PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22649236-0 2012 Serum response factor and cAMP response element binding protein are both required for cocaine induction of DeltaFosB. Cocaine 86-93 cAMP responsive element binding protein 1 Mus musculus 26-63 31704270-9 2020 Baseline p-p38/p38 MAPK and p-CREB/CREB ratios were downregulated in repeated cocaine-treated mice. Cocaine 78-85 cAMP responsive element binding protein 1 Mus musculus 30-34 31704270-9 2020 Baseline p-p38/p38 MAPK and p-CREB/CREB ratios were downregulated in repeated cocaine-treated mice. Cocaine 78-85 cAMP responsive element binding protein 1 Mus musculus 35-39 25319707-6 2014 Ablating or silencing neurons overexpressing CREB (but not a similar number of random LA neurons) before testing disrupted the expression of a previously acquired cocaine memory, suggesting that neurons overexpressing CREB become a critical hub in what is likely a larger cocaine memory engram. Cocaine 163-170 cAMP responsive element binding protein 1 Mus musculus 45-49 25319707-6 2014 Ablating or silencing neurons overexpressing CREB (but not a similar number of random LA neurons) before testing disrupted the expression of a previously acquired cocaine memory, suggesting that neurons overexpressing CREB become a critical hub in what is likely a larger cocaine memory engram. Cocaine 163-170 cAMP responsive element binding protein 1 Mus musculus 218-222 25319707-6 2014 Ablating or silencing neurons overexpressing CREB (but not a similar number of random LA neurons) before testing disrupted the expression of a previously acquired cocaine memory, suggesting that neurons overexpressing CREB become a critical hub in what is likely a larger cocaine memory engram. Cocaine 272-279 cAMP responsive element binding protein 1 Mus musculus 45-49 25319707-6 2014 Ablating or silencing neurons overexpressing CREB (but not a similar number of random LA neurons) before testing disrupted the expression of a previously acquired cocaine memory, suggesting that neurons overexpressing CREB become a critical hub in what is likely a larger cocaine memory engram. Cocaine 272-279 cAMP responsive element binding protein 1 Mus musculus 218-222 24966820-0 2014 CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects. Cocaine 67-74 cAMP responsive element binding protein 1 Mus musculus 0-4 24966820-2 2014 To test the cell-specificity of this hypothesis we examined the effects of a dominant-negative CREB protein variant expressed in dopamine receptor D1 (D1R) neurons on cocaine-induced behaviors. Cocaine 167-174 cAMP responsive element binding protein 1 Mus musculus 95-99 31704270-8 2020 Whereas acute cocaine-treated mice showed transient increases in p-ERK1/2/ERK1/2 and p-p65/p65 NFkappaB ratios after cocaine injection, repeated cocaine-treated mice showed transient increases in p-ERK1/2/ERK1/2, p-p38/p38 MAPK, p-NFkappaB p65/NF-kappaB p65 and p-CREB/CREB ratios. Cocaine 14-21 cAMP responsive element binding protein 1 Mus musculus 264-268 31704270-8 2020 Whereas acute cocaine-treated mice showed transient increases in p-ERK1/2/ERK1/2 and p-p65/p65 NFkappaB ratios after cocaine injection, repeated cocaine-treated mice showed transient increases in p-ERK1/2/ERK1/2, p-p38/p38 MAPK, p-NFkappaB p65/NF-kappaB p65 and p-CREB/CREB ratios. Cocaine 14-21 cAMP responsive element binding protein 1 Mus musculus 269-273 27734601-7 2017 Similarly, NGB2904 and SCH23390 showed opposite/differential effects on cocaine-induced structural plasticity, conditioned place preference and locomotor activity and signaling activation, including the activation of ERK, CREB and NR1 and the expression of c-fos and Cdk5. Cocaine 72-79 cAMP responsive element binding protein 1 Mus musculus 222-226 24205196-0 2013 Enhancement of behavioral sensitization, anxiety-like behavior, and hippocampal and frontal cortical CREB levels following cocaine abstinence in mice exposed to cocaine during adolescence. Cocaine 123-130 cAMP responsive element binding protein 1 Mus musculus 101-105 24205196-0 2013 Enhancement of behavioral sensitization, anxiety-like behavior, and hippocampal and frontal cortical CREB levels following cocaine abstinence in mice exposed to cocaine during adolescence. Cocaine 161-168 cAMP responsive element binding protein 1 Mus musculus 101-105 24205196-2 2013 Decreases in cyclic adenosine monophosphate response element binding protein (CREB) and phosphorylated CREB (pCREB) have been reported after repeated cocaine administration in animal models. Cocaine 150-157 cAMP responsive element binding protein 1 Mus musculus 78-82 24205196-2 2013 Decreases in cyclic adenosine monophosphate response element binding protein (CREB) and phosphorylated CREB (pCREB) have been reported after repeated cocaine administration in animal models. Cocaine 150-157 cAMP responsive element binding protein 1 Mus musculus 103-107 24205196-11 2013 Significant increases in CREB levels in the PFC and hippocampus and pCREB in the hippocampus were observed in cocaine-abstinent animals compared with the animals treated with cocaine in adulthood. Cocaine 110-117 cAMP responsive element binding protein 1 Mus musculus 25-29 24205196-11 2013 Significant increases in CREB levels in the PFC and hippocampus and pCREB in the hippocampus were observed in cocaine-abstinent animals compared with the animals treated with cocaine in adulthood. Cocaine 175-182 cAMP responsive element binding protein 1 Mus musculus 25-29 24205196-12 2013 Interestingly, significant negative correlations were observed between cocaine sensitization and CREB levels in both regions. Cocaine 71-78 cAMP responsive element binding protein 1 Mus musculus 97-101 23458740-2 2013 Cyclic AMP response element binding protein (CREB) is required for swim stress-induced reinstatement of cocaine conditioned place preference. Cocaine 104-111 cAMP responsive element binding protein 1 Mus musculus 0-43 23458740-2 2013 Cyclic AMP response element binding protein (CREB) is required for swim stress-induced reinstatement of cocaine conditioned place preference. Cocaine 104-111 cAMP responsive element binding protein 1 Mus musculus 45-49 23318871-4 2013 Phosphorylation of cAMP response element-binding protein (CREB) is also significantly increased in hypocretin neurons in cocaine-treated animals, suggesting that CREB-mediated pathways may contribute to synaptic potentiation in these cells. Cocaine 121-128 cAMP responsive element binding protein 1 Mus musculus 19-56 23318871-4 2013 Phosphorylation of cAMP response element-binding protein (CREB) is also significantly increased in hypocretin neurons in cocaine-treated animals, suggesting that CREB-mediated pathways may contribute to synaptic potentiation in these cells. Cocaine 121-128 cAMP responsive element binding protein 1 Mus musculus 58-62 23318871-4 2013 Phosphorylation of cAMP response element-binding protein (CREB) is also significantly increased in hypocretin neurons in cocaine-treated animals, suggesting that CREB-mediated pathways may contribute to synaptic potentiation in these cells. Cocaine 121-128 cAMP responsive element binding protein 1 Mus musculus 162-166 22649236-3 2012 CREB and SRF are both activated in NAc by cocaine and bind to the fosB gene promoter. Cocaine 42-49 cAMP responsive element binding protein 1 Mus musculus 0-4 22649236-5 2012 Furthermore, deletion of both SRF and CREB from NAc renders animals less sensitive to the rewarding effects of moderate doses of cocaine when tested in the conditioned place preference (CPP) procedure and also blocks locomotor sensitization to higher doses of cocaine. Cocaine 129-136 cAMP responsive element binding protein 1 Mus musculus 38-42 22649236-5 2012 Furthermore, deletion of both SRF and CREB from NAc renders animals less sensitive to the rewarding effects of moderate doses of cocaine when tested in the conditioned place preference (CPP) procedure and also blocks locomotor sensitization to higher doses of cocaine. Cocaine 260-267 cAMP responsive element binding protein 1 Mus musculus 38-42 22649236-6 2012 Deletion of CREB alone has the opposite effect and enhances both cocaine CPP and locomotor sensitization. Cocaine 65-72 cAMP responsive element binding protein 1 Mus musculus 12-16 22649236-9 2012 Our results also establish a complex mode of regulation of DeltaFosB induction in response to cocaine, which requires the concerted activities of both SRF and CREB. Cocaine 94-101 cAMP responsive element binding protein 1 Mus musculus 159-163 19447090-3 2009 Our findings reveal several interesting principles of gene regulation by cocaine and of the role of DeltaFosB and CREB, two prominent cocaine-induced transcription factors, in this brain region. Cocaine 134-141 cAMP responsive element binding protein 1 Mus musculus 114-118 22162970-10 2011 In sharp contrast to the observations in the Str, in the NAc, acute administration of cocaine or D1 agonist significantly increased P-CREB and P-ERK2 in PSAL mice, a response that was not evident in PCOC mice. Cocaine 86-93 cAMP responsive element binding protein 1 Mus musculus 134-138 21159975-4 2010 In contrast, in amphetamine- and cocaine-preexposed mice, an amphetamine or cocaine challenge no longer activates CREB unless Ca(v)1.2 LTCCs are blocked. Cocaine 33-40 cAMP responsive element binding protein 1 Mus musculus 114-118 21159975-4 2010 In contrast, in amphetamine- and cocaine-preexposed mice, an amphetamine or cocaine challenge no longer activates CREB unless Ca(v)1.2 LTCCs are blocked. Cocaine 76-83 cAMP responsive element binding protein 1 Mus musculus 114-118 19675537-2 2009 Previously, we have shown that a single exposure to forced swim (FS) reinstates extinguished conditioned place preference (CPP) to cocaine and that cAMP response element binding protein (CREB) is necessary for this response. Cocaine 131-138 cAMP responsive element binding protein 1 Mus musculus 187-191 19675537-4 2009 The present experiments investigate whether changes in cocaine reward elicited by previous exposure to stress are mediated by CREB and/or CRF(R1). Cocaine 55-62 cAMP responsive element binding protein 1 Mus musculus 126-130 22197517-9 2012 Repeated cocaine reduced GluR1, GluR2 and CREB expression in the NAc, and reductions of GluR1 and GluR2 but not CREB were further enhanced by ICSS. Cocaine 9-16 cAMP responsive element binding protein 1 Mus musculus 42-46 19826621-4 2009 Here we show, in startling contrast, that inhibition of striatal CREB facilitates cocaine- and morphine-place conditioning and enhances locomotor sensitization to cocaine. Cocaine 82-89 cAMP responsive element binding protein 1 Mus musculus 65-69 19826621-4 2009 Here we show, in startling contrast, that inhibition of striatal CREB facilitates cocaine- and morphine-place conditioning and enhances locomotor sensitization to cocaine. Cocaine 163-170 cAMP responsive element binding protein 1 Mus musculus 65-69 19212318-3 2009 Previous studies have implicated nucleus accumbens (NAc) CREB activity in the modulation of cocaine and morphine reward, and have shown that nicotine conditioned place preference (CPP) is associated with NAc CREB activation. Cocaine 92-99 cAMP responsive element binding protein 1 Mus musculus 57-61 19228458-5 2009 RESULTS: Acute cocaine injection significantly enhanced expressions of c-Fos, p-CREB and p-Elk-1 in the striatum. Cocaine 15-22 cAMP responsive element binding protein 1 Mus musculus 80-84 19244515-10 2009 Our results demonstrate that the Ca(2+)-stimulated adenylyl cyclases regulate long-lasting cocaine-induced behavioral plasticity via activation of the ERK/MSK1/CREB signaling pathway in striatonigral MSNs. Cocaine 91-98 cAMP responsive element binding protein 1 Mus musculus 160-164 19211892-6 2009 However, mCREB-expressing mice were more sensitive to the rewarding (threshold-lowering) effects of cocaine. Cocaine 100-107 cAMP responsive element binding protein 1 Mus musculus 9-14 19181855-4 2009 Compared with WT mice, tPA-/- mice injected with cocaine displayed attenuated phosphorylation of ERK, cAMP response element binding protein (CREB), and dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and blunted induction of immediate early genes (IEGs) c-Fos, Egr-1, and Homer 1a in the amygdala and the nucleus accumbens (NAc). Cocaine 49-56 cAMP responsive element binding protein 1 Mus musculus 102-139 19181855-4 2009 Compared with WT mice, tPA-/- mice injected with cocaine displayed attenuated phosphorylation of ERK, cAMP response element binding protein (CREB), and dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and blunted induction of immediate early genes (IEGs) c-Fos, Egr-1, and Homer 1a in the amygdala and the nucleus accumbens (NAc). Cocaine 49-56 cAMP responsive element binding protein 1 Mus musculus 141-145 19228458-8 2009 Blockade of this dopamine D1 receptor-dependent ERK1/2 activation by SL 327 could reduce cocaine-enhanced expressions of c-Fos, p-CREB and p-Elk-1 in the striatum. Cocaine 89-96 cAMP responsive element binding protein 1 Mus musculus 130-134 16339038-4 2005 Cocaine-induced phosphorylation of MSK1 threonine 581 and cAMP response element-binding protein (CREB) serine 133 (Ser133) were blocked by SL327, a drug that prevents ERK activation. Cocaine 0-7 cAMP responsive element binding protein 1 Mus musculus 58-95 18554320-0 2008 Enhanced CREB and DARPP-32 phosphorylation in the nucleus accumbens and CREB, ERK, and GluR1 phosphorylation in the dorsal hippocampus is associated with cocaine-conditioned place preference behavior. Cocaine 154-161 cAMP responsive element binding protein 1 Mus musculus 9-13 18554320-0 2008 Enhanced CREB and DARPP-32 phosphorylation in the nucleus accumbens and CREB, ERK, and GluR1 phosphorylation in the dorsal hippocampus is associated with cocaine-conditioned place preference behavior. Cocaine 154-161 cAMP responsive element binding protein 1 Mus musculus 72-76 18554320-4 2008 Our studies revealed that re-exposing mice to an environment in which they were previously given cocaine resulted in increased levels of Ser133 phospho-CREB and Thr34 phospho-DARPP-32 with a corresponding decrease in Thr75 phospho-DARPP-32 in the NAc. Cocaine 97-104 cAMP responsive element binding protein 1 Mus musculus 152-156 16905344-10 2007 We further found that intraaccumbal CREB antisense oligodeoxynucleotide infusion diminished cocaine-induced CPP, whereas did not affect the methamphetamine-induced CPP. Cocaine 92-99 cAMP responsive element binding protein 1 Mus musculus 36-40 16905344-11 2007 Taken together, these data suggest that protein synthesis and accumbal CREB phosphorylation are essential for the learning and consolidation of the cocaine-induced CPP, whereas methamphetamine-induced CPP may be unrelated to the synthesis of new proteins. Cocaine 148-155 cAMP responsive element binding protein 1 Mus musculus 71-75 16380431-3 2005 Here, we show that histone acetylation by the cAMP-response element binding protein (CREB)-binding protein (CBP) mediates sensitivity to cocaine by regulating expression of the fosB gene and its splice variant, DeltafosB, a transcription factor previously implicated in addiction. Cocaine 137-144 cAMP responsive element binding protein 1 Mus musculus 46-83 16380431-3 2005 Here, we show that histone acetylation by the cAMP-response element binding protein (CREB)-binding protein (CBP) mediates sensitivity to cocaine by regulating expression of the fosB gene and its splice variant, DeltafosB, a transcription factor previously implicated in addiction. Cocaine 137-144 cAMP responsive element binding protein 1 Mus musculus 85-89 16339038-4 2005 Cocaine-induced phosphorylation of MSK1 threonine 581 and cAMP response element-binding protein (CREB) serine 133 (Ser133) were blocked by SL327, a drug that prevents ERK activation. Cocaine 0-7 cAMP responsive element binding protein 1 Mus musculus 97-101 16339038-6 2005 In MSK1 knock-out (KO) mice CREB and H3 phosphorylation in response to cocaine (10 mg/kg) were blocked, and induction of c-Fos and dynorphin was prevented, whereas the induction of Egr-1 (early growth response-1)/zif268/Krox24 was unaltered. Cocaine 71-78 cAMP responsive element binding protein 1 Mus musculus 28-32 16046859-0 2005 Augmented constitutive CREB expression in the nucleus accumbens and striatum may contribute to the altered behavioral response to cocaine of adult mice exposed to cocaine in utero. Cocaine 130-137 cAMP responsive element binding protein 1 Mus musculus 23-27 16197514-0 2005 Deletion of dopamine D1 and D3 receptors differentially affects spontaneous behaviour and cocaine-induced locomotor activity, reward and CREB phosphorylation. Cocaine 90-97 cAMP responsive element binding protein 1 Mus musculus 137-141 16046859-0 2005 Augmented constitutive CREB expression in the nucleus accumbens and striatum may contribute to the altered behavioral response to cocaine of adult mice exposed to cocaine in utero. Cocaine 163-170 cAMP responsive element binding protein 1 Mus musculus 23-27 16046859-9 2005 Such alterations in constitutive CREB levels may contribute to some of the behavioral differences reported in adult mice exposed to cocaine in utero. Cocaine 132-139 cAMP responsive element binding protein 1 Mus musculus 33-37 11717377-11 2001 In contrast, CREB mutant mice demonstrate an enhanced response to the reinforcing properties of cocaine compared with their wild-type controls in both conditioned place preference and sensitization behaviors. Cocaine 96-103 cAMP responsive element binding protein 1 Mus musculus 13-17 14622103-6 2003 Phospho-CREB levels are increased in the NAc of both wild-type and CREBalphaDelta mutant animals after cocaine. Cocaine 103-110 cAMP responsive element binding protein 1 Mus musculus 8-12 14566342-5 2003 Gene expression induced by short-term DeltaFosB and by CREB was strikingly similar, and both reduced the rewarding effects of cocaine, whereas prolonged DeltaFosB expression increased drug reward. Cocaine 126-133 cAMP responsive element binding protein 1 Mus musculus 55-59 12021407-6 2002 Finally, there was a significant reduction in cocaine-induced locomotor activity in the CREB bitransgenic mice. Cocaine 46-53 cAMP responsive element binding protein 1 Mus musculus 88-92 12165570-2 2002 Drugs of abuse activate CREB in the nucleus accumbens, an important part of the brain"s reward pathways, and local manipulations of CREB activity have been shown to affect cocaine reward, suggesting an active role of CREB in adaptive processes that follow exposure to drugs of abuse. Cocaine 172-179 cAMP responsive element binding protein 1 Mus musculus 132-136 12165570-2 2002 Drugs of abuse activate CREB in the nucleus accumbens, an important part of the brain"s reward pathways, and local manipulations of CREB activity have been shown to affect cocaine reward, suggesting an active role of CREB in adaptive processes that follow exposure to drugs of abuse. Cocaine 172-179 cAMP responsive element binding protein 1 Mus musculus 132-136 11549750-3 2001 Rats treated with HSV-mCREB in place conditioning studies spent more time in environments associated with cocaine, indicating increased cocaine reward. Cocaine 106-113 cAMP responsive element binding protein 1 Mus musculus 22-27 33268547-8 2021 This study reveals a new cAMP-dependent signaling pathway for cocaine-induced behavioral adaptations, mediated through NCS-Rapgef2/phospho-ERK activation, independently of PKA/CREB signaling.SIGNIFICANCE STATEMENT:ERK phosphorylation in dopamine D1 receptor expressing neurons exerts a pivotal role in psychostimulant-induced neuronal gene regulation and behavioral adaptation, including locomotor sensitization and drug preference in rodents. Cocaine 62-69 cAMP responsive element binding protein 1 Mus musculus 176-180 8595201-0 1995 Cocaine-induced CREB phosphorylation and c-Fos expression are suppressed in Parkinsonism model mice. Cocaine 0-7 cAMP responsive element binding protein 1 Mus musculus 16-20