PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34050134-1 2021 Mutations in the GABRG2 gene encoding the gamma-aminobutyric acid (GABA) A receptor gamma 2 subunit are associated with genetic epilepsy with febrile seizures plus, febrile seizures plus, febrile seizures, and other symptoms of epilepsy. gamma-Aminobutyric Acid 42-65 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 17-23 34050134-1 2021 Mutations in the GABRG2 gene encoding the gamma-aminobutyric acid (GABA) A receptor gamma 2 subunit are associated with genetic epilepsy with febrile seizures plus, febrile seizures plus, febrile seizures, and other symptoms of epilepsy. gamma-Aminobutyric Acid 67-71 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 17-23 31636084-1 2019 Immune cells express gamma-aminobutyric acid receptors (GABA-R), and GABA administration can inhibit effector T cell responses in models of autoimmune disease. gamma-Aminobutyric Acid 21-44 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 56-62 31951019-10 2020 gamma2 and delta components of IPSCs were modulated similarly by presynaptic manipulations and manipulations of transmitter lifetime, suggesting that GABA release recruits delta receptors proportionally to gamma2 receptors. gamma-Aminobutyric Acid 150-154 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 0-6 33663578-9 2021 Strikingly, the GABA uptake inhibitor tiagabine (TGB) ameliorated abnormal gamma oscillations and levels of GABAAR subunits, suggesting a potential therapeutic strategy for early AD symptoms. gamma-Aminobutyric Acid 16-20 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 108-114 33344908-1 2020 We report the relaxation of methacholine-constricted airways with nebulized MIDD0301, a positive allosteric gamma-aminobutyric acid type A receptor (GABAAR) modulator. gamma-Aminobutyric Acid 108-131 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 149-155 31833596-1 2020 Tonic extrasynaptic GABAA receptor (GABAA R) activation is under the tight control of tonic GABA release from astrocytes to maintain the brain"s excitation/inhibition (E/I) balance; any slight E/I balance disturbance can cause serious pathological conditions including epileptic seizures. gamma-Aminobutyric Acid 20-24 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 36-43 31080408-2 2019 BZDs potentiate the actions of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the adult brain, through positive allosteric modulation of gamma2 subunit containing GABA type A receptors (GABAARs). gamma-Aminobutyric Acid 31-54 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 165-171 31080408-2 2019 BZDs potentiate the actions of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the adult brain, through positive allosteric modulation of gamma2 subunit containing GABA type A receptors (GABAARs). gamma-Aminobutyric Acid 56-60 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 165-171 25173217-1 2014 gamma-Aminobutyric acid A receptor (GABAAR)-mediated postsynaptic currents were recorded in brain slices from substantia nigra pars reticulate neurons. gamma-Aminobutyric Acid 0-23 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 36-42 29044621-4 2018 Our results showed that the expression of GABA synthesizing enzyme glutamic acid decarboxylase and type A GABA receptor (GABAA R) subunits was upregulated in ethanol-treated mice compared with saline-treated controls. gamma-Aminobutyric Acid 42-46 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 67-119 29044621-4 2018 Our results showed that the expression of GABA synthesizing enzyme glutamic acid decarboxylase and type A GABA receptor (GABAA R) subunits was upregulated in ethanol-treated mice compared with saline-treated controls. gamma-Aminobutyric Acid 42-46 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 121-128 29634983-2 2018 Indeed, exogenous GABA and muscimol, a GABAAR agonist, exacerbate acute inflammatory hypersensitivity in rodents. gamma-Aminobutyric Acid 18-22 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 39-45 27523033-3 2016 NEW METHOD: Using GABA-containing liposomes (GL) prepared by the freeze-thawing method, we determined the effect of sustained release of GABA on expression of neuronal nitric oxide synthase (nNOS) and GABAA receptor (GABAAR) in an in vitro neuronal model. gamma-Aminobutyric Acid 137-141 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 201-215 27523033-3 2016 NEW METHOD: Using GABA-containing liposomes (GL) prepared by the freeze-thawing method, we determined the effect of sustained release of GABA on expression of neuronal nitric oxide synthase (nNOS) and GABAA receptor (GABAAR) in an in vitro neuronal model. gamma-Aminobutyric Acid 137-141 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 217-223 26394279-4 2015 During postnatal development, the mRNA levels of GABA A receptor (GABAAR) subunits, including alpha1, alpha4, beta1, beta2, and delta; GABA B receptor (GABABR) subunit 2; and the expression of GABA-related proteins, including glutamic acid decarboxylase, vesicular GABA transporter (VGAT), and potassium chloride cotransporter 2 increased gradually in the mouse hippocampus. gamma-Aminobutyric Acid 49-53 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 66-72 21825029-4 2011 Surprisingly, we found that the kinetics of inhibitory postsynaptic currents (IPSCs) were slower in mature synapses (P26-40) due to the synaptic incorporation of the alpha5 subunit of the GABA(A) receptor (a5-GABA(A)R). gamma-Aminobutyric Acid 188-192 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 209-217 24162656-3 2013 The effect of alcohol on granule cell GABA(A)R inhibition was determined by a balance between two opposing effects: enhanced presynaptic vesicular release of GABA via alcohol inhibition of nitric oxide synthase (NOS) and a direct suppression of the activity of postsynaptic GABA(A)Rs. gamma-Aminobutyric Acid 158-162 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 38-46 22128345-2 2012 The PRIP-1 subtype is expressed predominantly in the central nervous system and binds directly to the GABA type A receptor (GABA(A)-R) beta-subunit and several other proteins involved in the trafficking of GABA(A)-Rs to the plasma membrane. gamma-Aminobutyric Acid 102-106 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 124-133 22700823-2 2012 GABA generates fast biological signaling through type A receptors (GABA(A)R), an anionic channel. gamma-Aminobutyric Acid 0-4 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 67-75 23071808-8 2012 We conclude that anxiety-like behavior in the Elevated Plus Maze and behavioral despair-like immobility in the Forced Swim Test are controlled by separate postnatal critical periods characterized by distinct developmental sensitivity to manipulation of GABAergic transmission via gamma2 subunit-containing GABA(A)Rs. gamma-Aminobutyric Acid 253-257 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 280-286 20543135-5 2010 Electrophysiological and biochemical studies of cultured cortical neurons of BERP-deficient mice showed a decrease in the amplitude of GABA(A) receptor (GABA(A)R)-mediated miniature inhibitory postsynaptic currents as well as reduced surface protein expression of GABA(A)Rs containing the gamma2-subunit. gamma-Aminobutyric Acid 135-139 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 153-161 21977012-1 2011 There is considerable evidence that ethanol (EtOH) potentiates gamma-aminobutyric acid type A receptor (GABA(A)R) action, but only GABA(A)Rs containing delta subunits appear sensitive to low millimolar EtOH. gamma-Aminobutyric Acid 104-108 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 63-102 20530218-4 2011 Furthermore, paired-pulse inhibition (PPI) of the population spike, a measure for gamma-aminobutyric acid (GABA)ergic network inhibition, was severely impaired and associated with reduced GABA(A) receptor (GABA(A)R)-mediated miniature inhibitory postsynaptic currents recorded from NL2-deficient GCs. gamma-Aminobutyric Acid 82-105 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 188-204 20530218-4 2011 Furthermore, paired-pulse inhibition (PPI) of the population spike, a measure for gamma-aminobutyric acid (GABA)ergic network inhibition, was severely impaired and associated with reduced GABA(A) receptor (GABA(A)R)-mediated miniature inhibitory postsynaptic currents recorded from NL2-deficient GCs. gamma-Aminobutyric Acid 82-105 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 206-214 20926585-2 2010 gamma-Aminobutyric acid (GABA)(A) receptor (GABA(A)-R)-mediated transmission is a major input to GnRH cells that can be excitatory. gamma-Aminobutyric Acid 0-23 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 44-53 20926585-2 2010 gamma-Aminobutyric acid (GABA)(A) receptor (GABA(A)-R)-mediated transmission is a major input to GnRH cells that can be excitatory. gamma-Aminobutyric Acid 25-29 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 44-53 12871648-2 2003 The proposed mechanism is suppression of inhibitory postsynaptic responses, mainly mediated by gamma-amino butyric acid (GABA)(A)-receptors (GABA(A)-R). gamma-Aminobutyric Acid 95-119 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 141-150 20018248-1 2010 The GABA(A)R alpha4 subunit is highly expressed in the dentate gyrus region of the hippocampus at predominantly extra synaptic locations where, along with the GABA(A)R delta subunit, it forms GABA(A) receptors that mediate a tonic inhibitory current. gamma-Aminobutyric Acid 4-8 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 159-167 15833735-2 2005 Because inhaled anesthetics robustly enhance GABA A receptor (GABA(A)-R) responses to GABA, these receptors are considered prime targets of anesthetic action. gamma-Aminobutyric Acid 45-49 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 62-71 15342728-3 2004 Application of GABA at 10 microm, a nondesensitizing concentration for GABA(A) receptors (GABA(A)Rs), reduced the rate (mean of approximately 50 microm/hr) of cell migration by 21% via GABA(A)R activation. gamma-Aminobutyric Acid 15-19 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 90-98 15342728-4 2004 Application of the GABA(A)R antagonist bicuculline enhanced the migration rate by 30%, suggesting that endogenous GABA tonically reduces the speed of cell migration via GABA(A)R activation. gamma-Aminobutyric Acid 19-23 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 169-177 20233604-6 2010 Tyrosine phosphorylation of the gamma2 subunit is not completely abolished in Fyn kinase mice, suggesting that other SFKs, such as Src, also contribute to maintaining and regulating the endogenous phosphorylation level of gamma2-containing GABA(A) receptors. gamma-Aminobutyric Acid 240-244 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 32-38 20233604-6 2010 Tyrosine phosphorylation of the gamma2 subunit is not completely abolished in Fyn kinase mice, suggesting that other SFKs, such as Src, also contribute to maintaining and regulating the endogenous phosphorylation level of gamma2-containing GABA(A) receptors. gamma-Aminobutyric Acid 240-244 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 222-228 18794205-2 2009 Brain dystrophin is thought to be involved in the stabilization of gamma-aminobutyric acid (GABA)(A)-receptor (GABA(A)-R)clusters in postsynaptic densities (PSDs) at inhibitory synapses onto pyramidal cells, and its loss has been linked to cognitive impairments in Duchenne muscular dystrophy. gamma-Aminobutyric Acid 67-90 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 111-120 18794205-2 2009 Brain dystrophin is thought to be involved in the stabilization of gamma-aminobutyric acid (GABA)(A)-receptor (GABA(A)-R)clusters in postsynaptic densities (PSDs) at inhibitory synapses onto pyramidal cells, and its loss has been linked to cognitive impairments in Duchenne muscular dystrophy. gamma-Aminobutyric Acid 92-96 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 111-120 19302153-1 2009 The sedative and hypnotic agent 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol (THIP) is a GABA(A) receptor (GABA(A)R) agonist that preferentially activates delta-subunit-containing GABA(A)Rs (delta-GABA(A)Rs). gamma-Aminobutyric Acid 92-96 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 110-118 17875639-4 2007 We used this mutant and PKCepsilon(-/-) mice to determine that PKCepsilon phosphorylates gamma2 subunits at serine 327 and that reduced phosphorylation of this site enhances the actions of ethanol and benzodiazepines at alpha1beta2gamma2 receptors, which is the most abundant GABA(A) receptor subtype in the brain. gamma-Aminobutyric Acid 276-280 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 89-95 17259375-2 2007 Added to isolated mouse islets in the presence of 0.5 mmol/l glucose, gamma-aminobutyric acid (GABA) inhibited glucagon release to a similar extent (46%) as 10 mmol/l glucose (55%), and the selective GABA(A) receptor (GABA(A)R) antagonist SR95531 substantially reversed the inhibition of glucagon release by high glucose. gamma-Aminobutyric Acid 70-93 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 200-216 17259375-2 2007 Added to isolated mouse islets in the presence of 0.5 mmol/l glucose, gamma-aminobutyric acid (GABA) inhibited glucagon release to a similar extent (46%) as 10 mmol/l glucose (55%), and the selective GABA(A) receptor (GABA(A)R) antagonist SR95531 substantially reversed the inhibition of glucagon release by high glucose. gamma-Aminobutyric Acid 70-93 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 218-226 17259375-2 2007 Added to isolated mouse islets in the presence of 0.5 mmol/l glucose, gamma-aminobutyric acid (GABA) inhibited glucagon release to a similar extent (46%) as 10 mmol/l glucose (55%), and the selective GABA(A) receptor (GABA(A)R) antagonist SR95531 substantially reversed the inhibition of glucagon release by high glucose. gamma-Aminobutyric Acid 95-99 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 200-216 17259375-2 2007 Added to isolated mouse islets in the presence of 0.5 mmol/l glucose, gamma-aminobutyric acid (GABA) inhibited glucagon release to a similar extent (46%) as 10 mmol/l glucose (55%), and the selective GABA(A) receptor (GABA(A)R) antagonist SR95531 substantially reversed the inhibition of glucagon release by high glucose. gamma-Aminobutyric Acid 95-99 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 218-226 17259375-6 2007 We conclude that 1) release of GABA from neighboring beta-cells contributes substantially to the acute inhibition of glucagon secretion from mouse islets by glucose and 2) that changes in GABA(A)R expression, mediated by changes in intracellular free Ca(2+) concentration, may modulate this response in the long term. gamma-Aminobutyric Acid 31-35 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 188-196 12871648-2 2003 The proposed mechanism is suppression of inhibitory postsynaptic responses, mainly mediated by gamma-amino butyric acid (GABA)(A)-receptors (GABA(A)-R). gamma-Aminobutyric Acid 121-125 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 141-150 9874145-3 1998 competitively reverse transcribed into cDNA, and amplified by the polymerase chain reaction (PCR), the relative intensities of the amplified, stained target and standard DNA bands enable measurement of small amounts of mRNAs for GABA(A) receptor subunits alpha1-6, beta1-3, gamma1-3 and delta and the three cellular markers beta-actin, light neurofilament protein, and glutamine synthetase. gamma-Aminobutyric Acid 229-233 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 274-282 12456806-1 2002 Gamma-aminobutyric acid (GABA), acting through GABA(A) receptors (GABA(A)R), is hypothesized to suppress reproduction by inhibiting GnRH secretion, but GABA actions directly on GnRH neurons are not well established. gamma-Aminobutyric Acid 0-23 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 47-64 12456806-1 2002 Gamma-aminobutyric acid (GABA), acting through GABA(A) receptors (GABA(A)R), is hypothesized to suppress reproduction by inhibiting GnRH secretion, but GABA actions directly on GnRH neurons are not well established. gamma-Aminobutyric Acid 0-23 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 66-74 12456806-1 2002 Gamma-aminobutyric acid (GABA), acting through GABA(A) receptors (GABA(A)R), is hypothesized to suppress reproduction by inhibiting GnRH secretion, but GABA actions directly on GnRH neurons are not well established. gamma-Aminobutyric Acid 25-29 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 47-64 12456806-1 2002 Gamma-aminobutyric acid (GABA), acting through GABA(A) receptors (GABA(A)R), is hypothesized to suppress reproduction by inhibiting GnRH secretion, but GABA actions directly on GnRH neurons are not well established. gamma-Aminobutyric Acid 25-29 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 66-74 12456806-1 2002 Gamma-aminobutyric acid (GABA), acting through GABA(A) receptors (GABA(A)R), is hypothesized to suppress reproduction by inhibiting GnRH secretion, but GABA actions directly on GnRH neurons are not well established. gamma-Aminobutyric Acid 47-51 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 66-74 11198298-2 2001 Altered transcription of genes encoding glutamatergic and gamma-aminobutyric acid (GABA)-ergic receptors and uptake sites may contribute to seizure initiation and may occur selectively in dysplastic neurons and giant cells. gamma-Aminobutyric Acid 58-81 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 83-87 11029618-1 2000 We have employed transgenic mouse models to examine the functional significance of the gamma2 subunit of the GABA(A) (gamma-aminobutyric acid) receptor to the correct development of gonadotropin-releasing hormone (GnRH) neurons in vivo. gamma-Aminobutyric Acid 109-113 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 87-93 34341497-1 2022 Reduced brain-derived neurotrophic factor (BDNF) and gamma-aminobutyric acid (GABA) neurotransmission co-occur in brain conditions (depression, schizophrenia and age-related disorders) and are associated with symptomatology. gamma-Aminobutyric Acid 53-76 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 78-82 34563056-3 2021 Activation of gamma-aminobutyric acid (GABA)-type A receptors (GABAAR) in the suprachiasmatic nucleus (SCN) can phase shift the clock and thus GABA and its receptors represent a putative pathway via which GA exerts its effect on the clock. gamma-Aminobutyric Acid 14-37 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 39-43 34563056-3 2021 Activation of gamma-aminobutyric acid (GABA)-type A receptors (GABAAR) in the suprachiasmatic nucleus (SCN) can phase shift the clock and thus GABA and its receptors represent a putative pathway via which GA exerts its effect on the clock. gamma-Aminobutyric Acid 14-37 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 63-69 34563056-3 2021 Activation of gamma-aminobutyric acid (GABA)-type A receptors (GABAAR) in the suprachiasmatic nucleus (SCN) can phase shift the clock and thus GABA and its receptors represent a putative pathway via which GA exerts its effect on the clock. gamma-Aminobutyric Acid 14-37 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 143-147 34502229-2 2021 Activation of the gamma-aminobutyric acid (GABA) receptors (GABAAR and GABABR) reduces cellular excitability through Cl- influx and K+ efflux in neurons. gamma-Aminobutyric Acid 18-41 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 43-47 34502229-2 2021 Activation of the gamma-aminobutyric acid (GABA) receptors (GABAAR and GABABR) reduces cellular excitability through Cl- influx and K+ efflux in neurons. gamma-Aminobutyric Acid 18-41 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 60-66 35455470-17 2022 Moreover, this study revealed that CBD also modified the gene expression of GABA(A) subunits alpha2 and gamma2 and CB1r, CB2r and GPR55, in a dose- and brain-region-dependent manner, supporting a multimodal mechanism of action for CBD. gamma-Aminobutyric Acid 76-80 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 104-110