PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29754307-0 2018 Effects of Cocaine Self-Administration and Its Extinction on the Rat Brain Cannabinoid CB1 and CB2 Receptors. Cocaine 11-18 cannabinoid receptor 1 Rattus norvegicus 87-90 12832001-5 2003 Treatment with SR141716A, a specific antagonist of the cannabinoid (CB1) receptor, resulted in a complete reversal of cocaine-induced antinociception when administered at a dose of 5.0mg/kg. Cocaine 118-125 cannabinoid receptor 1 Rattus norvegicus 68-71 12832001-7 2003 These findings suggest that activation of the CB1 receptor participates significantly in antinociception resulting from treatment with cocaine and with the NMDA receptor antagonist, MK-801. Cocaine 135-142 cannabinoid receptor 1 Rattus norvegicus 46-49 34930820-2 2022 We have previously shown negative allosteric modulators (NAMs) of the CB1 receptor attenuated the reinstatement of other drugs of abuse including cocaine and methamphetamine in rats; however, their effects on alcohol-related behaviors have not been investigated. Cocaine 146-153 cannabinoid receptor 1 Rattus norvegicus 70-73 32959420-10 2020 The cocaine-induced blockade of eCB-LTD in the VTA was mediated by an impaired function of presynaptic CB1 receptors. Cocaine 4-11 cannabinoid receptor 1 Rattus norvegicus 103-106 31437433-9 2020 Strikingly, this reduction in both cocaine self-administration and BSR was blocked by AM630 (cannabinoid CB2 receptor antagonist), WAY100135 (5-HT1A receptor antagonist), or capsazepine (TRPV1 channel blocker), but not by AM251 (CB1 receptor antagonist), CID16020046 (GPR55 antagonist), or naloxone (opioid receptor antagonist), suggesting the involvement of CB2, 5-HT1A, and TRPV1 receptors in CBD action. Cocaine 35-42 cannabinoid receptor 1 Rattus norvegicus 229-232 31596583-1 2019 We previously reported diarylurea derivatives as cannabinoid type-1 receptor (CB1) allosteric modulators which were effective in attenuating cocaine seeking behavior. Cocaine 141-148 cannabinoid receptor 1 Rattus norvegicus 49-76 31596583-1 2019 We previously reported diarylurea derivatives as cannabinoid type-1 receptor (CB1) allosteric modulators which were effective in attenuating cocaine seeking behavior. Cocaine 141-148 cannabinoid receptor 1 Rattus norvegicus 78-81 30901889-2 2019 In the latest study, we investigated the changes in the levels of the above molecules and expression of cannabinoid receptors (CB1 and CB2) in several brain regions during cocaine-induced reinstatement in rats. Cocaine 172-179 cannabinoid receptor 1 Rattus norvegicus 127-130 30901889-7 2019 At the level of cannabinoid receptors, a priming dose of cocaine evoked either upregulation of the CB1 and CB2 receptors in the prefrontal cortex and lateral septal nuclei or downregulation of the CB1 receptors in the ventral tegmental area. Cocaine 57-64 cannabinoid receptor 1 Rattus norvegicus 99-102 30901889-7 2019 At the level of cannabinoid receptors, a priming dose of cocaine evoked either upregulation of the CB1 and CB2 receptors in the prefrontal cortex and lateral septal nuclei or downregulation of the CB1 receptors in the ventral tegmental area. Cocaine 57-64 cannabinoid receptor 1 Rattus norvegicus 197-200 11125733-0 1999 CB1 cannabinoid receptor agonist WIN 55,212-2 decreases intravenous cocaine self-administration in rats. Cocaine 68-75 cannabinoid receptor 1 Rattus norvegicus 0-3 11125733-9 1999 These results indicate that stimulation of CB1 cannabinoid receptors activates rewarding mechanisms which produce reinforcing effects additional to those induced by cocaine. Cocaine 165-172 cannabinoid receptor 1 Rattus norvegicus 43-46 34544759-5 2021 Additionally, incubation of cocaine craving is associated with loss of the synaptic depression normally triggered by stimulation of metabotropic glutamate receptor 5 (mGlu5), leading to endocannabinoid production, and expressed presynaptically via cannabinoid receptor 1 activation. Cocaine 28-35 cannabinoid receptor 1 Rattus norvegicus 248-270 34058192-10 2021 These data suggest that cocaine-induced increases in motivation require 2-AG signaling at CB1 receptors in the VTA and may provide critical insight into cannabinoid-based pharmacotherapeutic targets for the successful treatment of substance abuse. Cocaine 24-31 cannabinoid receptor 1 Rattus norvegicus 90-93 29754307-1 2018 The aim of this study was to evaluate changes in the expression of cannabinoid type 1 (CB1) and 2 (CB2) receptor proteins in several brain regions in rats undergoing cocaine self-administration and extinction training. Cocaine 166-173 cannabinoid receptor 1 Rattus norvegicus 87-90 29754307-3 2018 Using immunohistochemistry, we observed a significant decrease in CB1 receptor expression in the prefrontal cortex, dorsal striatum, and the basolateral and basomedial amygdala following cocaine (0.5 mg/kg/infusion) self-administration. Cocaine 187-194 cannabinoid receptor 1 Rattus norvegicus 66-69 29754307-5 2018 Following cocaine abstinence after 10 days of extinction training, we detected increases in the expression of CB1 receptors in the substantia nigra in both cocaine groups and in the subregions of the amygdala for only the yoked cocaine controls, while any method of cocaine exposure resulted in a decrease in CB2 receptor expression in the prefrontal cortex (p < 0.01), nucleus accumbens (p < 0.01), and medial globus pallidus (p < 0.01). Cocaine 10-17 cannabinoid receptor 1 Rattus norvegicus 110-113 29754307-5 2018 Following cocaine abstinence after 10 days of extinction training, we detected increases in the expression of CB1 receptors in the substantia nigra in both cocaine groups and in the subregions of the amygdala for only the yoked cocaine controls, while any method of cocaine exposure resulted in a decrease in CB2 receptor expression in the prefrontal cortex (p < 0.01), nucleus accumbens (p < 0.01), and medial globus pallidus (p < 0.01). Cocaine 156-163 cannabinoid receptor 1 Rattus norvegicus 110-113 29754307-5 2018 Following cocaine abstinence after 10 days of extinction training, we detected increases in the expression of CB1 receptors in the substantia nigra in both cocaine groups and in the subregions of the amygdala for only the yoked cocaine controls, while any method of cocaine exposure resulted in a decrease in CB2 receptor expression in the prefrontal cortex (p < 0.01), nucleus accumbens (p < 0.01), and medial globus pallidus (p < 0.01). Cocaine 156-163 cannabinoid receptor 1 Rattus norvegicus 110-113 29754307-5 2018 Following cocaine abstinence after 10 days of extinction training, we detected increases in the expression of CB1 receptors in the substantia nigra in both cocaine groups and in the subregions of the amygdala for only the yoked cocaine controls, while any method of cocaine exposure resulted in a decrease in CB2 receptor expression in the prefrontal cortex (p < 0.01), nucleus accumbens (p < 0.01), and medial globus pallidus (p < 0.01). Cocaine 156-163 cannabinoid receptor 1 Rattus norvegicus 110-113 29754307-6 2018 Our findings further support the idea that the eCB system and CB1 receptors are involved in cocaine-reinforced behaviors. Cocaine 92-99 cannabinoid receptor 1 Rattus norvegicus 62-65 26797579-0 2016 Opposite regulation of cannabinoid CB1 and CB2 receptors in the prefrontal cortex of rats treated with cocaine during adolescence. Cocaine 103-110 cannabinoid receptor 1 Rattus norvegicus 35-38 27994006-0 2017 Attenuation of Cocaine-Induced Conditioned Place Preference and Motor Activity via Cannabinoid CB2 Receptor Agonism and CB1 Receptor Antagonism in Rats. Cocaine 15-22 cannabinoid receptor 1 Rattus norvegicus 120-123 27994006-2 2017 Most of these studies have focused on the role of CB1 receptors in the psychostimulant effects of cocaine, while very few have investigated the respective role of CB2 receptors. Cocaine 98-105 cannabinoid receptor 1 Rattus norvegicus 50-53 27994006-4 2017 Methods: The role of CB1 and CB2 receptors in the rewarding and motor properties of cocaine was assessed in conditioned place preference, conditioned motor activity, and open field activity in rats. Cocaine 84-91 cannabinoid receptor 1 Rattus norvegicus 21-24 27994006-5 2017 Results: The CB1 receptor antagonist rimonabant (3 mg/kg) decreased the acquisition and the expression of conditioned place preference induced by cocaine (20 mg/kg). Cocaine 146-153 cannabinoid receptor 1 Rattus norvegicus 13-16 27994006-12 2017 Conclusions: Cannabinoid CB1 and CB2 receptors modulate cocaine-induced rewarding behavior and appear to have opposite roles in the regulation of cocaine"s reinforcing and psychomotor effects. Cocaine 56-63 cannabinoid receptor 1 Rattus norvegicus 25-28 26797579-6 2016 Interestingly, cocaine only altered CB1 (+55+-10%, p<0.05) and CB2 (-25+-10%, p<0.05) receptors when administered during early adolescence and only in PFC. Cocaine 15-22 cannabinoid receptor 1 Rattus norvegicus 36-39 26365195-3 2015 We find that cocaine stimulates release of the eCB, 2-arachidonoylglycerol (2-AG), in the rat ventral midbrain to suppress GABAergic inhibition of DA neurons, through activation of presynaptic cannabinoid CB1 receptors. Cocaine 13-20 cannabinoid receptor 1 Rattus norvegicus 205-208 26450088-3 2015 However, recent reports have suggested that cannabinoid CB1 receptor antagonists may share similar behavioral effects with other drugs of abuse such as cocaine and amphetamine. Cocaine 152-159 cannabinoid receptor 1 Rattus norvegicus 56-59 22425184-4 2012 Our results demonstrate that repeated cocaine administration over 14 days induced up-regulation of CB1 receptors in the cortical and subcortical brain areas of animals who received cocaine, whether the cocaine was actively self-administered or received passively (the "yoked" control group) and that the neuroadaptation of CB1 receptors persisted after the 10-day extinction phase. Cocaine 181-188 cannabinoid receptor 1 Rattus norvegicus 99-102 24409127-0 2014 Pharmacological blockade of either cannabinoid CB1 or CB2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat. Cocaine 82-89 cannabinoid receptor 1 Rattus norvegicus 47-50 24409127-0 2014 Pharmacological blockade of either cannabinoid CB1 or CB2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat. Cocaine 125-132 cannabinoid receptor 1 Rattus norvegicus 47-50 24409127-9 2014 These results indicate that the changes in neurogenic, apoptotic and gliotic processes that were produced by repeated cocaine administration were normalized by pharmacological blockade of CB1 and CB2. Cocaine 118-125 cannabinoid receptor 1 Rattus norvegicus 188-191 23727505-6 2013 Chronic cocaine in mice and rats also reduced CB1 receptor protein (-41% and -80%) in the cerebral cortex inducing receptor redistribution and/or internalization. Cocaine 8-15 cannabinoid receptor 1 Rattus norvegicus 46-49 23680694-4 2013 Herein, we have investigated the consequences of MD and/or adolescent cocaine exposure in brain CB1Rs and CB2Rs in immune tissues. Cocaine 70-77 cannabinoid receptor 1 Rattus norvegicus 96-99 23680694-8 2013 In addition, the plastic changes induced by adolescent cocaine administration in brain CB1Rs were differentially influenced by early life events. Cocaine 55-62 cannabinoid receptor 1 Rattus norvegicus 87-90 22489809-0 2012 Cannabinoid CB1 receptors mediate the effects of corticotropin-releasing factor on the reinstatement of cocaine seeking and expression of cocaine-induced behavioural sensitization. Cocaine 104-111 cannabinoid receptor 1 Rattus norvegicus 12-15 22489809-0 2012 Cannabinoid CB1 receptors mediate the effects of corticotropin-releasing factor on the reinstatement of cocaine seeking and expression of cocaine-induced behavioural sensitization. Cocaine 138-145 cannabinoid receptor 1 Rattus norvegicus 12-15 22425184-7 2012 In conclusion, we demonstrated that chronic cocaine self-administration leads to increased CB1 receptor levels in numerous brain areas and that this neuroadaptation is maintained over a long-lasting extinction period. Cocaine 44-51 cannabinoid receptor 1 Rattus norvegicus 91-94 24138924-10 2014 RESULTS: Blockade of CB1Rs reversed and prevented cocaine-induced impulsivity. Cocaine 50-57 cannabinoid receptor 1 Rattus norvegicus 21-24 22425184-0 2012 Long-lasting increase in [3H]CP55,940 binding to CB1 receptors following cocaine self-administration and its withdrawal in rats. Cocaine 73-80 cannabinoid receptor 1 Rattus norvegicus 49-52 22425184-1 2012 The present work has aimed on the neuroadaptive changes in CB1 receptor density that are evoked by self-administered cocaine use and subsequent withdrawal in rats. Cocaine 117-124 cannabinoid receptor 1 Rattus norvegicus 59-62 22425184-4 2012 Our results demonstrate that repeated cocaine administration over 14 days induced up-regulation of CB1 receptors in the cortical and subcortical brain areas of animals who received cocaine, whether the cocaine was actively self-administered or received passively (the "yoked" control group) and that the neuroadaptation of CB1 receptors persisted after the 10-day extinction phase. Cocaine 38-45 cannabinoid receptor 1 Rattus norvegicus 99-102 22425184-4 2012 Our results demonstrate that repeated cocaine administration over 14 days induced up-regulation of CB1 receptors in the cortical and subcortical brain areas of animals who received cocaine, whether the cocaine was actively self-administered or received passively (the "yoked" control group) and that the neuroadaptation of CB1 receptors persisted after the 10-day extinction phase. Cocaine 38-45 cannabinoid receptor 1 Rattus norvegicus 323-326 22425184-4 2012 Our results demonstrate that repeated cocaine administration over 14 days induced up-regulation of CB1 receptors in the cortical and subcortical brain areas of animals who received cocaine, whether the cocaine was actively self-administered or received passively (the "yoked" control group) and that the neuroadaptation of CB1 receptors persisted after the 10-day extinction phase. Cocaine 181-188 cannabinoid receptor 1 Rattus norvegicus 99-102 22325096-1 2012 There is evidence that indicates that tonic activation of cannabinoid CB1 receptors plays a role in extinction/reinstatement of cocaine seeking-behavior but is not involved in the maintenance of cocaine self-administration. Cocaine 128-135 cannabinoid receptor 1 Rattus norvegicus 70-73 20477753-6 2010 We found that URB597 blocked effects of nicotine and cocaine in the ShNAc through activation of both surface cannabinoid CB1-receptors and alpha-type peroxisome proliferator-activated nuclear receptor. Cocaine 53-60 cannabinoid receptor 1 Rattus norvegicus 121-124 21784132-14 2012 Our findings suggest that the anxiogenic effects of CRF and cocaine withdrawal are mediated, at least in part, by CB1 receptor transmission, and provide evidence in support of eCB-CRF interactions that are independent of the hypothalamic-pituitary-adrenal axis. Cocaine 60-67 cannabinoid receptor 1 Rattus norvegicus 114-117 21749491-8 2011 Blocking cannabinoid receptor 1 (CB(1) ) reduced mGluR1-LTP in the saline-treated but not cocaine-withdrawn group. Cocaine 90-97 cannabinoid receptor 1 Rattus norvegicus 9-38 19401177-0 2009 Methanandamide attenuates cocaine-induced hyperthermia in rats by a cannabinoid CB1-dopamine D2 receptor mechanism. Cocaine 26-33 cannabinoid receptor 1 Rattus norvegicus 81-84 19369553-3 2009 Here, we investigate the effects of systemic and intra-accumbal administration of the CB1 antagonist SR141716A (Rimonabant) on cocaine self-administration (0.5 mg/kg/infusion) under a progressive ratio (PR) schedule in rats with extended [long access (LgA); 6 h/d] or limited [short access (ShA); 1 h/d] access to cocaine. Cocaine 127-134 cannabinoid receptor 1 Rattus norvegicus 86-89 19401177-13 2009 Our results demonstrate that methanandamide activates cannabinoid CB1 receptors to attenuate cocaine-induced hyperthermia, and that dopamine D2 receptor activation plays a permissive role in the thermoregulatory effects of methanandamide. Cocaine 93-100 cannabinoid receptor 1 Rattus norvegicus 66-69 16914679-1 2006 Blockade of cannabinoid CB1 receptors has been reported to inhibit cocaine- or cocaine cue-induced reinstatement of drug seeking. Cocaine 67-74 cannabinoid receptor 1 Rattus norvegicus 24-27 17728698-0 2008 Cannabinoid CB1 receptor antagonists attenuate cocaine"s rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Cocaine 47-54 cannabinoid receptor 1 Rattus norvegicus 12-15 17728698-2 2008 In the present study, we found that blockade of CB1 receptors by AM 251 (1-10 mg/kg), a novel CB1 receptor antagonist, dose-dependently lowered (by 30-70%) the break point for cocaine self-administration under a progressive-ratio (PR) reinforcement schedule in rats. Cocaine 176-183 cannabinoid receptor 1 Rattus norvegicus 48-51 17728698-2 2008 In the present study, we found that blockade of CB1 receptors by AM 251 (1-10 mg/kg), a novel CB1 receptor antagonist, dose-dependently lowered (by 30-70%) the break point for cocaine self-administration under a progressive-ratio (PR) reinforcement schedule in rats. Cocaine 176-183 cannabinoid receptor 1 Rattus norvegicus 94-97 17408430-0 2007 Chronic cocaine sensitizes striatal GABAergic synapses to the stimulation of cannabinoid CB1 receptors. Cocaine 8-15 cannabinoid receptor 1 Rattus norvegicus 89-92 17408430-5 2007 Seven days cocaine-treatment, conversely, caused conditioned place preference, and sensitized striatal GABAergic synapses to the presynaptic effect of cannabinoid CB1 receptor stimulation. Cocaine 11-18 cannabinoid receptor 1 Rattus norvegicus 163-166 17220538-0 2006 Involvement of cannabinoid CB1 receptors in drug addiction: effects of rimonabant on behavioral responses induced by cocaine. Cocaine 117-124 cannabinoid receptor 1 Rattus norvegicus 27-30 16914679-1 2006 Blockade of cannabinoid CB1 receptors has been reported to inhibit cocaine- or cocaine cue-induced reinstatement of drug seeking. Cocaine 79-86 cannabinoid receptor 1 Rattus norvegicus 24-27 16914679-11 2006 These data suggest the following: (1) CB1 receptors exert tonic inhibition over NAc glutamate release under cocaine-extinction conditions; (2) blockade of CB1 receptors by AM251 inhibits cocaine-enhanced NAc glutamate release and cocaine-triggered reinstatement; and (3) these effects appear to be mediated by activation of presynaptic mGluR2/3 autoreceptors secondary to AM251-induced increase (disinhibition) of NAc glutamate release. Cocaine 108-115 cannabinoid receptor 1 Rattus norvegicus 38-41 16914679-11 2006 These data suggest the following: (1) CB1 receptors exert tonic inhibition over NAc glutamate release under cocaine-extinction conditions; (2) blockade of CB1 receptors by AM251 inhibits cocaine-enhanced NAc glutamate release and cocaine-triggered reinstatement; and (3) these effects appear to be mediated by activation of presynaptic mGluR2/3 autoreceptors secondary to AM251-induced increase (disinhibition) of NAc glutamate release. Cocaine 187-194 cannabinoid receptor 1 Rattus norvegicus 38-41 16914679-11 2006 These data suggest the following: (1) CB1 receptors exert tonic inhibition over NAc glutamate release under cocaine-extinction conditions; (2) blockade of CB1 receptors by AM251 inhibits cocaine-enhanced NAc glutamate release and cocaine-triggered reinstatement; and (3) these effects appear to be mediated by activation of presynaptic mGluR2/3 autoreceptors secondary to AM251-induced increase (disinhibition) of NAc glutamate release. Cocaine 187-194 cannabinoid receptor 1 Rattus norvegicus 155-158