PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16723537-1 2006 It is widely accepted that cannabinoids regulate GABA release by activation of cannabinoid receptor type 1 (CB1). gamma-Aminobutyric Acid 49-53 cannabinoid receptor 1 (brain) Mus musculus 79-111 17475795-5 2007 In MCH cells, depolarizing WIN55,212,2 actions were abolished by the GABA(A) receptor antagonist bicuculline, suggesting that the CB1R-mediated depolarization was attributable to reduced synaptic GABA release. gamma-Aminobutyric Acid 69-73 cannabinoid receptor 1 (brain) Mus musculus 130-134 15953496-5 2005 In particular, whereas in control animals activation of cannabinoid CB1 receptors results in a significant inhibition of both evoked and spontaneous GABA-mediated synaptic events by a presynaptic mechanism, in R6/2 mice this treatment fails to reduce GABA currents but causes, in contrast, a slight increase of spontaneous inhibitory postsynaptic currents (sIPSCs). gamma-Aminobutyric Acid 149-153 cannabinoid receptor 1 (brain) Mus musculus 68-71 12152079-9 2002 In the basolateral amygdala, endocannabinoids and CB1 were crucially involved in long-term depression of GABA (gamma-aminobutyric acid)-mediated inhibitory currents. gamma-Aminobutyric Acid 105-109 cannabinoid receptor 1 (brain) Mus musculus 50-53 15147302-12 2004 In contrast, in a different subset of synapses, activation of M(1)/M(3) receptors causes endocannabinoid production and subsequent suppression of GABA release by activating presynaptic CB1 receptors. gamma-Aminobutyric Acid 146-150 cannabinoid receptor 1 (brain) Mus musculus 185-188 12152079-9 2002 In the basolateral amygdala, endocannabinoids and CB1 were crucially involved in long-term depression of GABA (gamma-aminobutyric acid)-mediated inhibitory currents. gamma-Aminobutyric Acid 111-134 cannabinoid receptor 1 (brain) Mus musculus 50-53 22036037-1 2012 BACKGROUND: Levels of cannabinoid 1 receptor (CB1R) messenger RNA (mRNA) and protein, which are expressed most heavily in the cholecystokinin class of gamma-aminobutyric acid (GABA) neurons, are lower in the dorsolateral prefrontal cortex in schizophrenia, and the magnitude of these differences is strongly correlated with that for glutamic acid decarboxylase 67 (GAD(67)) mRNA, a synthesizing enzyme for GABA. gamma-Aminobutyric Acid 151-174 cannabinoid receptor 1 (brain) Mus musculus 22-44 22036037-1 2012 BACKGROUND: Levels of cannabinoid 1 receptor (CB1R) messenger RNA (mRNA) and protein, which are expressed most heavily in the cholecystokinin class of gamma-aminobutyric acid (GABA) neurons, are lower in the dorsolateral prefrontal cortex in schizophrenia, and the magnitude of these differences is strongly correlated with that for glutamic acid decarboxylase 67 (GAD(67)) mRNA, a synthesizing enzyme for GABA. gamma-Aminobutyric Acid 406-410 cannabinoid receptor 1 (brain) Mus musculus 46-50 22036037-7 2012 CONCLUSIONS: The findings that reduced GAD(67) mRNA expression can induce lower CB1R mRNA expression support the hypothesis that lower cortical levels of CB1Rs in schizophrenia may partially compensate for deficient GAD(67)-mediated GABA synthesis by reducing endogenous cannabinoid suppression of GABA release. gamma-Aminobutyric Acid 233-237 cannabinoid receptor 1 (brain) Mus musculus 80-84 22036037-7 2012 CONCLUSIONS: The findings that reduced GAD(67) mRNA expression can induce lower CB1R mRNA expression support the hypothesis that lower cortical levels of CB1Rs in schizophrenia may partially compensate for deficient GAD(67)-mediated GABA synthesis by reducing endogenous cannabinoid suppression of GABA release. gamma-Aminobutyric Acid 233-237 cannabinoid receptor 1 (brain) Mus musculus 80-83 22036037-7 2012 CONCLUSIONS: The findings that reduced GAD(67) mRNA expression can induce lower CB1R mRNA expression support the hypothesis that lower cortical levels of CB1Rs in schizophrenia may partially compensate for deficient GAD(67)-mediated GABA synthesis by reducing endogenous cannabinoid suppression of GABA release. gamma-Aminobutyric Acid 298-302 cannabinoid receptor 1 (brain) Mus musculus 80-84 22036037-7 2012 CONCLUSIONS: The findings that reduced GAD(67) mRNA expression can induce lower CB1R mRNA expression support the hypothesis that lower cortical levels of CB1Rs in schizophrenia may partially compensate for deficient GAD(67)-mediated GABA synthesis by reducing endogenous cannabinoid suppression of GABA release. gamma-Aminobutyric Acid 298-302 cannabinoid receptor 1 (brain) Mus musculus 80-83 11564411-1 2001 Psychoactive effects of cannabinoids are thought to be mediated, at least in part, by suppression of both glutamate and GABA release via CB1 cannabinoid receptor. gamma-Aminobutyric Acid 120-124 cannabinoid receptor 1 (brain) Mus musculus 137-140 11564411-4 2001 Immunocytochemical and electrophysiological studies revealed that in the hippocampus CB1 receptors are expressed on axon terminals of GABAergic inhibitory interneurons (Tsou et al., 1999; Katona et al., 1999) and activation of these receptors decreases GABA release (Hajos et al., 2000). gamma-Aminobutyric Acid 134-138 cannabinoid receptor 1 (brain) Mus musculus 85-88 10998107-11 2000 We conclude that activation of presynaptic CB1 receptors decreases Ca2+-dependent GABA release, and thereby reduces the power of hippocampal network oscillations. gamma-Aminobutyric Acid 82-86 cannabinoid receptor 1 (brain) Mus musculus 43-46 10594647-7 1999 The majority of high CB1-expressing cells are GABAergic (gamma-aminobutyric acid) neurons belonging mainly to the cholecystokinin-positive and parvalbumin-negative type of interneurons (basket cells) and, to a lower extent, to the calbindin D28k-positive mid-proximal dendritic inhibitory interneurons. gamma-Aminobutyric Acid 57-80 cannabinoid receptor 1 (brain) Mus musculus 21-24 22036037-1 2012 BACKGROUND: Levels of cannabinoid 1 receptor (CB1R) messenger RNA (mRNA) and protein, which are expressed most heavily in the cholecystokinin class of gamma-aminobutyric acid (GABA) neurons, are lower in the dorsolateral prefrontal cortex in schizophrenia, and the magnitude of these differences is strongly correlated with that for glutamic acid decarboxylase 67 (GAD(67)) mRNA, a synthesizing enzyme for GABA. gamma-Aminobutyric Acid 151-174 cannabinoid receptor 1 (brain) Mus musculus 46-50 22036037-1 2012 BACKGROUND: Levels of cannabinoid 1 receptor (CB1R) messenger RNA (mRNA) and protein, which are expressed most heavily in the cholecystokinin class of gamma-aminobutyric acid (GABA) neurons, are lower in the dorsolateral prefrontal cortex in schizophrenia, and the magnitude of these differences is strongly correlated with that for glutamic acid decarboxylase 67 (GAD(67)) mRNA, a synthesizing enzyme for GABA. gamma-Aminobutyric Acid 176-180 cannabinoid receptor 1 (brain) Mus musculus 22-44 22036037-1 2012 BACKGROUND: Levels of cannabinoid 1 receptor (CB1R) messenger RNA (mRNA) and protein, which are expressed most heavily in the cholecystokinin class of gamma-aminobutyric acid (GABA) neurons, are lower in the dorsolateral prefrontal cortex in schizophrenia, and the magnitude of these differences is strongly correlated with that for glutamic acid decarboxylase 67 (GAD(67)) mRNA, a synthesizing enzyme for GABA. gamma-Aminobutyric Acid 176-180 cannabinoid receptor 1 (brain) Mus musculus 46-50 22036037-1 2012 BACKGROUND: Levels of cannabinoid 1 receptor (CB1R) messenger RNA (mRNA) and protein, which are expressed most heavily in the cholecystokinin class of gamma-aminobutyric acid (GABA) neurons, are lower in the dorsolateral prefrontal cortex in schizophrenia, and the magnitude of these differences is strongly correlated with that for glutamic acid decarboxylase 67 (GAD(67)) mRNA, a synthesizing enzyme for GABA. gamma-Aminobutyric Acid 406-410 cannabinoid receptor 1 (brain) Mus musculus 22-44 35240891-2 2022 Our previous study has proved that endocannabinoid (2-AG)-CB1R-GABA-5-HT pathway is involved in electroacupuncture (EA) mediated inhibition of chronic pain. gamma-Aminobutyric Acid 63-67 cannabinoid receptor 1 (brain) Mus musculus 58-62 34997582-8 2022 It resulted from reduced expression and function of cannabinoid receptor 1 (CB1R) co-localized with 5-HT3Rs on axon terminals, which led to diminishment of tonic inhibition of GABA release by CB1Rs. gamma-Aminobutyric Acid 176-180 cannabinoid receptor 1 (brain) Mus musculus 52-74 34997582-8 2022 It resulted from reduced expression and function of cannabinoid receptor 1 (CB1R) co-localized with 5-HT3Rs on axon terminals, which led to diminishment of tonic inhibition of GABA release by CB1Rs. gamma-Aminobutyric Acid 176-180 cannabinoid receptor 1 (brain) Mus musculus 76-80 33253450-8 2022 In contrast, GABA-CB1-RS animals showed the lowest exploratory drive in all paradigms, with an even stronger phenotype than Stop-CB1 mice. gamma-Aminobutyric Acid 13-17 cannabinoid receptor 1 (brain) Mus musculus 18-21 33617930-3 2021 VTA dopamine cells are regulated by local inhibitory GABA cells, which exhibit a form of pre-synaptic cannabinoid receptor 1-dependent long-term depression of their glutamatergic inputs. gamma-Aminobutyric Acid 53-57 cannabinoid receptor 1 (brain) Mus musculus 102-124 33613258-5 2021 In fact, by retrograde signaling to cannabinoid receptor type 1 (CB1R) at inhibitory inputs to DA neurons, 2-AG inhibited GABA release thus inducing an increase in DA concentration in the VTA and NAc of ob/ob mice. gamma-Aminobutyric Acid 122-126 cannabinoid receptor 1 (brain) Mus musculus 65-69 33538103-10 2021 Immunohistochemistry and RNAscope in situ hybridization assays indicated that CB1 Rs are expressed mainly in VTA GABA and glutamate neurons, while CB2 Rs are expressed mainly in VTA DA neurons. gamma-Aminobutyric Acid 113-117 cannabinoid receptor 1 (brain) Mus musculus 78-81 31215302-12 2019 We conclude that CB1 directly regulates GABAergic processes in the glomerular layer to control GABA release and, in turn, regulates mitral cell activity with potential effects on olfactory threshold and behavior.NEW & NOTEWORTHY Cannabinoid signaling with cannabinoid receptor type 1 (CB1) is involved in the regulation of glomerular activity in the main olfactory bulb (MOB). gamma-Aminobutyric Acid 40-44 cannabinoid receptor 1 (brain) Mus musculus 17-20 31974335-7 2020 RESULTS: Our results showed that AM281 injection and CB1R knockout of glutamatergic neurons eliminated the effect of exercise on learning and memory, and affected the increase of BDNF in hippocampus after exercise; CB1R-specific knockout mice on GABA neurons and glial cells did not affect the enhancement effect of learning and memory by exercise; In addition, the results of Golgi staining showed that exercise increased dendritic spine density in hippocampal neurons, but dendritic spine density did not change significantly in CB1R- specific knockout on glutamatergic neurons mice after exercise. gamma-Aminobutyric Acid 246-250 cannabinoid receptor 1 (brain) Mus musculus 53-57 31974335-7 2020 RESULTS: Our results showed that AM281 injection and CB1R knockout of glutamatergic neurons eliminated the effect of exercise on learning and memory, and affected the increase of BDNF in hippocampus after exercise; CB1R-specific knockout mice on GABA neurons and glial cells did not affect the enhancement effect of learning and memory by exercise; In addition, the results of Golgi staining showed that exercise increased dendritic spine density in hippocampal neurons, but dendritic spine density did not change significantly in CB1R- specific knockout on glutamatergic neurons mice after exercise. gamma-Aminobutyric Acid 246-250 cannabinoid receptor 1 (brain) Mus musculus 215-219 31974335-7 2020 RESULTS: Our results showed that AM281 injection and CB1R knockout of glutamatergic neurons eliminated the effect of exercise on learning and memory, and affected the increase of BDNF in hippocampus after exercise; CB1R-specific knockout mice on GABA neurons and glial cells did not affect the enhancement effect of learning and memory by exercise; In addition, the results of Golgi staining showed that exercise increased dendritic spine density in hippocampal neurons, but dendritic spine density did not change significantly in CB1R- specific knockout on glutamatergic neurons mice after exercise. gamma-Aminobutyric Acid 246-250 cannabinoid receptor 1 (brain) Mus musculus 215-219 31964686-4 2020 We demonstrated, in mice, that activation of cannabinoid-1 receptors (CB1R) with the agonist WIN 55,212-2 (WIN) reduced the miniature GABA receptor-mediated postsynaptic current (mGPSC) frequency by a mechanism that requires astrocytes and A1R. gamma-Aminobutyric Acid 134-138 cannabinoid receptor 1 (brain) Mus musculus 45-68 31964686-4 2020 We demonstrated, in mice, that activation of cannabinoid-1 receptors (CB1R) with the agonist WIN 55,212-2 (WIN) reduced the miniature GABA receptor-mediated postsynaptic current (mGPSC) frequency by a mechanism that requires astrocytes and A1R. gamma-Aminobutyric Acid 134-138 cannabinoid receptor 1 (brain) Mus musculus 70-74 31215302-16 2019 CB1 directly regulates GABAergic processes to control GABA release and, in turn, regulates mitral cell activity with potential effects on olfactory threshold and behavior. gamma-Aminobutyric Acid 23-27 cannabinoid receptor 1 (brain) Mus musculus 0-3 29038246-0 2017 CB1-Dependent Long-Term Depression in Ventral Tegmental Area GABA Neurons: A Novel Target for Marijuana. gamma-Aminobutyric Acid 61-65 cannabinoid receptor 1 (brain) Mus musculus 0-3 30210289-6 2018 We compared microglia density, morphology and cytokine expression in wild-type (WT) and GABAergic neuron-specific CB1 knockout mice (GABA/CB1-/-) under control conditions (saline-treatment) and after 3 h, 24 h or repeated lipopolysaccharide (LPS)-treatment. gamma-Aminobutyric Acid 88-92 cannabinoid receptor 1 (brain) Mus musculus 114-117 30355625-6 2018 When photostimulation of genetically identified terminals is used to release only GABA, CB1R-dependent DSI persists for many minutes. gamma-Aminobutyric Acid 82-86 cannabinoid receptor 1 (brain) Mus musculus 88-92 30355625-9 2018 These observations suggest that heterologous interactions between mGluRs and CB1Rs control the temporal window of DSI at GABA synapses, providing evidence for a powerful new way to affect functional circuit connectivity in the brain.SIGNIFICANCE STATEMENT Postsynaptic depolarization liberates endocannabinoids, resulting in a rapid and transient decrease in release probability at GABA synapses. gamma-Aminobutyric Acid 121-125 cannabinoid receptor 1 (brain) Mus musculus 77-80 30355625-9 2018 These observations suggest that heterologous interactions between mGluRs and CB1Rs control the temporal window of DSI at GABA synapses, providing evidence for a powerful new way to affect functional circuit connectivity in the brain.SIGNIFICANCE STATEMENT Postsynaptic depolarization liberates endocannabinoids, resulting in a rapid and transient decrease in release probability at GABA synapses. gamma-Aminobutyric Acid 382-386 cannabinoid receptor 1 (brain) Mus musculus 77-80 30348772-8 2018 Systemic blockade of OX1Rs or CB1Rs also restored vlPAG GABA levels after MNS-PC6. gamma-Aminobutyric Acid 56-60 cannabinoid receptor 1 (brain) Mus musculus 30-33 30114280-4 2018 We demonstrate that mice with a specific deletion of CB1 receptors on GABAergic neurons (GABA-Cnr1-/- mice), which show a phenotype of accelerated brain ageing, affects age-related changes in the morphology of astrocytes in the hippocampus. gamma-Aminobutyric Acid 70-74 cannabinoid receptor 1 (brain) Mus musculus 53-56 30114280-4 2018 We demonstrate that mice with a specific deletion of CB1 receptors on GABAergic neurons (GABA-Cnr1-/- mice), which show a phenotype of accelerated brain ageing, affects age-related changes in the morphology of astrocytes in the hippocampus. gamma-Aminobutyric Acid 70-74 cannabinoid receptor 1 (brain) Mus musculus 94-98 30114280-5 2018 Thus, GABA-Cnr1-/- mice showed a much more pronounced age-related and layer-specific increase in GFAP-positive areas in the hippocampus compared to wild-type animals. gamma-Aminobutyric Acid 6-10 cannabinoid receptor 1 (brain) Mus musculus 11-15 30114280-7 2018 Astrocytes in the hippocampus of old GABA-Cnr1-/- mice also showed a different morphology with enhanced GFAP-positive process branching and a less polarized intrahippocampal distribution. gamma-Aminobutyric Acid 37-41 cannabinoid receptor 1 (brain) Mus musculus 42-46 30114280-8 2018 Furthermore, astrocytic TNFalpha levels were higher in GABA-Cnr1-/- mice, indicating that these morphological changes were accompanied by a more pro-inflammatory function. gamma-Aminobutyric Acid 55-59 cannabinoid receptor 1 (brain) Mus musculus 60-64 28757328-6 2017 Intracerebroventricular delivery of IFN-gamma caused a depressive- and anxiety-like behavior in mice, associated with the selective dysfunction of CB1Rs controlling GABA transmission in the striatum. gamma-Aminobutyric Acid 165-169 cannabinoid receptor 1 (brain) Mus musculus 147-150 29038246-4 2017 A novel CB1-dependent LTD was induced in GABA cells that was dependent on metabotropic glutamate receptor 5, and cannabinoid receptor 1 (CB1). gamma-Aminobutyric Acid 41-45 cannabinoid receptor 1 (brain) Mus musculus 8-11 29038246-4 2017 A novel CB1-dependent LTD was induced in GABA cells that was dependent on metabotropic glutamate receptor 5, and cannabinoid receptor 1 (CB1). gamma-Aminobutyric Acid 41-45 cannabinoid receptor 1 (brain) Mus musculus 137-140 27905022-7 2017 In irradiated mice, GABA release from CB1BCs onto PCs was dramatically increased. gamma-Aminobutyric Acid 20-24 cannabinoid receptor 1 (brain) Mus musculus 38-41 29104536-7 2017 GABA-CB1-/- mice, in contrast, showed significantly lower levels of behavioral inhibition compared to wild-type controls and more escape behavior. gamma-Aminobutyric Acid 0-4 cannabinoid receptor 1 (brain) Mus musculus 5-8 27905022-8 2017 This effect was abolished by CB1 blockade, indicating that irradiation decreased CB1-dependent tonic inhibition of GABA release. gamma-Aminobutyric Acid 115-119 cannabinoid receptor 1 (brain) Mus musculus 29-32 27905022-8 2017 This effect was abolished by CB1 blockade, indicating that irradiation decreased CB1-dependent tonic inhibition of GABA release. gamma-Aminobutyric Acid 115-119 cannabinoid receptor 1 (brain) Mus musculus 81-84 27905022-9 2017 These alterations in GABA release were accompanied by decreased levels of the major CB1 ligand 2-arachidonoylglycerol. gamma-Aminobutyric Acid 21-25 cannabinoid receptor 1 (brain) Mus musculus 84-87 26612422-6 2016 In GABA-CB1, it concerns several cortical and non-cortical areas including the dorsal striatum, nucleus accumbens, thalamic, and hypothalamic nuclei. gamma-Aminobutyric Acid 3-7 cannabinoid receptor 1 (brain) Mus musculus 8-11 27737762-5 2017 RESULTS: Memory impairment during nicotine withdrawal was blocked by the CB1R antagonist rimonabant or the genetic deletion of CB1R in forebrain gamma-aminobutyric acidergic (GABAergic) neurons (GABA-CB1R). gamma-Aminobutyric Acid 175-179 cannabinoid receptor 1 (brain) Mus musculus 127-131 27737762-5 2017 RESULTS: Memory impairment during nicotine withdrawal was blocked by the CB1R antagonist rimonabant or the genetic deletion of CB1R in forebrain gamma-aminobutyric acidergic (GABAergic) neurons (GABA-CB1R). gamma-Aminobutyric Acid 175-179 cannabinoid receptor 1 (brain) Mus musculus 127-131 27339436-6 2017 The subcellular distribution of hippocampal CB1 receptors of rescue mice that express the gene exclusively in dorsal telencephalic glutamatergic neurons (Glu-CB1 -RS) or GABAergic neurons (GABA-CB1 -RS) was studied by immunoelectron microscopy. gamma-Aminobutyric Acid 170-174 cannabinoid receptor 1 (brain) Mus musculus 44-47 27339436-10 2017 The proportion of CB1 receptor-immunopositive excitatory and inhibitory synapses in the inner one-third of the dentate molecular layer was Glu-CB1 -RS, 53.19% (glutamatergic terminals); 2.30% (GABAergic terminals); GABA-CB1 -RS, 3.19% (glutamatergic terminals); 85.07% (GABAergic terminals). gamma-Aminobutyric Acid 193-197 cannabinoid receptor 1 (brain) Mus musculus 18-21 27589957-5 2016 RESULTS: We observed that EAE-induced anxiety was associated with the downregulation of CB1R-mediated control of striatal GABA synaptic transmission and was exacerbated in mice lacking CB1R (CB1R-KO mice). gamma-Aminobutyric Acid 122-126 cannabinoid receptor 1 (brain) Mus musculus 88-92 27589957-5 2016 RESULTS: We observed that EAE-induced anxiety was associated with the downregulation of CB1R-mediated control of striatal GABA synaptic transmission and was exacerbated in mice lacking CB1R (CB1R-KO mice). gamma-Aminobutyric Acid 122-126 cannabinoid receptor 1 (brain) Mus musculus 185-189 27589957-5 2016 RESULTS: We observed that EAE-induced anxiety was associated with the downregulation of CB1R-mediated control of striatal GABA synaptic transmission and was exacerbated in mice lacking CB1R (CB1R-KO mice). gamma-Aminobutyric Acid 122-126 cannabinoid receptor 1 (brain) Mus musculus 185-189 26612422-11 2016 Our findings demonstrate a critical distinction of the altered balance of Glu-CB1 and GABA-CB1 activity that could participate in the vulnerability to cocaine abuse and addiction. gamma-Aminobutyric Acid 86-90 cannabinoid receptor 1 (brain) Mus musculus 91-94 27448020-7 2016 2-AG retrogradely inhibits GABA release through presynaptic CB1Rs, leading to VTA dopaminergic disinhibition and reinstatement of cocaine CPP. gamma-Aminobutyric Acid 27-31 cannabinoid receptor 1 (brain) Mus musculus 60-63 25485758-4 2015 Furthermore, chronic Delta(9)-tetrahydrocannabinol administration, which reduces cannabinoid efficacy on GABA release, evoked marked CB1 downregulation in a dose-dependent manner. gamma-Aminobutyric Acid 105-109 cannabinoid receptor 1 (brain) Mus musculus 133-136 26157003-10 2015 Together, these findings are consistent with the possibility that constitutively active CB1 receptors substantially influence perisomatic GABA release probability and indicate that the synaptic effects of tonic 2-AG release are tightly controlled by presynaptic MGL activity and also by postsynaptic endovanilloid signaling and FAAH activity. gamma-Aminobutyric Acid 138-142 cannabinoid receptor 1 (brain) Mus musculus 88-91 26157003-14 2015 The findings indicate that constitutive CB1 activity has pivotal function in the tonic control of hippocampal GABA release. gamma-Aminobutyric Acid 110-114 cannabinoid receptor 1 (brain) Mus musculus 40-43 25740514-5 2015 Deletion of CB1 receptor in GABAergic neurons in GABA-CB1-KO mice leads to a significantly decreased hippocampal LTP compared with WT controls. gamma-Aminobutyric Acid 28-32 cannabinoid receptor 1 (brain) Mus musculus 12-15 25740514-5 2015 Deletion of CB1 receptor in GABAergic neurons in GABA-CB1-KO mice leads to a significantly decreased hippocampal LTP compared with WT controls. gamma-Aminobutyric Acid 28-32 cannabinoid receptor 1 (brain) Mus musculus 54-57 22734681-4 2012 Dual- and triple-label immunocytochemistry revealed the presence of CB1R in several GABA-immunopositive fibres juxtaposed to EWcp-Ucn1 neurones. gamma-Aminobutyric Acid 84-88 cannabinoid receptor 1 (brain) Mus musculus 68-72 24440366-4 2014 After induction of EAE, mice selectively lacking CB1R on GABAergic neurons (GABA-CB1R-KO) showed exacerbated alterations of sEPSC duration in GABAergic medium spiny neurons (MSN). gamma-Aminobutyric Acid 57-61 cannabinoid receptor 1 (brain) Mus musculus 49-53 24440366-4 2014 After induction of EAE, mice selectively lacking CB1R on GABAergic neurons (GABA-CB1R-KO) showed exacerbated alterations of sEPSC duration in GABAergic medium spiny neurons (MSN). gamma-Aminobutyric Acid 57-61 cannabinoid receptor 1 (brain) Mus musculus 81-85 24440366-6 2014 While EAE severity was enhanced in whole CB1R-KO mice, GABA-CB1R-KO and Glu-CB1R-KO mice had similar motor deficits as the respective wild-type (WT) counterparts. gamma-Aminobutyric Acid 55-59 cannabinoid receptor 1 (brain) Mus musculus 60-64 24440366-6 2014 While EAE severity was enhanced in whole CB1R-KO mice, GABA-CB1R-KO and Glu-CB1R-KO mice had similar motor deficits as the respective wild-type (WT) counterparts. gamma-Aminobutyric Acid 55-59 cannabinoid receptor 1 (brain) Mus musculus 60-64 23358238-9 2013 Using conditional knockout mice lacking CB1R in GABAergic or glutamatergic neurons, we found that GABAergic CB1Rs are mainly downregulated under chronic THC treatment conditions, and CB1-GABA-KO mice did not develop cognitive deficits after chronic THC exposure. gamma-Aminobutyric Acid 48-52 cannabinoid receptor 1 (brain) Mus musculus 40-44 23358238-9 2013 Using conditional knockout mice lacking CB1R in GABAergic or glutamatergic neurons, we found that GABAergic CB1Rs are mainly downregulated under chronic THC treatment conditions, and CB1-GABA-KO mice did not develop cognitive deficits after chronic THC exposure. gamma-Aminobutyric Acid 48-52 cannabinoid receptor 1 (brain) Mus musculus 40-43 23289830-6 2013 Conversely, GABA-CB1-KO mice showed a drastic reduction of these parameters, confirming that CB1 is present at much higher density on hippocampal GABAergic interneurons than glutamatergic neurons. gamma-Aminobutyric Acid 12-16 cannabinoid receptor 1 (brain) Mus musculus 17-20 23289830-6 2013 Conversely, GABA-CB1-KO mice showed a drastic reduction of these parameters, confirming that CB1 is present at much higher density on hippocampal GABAergic interneurons than glutamatergic neurons. gamma-Aminobutyric Acid 12-16 cannabinoid receptor 1 (brain) Mus musculus 93-96 23269835-1 2013 Activation of type 1 cannabinoid receptors (CB1R) decreases GABA and glutamate release in cortical and subcortical regions, with complex outcomes on cortical network activity. gamma-Aminobutyric Acid 60-64 cannabinoid receptor 1 (brain) Mus musculus 44-48 24899717-0 2014 Presynaptic calcium channel inhibition underlies CB1 cannabinoid receptor-mediated suppression of GABA release. gamma-Aminobutyric Acid 98-102 cannabinoid receptor 1 (brain) Mus musculus 49-52 24899717-5 2014 Altering CB1 function by either increasing endocannabinoid production or removing its tonic activity allowed us to demonstrate that CB1 controls GABA release by inhibiting Ca(2+) entry into presynaptic axon terminals via N-type (Cav2.2) Ca(2+) channels. gamma-Aminobutyric Acid 145-149 cannabinoid receptor 1 (brain) Mus musculus 9-12 24899717-5 2014 Altering CB1 function by either increasing endocannabinoid production or removing its tonic activity allowed us to demonstrate that CB1 controls GABA release by inhibiting Ca(2+) entry into presynaptic axon terminals via N-type (Cav2.2) Ca(2+) channels. gamma-Aminobutyric Acid 145-149 cannabinoid receptor 1 (brain) Mus musculus 132-135 24239560-4 2014 To investigate the role of the CNR1-positive GABA-ergic interneurons in behavioral and molecular processes, we employed a novel, miRNA-mediated transgenic mouse approach. gamma-Aminobutyric Acid 45-49 cannabinoid receptor 1 (brain) Mus musculus 31-35 23237313-3 2013 We then assessed the consequences of ventral tegmental area (VTA) CB1 receptor blockade on the wheel-running performances of wildtype (gamma-aminobutyric acid [GABA]-CB1+/+) and mutant (GABA-CB1-/-) mice for CB1 receptors in brain GABA neurons. gamma-Aminobutyric Acid 160-164 cannabinoid receptor 1 (brain) Mus musculus 166-169 23237313-3 2013 We then assessed the consequences of ventral tegmental area (VTA) CB1 receptor blockade on the wheel-running performances of wildtype (gamma-aminobutyric acid [GABA]-CB1+/+) and mutant (GABA-CB1-/-) mice for CB1 receptors in brain GABA neurons. gamma-Aminobutyric Acid 160-164 cannabinoid receptor 1 (brain) Mus musculus 166-169 23237313-3 2013 We then assessed the consequences of ventral tegmental area (VTA) CB1 receptor blockade on the wheel-running performances of wildtype (gamma-aminobutyric acid [GABA]-CB1+/+) and mutant (GABA-CB1-/-) mice for CB1 receptors in brain GABA neurons. gamma-Aminobutyric Acid 160-164 cannabinoid receptor 1 (brain) Mus musculus 166-169 23237313-4 2013 Using in vivo electrophysiology, the consequences of wheel running on VTA dopamine (DA) neuronal activity were examined in GABA-CB1+/+ and GABA-CB1-/- mice. gamma-Aminobutyric Acid 123-127 cannabinoid receptor 1 (brain) Mus musculus 128-131 23237313-5 2013 RESULTS: Conditional deletion of CB1 receptors from brain GABA neurons, but not from several other neuronal populations or from astrocytes, decreased wheel-running performance in mice. gamma-Aminobutyric Acid 58-62 cannabinoid receptor 1 (brain) Mus musculus 33-36 23237313-6 2013 The inhibitory consequences of either the systemic or the intra-VTA administration of CB1 receptor antagonists on running behavior were abolished in GABA-CB1-/- mice. gamma-Aminobutyric Acid 149-153 cannabinoid receptor 1 (brain) Mus musculus 86-89 23237313-6 2013 The inhibitory consequences of either the systemic or the intra-VTA administration of CB1 receptor antagonists on running behavior were abolished in GABA-CB1-/- mice. gamma-Aminobutyric Acid 149-153 cannabinoid receptor 1 (brain) Mus musculus 154-157 22850737-5 2012 On the contrary, the CB1 receptor on the GABAergic terminals is required to induce an anxiogenic-like effect under a high-dose treatment because of the fact that this effect was abolished specifically in GABA-CB1-KO mice. gamma-Aminobutyric Acid 41-45 cannabinoid receptor 1 (brain) Mus musculus 21-24 22850737-5 2012 On the contrary, the CB1 receptor on the GABAergic terminals is required to induce an anxiogenic-like effect under a high-dose treatment because of the fact that this effect was abolished specifically in GABA-CB1-KO mice. gamma-Aminobutyric Acid 41-45 cannabinoid receptor 1 (brain) Mus musculus 209-212 22368777-7 2012 These results indicate that CB1 receptors are transiently expressed on immature MF terminals where they counteract the enhanced neuronal excitability induced by the excitatory action of GABA. gamma-Aminobutyric Acid 186-190 cannabinoid receptor 1 (brain) Mus musculus 28-31 23035099-4 2012 We found that a single intracerebroventricular injection of IL-1beta caused anxiety in mice, and abrogated the sensitivity of cannabinoid CB1 receptors (CB1Rs) controlling GABA synapses in the striatum. gamma-Aminobutyric Acid 172-176 cannabinoid receptor 1 (brain) Mus musculus 138-141 22133429-0 2012 The inhibitory action of exo- and endocannabinoids on [3H]GABA release are mediated by both CB1and CB2receptors in the mouse hippocampus. gamma-Aminobutyric Acid 58-62 cannabinoid receptor 1 (brain) Mus musculus 92-95 20668190-8 2010 Within the SCN, cannabinoids were excitatory by a mechanism based on presynaptic CB1R attenuation of axonal GABA release. gamma-Aminobutyric Acid 108-112 cannabinoid receptor 1 (brain) Mus musculus 81-85 22022550-8 2011 Furthermore, the proportion of CB(1)R immunopositive terminals/preterminals in CB(1)R-WT and Glu-CB(1)R-KO mice was reduced in GABA-CB(1)R-KO mutants. gamma-Aminobutyric Acid 127-131 cannabinoid receptor 1 (brain) Mus musculus 31-37 20424126-4 2010 This behavioral effect was associated with preserved activity of CB1Rs regulating GABA transmission in the striatum, whereas these receptors were dramatically down-regulated by stress in control animals. gamma-Aminobutyric Acid 82-86 cannabinoid receptor 1 (brain) Mus musculus 65-68 20424126-6 2010 We also provided some physiological indications that striatal CB1Rs regulating GABA synapses are not the receptor targets of FAAH inhibition, which rather resulted in the stimulation of striatal CB1Rs regulating glutamate transmission. gamma-Aminobutyric Acid 79-83 cannabinoid receptor 1 (brain) Mus musculus 62-65 20424126-6 2010 We also provided some physiological indications that striatal CB1Rs regulating GABA synapses are not the receptor targets of FAAH inhibition, which rather resulted in the stimulation of striatal CB1Rs regulating glutamate transmission. gamma-Aminobutyric Acid 79-83 cannabinoid receptor 1 (brain) Mus musculus 195-198 22034972-5 2011 In DAT-CI mice, the blockade of CB1R((GABA)) function was complete even after cocaine or environmental manipulations activating the endogenous DA-dependent reward system, which are known to sensitize these receptors in control animals. gamma-Aminobutyric Acid 38-42 cannabinoid receptor 1 (brain) Mus musculus 32-36 22022550-5 2011 At light microscopy, CB(1)R immunolabeling was observed in the VMH of CB(1)R-WT and Glu-CB(1)R-KO animals, being remarkably reduced in GABA-CB(1)R-KO mice. gamma-Aminobutyric Acid 135-139 cannabinoid receptor 1 (brain) Mus musculus 21-27 20926585-9 2010 WIN55,212 decreased the frequency of GABA(A)-R-mediated miniature postsynaptic currents (mPSCs) (reflecting spontaneous vesicle fusion), which was prevented with the CB1 antagonist AM251, indicating collectively that activation of presynaptic CB1 inhibits GABA release. gamma-Aminobutyric Acid 37-41 cannabinoid receptor 1 (brain) Mus musculus 166-169 20417220-0 2010 Delta9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus. gamma-Aminobutyric Acid 66-70 cannabinoid receptor 1 (brain) Mus musculus 49-52 20417220-2 2010 CB1Rs are found on glutamate and GABA neuron axon terminals in the hippocampus where they control neurotransmitter release. gamma-Aminobutyric Acid 33-37 cannabinoid receptor 1 (brain) Mus musculus 0-3 20417220-8 2010 Concentration-response curves revealed that the maximal effects of Delta(9)-THC and WIN55,212-2 were similar, indicating that Delta(9)-THC is a full agonist at CB1Rs on GABA axon terminals. gamma-Aminobutyric Acid 169-173 cannabinoid receptor 1 (brain) Mus musculus 160-163 20417220-10 2010 Furthermore, full agonist effects of Delta(9)-THC on IPSCs likely result from a much higher expression of CB1Rs on GABA versus glutamate axon terminals in the hippocampus. gamma-Aminobutyric Acid 115-119 cannabinoid receptor 1 (brain) Mus musculus 106-109 19591937-5 2009 The sensitivity of striatal GABA synapses to the stimulation of cannabinoid CB1 receptors was dramatically downregulated following EAE induction, and was rescued by exercise in EAE mice with access to a running wheel. gamma-Aminobutyric Acid 28-32 cannabinoid receptor 1 (brain) Mus musculus 76-79 20111610-7 2010 Furthermore, 30% and 35% of presynaptic boutons localize CB1 in alBNST of conditional mutant mice lacking CB1 mainly from GABAergic neurons (GABA-CB1-KO mice) and mainly from cortical glutamatergic neurons (Glu-CB1-KO mice), respectively. gamma-Aminobutyric Acid 122-126 cannabinoid receptor 1 (brain) Mus musculus 57-60 19421027-1 2009 Neuroanatomical findings revealed that CB1 cannabinoid and 5-HT3 receptors are coexpressed by a subtype of gamma-aminobutyric acid (GABA)ergic interneurons in the prefrontal cortex, hippocampus, and basolateral amygdala, three brain regions that are crucial for the control of anxiety. gamma-Aminobutyric Acid 107-130 cannabinoid receptor 1 (brain) Mus musculus 39-42 19648913-4 2009 Moreover, using pharmacological and genetic tools, we found that THC long-term memory deficits were mediated by CB1Rs expressed on GABAergic interneurons through a glutamatergic mechanism, as both the amnesic-like effects and p70S6K phosphorylation were reduced in GABA-CB1R knockout mice and by NMDA blockade. gamma-Aminobutyric Acid 131-135 cannabinoid receptor 1 (brain) Mus musculus 112-115 19648913-4 2009 Moreover, using pharmacological and genetic tools, we found that THC long-term memory deficits were mediated by CB1Rs expressed on GABAergic interneurons through a glutamatergic mechanism, as both the amnesic-like effects and p70S6K phosphorylation were reduced in GABA-CB1R knockout mice and by NMDA blockade. gamma-Aminobutyric Acid 131-135 cannabinoid receptor 1 (brain) Mus musculus 112-116 19421027-1 2009 Neuroanatomical findings revealed that CB1 cannabinoid and 5-HT3 receptors are coexpressed by a subtype of gamma-aminobutyric acid (GABA)ergic interneurons in the prefrontal cortex, hippocampus, and basolateral amygdala, three brain regions that are crucial for the control of anxiety. gamma-Aminobutyric Acid 132-136 cannabinoid receptor 1 (brain) Mus musculus 39-42 19421027-10 2009 The disruption of CB1 receptors in CB1-KOs released GABA neurons from retrograde inhibition and made the effects of 5-HT3 stimulation conspicuous. gamma-Aminobutyric Acid 52-56 cannabinoid receptor 1 (brain) Mus musculus 18-21 19421027-10 2009 The disruption of CB1 receptors in CB1-KOs released GABA neurons from retrograde inhibition and made the effects of 5-HT3 stimulation conspicuous. gamma-Aminobutyric Acid 52-56 cannabinoid receptor 1 (brain) Mus musculus 35-38