PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28449558-2 2017 Aberration in BDNF signaling pathways directly or circuitously influences neurotransmitters like glutamate and gamma-aminobutyric acid (GABA). gamma-Aminobutyric Acid 111-134 brain derived neurotrophic factor Homo sapiens 14-18 28449558-4 2017 Methods: Using CellDesigner, we modeled BDNF interactions with calcium influx via N-methyl-D-aspartate receptor (NMDAR)- Calmodulin activation; synthesis of GABA via cell cycle regulators protein kinase B, glycogen synthase kinase and beta-catenin; transportation of glutamate and GABA. gamma-Aminobutyric Acid 281-285 brain derived neurotrophic factor Homo sapiens 40-44 28449558-7 2017 Deficient BDNF could suppress Glutamate decarboxylase 67-mediated GABA synthesis. gamma-Aminobutyric Acid 66-70 brain derived neurotrophic factor Homo sapiens 10-14 30334291-3 2018 We have previously shown that at inhibitory synapses in layer 2/3 of the somatosensory cortex, BDNF induces the mobilization of endogenous cannabinoids (eCBs) that act retrogradely to suppress GABA release. gamma-Aminobutyric Acid 193-197 brain derived neurotrophic factor Homo sapiens 95-99 30334291-12 2018 Collectively, these results suggest that in the hippocampus, BDNF-TrkB signaling induces the postsynaptic release of the endogenous cannabinoid 2-AG, which acts retrogradely on the presynaptic CB1 receptors to suppress GABA release. gamma-Aminobutyric Acid 219-223 brain derived neurotrophic factor Homo sapiens 61-65 28449558-2 2017 Aberration in BDNF signaling pathways directly or circuitously influences neurotransmitters like glutamate and gamma-aminobutyric acid (GABA). gamma-Aminobutyric Acid 136-140 brain derived neurotrophic factor Homo sapiens 14-18 28449558-3 2017 For the first time, this study attempts to construct and simulate the BDNF-neurotransmitter network in order to assess the effects of BDNF deficiency on glutamate and GABA. gamma-Aminobutyric Acid 167-171 brain derived neurotrophic factor Homo sapiens 70-74 28449558-3 2017 For the first time, this study attempts to construct and simulate the BDNF-neurotransmitter network in order to assess the effects of BDNF deficiency on glutamate and GABA. gamma-Aminobutyric Acid 167-171 brain derived neurotrophic factor Homo sapiens 134-138 28449558-4 2017 Methods: Using CellDesigner, we modeled BDNF interactions with calcium influx via N-methyl-D-aspartate receptor (NMDAR)- Calmodulin activation; synthesis of GABA via cell cycle regulators protein kinase B, glycogen synthase kinase and beta-catenin; transportation of glutamate and GABA. gamma-Aminobutyric Acid 157-161 brain derived neurotrophic factor Homo sapiens 40-44 25307426-2 2015 The aim of this study was to test the hypothesis that hyperactivation of BDNF-TrkB signaling pathways in surgically resected HH tissue is a possible mechanism for downregulation of KCC2 expression, which in turn underlies GABA-mediated excitation within HH. gamma-Aminobutyric Acid 222-226 brain derived neurotrophic factor Homo sapiens 73-77 27417517-10 2016 Together, these findings suggest that age-dependent decrease in BDNF signaling may cause synaptic alterations through an initial and preferential effect on GABA presynaptic genes. gamma-Aminobutyric Acid 156-160 brain derived neurotrophic factor Homo sapiens 64-68 27107672-2 2016 Also, interactions of gamma-aminobutyric acid (GABA)-ergic compounds and BDNF have been reported. gamma-Aminobutyric Acid 22-45 brain derived neurotrophic factor Homo sapiens 73-77 27107672-2 2016 Also, interactions of gamma-aminobutyric acid (GABA)-ergic compounds and BDNF have been reported. gamma-Aminobutyric Acid 47-51 brain derived neurotrophic factor Homo sapiens 73-77 27311077-3 2016 The results highlight presynaptic roles of mGluR1 receptors and of BDNF as a retrograde signal to regulate GABA synthesis and tune transmission. gamma-Aminobutyric Acid 107-111 brain derived neurotrophic factor Homo sapiens 67-71 27323945-6 2016 Partial activation of BDNF TrkB receptors with a small molecule reverses structural abnormalities in FS interneuronal terminals, increases the frequency of mIPSCs, and increases probability of GABA release. gamma-Aminobutyric Acid 193-197 brain derived neurotrophic factor Homo sapiens 22-26 25881116-8 2015 These results suggest that DNAm may be a proximal mechanism for decreased expression of BDNF, SST, and other BDNF- and GABA-related genes with brain aging and, by extension, for brain disorders in which their expression is decreased. gamma-Aminobutyric Acid 119-123 brain derived neurotrophic factor Homo sapiens 88-92 28164368-5 2017 In contrast, we have shown that BDNF attenuates inhibitory transmission by inducing postsynaptic release of eCBs that act retrogradely to suppress GABA release in layer 2/3 of somatosensory cortex. gamma-Aminobutyric Acid 147-151 brain derived neurotrophic factor Homo sapiens 32-36 27660699-8 2016 RESULTS: In weanlings, we found an effect of sex chromosome complement, with lower expression of GABA/BDNF-related genes in XY mice. gamma-Aminobutyric Acid 97-101 brain derived neurotrophic factor Homo sapiens 102-106 25249941-15 2014 It is suggested that BDNF has a restorative effect because it up-regulates KCC2 and re-establishes GABA-mediated inhibition. gamma-Aminobutyric Acid 99-103 brain derived neurotrophic factor Homo sapiens 21-25 25454160-0 2014 BDNF-trkB-KCC2-GABA pathway may be related to chronic stress-induced hyperalgesia at both the spinal and supraspinal level. gamma-Aminobutyric Acid 15-19 brain derived neurotrophic factor Homo sapiens 0-4 25454160-5 2014 We therefore hypothesized that SIH may be owned to disinhibition caused by the activation of BDNF-trkB-KCC2-GABA pathway, which would provide a new understanding for SIH. gamma-Aminobutyric Acid 108-112 brain derived neurotrophic factor Homo sapiens 93-97 24089642-5 2013 The efforts made by different laboratories during the last decade have collectively provided a robust mechanistic paradigm which elucidates the mechanisms involved in the synthesis and release of BDNF from microglia, the downstream TrkB-mediated signals in neurons, and the biophysical mechanism by which disinhibition occurs, via the downregulation of the K+-Cl- cotransporter KCC2, dysrupting Cl- homeostasis, and hence the strength of GABA(A)- and glycine receptor-mediated inhibition. gamma-Aminobutyric Acid 438-442 brain derived neurotrophic factor Homo sapiens 196-200 23341142-5 2013 We also found that the effect of BDNF is highly localized at the GABA-A synapse and is secured by physical coupling between GABA-A receptor and KCC2, as revealed by coimmunoprecipitation studies. gamma-Aminobutyric Acid 65-69 brain derived neurotrophic factor Homo sapiens 33-37 23157625-2 2013 BDNF is also believed to interact with other neurotransmitter systems implicated in schizophrenia, such as dopamine, glutamate, serotonin and GABA. gamma-Aminobutyric Acid 142-146 brain derived neurotrophic factor Homo sapiens 0-4 24908484-6 2014 Activation of TrkB receptors triggers a signaling cascade involving JNK-mediated activation of cJun that regulates tlx3, a glutamate/GABA selector gene, accounting for calcium-spike BDNF-dependent transmitter switching. gamma-Aminobutyric Acid 133-137 brain derived neurotrophic factor Homo sapiens 182-186 24608543-0 2014 A conserved BDNF, glutamate- and GABA-enriched gene module related to human depression identified by coexpression meta-analysis and DNA variant genome-wide association studies. gamma-Aminobutyric Acid 33-37 brain derived neurotrophic factor Homo sapiens 12-16 19339612-6 2009 Interestingly, GABA released from neuroblasts induces Ca(2+)-dependent insertion of high-affinity TrkB receptors on the plasma membrane of astrocytes that trap extracellular BDNF. gamma-Aminobutyric Acid 15-19 brain derived neurotrophic factor Homo sapiens 174-178 22922352-0 2012 Brain-derived neurotrophic factor increases the motility of a particular N-methyl-D-aspartate /GABA-responsive subset of neural progenitor cells. gamma-Aminobutyric Acid 95-99 brain derived neurotrophic factor Homo sapiens 0-33 22922352-11 2012 BDNF did not appreciably affect the distribution of these cells but promoted the redistribution of a small subpopulation (about 20%) of N-methyl-D-aspartate (NMDA)- and GABA-responsive cells to the outermost layers of migration. gamma-Aminobutyric Acid 169-173 brain derived neurotrophic factor Homo sapiens 0-4 22922352-12 2012 The results demonstrate that BDNF does not affect cell motility per se but alters the phasic behavior of cell movement by promoting periods of high motility in a defined subpopulation of cells which give a robust Ca(2+) response to NMDA and GABA. gamma-Aminobutyric Acid 241-245 brain derived neurotrophic factor Homo sapiens 29-33 22457755-3 2012 Growth factors, such as PDGF, and BDNF, regulate the GABA phenotype by inducing the expression of GAD67 and stimulating the growth of cellular processes, many with growth cones that form appositions with the cell bodies and processes of other GAD67-positive cells. gamma-Aminobutyric Acid 53-57 brain derived neurotrophic factor Homo sapiens 34-38 22457755-5 2012 The addition of BDNF, together with PDGF, increases the levels of mRNA and protein for GAD67, as well as the high affinity GABA uptake protein, GAT1. gamma-Aminobutyric Acid 123-127 brain derived neurotrophic factor Homo sapiens 16-20 21474450-4 2011 We further demonstrate that GABA(A)R activity triggers release of the brain-derived neurotrophic factor (BDNF), which, in turn by activating TrkB receptors, mediates the observed increase in cell surface expression of GABA(A)Rs. gamma-Aminobutyric Acid 28-32 brain derived neurotrophic factor Homo sapiens 70-103 21474450-4 2011 We further demonstrate that GABA(A)R activity triggers release of the brain-derived neurotrophic factor (BDNF), which, in turn by activating TrkB receptors, mediates the observed increase in cell surface expression of GABA(A)Rs. gamma-Aminobutyric Acid 28-32 brain derived neurotrophic factor Homo sapiens 105-109 21474450-4 2011 We further demonstrate that GABA(A)R activity triggers release of the brain-derived neurotrophic factor (BDNF), which, in turn by activating TrkB receptors, mediates the observed increase in cell surface expression of GABA(A)Rs. gamma-Aminobutyric Acid 218-222 brain derived neurotrophic factor Homo sapiens 70-103 21474450-4 2011 We further demonstrate that GABA(A)R activity triggers release of the brain-derived neurotrophic factor (BDNF), which, in turn by activating TrkB receptors, mediates the observed increase in cell surface expression of GABA(A)Rs. gamma-Aminobutyric Acid 218-222 brain derived neurotrophic factor Homo sapiens 105-109 21474450-5 2011 This BDNF/TrkB-dependent increase in surface levels of GABA(A)Rs requires the activity of phosphoinositide 3-kinase (PI3K) and protein kinase C (PKC) and does not involve the extracellular signal-regulated kinase (ERK) 1/2 activity. gamma-Aminobutyric Acid 55-59 brain derived neurotrophic factor Homo sapiens 5-9 21474450-6 2011 The increase in GABA(A)R surface levels occurs due to an inhibition of the receptor endocytosis by BDNF, whereas the receptor reinsertion into the plasma membrane remains unaltered. gamma-Aminobutyric Acid 16-20 brain derived neurotrophic factor Homo sapiens 99-103 21474450-7 2011 Thus, GABA(A)R activity is a potent regulator of the BDNF release during neuronal development, and at the same time, it is strongly enhanced by the activity of the BDNF/TrkB/PI3K/PKC signaling pathway. gamma-Aminobutyric Acid 6-10 brain derived neurotrophic factor Homo sapiens 53-57 21474450-7 2011 Thus, GABA(A)R activity is a potent regulator of the BDNF release during neuronal development, and at the same time, it is strongly enhanced by the activity of the BDNF/TrkB/PI3K/PKC signaling pathway. gamma-Aminobutyric Acid 6-10 brain derived neurotrophic factor Homo sapiens 164-168 20739478-2 2011 Previous studies have suggested that the expression levels of the rate-limiting GABA synthetic enzyme, GAD65, depend on brain derived neurotrophic factor (BDNF)/TrkB activation. gamma-Aminobutyric Acid 80-84 brain derived neurotrophic factor Homo sapiens 120-153 20739478-2 2011 Previous studies have suggested that the expression levels of the rate-limiting GABA synthetic enzyme, GAD65, depend on brain derived neurotrophic factor (BDNF)/TrkB activation. gamma-Aminobutyric Acid 80-84 brain derived neurotrophic factor Homo sapiens 155-159 19804761-5 2009 A sensory-specific source of brain derived neurotrophic factor induces synaptic expression of the GABA synthetic enzyme GAD65--a defining biochemical feature of this set of interneurons. gamma-Aminobutyric Acid 98-102 brain derived neurotrophic factor Homo sapiens 29-62 23077067-8 2012 In primary neurons, a reduction in the number of gephyrin clusters due to manipulation of the BDNF-mTOR signaling is associated with reduced GABA(A) receptor clustering, suggesting functional impairment of GABA signaling. gamma-Aminobutyric Acid 141-145 brain derived neurotrophic factor Homo sapiens 94-98 21902679-1 2012 OBJECTIVE: The aims of this study were to test the individual association of the serotonin transporter gene (SLC6A4), the brain-derived neurotrophic factor gene (BDNF) and the GABA(A) alpha(6) receptor subunit gene (GABRA6) with anxiety-related traits and to explore putative gene-gene interactions in a Spanish healthy sample. gamma-Aminobutyric Acid 176-180 brain derived neurotrophic factor Homo sapiens 122-155 21902679-1 2012 OBJECTIVE: The aims of this study were to test the individual association of the serotonin transporter gene (SLC6A4), the brain-derived neurotrophic factor gene (BDNF) and the GABA(A) alpha(6) receptor subunit gene (GABRA6) with anxiety-related traits and to explore putative gene-gene interactions in a Spanish healthy sample. gamma-Aminobutyric Acid 176-180 brain derived neurotrophic factor Homo sapiens 162-166 19493166-9 2009 BDNF-treated cells showed the following: increases in intracellular Ca2+ upon depolarization and after stimulation with the neurotransmitters acetylcholine and GABA and, post-synaptic currents by electrophysiological analyses. gamma-Aminobutyric Acid 160-164 brain derived neurotrophic factor Homo sapiens 0-4 18922788-5 2008 JAK/STAT pathway inhibition prevents the seizure-induced decrease in GABA(A)R alpha1 abundance in vivo and, given that BDNF is known to increase the abundance of GABA(A)R alpha4 in a JAK/STAT-independent manner, indicates that BDNF acts through at least two distinct pathways to influence GABA(A)R-dependent synaptic inhibition. gamma-Aminobutyric Acid 162-166 brain derived neurotrophic factor Homo sapiens 119-123 18922788-3 2008 We report that the seizure-induced decrease in GABA(A)R alpha1 subunit expression associated with epilepsy is mediated by the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway regulated by brain-derived neurotrophic factor (BDNF). gamma-Aminobutyric Acid 47-51 brain derived neurotrophic factor Homo sapiens 222-255 18922788-3 2008 We report that the seizure-induced decrease in GABA(A)R alpha1 subunit expression associated with epilepsy is mediated by the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway regulated by brain-derived neurotrophic factor (BDNF). gamma-Aminobutyric Acid 47-51 brain derived neurotrophic factor Homo sapiens 257-261 18922788-5 2008 JAK/STAT pathway inhibition prevents the seizure-induced decrease in GABA(A)R alpha1 abundance in vivo and, given that BDNF is known to increase the abundance of GABA(A)R alpha4 in a JAK/STAT-independent manner, indicates that BDNF acts through at least two distinct pathways to influence GABA(A)R-dependent synaptic inhibition. gamma-Aminobutyric Acid 162-166 brain derived neurotrophic factor Homo sapiens 119-123 18497106-3 2008 BDNF is the main, activity-dependent, neurotrophin and sculpts neuronal organisation dependent on activity, thereby coupling and balancing effects on excitatory (glutamate) and inhibitory (GABA) transmission--in a synapse-specific manner. gamma-Aminobutyric Acid 189-193 brain derived neurotrophic factor Homo sapiens 0-4 18596173-0 2008 Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons. gamma-Aminobutyric Acid 14-18 brain derived neurotrophic factor Homo sapiens 82-115 18596173-5 2008 This mechanism is required by a population of neurons to survive in a BDNF-dependent manner after injury, because blocking GABA(A)-depolarization with the NKCC1 inhibitor bumetanide prevents the loss of neurons on BDNF withdrawal. gamma-Aminobutyric Acid 123-127 brain derived neurotrophic factor Homo sapiens 70-74 18596173-5 2008 This mechanism is required by a population of neurons to survive in a BDNF-dependent manner after injury, because blocking GABA(A)-depolarization with the NKCC1 inhibitor bumetanide prevents the loss of neurons on BDNF withdrawal. gamma-Aminobutyric Acid 123-127 brain derived neurotrophic factor Homo sapiens 214-218 18497106-3 2008 BDNF is the main, activity-dependent, neurotrophin and sculpts neuronal organisation dependent on activity, thereby coupling and balancing effects on excitatory (glutamate) and inhibitory (GABA) transmission--in a synapse-specific manner. gamma-Aminobutyric Acid 189-193 brain derived neurotrophic factor Homo sapiens 38-50 17379385-4 2007 Furthermore, cortical BDNF production is required for the correct activity of the corticostriatal synapse and the survival of the GABA-ergic medium-sized spiny striatal neurons that die in HD. gamma-Aminobutyric Acid 130-134 brain derived neurotrophic factor Homo sapiens 22-26 16702976-2 2006 However, the effect of BDNF on the expression of transcripts whose protein products are involved in gamma amino butric acid (GABA) neurotransmission has not been assessed. gamma-Aminobutyric Acid 125-129 brain derived neurotrophic factor Homo sapiens 23-27 17029981-4 2006 Blocking transmission through NMDA receptors with APV blocked the BDNF effect; increasing spontaneous excitatory activity with the GABA(A) receptor antagonist bicuculline replicated the BDNF effect. gamma-Aminobutyric Acid 131-135 brain derived neurotrophic factor Homo sapiens 186-190 16754670-5 2006 Instead, a gradual increase in GABA-evoked currents in these neurons correlated with a gradual increase in phosphorylation of GABA(A) receptor beta3 subunit in response to BDNF. gamma-Aminobutyric Acid 31-35 brain derived neurotrophic factor Homo sapiens 172-176 16754670-9 2006 Importantly, a peptide mimicking a domain of PRIP involved in binding to beta subunits disrupted the co-localization of these proteins in HEK293 cells and potently inhibited the BDNF-mediated attenuation of GABA(A) receptor currents in wild type neurons. gamma-Aminobutyric Acid 207-211 brain derived neurotrophic factor Homo sapiens 178-182 16702976-5 2006 BDNF appeared to be required to maintain gene expression in the SST-NPY-TAC1 subclass of GABA neurons, although the absence of BDNF did not alter their general phenotype as inhibitory neurons. gamma-Aminobutyric Acid 89-93 brain derived neurotrophic factor Homo sapiens 0-4 16217016-5 2005 Use-dependent GABA(A)-receptor rundown is also found in the pyramidal neurons of TLE neocortical slices and is antagonized by BDNF. gamma-Aminobutyric Acid 14-18 brain derived neurotrophic factor Homo sapiens 126-130 16214365-0 2006 Brain-derived neurotrophic factor-induced potentiation of glutamate and GABA release: different dependency on signaling pathways and neuronal activity. gamma-Aminobutyric Acid 72-76 brain derived neurotrophic factor Homo sapiens 0-33 16214365-2 2006 Here, we found that 24-h exposure of postnatal cortical neurons to BDNF potentiated depolarization-evoked glutamate and GABA release in a protein synthesis-dependent manner. gamma-Aminobutyric Acid 120-124 brain derived neurotrophic factor Homo sapiens 67-71 16214365-5 2006 In contrast, BDNF-up-regulated GABA release and GAD65/67 expression depended on MAPK. gamma-Aminobutyric Acid 31-35 brain derived neurotrophic factor Homo sapiens 13-17 16407427-0 2006 Brain-derived neurotrophic factor silences GABA synapses onto hypothalamic neuroendocrine cells through a postsynaptic dynamin-mediated mechanism. gamma-Aminobutyric Acid 43-47 brain derived neurotrophic factor Homo sapiens 0-33 16407427-1 2006 In the paraventricular nucleus of the hypothalamus (PVN), experimental stress paradigms that suppress gamma-aminobutyric acid (GABA) inputs to parvocellular neuroendocrine cells (PNCs) also increase the expression of brain-derived neurotrophic factor (BDNF). gamma-Aminobutyric Acid 102-125 brain derived neurotrophic factor Homo sapiens 217-250 16513879-1 2006 OBJECTIVE: In the prefrontal cortex of subjects with schizophrenia, decreased signaling mediated by brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase (TrkB) appears to contribute to the reduced expression of mRNA encoding the 67-kilodalton isoform of glutamate decarboxylase (GAD(67)), an enzyme for GABA synthesis. gamma-Aminobutyric Acid 324-328 brain derived neurotrophic factor Homo sapiens 100-133 16513879-1 2006 OBJECTIVE: In the prefrontal cortex of subjects with schizophrenia, decreased signaling mediated by brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase (TrkB) appears to contribute to the reduced expression of mRNA encoding the 67-kilodalton isoform of glutamate decarboxylase (GAD(67)), an enzyme for GABA synthesis. gamma-Aminobutyric Acid 324-328 brain derived neurotrophic factor Homo sapiens 135-139 15800191-0 2005 Brain-derived neurotrophic factor enhances GABA release probability and nonuniform distribution of N- and P/Q-type channels on release sites of hippocampal inhibitory synapses. gamma-Aminobutyric Acid 43-47 brain derived neurotrophic factor Homo sapiens 0-33 15814795-6 2005 ACM from BDNF- or tyrosine receptor kinase B (TrkB)-deficient astrocytes increased inhibitory presynaptic terminals and postsynaptic GABA(A)R clusters in wild-type neurons, suggesting that BDNF and TrkB expression in astrocytes is not required for these effects. gamma-Aminobutyric Acid 133-137 brain derived neurotrophic factor Homo sapiens 9-13 15341601-7 2004 In addition, BDNF treatment led to a significant up-regulation of synaptophysin and vesicular GABA transporter expression, components of the synaptic machinery critical for GABA release, which was paralleled by an increase in synaptic strength. gamma-Aminobutyric Acid 94-98 brain derived neurotrophic factor Homo sapiens 13-17 15238431-3 2005 At 48 h after transfection, the expression level of glutamic acid decarboxylase 65 (GAD65), a GABA synthetic enzyme that resides mainly in GABAergic terminals, was selectively enhanced around the BDNF-expressing neurons, in comparison with the neighboring control neurons interposed between the BDNF-expressing neurons and inhibitory neurons. gamma-Aminobutyric Acid 94-98 brain derived neurotrophic factor Homo sapiens 196-200 15238431-4 2005 Exogenous BDNF application for 48 h also increased the GAD level and enhanced the GABA release probability. gamma-Aminobutyric Acid 82-86 brain derived neurotrophic factor Homo sapiens 10-14 15665077-3 2005 It was found that exposure to the neurotrophin BDNF increased the amplitude of the "GABA currents" (currents elicited by GABA) generated by the epileptic receptors and decreased their run-down; both events being blocked by K252A, a neurotrophin tyrosine kinase receptor B inhibitor. gamma-Aminobutyric Acid 84-88 brain derived neurotrophic factor Homo sapiens 47-51 15665077-3 2005 It was found that exposure to the neurotrophin BDNF increased the amplitude of the "GABA currents" (currents elicited by GABA) generated by the epileptic receptors and decreased their run-down; both events being blocked by K252A, a neurotrophin tyrosine kinase receptor B inhibitor. gamma-Aminobutyric Acid 121-125 brain derived neurotrophic factor Homo sapiens 47-51 15665077-7 2005 However, staurosporine (a broad spectrum PK inhibitor), bisindolylmaleimide I (a PKC inhibitor), and U73122 (a phospholipase C inhibitor) blocked the BDNF-induced effects on the epileptic GABA currents. gamma-Aminobutyric Acid 188-192 brain derived neurotrophic factor Homo sapiens 150-154 12929140-0 2003 Brain-derived neurotrophic factor mitigates chronic ethanol-induced attenuation of gamma-aminobutyric acid responses in cultured cerebellar granule cells. gamma-Aminobutyric Acid 83-106 brain derived neurotrophic factor Homo sapiens 0-33 12929140-8 2003 We propose that different mechanisms regulating responsiveness to GABA underlie the effects induced by ethanol and BDNF, with the former influencing the expression of functional GABA(A) receptors and the latter involving the activation of the TrkB receptor and its downstream signaling pathways. gamma-Aminobutyric Acid 66-70 brain derived neurotrophic factor Homo sapiens 115-119 12929140-1 2003 This study examined the effect of chronic exposure to ethanol and brain-derived neurotrophic factor (BDNF) on the responsiveness of cerebellar granule cells to gamma-aminobutyric acid (GABA). gamma-Aminobutyric Acid 160-183 brain derived neurotrophic factor Homo sapiens 66-99 12929140-1 2003 This study examined the effect of chronic exposure to ethanol and brain-derived neurotrophic factor (BDNF) on the responsiveness of cerebellar granule cells to gamma-aminobutyric acid (GABA). gamma-Aminobutyric Acid 160-183 brain derived neurotrophic factor Homo sapiens 101-105 12929140-1 2003 This study examined the effect of chronic exposure to ethanol and brain-derived neurotrophic factor (BDNF) on the responsiveness of cerebellar granule cells to gamma-aminobutyric acid (GABA). gamma-Aminobutyric Acid 185-189 brain derived neurotrophic factor Homo sapiens 66-99 12929140-1 2003 This study examined the effect of chronic exposure to ethanol and brain-derived neurotrophic factor (BDNF) on the responsiveness of cerebellar granule cells to gamma-aminobutyric acid (GABA). gamma-Aminobutyric Acid 185-189 brain derived neurotrophic factor Homo sapiens 101-105 12929140-5 2003 Concomitant exposure of cultures to ethanol and BDNF mitigated the ethanol-induced attenuation of GABA response, although BDNF, by itself, did not affect responsiveness to GABA. gamma-Aminobutyric Acid 98-102 brain derived neurotrophic factor Homo sapiens 48-52 12470709-0 2003 GABA-glutamate interaction in the control of BDNF expression in hypothalamic neurons. gamma-Aminobutyric Acid 0-4 brain derived neurotrophic factor Homo sapiens 45-49 12588844-8 2003 Interestingly, whereas BDNF does not alter the expression of GABA and glutamate ionotropic receptors, it does raise the expression of the recently cloned K(+)/Cl(-) KCC2 co-transporter, which is responsible for the conversion of GABA responses from depolarizing to inhibitory, through the control of the Cl(-) potential. gamma-Aminobutyric Acid 229-233 brain derived neurotrophic factor Homo sapiens 23-27 12470709-3 2003 In the present study, we investigated whether GABA interacts with glutamate in the regulation of BDNF gene expression. gamma-Aminobutyric Acid 46-50 brain derived neurotrophic factor Homo sapiens 97-101 12470709-9 2003 In addition, GABA also inhibited the stimulatory effect of glutamate on BDNF peptide content. gamma-Aminobutyric Acid 13-17 brain derived neurotrophic factor Homo sapiens 72-76 12470709-10 2003 Our findings show an interaction between glutamate and GABA on BDNF expression (mRNA, transcripts and peptide) in fetal hypothalamic neurons. gamma-Aminobutyric Acid 55-59 brain derived neurotrophic factor Homo sapiens 63-67 12163549-0 2002 Excitatory actions of GABA increase BDNF expression via a MAPK-CREB-dependent mechanism--a positive feedback circuit in developing neurons. gamma-Aminobutyric Acid 22-26 brain derived neurotrophic factor Homo sapiens 36-40 12196581-3 2002 Here we show that BDNF facilitates high K(+)-elicited release of GABA but not of glutamate and induces an increase in immunoreactive signals of glutamic acid decarboxylase, a GABA-synthesizing enzyme. gamma-Aminobutyric Acid 65-69 brain derived neurotrophic factor Homo sapiens 18-22 12196581-3 2002 Here we show that BDNF facilitates high K(+)-elicited release of GABA but not of glutamate and induces an increase in immunoreactive signals of glutamic acid decarboxylase, a GABA-synthesizing enzyme. gamma-Aminobutyric Acid 175-179 brain derived neurotrophic factor Homo sapiens 18-22 12163549-13 2002 Both GABA and muscimol stimulated BDNF expression, and pretreatment with U0126 attenuated GABA-induced BDNF expression. gamma-Aminobutyric Acid 5-9 brain derived neurotrophic factor Homo sapiens 34-38 12163549-13 2002 Both GABA and muscimol stimulated BDNF expression, and pretreatment with U0126 attenuated GABA-induced BDNF expression. gamma-Aminobutyric Acid 90-94 brain derived neurotrophic factor Homo sapiens 103-107 12163549-14 2002 Whole cell electrophysiological recording was used to assess the effects of BDNF on GABA release. gamma-Aminobutyric Acid 84-88 brain derived neurotrophic factor Homo sapiens 76-80 12163549-16 2002 Together, these data suggest a positive excitatory feedback loop between GABA and BDNF expression during early development, where GABA facilitates BDNF expression, and BDNF facilitates the synaptic release of GABA. gamma-Aminobutyric Acid 73-77 brain derived neurotrophic factor Homo sapiens 82-86 12163549-16 2002 Together, these data suggest a positive excitatory feedback loop between GABA and BDNF expression during early development, where GABA facilitates BDNF expression, and BDNF facilitates the synaptic release of GABA. gamma-Aminobutyric Acid 73-77 brain derived neurotrophic factor Homo sapiens 147-151 12163549-16 2002 Together, these data suggest a positive excitatory feedback loop between GABA and BDNF expression during early development, where GABA facilitates BDNF expression, and BDNF facilitates the synaptic release of GABA. gamma-Aminobutyric Acid 73-77 brain derived neurotrophic factor Homo sapiens 147-151 12163549-16 2002 Together, these data suggest a positive excitatory feedback loop between GABA and BDNF expression during early development, where GABA facilitates BDNF expression, and BDNF facilitates the synaptic release of GABA. gamma-Aminobutyric Acid 130-134 brain derived neurotrophic factor Homo sapiens 82-86 12163549-16 2002 Together, these data suggest a positive excitatory feedback loop between GABA and BDNF expression during early development, where GABA facilitates BDNF expression, and BDNF facilitates the synaptic release of GABA. gamma-Aminobutyric Acid 130-134 brain derived neurotrophic factor Homo sapiens 147-151 12163549-16 2002 Together, these data suggest a positive excitatory feedback loop between GABA and BDNF expression during early development, where GABA facilitates BDNF expression, and BDNF facilitates the synaptic release of GABA. gamma-Aminobutyric Acid 130-134 brain derived neurotrophic factor Homo sapiens 147-151 12163549-16 2002 Together, these data suggest a positive excitatory feedback loop between GABA and BDNF expression during early development, where GABA facilitates BDNF expression, and BDNF facilitates the synaptic release of GABA. gamma-Aminobutyric Acid 130-134 brain derived neurotrophic factor Homo sapiens 82-86 12163549-16 2002 Together, these data suggest a positive excitatory feedback loop between GABA and BDNF expression during early development, where GABA facilitates BDNF expression, and BDNF facilitates the synaptic release of GABA. gamma-Aminobutyric Acid 130-134 brain derived neurotrophic factor Homo sapiens 147-151 12163549-16 2002 Together, these data suggest a positive excitatory feedback loop between GABA and BDNF expression during early development, where GABA facilitates BDNF expression, and BDNF facilitates the synaptic release of GABA. gamma-Aminobutyric Acid 130-134 brain derived neurotrophic factor Homo sapiens 147-151 10980241-3 2000 This effect was mimicked by co-treatment with a growth factor (aFGF, bFGF or BDNF; but not GDNF, IGF-1, EGF or TGF) and the neurotransmitter 5-HT (but not GABA, dopamine, glutamate) and/or a protein kinase activator (IBMX, forskolin, TPA). gamma-Aminobutyric Acid 155-159 brain derived neurotrophic factor Homo sapiens 77-81 12111841-3 2002 We hypothesized that medial septal cholinergic and/or gamma amino butyric acid (GABA)ergic neurons, which provide a major input to the hippocampus, may regulate the baseline gene expression and exercise-dependent gene upregulation of this neurotrophin. gamma-Aminobutyric Acid 54-78 brain derived neurotrophic factor Homo sapiens 239-251 12111841-3 2002 We hypothesized that medial septal cholinergic and/or gamma amino butyric acid (GABA)ergic neurons, which provide a major input to the hippocampus, may regulate the baseline gene expression and exercise-dependent gene upregulation of this neurotrophin. gamma-Aminobutyric Acid 80-84 brain derived neurotrophic factor Homo sapiens 239-251 10501176-1 1999 GABA, which is present in the brain in large amounts, is distributed among distinctly different cellular pools, possibly reflecting its multiple functions as metabolite, neurotransmitter, and neurotrophin. gamma-Aminobutyric Acid 0-4 brain derived neurotrophic factor Homo sapiens 192-204 8093484-2 1993 Brain-derived neurotrophic factor (BDNF) specifically increased contents of the neuropeptides somatostatin (SOM) and neuropeptide Y (NPY), but its effect on contents of cholecystokinin octapeptide and GABA was much less significant. gamma-Aminobutyric Acid 201-205 brain derived neurotrophic factor Homo sapiens 0-33 7852991-4 1994 The production of NGF and BDNF is controlled by neuronal activity: up-regulation by glutamate and acetylcholine, down-regulation by gamma-aminobutyric acid. gamma-Aminobutyric Acid 132-155 brain derived neurotrophic factor Homo sapiens 26-30 8785053-1 1996 Gamma-Aminobutyric acid (GABA) switches from enhancing to repressing brain-derived neurotrophic factor (BDNF) mRNA synthesis during the maturation of hippocampal neurons in vitro. gamma-Aminobutyric Acid 0-23 brain derived neurotrophic factor Homo sapiens 69-102 8785053-1 1996 Gamma-Aminobutyric acid (GABA) switches from enhancing to repressing brain-derived neurotrophic factor (BDNF) mRNA synthesis during the maturation of hippocampal neurons in vitro. gamma-Aminobutyric Acid 0-23 brain derived neurotrophic factor Homo sapiens 104-108 8785053-1 1996 Gamma-Aminobutyric acid (GABA) switches from enhancing to repressing brain-derived neurotrophic factor (BDNF) mRNA synthesis during the maturation of hippocampal neurons in vitro. gamma-Aminobutyric Acid 25-29 brain derived neurotrophic factor Homo sapiens 69-102 8785053-1 1996 Gamma-Aminobutyric acid (GABA) switches from enhancing to repressing brain-derived neurotrophic factor (BDNF) mRNA synthesis during the maturation of hippocampal neurons in vitro. gamma-Aminobutyric Acid 25-29 brain derived neurotrophic factor Homo sapiens 104-108 8785053-6 1996 At later developmental stages, when GABA represses BDNF synthesis, treatment with muscimol induced a decrease in cell size and NPY immunoreactivity of interneurons. gamma-Aminobutyric Acid 36-40 brain derived neurotrophic factor Homo sapiens 51-55 8093484-2 1993 Brain-derived neurotrophic factor (BDNF) specifically increased contents of the neuropeptides somatostatin (SOM) and neuropeptide Y (NPY), but its effect on contents of cholecystokinin octapeptide and GABA was much less significant. gamma-Aminobutyric Acid 201-205 brain derived neurotrophic factor Homo sapiens 35-39 31694441-9 2020 Besides, BDNF overexpression changes the expression of GABA(B) receptors. gamma-Aminobutyric Acid 55-59 brain derived neurotrophic factor Homo sapiens 9-13 1658793-0 1991 Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons. gamma-Aminobutyric Acid 32-55 brain derived neurotrophic factor Homo sapiens 111-144 1658793-2 1991 Here we demonstrate that the balance between the activity of the glutamatergic and gamma-aminobutyric acid (GABA)ergic systems controls the physiological levels of BDNF and NGF mRNAs in hippocampal neurons in vitro and in vivo. gamma-Aminobutyric Acid 83-106 brain derived neurotrophic factor Homo sapiens 164-168 1658793-2 1991 Here we demonstrate that the balance between the activity of the glutamatergic and gamma-aminobutyric acid (GABA)ergic systems controls the physiological levels of BDNF and NGF mRNAs in hippocampal neurons in vitro and in vivo. gamma-Aminobutyric Acid 108-112 brain derived neurotrophic factor Homo sapiens 164-168 1658793-6 1991 The refined and rapid regulation of BDNF and NGF synthesis by the glutamate and GABA transmitter systems suggests that BDNF and NGF might be involved in activity-dependent synaptic plasticity. gamma-Aminobutyric Acid 80-84 brain derived neurotrophic factor Homo sapiens 36-40 1658793-6 1991 The refined and rapid regulation of BDNF and NGF synthesis by the glutamate and GABA transmitter systems suggests that BDNF and NGF might be involved in activity-dependent synaptic plasticity. gamma-Aminobutyric Acid 80-84 brain derived neurotrophic factor Homo sapiens 119-123 1776765-4 1991 Enhancement of the effectiveness of the GABAergic system by benzodiazepam or direct GABA agonists blocks the effect of kainic acid and reduces the basic levels of NGF- and BDNF-mRNAs. gamma-Aminobutyric Acid 40-44 brain derived neurotrophic factor Homo sapiens 172-176 32490241-0 2020 Negative association between left prefrontal GABA concentration and BDNF serum concentration in young adults. gamma-Aminobutyric Acid 45-49 brain derived neurotrophic factor Homo sapiens 68-72 32490241-3 2020 We investigated the relationship between GABA concentration in the left dorsolateral prefrontal cortex (DLPFC) and BDNF concentration in the serum in a community-based sample of young subjects. gamma-Aminobutyric Acid 41-45 brain derived neurotrophic factor Homo sapiens 115-119 32490241-8 2020 Results: GABA concentration in the left DLPFC was negatively associated with BDNF serum concentration (r = -.264, p = .001). gamma-Aminobutyric Acid 9-13 brain derived neurotrophic factor Homo sapiens 77-81 30609300-9 2019 Pearson correlation analysis revealed that the change of PSQI score was negatively associated with the alteration of serum BDNF level and serum GABA level, and positively associated with the change of MEPs amplitude; the change of MEPs amplitude was negatively associated with fold change in the serum BDNF level and the serum GABA level; the increase in serum GABA level was positively associated with the serum BDNF level. gamma-Aminobutyric Acid 327-331 brain derived neurotrophic factor Homo sapiens 302-306 30609300-9 2019 Pearson correlation analysis revealed that the change of PSQI score was negatively associated with the alteration of serum BDNF level and serum GABA level, and positively associated with the change of MEPs amplitude; the change of MEPs amplitude was negatively associated with fold change in the serum BDNF level and the serum GABA level; the increase in serum GABA level was positively associated with the serum BDNF level. gamma-Aminobutyric Acid 327-331 brain derived neurotrophic factor Homo sapiens 302-306 30609300-9 2019 Pearson correlation analysis revealed that the change of PSQI score was negatively associated with the alteration of serum BDNF level and serum GABA level, and positively associated with the change of MEPs amplitude; the change of MEPs amplitude was negatively associated with fold change in the serum BDNF level and the serum GABA level; the increase in serum GABA level was positively associated with the serum BDNF level. gamma-Aminobutyric Acid 327-331 brain derived neurotrophic factor Homo sapiens 302-306 30609300-9 2019 Pearson correlation analysis revealed that the change of PSQI score was negatively associated with the alteration of serum BDNF level and serum GABA level, and positively associated with the change of MEPs amplitude; the change of MEPs amplitude was negatively associated with fold change in the serum BDNF level and the serum GABA level; the increase in serum GABA level was positively associated with the serum BDNF level. gamma-Aminobutyric Acid 327-331 brain derived neurotrophic factor Homo sapiens 302-306