PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26988269-4 2016 However, a deficit was observed in cocaine SA in the trpc4 KO group, which infused significantly less cocaine than WT controls despite displaying normal sucrose SA. Cocaine 35-42 transient receptor potential cation channel, subfamily C, member 4 Rattus norvegicus 53-58 26988269-5 2016 Given the important role of ventral tegmental area (VTA) dopamine neurons in cocaine SA, we hypothesized that TRPC4 channels may regulate basal dopamine neuron excitability. Cocaine 77-84 transient receptor potential cation channel, subfamily C, member 4 Rattus norvegicus 110-115 26988269-8 2016 Since deletion of the trpc4 gene does not impair learning involving natural rewards, but reduces cocaine SA, these data demonstrate a potentially novel role for TRPC4 channels in dopamine systems and may offer a new pharmacological target for more effective treatment of a variety of dopamine disorders. Cocaine 97-104 transient receptor potential cation channel, subfamily C, member 4 Rattus norvegicus 22-27 26988269-0 2016 Loss of the trpc4 gene is associated with a reduction in cocaine self-administration and reduced spontaneous ventral tegmental area dopamine neuronal activity, without deficits in learning for natural rewards. Cocaine 57-64 transient receptor potential cation channel, subfamily C, member 4 Rattus norvegicus 12-17 24555056-0 2013 Cocaine self-administration in rats lacking a functional trpc4 gene. Cocaine 0-7 transient receptor potential cation channel, subfamily C, member 4 Rattus norvegicus 57-62 24555056-6 2013 However, when they were switched to cocaine, the trpc4-KO rats had substantially reduced cocaine-paired lever pressing compared to WT controls. Cocaine 36-43 transient receptor potential cation channel, subfamily C, member 4 Rattus norvegicus 49-54 24555056-6 2013 However, when they were switched to cocaine, the trpc4-KO rats had substantially reduced cocaine-paired lever pressing compared to WT controls. Cocaine 89-96 transient receptor potential cation channel, subfamily C, member 4 Rattus norvegicus 49-54