PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25435874-5 2014 Human umbilical vein endothelial cells (HUVEC) were treated with XYL (60 muM), COC (160 muM), 6-MAM (160 muM), camptothecin (positive control, 50 muM), XYL/COC (50 muM), XYL/6-MAM (50 muM), and XYL/COC/6-MAM (40 muM) for a period of 24 hours. Cocaine 79-82 latexin Homo sapiens 88-91 25435874-5 2014 Human umbilical vein endothelial cells (HUVEC) were treated with XYL (60 muM), COC (160 muM), 6-MAM (160 muM), camptothecin (positive control, 50 muM), XYL/COC (50 muM), XYL/6-MAM (50 muM), and XYL/COC/6-MAM (40 muM) for a period of 24 hours. Cocaine 79-82 latexin Homo sapiens 88-91 25435874-5 2014 Human umbilical vein endothelial cells (HUVEC) were treated with XYL (60 muM), COC (160 muM), 6-MAM (160 muM), camptothecin (positive control, 50 muM), XYL/COC (50 muM), XYL/6-MAM (50 muM), and XYL/COC/6-MAM (40 muM) for a period of 24 hours. Cocaine 79-82 latexin Homo sapiens 88-91 25435874-5 2014 Human umbilical vein endothelial cells (HUVEC) were treated with XYL (60 muM), COC (160 muM), 6-MAM (160 muM), camptothecin (positive control, 50 muM), XYL/COC (50 muM), XYL/6-MAM (50 muM), and XYL/COC/6-MAM (40 muM) for a period of 24 hours. Cocaine 79-82 latexin Homo sapiens 88-91 25435874-5 2014 Human umbilical vein endothelial cells (HUVEC) were treated with XYL (60 muM), COC (160 muM), 6-MAM (160 muM), camptothecin (positive control, 50 muM), XYL/COC (50 muM), XYL/6-MAM (50 muM), and XYL/COC/6-MAM (40 muM) for a period of 24 hours. Cocaine 79-82 latexin Homo sapiens 88-91 25435874-5 2014 Human umbilical vein endothelial cells (HUVEC) were treated with XYL (60 muM), COC (160 muM), 6-MAM (160 muM), camptothecin (positive control, 50 muM), XYL/COC (50 muM), XYL/6-MAM (50 muM), and XYL/COC/6-MAM (40 muM) for a period of 24 hours. Cocaine 79-82 latexin Homo sapiens 88-91 23942575-5 2013 The limit of detection was 0.1 muM for cocaine in purified water, and well defined results were also obtained in biological fluids and the specificity experiment, which expands the feasibility of the as-prepared sensor for practical applications. Cocaine 39-46 latexin Homo sapiens 31-34 21802935-6 2011 As a result, DNA-Ag NCs are demonstrated as a novel, cost-effective and turn-on fluorescent probe for the analysis of cocaine, with a detection limit of 0.1 muM. Cocaine 118-125 latexin Homo sapiens 157-160 22710029-7 2012 Also, individuals with lower levels of persistence on the TCI reported more days of cocaine use over the previous month. Cocaine 84-91 latexin Homo sapiens 58-61 23998357-7 2013 The aptasensor realized the quantification of cocaine ranging from 1 to 500 muM with high specificity. Cocaine 46-53 latexin Homo sapiens 76-79 23081856-6 2012 The detection limits for the sensing of Cu(2+) ions, Hg(2+) ions, and cocaine correspond to 1 nM, 10 nM and 2.5 muM, respectively. Cocaine 70-77 latexin Homo sapiens 112-115 22877698-4 2012 However, when applied over the same concentration range, harmine significantly inhibited C-shapes elicited by cocaine, with a concentration of 0.1 muM producing almost 90% inhibition. Cocaine 110-117 latexin Homo sapiens 147-150 21875108-5 2011 However, as the cocaine concentration was increased beyond 100 muM, the surface stress values demonstrated a weaker dependence on the affinity complex surface coverage. Cocaine 16-23 latexin Homo sapiens 63-66 21875108-6 2011 On the basis of a sensitivity of 3 mN/m for the surface stress measurement, the lowest detectable threshold for the cocaine concentration is estimated to be 5 muM. Cocaine 116-123 latexin Homo sapiens 159-162 12175205-1 2002 Complex of an anti-cocaine aptamer and the dye diethylthiotricarbocyanine behaves as a colorimetric sensor with attenuation in absorbance at 760 nm for cocaine in the concentration range of 2-600 muM. Cocaine 19-26 latexin Homo sapiens 196-199 21612269-11 2011 Successful detection of cocaine with detection limit of 0.1 muM demonstrates its potential to be a general method. Cocaine 24-31 latexin Homo sapiens 60-63 18696374-6 2008 Cocaine users with low Self-Directedness, low Cooperativeness, and high Self-Transcendence scores in the TCI-R, with high severity of substance use and psychiatric comorbidity, would be suggestive of a possible specific phenotype. Cocaine 0-7 latexin Homo sapiens 105-108 18813882-5 2008 Acute exposure to cocaine (1 and 3 muM) significantly increased ET-1 production (2-fold) and ET-1 receptor type-A (ET(A)R) protein expression, within 6-12 h. Cocaine exposure for a longer duration (24-72 h) showed a temporal decrease in both NO production and endothelial NO-synthase (eNOS) expression. Cocaine 18-25 latexin Homo sapiens 35-38 18813882-5 2008 Acute exposure to cocaine (1 and 3 muM) significantly increased ET-1 production (2-fold) and ET-1 receptor type-A (ET(A)R) protein expression, within 6-12 h. Cocaine exposure for a longer duration (24-72 h) showed a temporal decrease in both NO production and endothelial NO-synthase (eNOS) expression. Cocaine 158-165 latexin Homo sapiens 35-38 18813882-6 2008 The cocaine-mediated suppression of NO was ameliorated by co-treatment of cells with the ET(A)R blocker, BQ-123 (5 muM). Cocaine 4-11 latexin Homo sapiens 115-118 18666292-5 2008 Under optimized assay conditions, one can determine cocaine at a concentration of 1 muM, which compares favorably with analogous aptameric sensors based on electrochemical and fluorescence techniques. Cocaine 52-59 latexin Homo sapiens 84-87 12175205-1 2002 Complex of an anti-cocaine aptamer and the dye diethylthiotricarbocyanine behaves as a colorimetric sensor with attenuation in absorbance at 760 nm for cocaine in the concentration range of 2-600 muM. Cocaine 152-159 latexin Homo sapiens 196-199 1148495-6 1975 The atrial stimulation produced by burimamide was reduced by (-)propranolol (34-68 nM) and by cocaine (3 muM). Cocaine 94-101 latexin Homo sapiens 105-108 31655900-8 2019 The assay works in the 1 nM to 10 muM cocaine concentration range and is specific. Cocaine 38-45 latexin Homo sapiens 34-37 31526813-8 2019 All amphetamine-type stimulants and alpha-PVP decreased the beat rate at 300 muM, while cocaine and MDPV did so at 10 muM and 30 muM, respectively. Cocaine 88-95 latexin Homo sapiens 118-121 31526813-8 2019 All amphetamine-type stimulants and alpha-PVP decreased the beat rate at 300 muM, while cocaine and MDPV did so at 10 muM and 30 muM, respectively. Cocaine 88-95 latexin Homo sapiens 118-121 31250860-5 2019 Under optimized conditions, the oxidation peak current varied linearly with cocaine concentration in the range of 100-500 muM, with a detection limit of 50 muM (RSD 0.71%, n = 3). Cocaine 76-83 latexin Homo sapiens 122-125 31250860-5 2019 Under optimized conditions, the oxidation peak current varied linearly with cocaine concentration in the range of 100-500 muM, with a detection limit of 50 muM (RSD 0.71%, n = 3). Cocaine 76-83 latexin Homo sapiens 156-159 25496724-7 2015 Cocaine (1 muM) produced EPC that was abolished when S-MEPH (100 muM) was administered after cocaine conditioning. Cocaine 0-7 latexin Homo sapiens 11-14 29572046-6 2018 Of the "classic" drugs, cocaine most potently inhibited the wMFR (IC50 9.8 muM), whereas methamphetamine and the structurally-related NPS PMMA were much less potent (IC50 100 muM and IC50 112 muM, respectively). Cocaine 24-31 latexin Homo sapiens 75-78 31050407-6 2019 In an initial demonstration, we generate a cocaine-binding CBSAzyme that enables naked-eye detection of cocaine at concentrations as low as 10 muM. Cocaine 43-50 latexin Homo sapiens 143-146 31050407-6 2019 In an initial demonstration, we generate a cocaine-binding CBSAzyme that enables naked-eye detection of cocaine at concentrations as low as 10 muM. Cocaine 104-111 latexin Homo sapiens 143-146 25496724-7 2015 Cocaine (1 muM) produced EPC that was abolished when S-MEPH (100 muM) was administered after cocaine conditioning. Cocaine 0-7 latexin Homo sapiens 65-68 25496724-8 2015 Spontaneous withdrawal from chronic cocaine exposure caused a reduction in motility that was not evident during acute or continuous cocaine treatment but was attenuated by S-MEPH (100 muM) treatment during the cocaine abstinence interval. Cocaine 36-43 latexin Homo sapiens 184-187 25212751-8 2014 Cocaine (0.001-1 muM) produced an inverted U-shaped concentration-effect curve, with a significant environmental shift observed at 0.01 muM. Cocaine 0-7 latexin Homo sapiens 17-20 25467461-5 2015 In an optimized condition the calibration curve for cocaine concentration was linear up to 11 muM with detection limit (signal-to-noise ratio of 3) of 100 pM. Cocaine 52-59 latexin Homo sapiens 94-97 24996625-3 2015 The release of extracellular vesicles (mainly exosomes) into the medium was stimulated by cocaine at each concentration used with a maximum effect at the highest concentration tested (150 muM). Cocaine 90-97 latexin Homo sapiens 188-191 24996625-4 2015 Moreover, cocaine (150 nM) significantly increased the number of vesicles with 61-80 nm diameter while at concentrations of 300 nM and 150 muM, and the smaller vesicles (30-40 nm diameter) were significantly increased with a reduction of the larger vesicles (41-60 nm diameter). Cocaine 10-17 latexin Homo sapiens 139-142 25017475-5 2014 Results indicated IC50 values at 24h as follow: xylazine 62 muM, cocaine 210 muM, 6-monoacetylmorphine 300 muM. Cocaine 65-72 latexin Homo sapiens 77-80 25017475-5 2014 Results indicated IC50 values at 24h as follow: xylazine 62 muM, cocaine 210 muM, 6-monoacetylmorphine 300 muM. Cocaine 65-72 latexin Homo sapiens 77-80 25212751-8 2014 Cocaine (0.001-1 muM) produced an inverted U-shaped concentration-effect curve, with a significant environmental shift observed at 0.01 muM. Cocaine 0-7 latexin Homo sapiens 136-139 25212751-10 2014 For each concentration of cocaine, the environmental shift was enhanced by ethanol, with significance detected at 1 muM. Cocaine 26-33 latexin Homo sapiens 116-119 23962705-4 2014 The Faradaic impedance responses were linearly related to cocaine concentration between 1.0 nM and 2.0 muM with a correlation coefficient of 0.993. Cocaine 58-65 latexin Homo sapiens 103-106