027151-4	2007	It was found that GABA stimulation promoted the phosphorylation of MAPKs, including ERK1/2, JNK, and p38.	gamma-Aminobutyric Acid	18-22	mitogen-activated protein kinase 1	Homo sapiens	101-104	
18027151-6	2007	It was noteworthy that the ras/raf/MEK/ERK pathway inhibitor PD98059 attenuated GABA-induced MMP-9 expression and that both PD98059 and MMP inhibitors attenuated the GABA-induced invasive activity of Caki-2 cells.	gamma-Aminobutyric Acid	80-84	mitogen-activated protein kinase 1	Homo sapiens	39-42	
18027151-7	2007	Moreover, data obtained by depletion of the MEK/ERK pathway using interfering RNA transfection of Caki-2 cells clearly corroborated the above results, as both MMP-9 expression and GABA-induced invasive ability were decreased significantly.	gamma-Aminobutyric Acid	180-184	mitogen-activated protein kinase 1	Homo sapiens	48-51	
30439377-4	2018	GABA- and piperine-mediated activation of the mitogen-activated protein kinase (MAPK) signaling pathway was investigated.	gamma-Aminobutyric Acid	0-4	mitogen-activated protein kinase 1	Homo sapiens	80-84	
30439377-12	2018	SIGNIFICANCE: These findings demonstrate that GABA plus piperine-mediated p38 and JNK MAPK activation increases EPO and EPO-R expression, resulting in up-regulation of IL-10 and NF-kappaB.	gamma-Aminobutyric Acid	46-50	mitogen-activated protein kinase 1	Homo sapiens	86-90	
30439377-8	2018	GABA plus piperine synergistically enhanced EPO and EPO-R expression through p38 and c-Jun N-terminal kinase (JNK) MAPK signaling pathways, but not through the extracellular signal-regulated kinase (ERK) MAPK pathway.	gamma-Aminobutyric Acid	0-4	mitogen-activated protein kinase 1	Homo sapiens	115-119	
27167129-7	2017	Mutations in neurofibromin thus lead to perturbed ERK signaling, which alters GABA release, LTP, and subsequently leads to learning deficits.	gamma-Aminobutyric Acid	78-82	mitogen-activated protein kinase 1	Homo sapiens	50-53