PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23384353-5 2013 The levels of interleukin (IL)-1beta, lipopolysaccharide-induced tumor necrosis factor-alpha and IL-6 in serum were significantly decreased by GABA at 80 mg/kg (P < 0.05). gamma-Aminobutyric Acid 143-147 interleukin 6 Homo sapiens 97-101 18480275-7 2008 Consistently, TNFalpha and IL-1beta enhanced AMPA- or NMDA-induced currents, and IL-1beta and IL-6 suppressed GABA- and glycine-induced currents. gamma-Aminobutyric Acid 110-114 interleukin 6 Homo sapiens 94-98 18171484-2 2008 Integrating these data suggests that GABA may play a role in downregulating mechanisms that lead to the production of proinflammatory agents such as interleukin-1, interleukin-6, and matrix metalloproteinase 3 - agents implicated in the pathogenesis of rheumatoid arthritis (RA). gamma-Aminobutyric Acid 37-41 interleukin 6 Homo sapiens 164-177 33146673-8 2021 Molecular docking results showed that the molecular binding affinity with IL-6 of all compounds except gamma-aminobutyric acid was < -5.0 kJ/mol, indicating the potential of numerous active compounds in TCM to directly interact with IL-6, leading to an anti-inflammation effect. gamma-Aminobutyric Acid 103-126 interleukin 6 Homo sapiens 74-78 33146673-8 2021 Molecular docking results showed that the molecular binding affinity with IL-6 of all compounds except gamma-aminobutyric acid was < -5.0 kJ/mol, indicating the potential of numerous active compounds in TCM to directly interact with IL-6, leading to an anti-inflammation effect. gamma-Aminobutyric Acid 103-126 interleukin 6 Homo sapiens 233-237 31547604-0 2019 Regulation of Heat Shock Factor Pathways by gamma-aminobutyric Acid (GABA) Associated with Thermotolerance of Creeping Bentgrass. gamma-Aminobutyric Acid 44-67 interleukin 6 Homo sapiens 14-31 31547604-0 2019 Regulation of Heat Shock Factor Pathways by gamma-aminobutyric Acid (GABA) Associated with Thermotolerance of Creeping Bentgrass. gamma-Aminobutyric Acid 69-73 interleukin 6 Homo sapiens 14-31 31547604-6 2019 Transcriptional analyses showed that exogenous GABA could significantly upregulate transcript levels of genes encoding heat shock factor HSFs (HSFA-6a, HSFA-2c, and HSFB-2b), heat shock proteins (HSP17.8, HSP26.7, HSP70, and HSP90.1-b1), and ascorbate peroxidase 3 (APX3), whereas the inhibition of GABA biosynthesis depressed these genes expression under heat stress. gamma-Aminobutyric Acid 47-51 interleukin 6 Homo sapiens 119-136 31547604-6 2019 Transcriptional analyses showed that exogenous GABA could significantly upregulate transcript levels of genes encoding heat shock factor HSFs (HSFA-6a, HSFA-2c, and HSFB-2b), heat shock proteins (HSP17.8, HSP26.7, HSP70, and HSP90.1-b1), and ascorbate peroxidase 3 (APX3), whereas the inhibition of GABA biosynthesis depressed these genes expression under heat stress. gamma-Aminobutyric Acid 299-303 interleukin 6 Homo sapiens 119-136 31547604-7 2019 Our results indicate GABA regulates thermotolerance associated with activation and enhancement of HSF pathways in creeping bentgrass. gamma-Aminobutyric Acid 21-25 interleukin 6 Homo sapiens 98-101