PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31178828-2 2019 Here, I review findings from mouse studies on the direct modulation of GnRH neuron activity and GnRH secretion by non-peptide neurotransmitters (GABA, glutamate, dopamine, serotonin, norepinephrine, epinephrine, histamine, ATP, adenosine, and acetylcholine), gasotransmitters (nitric oxide and carbon monoxide), and gliotransmitters (prostaglandin E2 and possibly GABA, glutamate, and ATP). gamma-Aminobutyric Acid 145-149 gonadotropin releasing hormone 1 Mus musculus 71-75 31178425-6 2019 In addition, GnRH neuron responses to ARN GABA fiber stimulation were recorded in ex vivo brain slices. gamma-Aminobutyric Acid 42-46 gonadotropin releasing hormone 1 Mus musculus 13-17 31178828-2 2019 Here, I review findings from mouse studies on the direct modulation of GnRH neuron activity and GnRH secretion by non-peptide neurotransmitters (GABA, glutamate, dopamine, serotonin, norepinephrine, epinephrine, histamine, ATP, adenosine, and acetylcholine), gasotransmitters (nitric oxide and carbon monoxide), and gliotransmitters (prostaglandin E2 and possibly GABA, glutamate, and ATP). gamma-Aminobutyric Acid 364-368 gonadotropin releasing hormone 1 Mus musculus 96-100 31178828-2 2019 Here, I review findings from mouse studies on the direct modulation of GnRH neuron activity and GnRH secretion by non-peptide neurotransmitters (GABA, glutamate, dopamine, serotonin, norepinephrine, epinephrine, histamine, ATP, adenosine, and acetylcholine), gasotransmitters (nitric oxide and carbon monoxide), and gliotransmitters (prostaglandin E2 and possibly GABA, glutamate, and ATP). gamma-Aminobutyric Acid 145-149 gonadotropin releasing hormone 1 Mus musculus 96-100 31178828-2 2019 Here, I review findings from mouse studies on the direct modulation of GnRH neuron activity and GnRH secretion by non-peptide neurotransmitters (GABA, glutamate, dopamine, serotonin, norepinephrine, epinephrine, histamine, ATP, adenosine, and acetylcholine), gasotransmitters (nitric oxide and carbon monoxide), and gliotransmitters (prostaglandin E2 and possibly GABA, glutamate, and ATP). gamma-Aminobutyric Acid 364-368 gonadotropin releasing hormone 1 Mus musculus 71-75 30415474-0 2018 Mapping GABA and glutamate inputs to gonadotrophin-releasing hormone neurones in male and female mice. gamma-Aminobutyric Acid 8-12 gonadotropin releasing hormone 1 Mus musculus 37-68 30415474-2 2018 The classical neurotransmitters GABA and glutamate are important regulators of GnRH neurone activity and are implicated in mediating feedback signals. gamma-Aminobutyric Acid 32-36 gonadotropin releasing hormone 1 Mus musculus 79-83 30079374-0 2018 Estradiol Increases Glutamate and GABA Neurotransmission into GnRH Neurons via Retrograde NO-Signaling in Proestrous Mice during the Positive Estradiol Feedback Period. gamma-Aminobutyric Acid 34-38 gonadotropin releasing hormone 1 Mus musculus 62-66 30079374-8 2018 These results indicate that estradiol acts directly on GnRH neurons via the ERbeta/Akt/nNOS pathway at proestrus afternoon generating NO that retrogradely accelerates GABA and glutamate release from the presynaptic terminals contacting GnRH neurons. gamma-Aminobutyric Acid 167-171 gonadotropin releasing hormone 1 Mus musculus 55-59 29374136-11 2018 PNA also alters the functional response of GnRH neurons to GABA. gamma-Aminobutyric Acid 59-63 gonadotropin releasing hormone 1 Mus musculus 43-47 29618656-5 2018 Using GnRH-GFP-transgenic mice, we determined that increased GABA input to GnRH neurons occurs prior to androgen excess and the manifestation of reproductive impairments in PNA mice. gamma-Aminobutyric Acid 61-65 gonadotropin releasing hormone 1 Mus musculus 6-10 29618656-5 2018 Using GnRH-GFP-transgenic mice, we determined that increased GABA input to GnRH neurons occurs prior to androgen excess and the manifestation of reproductive impairments in PNA mice. gamma-Aminobutyric Acid 61-65 gonadotropin releasing hormone 1 Mus musculus 75-79 26716764-13 2016 Our findings suggest that LEPR-expressing GABA neurones from the ARC may be mediators of leptin-to-GnRH signalling. gamma-Aminobutyric Acid 42-46 gonadotropin releasing hormone 1 Mus musculus 99-103 29109970-0 2017 Dynamics of GnRH Neuron Ionotropic GABA and Glutamate Synaptic Receptors Are Unchanged during Estrogen Positive and Negative Feedback in Female Mice. gamma-Aminobutyric Acid 35-39 gonadotropin releasing hormone 1 Mus musculus 12-16 22177387-7 2012 The GnRH-rPericam mouse was also valuable in determining differential mechanisms of GABA and glutamate control of calcium levels in GnRH neurons as well as effects of G-protein-coupled receptors for GnRH and kisspeptin. gamma-Aminobutyric Acid 84-88 gonadotropin releasing hormone 1 Mus musculus 4-8 25355308-1 2015 Acting via ionotropic GABAA receptors, the neurotransmitter gamma-aminobutyric acid (GABA) is an important modulator of gonadotropin-releasing hormone (GnRH) neurons. gamma-Aminobutyric Acid 60-83 gonadotropin releasing hormone 1 Mus musculus 120-150 25355308-1 2015 Acting via ionotropic GABAA receptors, the neurotransmitter gamma-aminobutyric acid (GABA) is an important modulator of gonadotropin-releasing hormone (GnRH) neurons. gamma-Aminobutyric Acid 60-83 gonadotropin releasing hormone 1 Mus musculus 152-156 25355308-1 2015 Acting via ionotropic GABAA receptors, the neurotransmitter gamma-aminobutyric acid (GABA) is an important modulator of gonadotropin-releasing hormone (GnRH) neurons. gamma-Aminobutyric Acid 22-26 gonadotropin releasing hormone 1 Mus musculus 120-150 25355308-1 2015 Acting via ionotropic GABAA receptors, the neurotransmitter gamma-aminobutyric acid (GABA) is an important modulator of gonadotropin-releasing hormone (GnRH) neurons. gamma-Aminobutyric Acid 22-26 gonadotropin releasing hormone 1 Mus musculus 152-156 25550522-7 2015 To address whether increased GABA innervation to GnRH neurons originates in the ARN, a viral-mediated Cre-lox approach was taken to trace the projections of ARN GABA neurons in vivo. gamma-Aminobutyric Acid 29-33 gonadotropin releasing hormone 1 Mus musculus 49-53 23351167-8 2013 These results demonstrate that genistein acts on GnRH neurones in juvenile female mice to induce excitation via GABA neurotransmission and TRPCs to enhance kisspeptin-induced activation. gamma-Aminobutyric Acid 112-116 gonadotropin releasing hormone 1 Mus musculus 49-53 23239814-7 2013 The role of dopamine in presynaptic modulation of the anteroventral periventricular nucleus (AVPV) gamma-aminobutyric acid/glutamate input to GnRH neurons was examined. gamma-Aminobutyric Acid 99-122 gonadotropin releasing hormone 1 Mus musculus 142-146 23239814-8 2013 Exogenous dopamine was found to presynaptically inhibit AVPV-evoked gamma-aminobutyric acid /glutamate postsynaptic currents in about 50% of GnRH neurons. gamma-Aminobutyric Acid 68-91 gonadotropin releasing hormone 1 Mus musculus 141-145 22745478-0 2012 Simulated GABA synaptic input and L-type calcium channels form functional microdomains in hypothalamic gonadotropin-releasing hormone neurons. gamma-Aminobutyric Acid 10-14 gonadotropin releasing hormone 1 Mus musculus 103-133 21518033-5 2011 Although it remains difficult to reconcile the results of the early studies, there is a growing consensus that GABA can act through the GABA(A) receptor to exert both depolarising and hyperpolarising effects on GnRH neurones. gamma-Aminobutyric Acid 111-115 gonadotropin releasing hormone 1 Mus musculus 211-215 21917995-7 2011 We hypothesized the local GnRH-GABA circuit utilizes glia-derived and/or cannabinoid mechanisms and is altered by steroid milieu. gamma-Aminobutyric Acid 31-35 gonadotropin releasing hormone 1 Mus musculus 26-30 21518033-6 2011 The most recent studies examining the effects of endogenous GABA release on GnRH neurones indicate that the predominant action is that of excitation. gamma-Aminobutyric Acid 60-64 gonadotropin releasing hormone 1 Mus musculus 76-80 18556136-3 2008 Regardless of whether GABA is inhibitory or excitatory in GnRH neurons, GABAergic input would be integrated with post-synaptic potentials generated by other synaptic inputs. gamma-Aminobutyric Acid 22-26 gonadotropin releasing hormone 1 Mus musculus 58-62 20807514-2 2010 It is widely accepted that the amino acid transmitters GABA and glutamate play important roles in controlling GnRH neuron excitability. gamma-Aminobutyric Acid 55-59 gonadotropin releasing hormone 1 Mus musculus 110-114 20009027-10 2010 In GABA(B1)KO females, GnRH pulse frequency was increased and GABA and glutamate contents were augmented. gamma-Aminobutyric Acid 3-7 gonadotropin releasing hormone 1 Mus musculus 23-27 20009027-14 2010 These results support the hypothesis that the absence of functional GABA(B)Rs alters GnRH physiology and critically affects sexual dimorphic expression of GnRH and GAD-67 in POA-AH. gamma-Aminobutyric Acid 68-72 gonadotropin releasing hormone 1 Mus musculus 85-89 20009027-14 2010 These results support the hypothesis that the absence of functional GABA(B)Rs alters GnRH physiology and critically affects sexual dimorphic expression of GnRH and GAD-67 in POA-AH. gamma-Aminobutyric Acid 68-72 gonadotropin releasing hormone 1 Mus musculus 155-159 19657033-6 2009 ORX enhanced the frequency of GABA transmission to GnRH neurons, but had no effect on glutamatergic transmission. gamma-Aminobutyric Acid 30-34 gonadotropin releasing hormone 1 Mus musculus 51-55 19403828-13 2009 ERalpha agonists reduced the frequency of GABA transmission to GnRH neurons; GABA can excite to these cells. gamma-Aminobutyric Acid 42-46 gonadotropin releasing hormone 1 Mus musculus 63-67 19403828-13 2009 ERalpha agonists reduced the frequency of GABA transmission to GnRH neurons; GABA can excite to these cells. gamma-Aminobutyric Acid 77-81 gonadotropin releasing hormone 1 Mus musculus 63-67 11897704-10 2002 They also provide the first direct evidence that GABA inhibits the electrical activity of postpubertal GnRH neurons. gamma-Aminobutyric Acid 49-53 gonadotropin releasing hormone 1 Mus musculus 103-107 17916627-4 2008 This study reports the expression of the CNGA2 subunit in GnRH-1 neurons obtained from mouse nasal explants and shows the ability of GnRH-1 neurons to increase their activity in response to forskolin (activator of adenylyl cyclases), or 3-isobutyl-1-methylxanthine (inhibitor of phosphodiesterases) even after removal of gamma-aminobutyric acid (A)-ergic input. gamma-Aminobutyric Acid 321-344 gonadotropin releasing hormone 1 Mus musculus 133-139 15096602-6 2004 GnRH neurons receive a major input from gamma-aminobutyric acid (GABA)ergic neurons, and GABA type A receptor activation may play a role in their regulation by steroids. gamma-Aminobutyric Acid 40-63 gonadotropin releasing hormone 1 Mus musculus 0-4 15096602-6 2004 GnRH neurons receive a major input from gamma-aminobutyric acid (GABA)ergic neurons, and GABA type A receptor activation may play a role in their regulation by steroids. gamma-Aminobutyric Acid 65-69 gonadotropin releasing hormone 1 Mus musculus 0-4 11897704-0 2002 Effect of GABA on GnRH neurons switches from depolarization to hyperpolarization at puberty in the female mouse. gamma-Aminobutyric Acid 10-14 gonadotropin releasing hormone 1 Mus musculus 18-22 11897704-1 2002 The amino acid gamma-aminobutyric acid (GABA) plays an important role in the regulation of the GnRH neurons. gamma-Aminobutyric Acid 15-38 gonadotropin releasing hormone 1 Mus musculus 95-99 11897704-1 2002 The amino acid gamma-aminobutyric acid (GABA) plays an important role in the regulation of the GnRH neurons. gamma-Aminobutyric Acid 40-44 gonadotropin releasing hormone 1 Mus musculus 95-99 11897704-3 2002 The basic membrane properties and GABA responsiveness of GnRH neurons were not altered by transgene expression or fluorescence. gamma-Aminobutyric Acid 34-38 gonadotropin releasing hormone 1 Mus musculus 57-61 11897704-4 2002 Ten of 12 immature GnRH neurons (10-17 d) were depolarized by GABA in a direct and dose-dependent manner that was blocked by a GABA(A) receptor antagonist. gamma-Aminobutyric Acid 62-66 gonadotropin releasing hormone 1 Mus musculus 19-23 11897704-5 2002 In peripubertal GnRH neurons (25-30 d), GABA exerted depolarizing (4/11) as well as hyperpolarizing (5/11) effects on GnRH neurons. gamma-Aminobutyric Acid 40-44 gonadotropin releasing hormone 1 Mus musculus 16-20 11897704-5 2002 In peripubertal GnRH neurons (25-30 d), GABA exerted depolarizing (4/11) as well as hyperpolarizing (5/11) effects on GnRH neurons. gamma-Aminobutyric Acid 40-44 gonadotropin releasing hormone 1 Mus musculus 118-122 11897704-6 2002 In adult female mice, GABA was found to exert exclusively hyperpolarizing actions on GnRH neurons (9/10) that were direct and mediated by the GABA(A) receptor. gamma-Aminobutyric Acid 22-26 gonadotropin releasing hormone 1 Mus musculus 85-89 11897704-9 2002 These findings demonstrate that GnRH neurons display an unusually late postnatal switch in their response to GABA. gamma-Aminobutyric Acid 109-113 gonadotropin releasing hormone 1 Mus musculus 32-36 18363808-3 2008 Two contradictory reports on the action of GABA in the GnRH neurones of adult mice have been published. gamma-Aminobutyric Acid 43-47 gonadotropin releasing hormone 1 Mus musculus 55-59 18363808-5 2008 (Mol Endocrinol 2002; 16: 2872) demonstrated that activation of GABA(A)Rs excites the GnRH neurones of adult mice, whereas Han et al. gamma-Aminobutyric Acid 64-68 gonadotropin releasing hormone 1 Mus musculus 86-90 18363808-6 2008 (Endocrinology 2002; 143: 1459) showed that the response to GABA on GnRH neurones switches from depolarisation to hyperpolarisation around puberty in female mice. gamma-Aminobutyric Acid 60-64 gonadotropin releasing hormone 1 Mus musculus 68-72 18081557-5 2008 Both in vivo and in vitro experiments suggest that GABA inhibits migration of GnRH-1 neurones. gamma-Aminobutyric Acid 51-55 gonadotropin releasing hormone 1 Mus musculus 78-84 18081557-13 2008 These data indicate that attenuated levels of GABA accelerate GnRH-1 cell migration in nasal areas as well as movement of GnRH-1 cells into the central nervous system at the NFJ. gamma-Aminobutyric Acid 46-50 gonadotropin releasing hormone 1 Mus musculus 62-68 17551263-0 2007 GABA inhibition of cyclic AMP production in immortalized GnRH neurons is mediated by calcineurin-dependent dephosphorylation of adenylyl cyclase 9. gamma-Aminobutyric Acid 0-4 gonadotropin releasing hormone 1 Mus musculus 57-61 17551263-1 2007 The neurotransmitter gamma-aminobutyric acid (GABA) is an important modulator of gonadotropin-releasing hormone (GnRH), and consequently of reproduction. gamma-Aminobutyric Acid 21-44 gonadotropin releasing hormone 1 Mus musculus 81-111 17551263-1 2007 The neurotransmitter gamma-aminobutyric acid (GABA) is an important modulator of gonadotropin-releasing hormone (GnRH), and consequently of reproduction. gamma-Aminobutyric Acid 21-44 gonadotropin releasing hormone 1 Mus musculus 113-117 17551263-1 2007 The neurotransmitter gamma-aminobutyric acid (GABA) is an important modulator of gonadotropin-releasing hormone (GnRH), and consequently of reproduction. gamma-Aminobutyric Acid 46-50 gonadotropin releasing hormone 1 Mus musculus 81-111 17551263-1 2007 The neurotransmitter gamma-aminobutyric acid (GABA) is an important modulator of gonadotropin-releasing hormone (GnRH), and consequently of reproduction. gamma-Aminobutyric Acid 46-50 gonadotropin releasing hormone 1 Mus musculus 113-117 17551263-2 2007 GABA, acting via ionotropic GABAA receptors, exerts a biphasic effect on GnRH secretion in immortalized GnRH cells. gamma-Aminobutyric Acid 0-4 gonadotropin releasing hormone 1 Mus musculus 73-77 17551263-2 2007 GABA, acting via ionotropic GABAA receptors, exerts a biphasic effect on GnRH secretion in immortalized GnRH cells. gamma-Aminobutyric Acid 0-4 gonadotropin releasing hormone 1 Mus musculus 104-108 17551263-11 2007 Collectively, our results show that the ionotropic action of GABA via the activation of GABAA receptors can decrease AC activity in immortalized GnRH neurons, and that the effect of GABA appears to be mediated by a transient increase in [Ca2+]i followed by activation of calcineurin and CamKII, leading to dephosphorylation of AC9 and phosphorylation of AC3, respectively, and subsequently reducing the synthesis of cAMP. gamma-Aminobutyric Acid 61-65 gonadotropin releasing hormone 1 Mus musculus 145-149 17551263-11 2007 Collectively, our results show that the ionotropic action of GABA via the activation of GABAA receptors can decrease AC activity in immortalized GnRH neurons, and that the effect of GABA appears to be mediated by a transient increase in [Ca2+]i followed by activation of calcineurin and CamKII, leading to dephosphorylation of AC9 and phosphorylation of AC3, respectively, and subsequently reducing the synthesis of cAMP. gamma-Aminobutyric Acid 88-92 gonadotropin releasing hormone 1 Mus musculus 145-149 13679427-3 2003 We hypothesized that fasting alters homeostatic mechanisms to eliminate excitatory responses to GABA but rejected this hypothesis when brief, local GABA application elicited action currents in GnRH neurons from fed and fasted mice. gamma-Aminobutyric Acid 148-152 gonadotropin releasing hormone 1 Mus musculus 193-197 11394636-1 2001 Gamma-aminobutyric acid (GABA) has been implicated in the regulation of reproduction, particularly in the developmental modulation of gonadotropin-releasing hormone (GnRH) secretion. gamma-Aminobutyric Acid 0-23 gonadotropin releasing hormone 1 Mus musculus 134-164 11694762-0 2001 Profiling gamma-aminobutyric acid (GABA(A)) receptor subunit mRNA expression in postnatal gonadotropin-releasing hormone (GnRH) neurons of the male mouse with single cell RT-PCR. gamma-Aminobutyric Acid 10-33 gonadotropin releasing hormone 1 Mus musculus 90-120 11694762-0 2001 Profiling gamma-aminobutyric acid (GABA(A)) receptor subunit mRNA expression in postnatal gonadotropin-releasing hormone (GnRH) neurons of the male mouse with single cell RT-PCR. gamma-Aminobutyric Acid 10-33 gonadotropin releasing hormone 1 Mus musculus 122-126 11694762-0 2001 Profiling gamma-aminobutyric acid (GABA(A)) receptor subunit mRNA expression in postnatal gonadotropin-releasing hormone (GnRH) neurons of the male mouse with single cell RT-PCR. gamma-Aminobutyric Acid 35-39 gonadotropin releasing hormone 1 Mus musculus 90-120 11694762-0 2001 Profiling gamma-aminobutyric acid (GABA(A)) receptor subunit mRNA expression in postnatal gonadotropin-releasing hormone (GnRH) neurons of the male mouse with single cell RT-PCR. gamma-Aminobutyric Acid 35-39 gonadotropin releasing hormone 1 Mus musculus 122-126 11394636-0 2001 GABA inhibition of immortalized gonadotropin-releasing hormone neuronal excitability involves GABA(A) receptors negatively coupled to cyclic adenosine monophosphate formation. gamma-Aminobutyric Acid 0-4 gonadotropin releasing hormone 1 Mus musculus 32-62 11394636-1 2001 Gamma-aminobutyric acid (GABA) has been implicated in the regulation of reproduction, particularly in the developmental modulation of gonadotropin-releasing hormone (GnRH) secretion. gamma-Aminobutyric Acid 0-23 gonadotropin releasing hormone 1 Mus musculus 166-170 11394636-1 2001 Gamma-aminobutyric acid (GABA) has been implicated in the regulation of reproduction, particularly in the developmental modulation of gonadotropin-releasing hormone (GnRH) secretion. gamma-Aminobutyric Acid 25-29 gonadotropin releasing hormone 1 Mus musculus 134-164 11394636-1 2001 Gamma-aminobutyric acid (GABA) has been implicated in the regulation of reproduction, particularly in the developmental modulation of gonadotropin-releasing hormone (GnRH) secretion. gamma-Aminobutyric Acid 25-29 gonadotropin releasing hormone 1 Mus musculus 166-170 11394636-2 2001 GnRH neurons are innervated by GABA-containing processes, and the administration of GABA stimulates and inhibits GnRH secretion in vivo and in vitro. gamma-Aminobutyric Acid 31-35 gonadotropin releasing hormone 1 Mus musculus 0-4 11394636-2 2001 GnRH neurons are innervated by GABA-containing processes, and the administration of GABA stimulates and inhibits GnRH secretion in vivo and in vitro. gamma-Aminobutyric Acid 84-88 gonadotropin releasing hormone 1 Mus musculus 113-117 11394636-3 2001 We have previously shown that GABA can exert both of these actions in sequence, by acting directly on immortalized GnRH neurons. gamma-Aminobutyric Acid 30-34 gonadotropin releasing hormone 1 Mus musculus 115-119 11394636-11 2001 Altogether, these results show that GABA(A) receptors mediate a sustained inhibitory effect of GABA on GnRH neurons, and suggest the involvement of the cAMP pathway decreasing cellular excitability. gamma-Aminobutyric Acid 36-40 gonadotropin releasing hormone 1 Mus musculus 103-107 11102573-0 2000 Sodium valproate alters GnRH-GABA interactions during development in seizure-prone mice. gamma-Aminobutyric Acid 29-33 gonadotropin releasing hormone 1 Mus musculus 24-28 11102573-7 2000 Additionally, VPA animals had greater numbers of bipolar and unipolar GnRH neurons with GABA associations across all ages. gamma-Aminobutyric Acid 88-92 gonadotropin releasing hormone 1 Mus musculus 70-74 9042529-0 1997 Gonadotropin releasing hormone modulates gamma-aminobutyric acid-evoked intracellular calcium increase in immortalized hypothalamic gonadotropin releasing hormone neurons. gamma-Aminobutyric Acid 41-64 gonadotropin releasing hormone 1 Mus musculus 0-30 11029618-1 2000 We have employed transgenic mouse models to examine the functional significance of the gamma2 subunit of the GABA(A) (gamma-aminobutyric acid) receptor to the correct development of gonadotropin-releasing hormone (GnRH) neurons in vivo. gamma-Aminobutyric Acid 109-113 gonadotropin releasing hormone 1 Mus musculus 182-212 11029618-1 2000 We have employed transgenic mouse models to examine the functional significance of the gamma2 subunit of the GABA(A) (gamma-aminobutyric acid) receptor to the correct development of gonadotropin-releasing hormone (GnRH) neurons in vivo. gamma-Aminobutyric Acid 109-113 gonadotropin releasing hormone 1 Mus musculus 214-218 11029619-7 2000 However, marked heterogeneity in the sensitivity of individual juvenile GnRH neurons to GABA was revealed and, in parallel with the change in subunit mRNA profile, this was dramatically reduced in the reproductively competent adult GnRH neurons. gamma-Aminobutyric Acid 88-92 gonadotropin releasing hormone 1 Mus musculus 72-76 11029619-7 2000 However, marked heterogeneity in the sensitivity of individual juvenile GnRH neurons to GABA was revealed and, in parallel with the change in subunit mRNA profile, this was dramatically reduced in the reproductively competent adult GnRH neurons. gamma-Aminobutyric Acid 88-92 gonadotropin releasing hormone 1 Mus musculus 232-236 10066257-0 1999 GABA- and glutamate-activated channels in green fluorescent protein-tagged gonadotropin-releasing hormone neurons in transgenic mice. gamma-Aminobutyric Acid 0-4 gonadotropin releasing hormone 1 Mus musculus 75-105 10066257-4 1999 Nucleated patches of GFP-expressing GnRH neurons exhibited pronounced responses to fast application of GABA and smaller responses to L-glutamate and AMPA. gamma-Aminobutyric Acid 103-107 gonadotropin releasing hormone 1 Mus musculus 36-40 9607779-2 1998 Evidence points to gamma-aminobutyric acid (GABA) as the major negative regulator of postnatal LHRH neuronal activity. gamma-Aminobutyric Acid 19-42 gonadotropin releasing hormone 1 Mus musculus 95-99 9607779-2 1998 Evidence points to gamma-aminobutyric acid (GABA) as the major negative regulator of postnatal LHRH neuronal activity. gamma-Aminobutyric Acid 44-48 gonadotropin releasing hormone 1 Mus musculus 95-99 9607779-4 1998 However, the extent to which GABA acts directly on LHRH neurons to effect LHRH mRNA levels has been difficult to ascertain. gamma-Aminobutyric Acid 29-33 gonadotropin releasing hormone 1 Mus musculus 51-55 9607779-4 1998 However, the extent to which GABA acts directly on LHRH neurons to effect LHRH mRNA levels has been difficult to ascertain. gamma-Aminobutyric Acid 29-33 gonadotropin releasing hormone 1 Mus musculus 74-78 9607779-9 1998 In contrast, LHRH mRNA levels decreased in explants cultured with the GABA(A) receptor agonist, muscimol (10(-4) M), or KCl (50 mM). gamma-Aminobutyric Acid 70-74 gonadotropin releasing hormone 1 Mus musculus 13-17 9650816-0 1997 Granulocyte-macrophage colony stimulating factor suppresses LHRH release by inhibition of nitric oxide synthase and stimulation of gamma-aminobutyric acid release. gamma-Aminobutyric Acid 131-154 gonadotropin releasing hormone 1 Mus musculus 60-64 9650816-13 1997 This dose completely reversed the suppression of LHRH release induced by GABA. gamma-Aminobutyric Acid 73-77 gonadotropin releasing hormone 1 Mus musculus 49-53 9650816-15 1997 The stimulated release of GABA acts on the GABA-a receptors on the LHRH terminals to inhibit their response to NO. gamma-Aminobutyric Acid 26-30 gonadotropin releasing hormone 1 Mus musculus 67-71 9042529-0 1997 Gonadotropin releasing hormone modulates gamma-aminobutyric acid-evoked intracellular calcium increase in immortalized hypothalamic gonadotropin releasing hormone neurons. gamma-Aminobutyric Acid 41-64 gonadotropin releasing hormone 1 Mus musculus 132-162 9042529-1 1997 To examine the functional role of calcium signaling in the interactive modulation of gonadotropin releasing hormone (GnRH) neurons by gamma-aminobutyric acid (GABA) and GnRH itself, we analyzed the intracellular calcium level ([Ca2+]i), using fura-2AM fluorescent dye in immortalized hypothalamic GT1-1 cells. gamma-Aminobutyric Acid 134-157 gonadotropin releasing hormone 1 Mus musculus 85-115 9042529-1 1997 To examine the functional role of calcium signaling in the interactive modulation of gonadotropin releasing hormone (GnRH) neurons by gamma-aminobutyric acid (GABA) and GnRH itself, we analyzed the intracellular calcium level ([Ca2+]i), using fura-2AM fluorescent dye in immortalized hypothalamic GT1-1 cells. gamma-Aminobutyric Acid 134-157 gonadotropin releasing hormone 1 Mus musculus 117-121 9042529-1 1997 To examine the functional role of calcium signaling in the interactive modulation of gonadotropin releasing hormone (GnRH) neurons by gamma-aminobutyric acid (GABA) and GnRH itself, we analyzed the intracellular calcium level ([Ca2+]i), using fura-2AM fluorescent dye in immortalized hypothalamic GT1-1 cells. gamma-Aminobutyric Acid 159-163 gonadotropin releasing hormone 1 Mus musculus 85-115 9042529-1 1997 To examine the functional role of calcium signaling in the interactive modulation of gonadotropin releasing hormone (GnRH) neurons by gamma-aminobutyric acid (GABA) and GnRH itself, we analyzed the intracellular calcium level ([Ca2+]i), using fura-2AM fluorescent dye in immortalized hypothalamic GT1-1 cells. gamma-Aminobutyric Acid 159-163 gonadotropin releasing hormone 1 Mus musculus 117-121 9042529-8 1997 These results show that GABAergic agents may exert both stimulatory and inhibitory controls over the GnRH neuronal activity, and GnRH can block the stimulatory effect of GABA, implicating the possible existence of an ultrashort feedback circuit. gamma-Aminobutyric Acid 24-28 gonadotropin releasing hormone 1 Mus musculus 101-105 26084811-3 2015 With immunohistochemistry and GAD67-GFP knockin mice, this study shows for the first time that a subset of GnRH neurons in the forebrain of adult mouse is gamma-aminobutyric acid (GABA)-ergic. gamma-Aminobutyric Acid 155-178 gonadotropin releasing hormone 1 Mus musculus 107-111 8954733-1 1996 In previous work, we showed a robust gamma-aminobutyric acid (GABAergic) synaptic input onto embryonic luteinizing hormone-releasing hormone (LHRH) neurons maintained in olfactory explants. gamma-Aminobutyric Acid 37-60 gonadotropin releasing hormone 1 Mus musculus 103-140 8954733-1 1996 In previous work, we showed a robust gamma-aminobutyric acid (GABAergic) synaptic input onto embryonic luteinizing hormone-releasing hormone (LHRH) neurons maintained in olfactory explants. gamma-Aminobutyric Acid 37-60 gonadotropin releasing hormone 1 Mus musculus 142-146 7731981-2 1995 Experiments performed in vitro with hypothalamic fragments have previously shown that GABA could modulate the release of gonadotropin-releasing hormone (GnRH). gamma-Aminobutyric Acid 86-90 gonadotropin releasing hormone 1 Mus musculus 121-151 7731981-2 1995 Experiments performed in vitro with hypothalamic fragments have previously shown that GABA could modulate the release of gonadotropin-releasing hormone (GnRH). gamma-Aminobutyric Acid 86-90 gonadotropin releasing hormone 1 Mus musculus 153-157 8022517-2 1994 This report investigates the direct effect of gamma-aminobutyric acid (GABA) and subtype selective GABA agonists on GnRH secretion by GT1 cells in perifusion. gamma-Aminobutyric Acid 46-69 gonadotropin releasing hormone 1 Mus musculus 116-120 8022517-2 1994 This report investigates the direct effect of gamma-aminobutyric acid (GABA) and subtype selective GABA agonists on GnRH secretion by GT1 cells in perifusion. gamma-Aminobutyric Acid 71-75 gonadotropin releasing hormone 1 Mus musculus 116-120 8022517-2 1994 This report investigates the direct effect of gamma-aminobutyric acid (GABA) and subtype selective GABA agonists on GnRH secretion by GT1 cells in perifusion. gamma-Aminobutyric Acid 99-103 gonadotropin releasing hormone 1 Mus musculus 116-120 8022517-3 1994 Treatment of GT1-1 cells with GABA (10 microM) for 100 min resulted in a biphasic release of GnRH. gamma-Aminobutyric Acid 30-34 gonadotropin releasing hormone 1 Mus musculus 93-97 8022517-8 1994 These results demonstrate a direct biphasic effect of GABA upon GnRH release. gamma-Aminobutyric Acid 54-58 gonadotropin releasing hormone 1 Mus musculus 64-68 8404645-2 1993 GABA apparently exerts these effects at the hypothalamic level by regulating the release of LHRH. gamma-Aminobutyric Acid 0-4 gonadotropin releasing hormone 1 Mus musculus 92-96 8404645-4 1993 LHRH secretion was stimulated in a dose-dependent manner with increasing concentrations of GABA. gamma-Aminobutyric Acid 91-95 gonadotropin releasing hormone 1 Mus musculus 0-4 26084811-3 2015 With immunohistochemistry and GAD67-GFP knockin mice, this study shows for the first time that a subset of GnRH neurons in the forebrain of adult mouse is gamma-aminobutyric acid (GABA)-ergic. gamma-Aminobutyric Acid 180-184 gonadotropin releasing hormone 1 Mus musculus 107-111 26084811-9 2015 In conclusion, our data suggest that 1) a subset of GnRH neurons in mouse forebrain is GABA-ergic, 2) expression of GAD67-GFP in GnRH neurons is at least in part regulated by estrogen, and 3) GnRH neurons secrete GABA to regulate themselves. gamma-Aminobutyric Acid 87-91 gonadotropin releasing hormone 1 Mus musculus 52-56 26084811-9 2015 In conclusion, our data suggest that 1) a subset of GnRH neurons in mouse forebrain is GABA-ergic, 2) expression of GAD67-GFP in GnRH neurons is at least in part regulated by estrogen, and 3) GnRH neurons secrete GABA to regulate themselves. gamma-Aminobutyric Acid 87-91 gonadotropin releasing hormone 1 Mus musculus 129-133 26084811-9 2015 In conclusion, our data suggest that 1) a subset of GnRH neurons in mouse forebrain is GABA-ergic, 2) expression of GAD67-GFP in GnRH neurons is at least in part regulated by estrogen, and 3) GnRH neurons secrete GABA to regulate themselves. gamma-Aminobutyric Acid 87-91 gonadotropin releasing hormone 1 Mus musculus 129-133 26084811-9 2015 In conclusion, our data suggest that 1) a subset of GnRH neurons in mouse forebrain is GABA-ergic, 2) expression of GAD67-GFP in GnRH neurons is at least in part regulated by estrogen, and 3) GnRH neurons secrete GABA to regulate themselves. gamma-Aminobutyric Acid 213-217 gonadotropin releasing hormone 1 Mus musculus 52-56 26084811-9 2015 In conclusion, our data suggest that 1) a subset of GnRH neurons in mouse forebrain is GABA-ergic, 2) expression of GAD67-GFP in GnRH neurons is at least in part regulated by estrogen, and 3) GnRH neurons secrete GABA to regulate themselves. gamma-Aminobutyric Acid 213-217 gonadotropin releasing hormone 1 Mus musculus 129-133 26084811-9 2015 In conclusion, our data suggest that 1) a subset of GnRH neurons in mouse forebrain is GABA-ergic, 2) expression of GAD67-GFP in GnRH neurons is at least in part regulated by estrogen, and 3) GnRH neurons secrete GABA to regulate themselves. gamma-Aminobutyric Acid 213-217 gonadotropin releasing hormone 1 Mus musculus 129-133 33361699-8 2021 DISCUSSION/CONCLUSION: These findings indicate that IGF-1 arrests the tonic retrograde endocannabinoid pathway in GnRH neurons and this disinhibition increases the release of GABA from presynaptic terminals that, in turn, activates GnRH neurons leading to the fine-tuning of the hypothalamo-pituitary-gonadal axis. gamma-Aminobutyric Acid 175-179 gonadotropin releasing hormone 1 Mus musculus 232-236 32798220-0 2020 A CRH Receptor Type 1 Agonist Increases GABA Transmission to GnRH Neurons in a Circulating-Estradiol-Dependent Manner. gamma-Aminobutyric Acid 40-44 gonadotropin releasing hormone 1 Mus musculus 61-65 33094210-0 2020 Investigating the NPY/AgRP/GABA to GnRH Neuron Circuit in Prenatally Androgenized PCOS-Like Mice. gamma-Aminobutyric Acid 27-31 gonadotropin releasing hormone 1 Mus musculus 35-39 33094210-3 2020 One-third of ARN GABA neurons co-express neuropeptide Y (NPY), which has a known yet complex role in regulating GnRH neurons and reproductive function. gamma-Aminobutyric Acid 17-21 gonadotropin releasing hormone 1 Mus musculus 112-116 32560611-17 2020 for 99mTc-HYNIC-Gaba-D-Lys6GnRH. gamma-Aminobutyric Acid 16-20 gonadotropin releasing hormone 1 Mus musculus 27-31 32560611-22 2020 Moreover, this report shows that 99mTc-HYNIC (tricine/EDDA)-Gaba-D-Lys6GnRH may be a suitable candidate for further evaluation on prostate cancer. gamma-Aminobutyric Acid 60-64 gonadotropin releasing hormone 1 Mus musculus 71-75