PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21075083-13 2011 Prenatal cocaine enhanced the CORT response to CRH/saline injections up to 60 min in males but not in females. Cocaine 9-16 corticotropin releasing hormone Homo sapiens 47-50 21843515-0 2012 Relevance of both type-1 and type-2 corticotropin releasing factor receptors in stress-induced relapse to cocaine seeking behaviour. Cocaine 106-113 corticotropin releasing hormone Homo sapiens 36-66 21306838-8 2011 Cocaine use in the 30 days following CRH administration was measured. Cocaine 0-7 corticotropin releasing hormone Homo sapiens 37-40 21306838-10 2011 Cocaine-dependent individuals also had a greater subjective stress response to CRH than controls (p<0.01). Cocaine 0-7 corticotropin releasing hormone Homo sapiens 79-82 21306838-12 2011 Finally, there was a trend for an indirect effect of neuroticism on frequency of cocaine use through subjective reactivity to CRH. Cocaine 81-88 corticotropin releasing hormone Homo sapiens 126-129 18184795-0 2008 Dopamine and corticotropin-releasing factor synergistically alter basolateral amygdala-to-medial prefrontal cortex synaptic transmission: functional switch after chronic cocaine administration. Cocaine 170-177 corticotropin releasing hormone Homo sapiens 13-43 19717245-4 2009 Cocaine-dependent participants received 1 microg/kg of corticotropin releasing hormone intravenously, underwent the Trier Social Stress Task, and were exposed to drug cues and various measures obtained. Cocaine 0-7 corticotropin releasing hormone Homo sapiens 55-86 19349312-0 2009 Response to corticotropin-releasing hormone infusion in cocaine-dependent individuals. Cocaine 56-63 corticotropin releasing hormone Homo sapiens 12-43 19349312-2 2009 Little is known about the response of cocaine-dependent individuals to CRH administration. Cocaine 38-45 corticotropin releasing hormone Homo sapiens 71-74 19349312-3 2009 OBJECTIVE: The primary objective was to examine the hypothalamic-pituitary-adrenal axis and the subjective and physiologic response to CRH in cocaine-dependent individuals and controls. Cocaine 142-149 corticotropin releasing hormone Homo sapiens 135-138 20570051-0 2010 Influence of cocaine dependence and early life stress on pituitary-adrenal axis responses to CRH and the Trier social stressor. Cocaine 13-20 corticotropin releasing hormone Homo sapiens 93-96 20570051-2 2010 In this study, the neuroendocrine, physiologic (HR), and subjective responses to corticotropin releasing hormone (CRH) and the Trier Social Stress Task (TSST) in individuals with cocaine dependence, with (n=21)/without early life stress (n=21), non-dependent individuals with early life stress (n=22), and a control group were examined (n=21). Cocaine 179-186 corticotropin releasing hormone Homo sapiens 114-117 20570051-10 2010 In response to CRH, subjective stress and craving were positively correlated in cocaine-dependent subjects regardless of early life stress history, while stress and craving following the TSST were correlated only in cocaine-dependent subjects without a history of early life stress. Cocaine 80-87 corticotropin releasing hormone Homo sapiens 15-18 19349312-10 2009 RESULTS: Cocaine-dependent individuals exhibited higher stress (P < .001) and craving for CRH compared with controls. Cocaine 9-16 corticotropin releasing hormone Homo sapiens 93-96 19349312-12 2009 Intravenous CRH elevated heart rates in all groups; however, cocaine-dependent women demonstrated a significantly higher heart rate at all time points (P = .05). Cocaine 61-68 corticotropin releasing hormone Homo sapiens 12-15 19349312-15 2009 The corticotropin response to CRH was independent of sex and cocaine dependence. Cocaine 61-68 corticotropin releasing hormone Homo sapiens 30-33 19349312-18 2009 The lack of difference in hypothalamic pituitary adrenal axis response between the cocaine-dependent and control groups suggests that the heart rate and subjective responses in the cocaine group may be mediated by sensitization of nonhypothalamic stress-responsive CRH systems. Cocaine 181-188 corticotropin releasing hormone Homo sapiens 265-268 16822557-0 2006 A role for corticotropin-releasing factor in the long-term expression of behavioral sensitization to cocaine. Cocaine 101-108 corticotropin releasing hormone Homo sapiens 11-41 17702903-10 2007 The results point to interactions between a subpopulation of kappa opioid receptors and central corticotropin-releasing factor and noradrenergic stress systems in the reinstatement of cocaine seeking induced by kappa agonists. Cocaine 184-191 corticotropin releasing hormone Homo sapiens 96-126 16822557-1 2006 Corticotropin-releasing factor (CRF) has been implicated in a number of the behavioral and biochemical effects of cocaine. Cocaine 114-121 corticotropin releasing hormone Homo sapiens 0-30 16987545-0 2006 A study of the lasting effects of cocaine pre-exposure on anxiety-like behaviors under baseline conditions and in response to central injections of corticotropin-releasing factor. Cocaine 34-41 corticotropin releasing hormone Homo sapiens 148-178 17004937-0 2006 Cocaine withdrawal enhances long-term potentiation induced by corticotropin-releasing factor at central amygdala glutamatergic synapses via CRF, NMDA receptors and PKA. Cocaine 0-7 corticotropin releasing hormone Homo sapiens 62-92 16987545-2 2006 The stress-related neuropeptide, corticotropin-releasing factor (CRF), has been implicated in the anxiogenic effects of cocaine withdrawal, as well as in some of the long-lasting effects of cocaine. Cocaine 120-127 corticotropin releasing hormone Homo sapiens 33-63 16987545-2 2006 The stress-related neuropeptide, corticotropin-releasing factor (CRF), has been implicated in the anxiogenic effects of cocaine withdrawal, as well as in some of the long-lasting effects of cocaine. Cocaine 190-197 corticotropin releasing hormone Homo sapiens 33-63 12782395-7 2003 Our findings of an increase in amygdalar CRH gene expression during early cocaine withdrawal support a potentially important role for amygdalar CRH activity in the anxiogenic and aversive consequences of withdrawal from cocaine during a time when humans are most subject to relapse. Cocaine 74-81 corticotropin releasing hormone Homo sapiens 41-44 15784652-0 2005 Acute and chronic corticotropin-releasing factor 1 receptor blockade inhibits cocaine-induced dopamine release: correlation with dopamine neuron activity. Cocaine 78-85 corticotropin releasing hormone Homo sapiens 18-48 16674926-1 2006 Apart from activation of the brain reward system, cocaine administration influences the activity of the hypothalamo-pituitary-adrenal (HPA) axis by affecting CRH neurons in the paraventricular nucleus of the hypothalamus (PVN). Cocaine 50-57 corticotropin releasing hormone Homo sapiens 158-161 12023504-6 2002 Corticotropin-releasing hormone (CRH) seems to play a more prominent role in the maintenance of cocaine self-administration and may even be involved in the incentive motivation for the drug. Cocaine 96-103 corticotropin releasing hormone Homo sapiens 0-31 12686370-0 2003 CSF CRH in abstinent cocaine-dependent patients. Cocaine 21-28 corticotropin releasing hormone Homo sapiens 4-7 12023504-6 2002 Corticotropin-releasing hormone (CRH) seems to play a more prominent role in the maintenance of cocaine self-administration and may even be involved in the incentive motivation for the drug. Cocaine 96-103 corticotropin releasing hormone Homo sapiens 33-36 12023504-7 2002 Corticosterone and CRH are also critical for the stress- and cue-induced reinstatement of extinguished cocaine-seeking behavior. Cocaine 103-110 corticotropin releasing hormone Homo sapiens 19-22 12204195-4 2002 Current therapeutic strategies focus on counteracting the cocaine effects directly on the dopamine transporter, through post-synaptic D(1), D(2) or D(3) receptors or through the glutamatergic, serotoninergic, opioid or corticotropin-releasing hormone systems. Cocaine 58-65 corticotropin releasing hormone Homo sapiens 219-250 33660857-5 2021 Stressors trigger cocaine seeking by activating noradrenergic projections originating in the lateral tegmentum that innervate the bed nucleus of the stria terminalis to produce beta adrenergic receptor-dependent regulation of neurons that release corticotropin releasing factor (CRF) into the ventral tegmental area (VTA). Cocaine 18-25 corticotropin releasing hormone Homo sapiens 247-277 1547754-2 1992 Cocaine and lidocaine release corticotropin-releasing hormone (CRH) in hypothalamic cell cultures, and this effect is also blocked by CBZ. Cocaine 0-7 corticotropin releasing hormone Homo sapiens 63-66 1547754-5 1992 CRH (at doses of 5, 10, and 100 micrograms) potentiated cocaine-kindled seizure development and lethality in a dose-related fashion. Cocaine 56-63 corticotropin releasing hormone Homo sapiens 0-3 1547754-8 1992 The findings suggest a potentially important role for CRH in exacerbating cocaine-seizure evolution and its associated lethality and confirm the inhibition of cocaine kindling and lethality by CBZ. Cocaine 74-81 corticotropin releasing hormone Homo sapiens 54-57 11750768-9 2002 On the other hand, the self-administration of doses falling on both the ascending and descending limbs of the cocaine dose-response curve can each be attenuated by drugs that block central corticotropin-releasing hormone (CRH) receptors. Cocaine 110-117 corticotropin releasing hormone Homo sapiens 189-220 11750768-9 2002 On the other hand, the self-administration of doses falling on both the ascending and descending limbs of the cocaine dose-response curve can each be attenuated by drugs that block central corticotropin-releasing hormone (CRH) receptors. Cocaine 110-117 corticotropin releasing hormone Homo sapiens 222-225 11750768-10 2002 Finally, corticosterone and CRH are also critical for the stress- and cue-induced reinstatement of extinguished cocaine-seeking behavior, demonstrating an involvement of the HPA axis in the relapse to cocaine use as well. Cocaine 112-119 corticotropin releasing hormone Homo sapiens 28-31 7932162-12 1994 We postulate that cocaine stimulates the release of corticotropin releasing factor and that the cocaine-induced secretion of corticotropin releasing factor increases the amplitude of ACTH pulses, because ACTH pulse frequency was not altered by cocaine. Cocaine 18-25 corticotropin releasing hormone Homo sapiens 52-82 1336674-2 1992 Cocaine has been shown to alter circulating levels of the neurotransmitters, dopamine, norepinephrine, epinephrine, as well as the hypothalamic-pituitary-adrenal axis hormones corticotropin-releasing factor (CRF), adrenocorticotropic hormone (ACTH), and cortisol. Cocaine 0-7 corticotropin releasing hormone Homo sapiens 176-206 27870396-3 2017 Preclinical models have demonstrated increased sensitivity of females to CRF and noradrenergic-induced drug reinstatement compared with males, and, consistent with these findings, human laboratory studies have demonstrated greater sensitivity to corticotropin-releasing hormone (CRH) and noradrenergic stimulation in cocaine-dependent women compared with men. Cocaine 317-324 corticotropin releasing hormone Homo sapiens 246-277 29949237-7 2018 Larry also applied microdialysis to study GABA and glutamate"s role in ethanol dependence and heroin reinforcement, providing in vivo evidence for a sensitization of corticotropin-releasing factor-dependent release of GABA in the central amygdala in withdrawal from chronic ethanol and for a reduction of GABA transmission in the ventral pallidum in heroin but not cocaine intravenous self-administration. Cocaine 365-372 corticotropin releasing hormone Homo sapiens 166-196