PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22972230-4 2012 The ICV injection of NPY strongly stimulated food intake while co-administration of NPY and picrotoxin, a GABA(A) antagonist, (but not CGP54626, a GABA(B) antagonist) weakened food intake induced by NPY. gamma-Aminobutyric Acid 106-110 neuropeptide Y Rattus norvegicus 21-24 26790345-7 2016 The number of NPY fibers juxtaposed to NPY neurons is correlated with the frequency of postsynaptic currents, suggesting that NPY/GABA release may facilitate maturation of synapses on their innervated neurons. gamma-Aminobutyric Acid 130-134 neuropeptide Y Rattus norvegicus 14-17 26790345-7 2016 The number of NPY fibers juxtaposed to NPY neurons is correlated with the frequency of postsynaptic currents, suggesting that NPY/GABA release may facilitate maturation of synapses on their innervated neurons. gamma-Aminobutyric Acid 130-134 neuropeptide Y Rattus norvegicus 39-42 26790345-7 2016 The number of NPY fibers juxtaposed to NPY neurons is correlated with the frequency of postsynaptic currents, suggesting that NPY/GABA release may facilitate maturation of synapses on their innervated neurons. gamma-Aminobutyric Acid 130-134 neuropeptide Y Rattus norvegicus 39-42 25620912-0 2014 Parvalbumin and neuropeptide Y expressing hippocampal GABA-ergic inhibitory interneuron numbers decline in a model of Gulf War illness. gamma-Aminobutyric Acid 54-58 neuropeptide Y Rattus norvegicus 16-30 24252118-12 2014 Double-immunostaining also showed that the GABA-immunoreactive nerve fibers were in close contact with NOS- or neuropeptide tyrosine (NPY)-immunoreactive ganglion cells. gamma-Aminobutyric Acid 43-47 neuropeptide Y Rattus norvegicus 111-132 24252118-12 2014 Double-immunostaining also showed that the GABA-immunoreactive nerve fibers were in close contact with NOS- or neuropeptide tyrosine (NPY)-immunoreactive ganglion cells. gamma-Aminobutyric Acid 43-47 neuropeptide Y Rattus norvegicus 134-137 22972230-4 2012 The ICV injection of NPY strongly stimulated food intake while co-administration of NPY and picrotoxin, a GABA(A) antagonist, (but not CGP54626, a GABA(B) antagonist) weakened food intake induced by NPY. gamma-Aminobutyric Acid 147-151 neuropeptide Y Rattus norvegicus 21-24 22415080-5 2012 These findings indicate that long-term NPY administration in the periphery leads to abnormal baroreflex sensitivity due, at least in part, to the down-regulated expression of SP/GluR2 and elevated expression of GABA(A)R in both protein and RNA levels, which indicate the alternations in glutamate function and GABA action in the nucleus tractus solitarii in NPY-treated rats. gamma-Aminobutyric Acid 211-215 neuropeptide Y Rattus norvegicus 39-42 22508053-8 2012 The expressions of substance P (SP) and gamma aminobutyric acid A receptor (GABA(A)R) in nucleus tractus solitarius were increased in chronic stress rats, which were counteracted by NPY pretreatment. gamma-Aminobutyric Acid 76-80 neuropeptide Y Rattus norvegicus 182-185 22415080-5 2012 These findings indicate that long-term NPY administration in the periphery leads to abnormal baroreflex sensitivity due, at least in part, to the down-regulated expression of SP/GluR2 and elevated expression of GABA(A)R in both protein and RNA levels, which indicate the alternations in glutamate function and GABA action in the nucleus tractus solitarii in NPY-treated rats. gamma-Aminobutyric Acid 310-314 neuropeptide Y Rattus norvegicus 39-42 20236227-2 2010 The pivotal role of these neuropeptides in energy homeostasis is well-known, although GABA may also be an important signal because targeted knockout of the GABA transporter in NPY/AgRP/GABA neurones results in a lean, obesity-resistant phenotype. gamma-Aminobutyric Acid 156-160 neuropeptide Y Rattus norvegicus 176-179 21459365-0 2011 Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence. gamma-Aminobutyric Acid 42-65 neuropeptide Y Rattus norvegicus 0-14 21459365-5 2011 Neuropeptide Y decreased baseline GABAergic transmission and reversed alcohol-induced enhancement of inhibitory transmission in CeA by suppressing GABA release via actions at presynaptic Y(2) receptors. gamma-Aminobutyric Acid 34-38 neuropeptide Y Rattus norvegicus 0-14 21224009-12 2011 As no differences were noted by sex or estrous cycle phase, DOR activation on NPY-labeled axon terminals would inhibit GABA release probability equally in males and females. gamma-Aminobutyric Acid 119-123 neuropeptide Y Rattus norvegicus 78-81 20236227-4 2010 K(+)-evoked GABA release was sensitive to leptin, insulin and PYY(3-36), indicating that GABA was released by arcuate NPY/AgRP/GABA neurones. gamma-Aminobutyric Acid 89-93 neuropeptide Y Rattus norvegicus 118-121 20236227-4 2010 K(+)-evoked GABA release was sensitive to leptin, insulin and PYY(3-36), indicating that GABA was released by arcuate NPY/AgRP/GABA neurones. gamma-Aminobutyric Acid 89-93 neuropeptide Y Rattus norvegicus 118-121 20236227-13 2010 The inhibitory effect of rimonabant was also prevented by naloxone and a kappa-opioid receptor selective antagonist, suggesting that GABA release from arcuate NPY/AgRP/GABA neurones can be inhibited by endogenous opioid peptides, and that the release of opioid peptides is sensitive to cannabinoids. gamma-Aminobutyric Acid 133-137 neuropeptide Y Rattus norvegicus 159-162 20236227-13 2010 The inhibitory effect of rimonabant was also prevented by naloxone and a kappa-opioid receptor selective antagonist, suggesting that GABA release from arcuate NPY/AgRP/GABA neurones can be inhibited by endogenous opioid peptides, and that the release of opioid peptides is sensitive to cannabinoids. gamma-Aminobutyric Acid 168-172 neuropeptide Y Rattus norvegicus 159-162 11287104-0 2001 A GABA-neuropeptide Y (NPY) interplay in LH release. gamma-Aminobutyric Acid 2-6 neuropeptide Y Rattus norvegicus 7-21 12482942-2 2002 In the neocortex, where NPY is present in gamma-aminobutyric acid (GABA)ergic interneurons, its effects on inhibitory and excitatory synaptic activities have not been completely explored. gamma-Aminobutyric Acid 42-65 neuropeptide Y Rattus norvegicus 24-27 12482942-2 2002 In the neocortex, where NPY is present in gamma-aminobutyric acid (GABA)ergic interneurons, its effects on inhibitory and excitatory synaptic activities have not been completely explored. gamma-Aminobutyric Acid 67-71 neuropeptide Y Rattus norvegicus 24-27 12482942-4 2002 The novel, late, NPY-mediated increase of inhibitory synaptic transmission is caused by modulation of Ca2+-dependent GABA release onto pyramidal neurons, as it was accompanied by an increase in Ca2+-dependent miniature IPSC frequency. gamma-Aminobutyric Acid 117-121 neuropeptide Y Rattus norvegicus 17-20 12445967-4 2002 Since a subpopulation of neuropeptide Y (NPY) neurons in the hypothalamic arcuate nucleus co-synthesize GABA, and NPY-containing neurons of arcuate nucleus origin densely innervate TRH neurons in the PVN, we performed triple labeling immunocytochemistry to elucidate the origin of the GAD-IR innervation of hypophysiotropic TRH neurons. gamma-Aminobutyric Acid 104-108 neuropeptide Y Rattus norvegicus 41-44 12445967-6 2002 We conclude that GABA-ergic neurons are in position to act directly on hypophysiotropic TRH neurons and while this innervation arises partly from neurons in the arcuate nucleus that co-synthesize NPY, the majority of the GABA-ergic input arises from other neuronal groups. gamma-Aminobutyric Acid 17-21 neuropeptide Y Rattus norvegicus 196-199 11932938-8 2002 NPY-immunoreactive cells contained GABA immunoreactivity, and some amacrine cells also contained tyrosine hydroxylase immunoreactivity. gamma-Aminobutyric Acid 35-39 neuropeptide Y Rattus norvegicus 0-3 11796508-0 2002 Multiple NPY receptors Inhibit GABA(A) synaptic responses of rat medial parvocellular effector neurons in the hypothalamic paraventricular nucleus. gamma-Aminobutyric Acid 31-35 neuropeptide Y Rattus norvegicus 9-12 11796508-3 2002 Focal electrical stimulation within the PVN elicited a GABA(A) synaptic response in some mpPVN neurons, which was reversibly inhibited by NPY in a concentration-dependent manner (EC(50) = 28 nM). gamma-Aminobutyric Acid 55-59 neuropeptide Y Rattus norvegicus 138-141 11796508-8 2002 NPY inhibits GABA(A) synaptic transmission onto mpPVN neurons, but this can be mediated by three different NPY receptors. gamma-Aminobutyric Acid 13-17 neuropeptide Y Rattus norvegicus 0-3 12182884-14 2002 However, we found that co-treatment of the cells by NPY and neuromediators such as NMDA or GABA strongly promoted the survival of granule neurones. gamma-Aminobutyric Acid 91-95 neuropeptide Y Rattus norvegicus 52-55 18579133-6 2008 Graft cell survival was approximately 33% of injected cells and approximately 69% of surviving cells differentiated into GABA-ergic neurons, which comprised subclasses expressing calbindin, parvalbumin, calretinin and neuropeptide Y. gamma-Aminobutyric Acid 121-125 neuropeptide Y Rattus norvegicus 218-232 15731400-3 2005 In the present study, we tested the hypothesis that responsiveness to GABA, a putative potentiator of NPY"s effect, is also diminished. gamma-Aminobutyric Acid 70-74 neuropeptide Y Rattus norvegicus 102-105 14967739-12 2004 NPY is less effective at the mpPVN GABA synapse in obese than in lean Zucker rats. gamma-Aminobutyric Acid 35-39 neuropeptide Y Rattus norvegicus 0-3 11287104-0 2001 A GABA-neuropeptide Y (NPY) interplay in LH release. gamma-Aminobutyric Acid 2-6 neuropeptide Y Rattus norvegicus 23-26 11287104-3 2001 First by employing light and electron microscopic double staining for NPY and GABA, using pre and post-immunolabeling on rat brain sections, we detected GABA in NPY immunoreactive axon terminals in the MPOA, one of the primary sites of action of these neurotransmitters/neuromodulators in the regulation of LH release. gamma-Aminobutyric Acid 78-82 neuropeptide Y Rattus norvegicus 161-164 11287104-3 2001 First by employing light and electron microscopic double staining for NPY and GABA, using pre and post-immunolabeling on rat brain sections, we detected GABA in NPY immunoreactive axon terminals in the MPOA, one of the primary sites of action of these neurotransmitters/neuromodulators in the regulation of LH release. gamma-Aminobutyric Acid 153-157 neuropeptide Y Rattus norvegicus 70-73 11287104-3 2001 First by employing light and electron microscopic double staining for NPY and GABA, using pre and post-immunolabeling on rat brain sections, we detected GABA in NPY immunoreactive axon terminals in the MPOA, one of the primary sites of action of these neurotransmitters/neuromodulators in the regulation of LH release. gamma-Aminobutyric Acid 153-157 neuropeptide Y Rattus norvegicus 161-164 11287104-4 2001 These morphological findings raised the possibility that inhibitory GABA co-released with NPY may act to restrain the excitatory effects of NPY on LH release. gamma-Aminobutyric Acid 68-72 neuropeptide Y Rattus norvegicus 140-143 11287104-8 2001 These results support the possibility that in the event of co-release of these neurotransmitters/neuromodulators, GABA may act to restrain stimulation of LH release by NPY during the basal episodic and cyclic release of LH in vivo. gamma-Aminobutyric Acid 114-118 neuropeptide Y Rattus norvegicus 168-171 9526018-6 1998 NPY-induced phase advances, but not inhibition, were blocked by the GABAA antagonist bicuculline, suggesting that NPY-mediated modulation of GABA may be an underlying mechanism whereby NPY phase shifts the circadian clock. gamma-Aminobutyric Acid 68-72 neuropeptide Y Rattus norvegicus 0-3 11226718-1 2001 The effects of hippocampal treatment with a phosphorothioate oligodeoxynucleotide (ODN) antisense to the gamma-aminobutyric acid (GABA)A receptor gamma2 subunit on neuropeptide Y (NPY) were studied. gamma-Aminobutyric Acid 130-134 neuropeptide Y Rattus norvegicus 164-178 9927326-2 1999 We recently reported that gamma-aminobutyric acid (GABA) is coexpressed in a subpopulation of NPY neurons in the arcuate nucleus. gamma-Aminobutyric Acid 26-49 neuropeptide Y Rattus norvegicus 94-97 9927326-2 1999 We recently reported that gamma-aminobutyric acid (GABA) is coexpressed in a subpopulation of NPY neurons in the arcuate nucleus. gamma-Aminobutyric Acid 51-55 neuropeptide Y Rattus norvegicus 94-97 9927326-4 1999 GABA was detected in NPY-immunopositive axons and axon terminals within both the parvocellular and magnocellular divisions of the PVN. gamma-Aminobutyric Acid 0-4 neuropeptide Y Rattus norvegicus 21-24 9927326-5 1999 These morphological findings suggested a NPY-GABA interaction in the hypothalamic control of feeding. gamma-Aminobutyric Acid 45-49 neuropeptide Y Rattus norvegicus 41-44 9927326-7 1999 When injected intracerebroventricularly, both NPY and MUS elicited dose-dependent feeding responses that were blocked by the administration of 1229U91 (a putative Y1 receptor antagonist) or bicuculline (a GABA(A) receptor antagonist), respectively. gamma-Aminobutyric Acid 205-209 neuropeptide Y Rattus norvegicus 46-49 10717429-1 2000 Neuropeptide Y reduced spontaneous and stimulation-evoked epileptiform discharges in rat frontal cortex slices perfused with a magnesium-free solution and with the GABA(A) receptor antagonist picrotoxin. gamma-Aminobutyric Acid 164-168 neuropeptide Y Rattus norvegicus 0-14 10047974-7 1999 It is possible that some of these may represent the physiologically relevant "off" switches under the influence of GABA alone, or AgrP alone, or in combination with NPY released from the NPY-, GABA-, and AgrP-coproducing neurons. gamma-Aminobutyric Acid 115-119 neuropeptide Y Rattus norvegicus 165-168 10047974-7 1999 It is possible that some of these may represent the physiologically relevant "off" switches under the influence of GABA alone, or AgrP alone, or in combination with NPY released from the NPY-, GABA-, and AgrP-coproducing neurons. gamma-Aminobutyric Acid 115-119 neuropeptide Y Rattus norvegicus 187-190 10047974-7 1999 It is possible that some of these may represent the physiologically relevant "off" switches under the influence of GABA alone, or AgrP alone, or in combination with NPY released from the NPY-, GABA-, and AgrP-coproducing neurons. gamma-Aminobutyric Acid 193-197 neuropeptide Y Rattus norvegicus 165-168 9526018-6 1998 NPY-induced phase advances, but not inhibition, were blocked by the GABAA antagonist bicuculline, suggesting that NPY-mediated modulation of GABA may be an underlying mechanism whereby NPY phase shifts the circadian clock. gamma-Aminobutyric Acid 68-72 neuropeptide Y Rattus norvegicus 114-117 9526018-6 1998 NPY-induced phase advances, but not inhibition, were blocked by the GABAA antagonist bicuculline, suggesting that NPY-mediated modulation of GABA may be an underlying mechanism whereby NPY phase shifts the circadian clock. gamma-Aminobutyric Acid 68-72 neuropeptide Y Rattus norvegicus 114-117 9187344-3 1997 In this study, we report the coexistence of neuropeptide Y and the amino acid transmitter, gamma-aminobutyric acid (GABA), in neuronal perikarya of the arcuate nucleus. gamma-Aminobutyric Acid 116-120 neuropeptide Y Rattus norvegicus 44-58 9303524-8 1997 Dual-labeling studies on separate rats showed that a small subpopulation of the NPY- and SOM-labeled neurons, primarily in the infragranular hilus, were colocalized with neurons containing GABA immunoreactivity (18% and 5%, respectively). gamma-Aminobutyric Acid 189-193 neuropeptide Y Rattus norvegicus 80-83 9187344-7 1997 These results show that there are at least two distinct populations of neuropeptide Y-producing neurons in the arcuate nucleus: a subset of neuropeptide Y and GABA-co-producing neurons located in the dorsomedial arcuate nucleus and a subset of non-GABAergic neuropeptide Y cells located in the ventral arcuate nucleus. gamma-Aminobutyric Acid 159-163 neuropeptide Y Rattus norvegicus 71-85 8492914-2 1993 All of the neuropeptide Y-immuno-reactive neurons were also GABA-immunoreactive, but they were either non-immunoreactive or weakly immunoreactive with the glycine antiserum. gamma-Aminobutyric Acid 60-64 neuropeptide Y Rattus norvegicus 11-25 7526265-5 1994 Neurons that possess GABA- but not glycine-immunoreactivity may contain neuropeptide Y, enkephalin, acetylcholine or NADPH diaphorase, and all of the cholinergic neurons appear to contain NADPH diaphorase. gamma-Aminobutyric Acid 21-25 neuropeptide Y Rattus norvegicus 72-86 2566924-10 1989 Increased NPY levels suggest "upregulation" of NPY/somatostatin/GABA neurons due to the decreased seizure threshold of the animals. gamma-Aminobutyric Acid 64-68 neuropeptide Y Rattus norvegicus 10-13 1360868-7 1992 The effect of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801, on striatal NPY-LI content resembled that of PCP and was also blocked by the two indirect GABA agonists. gamma-Aminobutyric Acid 181-185 neuropeptide Y Rattus norvegicus 103-106 2702468-12 1989 These results provide ultrastructural evidence that in the mNTS, NPY-LI is localized principally to large dense-vesicles within neurons whose output is partially regulated by GABA. gamma-Aminobutyric Acid 175-179 neuropeptide Y Rattus norvegicus 65-68 1596740-0 1992 Intracerebroventricular administration of neuropeptide Y affects parameters of dopamine, glutamate and GABA activities in the rat striatum. gamma-Aminobutyric Acid 103-107 neuropeptide Y Rattus norvegicus 42-56 1596740-8 1992 In parallel, the GABA uptake was found to decrease slightly at the higher doses of NPY tested, whereas no significant alteration of the striatal concentrations of either DA, DOPAC, Glu or GABA was observed. gamma-Aminobutyric Acid 17-21 neuropeptide Y Rattus norvegicus 83-86 1596740-9 1992 These results indicate that NPY may be involved in regulating the activity of nigral dopaminergic and cortical glutamatergic afferent pathways and that of intrinsic GABA neurons in the rat striatum. gamma-Aminobutyric Acid 165-169 neuropeptide Y Rattus norvegicus 28-31 12106285-0 1990 Striatal NPY-Containing Neurons Receive GABAergic Afferents and may also Contain GABA: An Electron Microscopic Study in the Rat. gamma-Aminobutyric Acid 40-44 neuropeptide Y Rattus norvegicus 9-12 12106285-8 1990 All in all, these data show that NPY aspiny type neurons of the rat CP receive GABAergic afferents and provide morphological support for two hypotheses: that NPY is co-localized with GABA in some cell bodies, dendrites and axons, and that presynaptic interactions may occur between NPY and GABAergic neuronal systems. gamma-Aminobutyric Acid 79-83 neuropeptide Y Rattus norvegicus 33-36 12106285-8 1990 All in all, these data show that NPY aspiny type neurons of the rat CP receive GABAergic afferents and provide morphological support for two hypotheses: that NPY is co-localized with GABA in some cell bodies, dendrites and axons, and that presynaptic interactions may occur between NPY and GABAergic neuronal systems. gamma-Aminobutyric Acid 79-83 neuropeptide Y Rattus norvegicus 158-161 12106285-8 1990 All in all, these data show that NPY aspiny type neurons of the rat CP receive GABAergic afferents and provide morphological support for two hypotheses: that NPY is co-localized with GABA in some cell bodies, dendrites and axons, and that presynaptic interactions may occur between NPY and GABAergic neuronal systems. gamma-Aminobutyric Acid 79-83 neuropeptide Y Rattus norvegicus 158-161 2687439-8 1989 NPY terminals lacking detectable GABA immunoreactivity also were found within the cortex, thus suggesting additional heterogeneity in cortical NPY innervation. gamma-Aminobutyric Acid 33-37 neuropeptide Y Rattus norvegicus 0-3 2687439-12 1989 In both regions, nearly all NPY- and NPY-GABA-labeled terminals formed symmetric junctions suggestive of inhibitory action. gamma-Aminobutyric Acid 41-45 neuropeptide Y Rattus norvegicus 37-40 2687439-15 1989 Thus, NPY may play a more prominent role in modulation of certain GABAergic neurons than would be predicted by the observed frequency of NPY-to-GABA contacts in the two regions. gamma-Aminobutyric Acid 66-70 neuropeptide Y Rattus norvegicus 6-9 33574739-12 2020 NPY may, through the GABA A receptor, significantly antagonize the overexpressed central CRF and attenuate the HPA axis activities in CCS conditions, exerting influences and helping to restore gastric motor function. gamma-Aminobutyric Acid 21-25 neuropeptide Y Rattus norvegicus 0-3 2848110-3 1988 NPY"s inhibitory action at the stratum radiatum-CA1 synapse was unaffected by high concentrations of the antagonists bicuculline, theophylline, or atropine, suggesting that it does not act by stimulating the release of the known presynaptic inhibitory transmitters GABA, adenosine, or ACh, respectively. gamma-Aminobutyric Acid 265-269 neuropeptide Y Rattus norvegicus 0-3 3367392-16 1988 We conclude (1) that in the rat nucleus accumbens, NPY-LI is found principally in neurons of the aspiny type and (2) that the output from these presumably intrinsic neurons to other neighboring neurons or blood vessels is at least partially modulated by GABA. gamma-Aminobutyric Acid 254-258 neuropeptide Y Rattus norvegicus 51-54 27847128-3 2017 Depending on the neuron in which they are expressed they mediate inhibition of release of NPY and of the neuron"s classical transmitter GABA, glutamate or noradrenaline, respectively. gamma-Aminobutyric Acid 136-140 neuropeptide Y Rattus norvegicus 90-93 32827566-1 2021 Neuropeptide Y (NPY) is highly abundant in the brain and is released as a co-transmitter with plasticity-related neurotransmitters such as glutamate, GABA and noradrenaline. gamma-Aminobutyric Acid 150-154 neuropeptide Y Rattus norvegicus 0-14 32827566-1 2021 Neuropeptide Y (NPY) is highly abundant in the brain and is released as a co-transmitter with plasticity-related neurotransmitters such as glutamate, GABA and noradrenaline. gamma-Aminobutyric Acid 150-154 neuropeptide Y Rattus norvegicus 16-19 32376539-11 2020 DBP-induced neurotoxicity is probably associated with GABA-mediated blockage of the ERbeta-BDNF-NPY signaling communication. gamma-Aminobutyric Acid 54-58 neuropeptide Y Rattus norvegicus 96-99