PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18581099-5 2008 RESULTS: Cocaine-induced hyperactivity and conditioned place preference, as well as intravenous cocaine self-administration were enhanced in SERT-/- rats. Cocaine 9-16 solute carrier family 6 member 4 Rattus norvegicus 141-145 18581099-5 2008 RESULTS: Cocaine-induced hyperactivity and conditioned place preference, as well as intravenous cocaine self-administration were enhanced in SERT-/- rats. Cocaine 96-103 solute carrier family 6 member 4 Rattus norvegicus 141-145 18581099-9 2008 We further found that both 8-OHDPAT and S-15535 pretreatment increased low-dose cocaine-induced locomotor activity in SERT-/- rats, but not SERT+/+ rats. Cocaine 80-87 solute carrier family 6 member 4 Rattus norvegicus 118-122 18581099-10 2008 At a high cocaine dose, only SERT+/+ animals responded to 8-OHDPAT and S-15535. Cocaine 10-17 solute carrier family 6 member 4 Rattus norvegicus 29-33 18581099-11 2008 CONCLUSION: These data indicate that SERT-/- -associated 5-HT1A receptor adaptations facilitate low-dose cocaine effects and attenuate high-dose cocaine effects in cocaine supersensitive animals. Cocaine 105-112 solute carrier family 6 member 4 Rattus norvegicus 37-41 18581099-11 2008 CONCLUSION: These data indicate that SERT-/- -associated 5-HT1A receptor adaptations facilitate low-dose cocaine effects and attenuate high-dose cocaine effects in cocaine supersensitive animals. Cocaine 145-152 solute carrier family 6 member 4 Rattus norvegicus 37-41 11904159-4 2002 Transient currents at hSERT and rSERT are also blocked by spermine and spermidine in the mM range, and by fluoxetine, cocaine, QX-314, and QX-222 in the microM range. Cocaine 118-125 solute carrier family 6 member 4 Rattus norvegicus 32-37 17540345-1 2007 Irreversible tropane analogs have been useful in identifying binding sites of cocaine on biogenic amine transporters, including transporters for dopamine (DAT), serotonin (SERT) and norepinephrine (NET). Cocaine 78-85 solute carrier family 6 member 4 Rattus norvegicus 172-176 17382495-4 2007 5-MeO-DIPT specifically inhibited the uptake of [3H]serotonin (5-HT) by the SERT-expressing COS-7 cells and rat striatal synaptosomes in a high affinity manner at concentrations similar to those for cocaine. Cocaine 199-206 solute carrier family 6 member 4 Rattus norvegicus 76-80 12235253-8 2002 (+)-CPCA was less than 1/10 as potent as cocaine at the serotonin transporter. Cocaine 41-48 solute carrier family 6 member 4 Rattus norvegicus 56-77 12234655-5 2002 In addition, serotonin transporter densities were increased in the ventromedial caudate putamen, nucleus accumbens shell, and the olfactory tubercle in cocaine-treated adult rats compared to vehicle-treated adult rats. Cocaine 152-159 solute carrier family 6 member 4 Rattus norvegicus 13-34 11062247-0 2001 Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analogue as a molecular reporter. Cocaine 36-43 solute carrier family 6 member 4 Rattus norvegicus 66-87 11797070-2 2001 Although cocaine is an indirect DA agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (DAT) than norepinephrine (NET) and serotonin (SERT) transporters in the behavioral effects of cocaine. Cocaine 9-16 solute carrier family 6 member 4 Rattus norvegicus 194-203 11797070-2 2001 Although cocaine is an indirect DA agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (DAT) than norepinephrine (NET) and serotonin (SERT) transporters in the behavioral effects of cocaine. Cocaine 9-16 solute carrier family 6 member 4 Rattus norvegicus 205-209 11334571-6 2001 However, the analogous bivalent ligand 15 comprised of two (-)-trans-piperidine units, which is SERT selective, was less effective in antagonizing cocaine"s locomotor stimulant activity. Cocaine 147-154 solute carrier family 6 member 4 Rattus norvegicus 96-100 11756522-9 2002 SERT antagonists (e.g., fluoxetine, cocaine) reduced total SERT expression levels and the time course of SERT expression. Cocaine 36-43 solute carrier family 6 member 4 Rattus norvegicus 0-4 11756522-9 2002 SERT antagonists (e.g., fluoxetine, cocaine) reduced total SERT expression levels and the time course of SERT expression. Cocaine 36-43 solute carrier family 6 member 4 Rattus norvegicus 59-63 11756522-9 2002 SERT antagonists (e.g., fluoxetine, cocaine) reduced total SERT expression levels and the time course of SERT expression. Cocaine 36-43 solute carrier family 6 member 4 Rattus norvegicus 59-63 11592963-8 2001 Both serotonin and cocaine protected SERT from inactivation by MTSEA at Cys-357. Cocaine 19-26 solute carrier family 6 member 4 Rattus norvegicus 37-41 11062247-0 2001 Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analogue as a molecular reporter. Cocaine 108-115 solute carrier family 6 member 4 Rattus norvegicus 66-87 10958121-8 2000 The ability of U69593 to attenuate RTI-55-produced cocaine seeking raises the possibility that kappa-opioids and cocaine may interact at common sites on the serotonin transporter. Cocaine 113-120 solute carrier family 6 member 4 Rattus norvegicus 157-178 9843724-0 1998 Relationship between [125I]RTI-55-labeled cocaine binding sites and the serotonin transporter in rat placenta. Cocaine 42-49 solute carrier family 6 member 4 Rattus norvegicus 72-93 10051233-26 1999 As a target for drugs, such as cocaine, amphetamine derivatives and antidepressants, expression of serotonin transporter during development may reflect critical periods of vulnerability for fetal drug exposure. Cocaine 31-38 solute carrier family 6 member 4 Rattus norvegicus 99-120 9502257-13 1998 Since the serotonin transporter is a target for a number of addictive substances including cocaine and amphetamine derivatives as well as antidepressants, transient expression of the serotonin transporter might suggest a window of vulnerability of associated cells to fetal drug exposure. Cocaine 91-98 solute carrier family 6 member 4 Rattus norvegicus 10-31 9502257-13 1998 Since the serotonin transporter is a target for a number of addictive substances including cocaine and amphetamine derivatives as well as antidepressants, transient expression of the serotonin transporter might suggest a window of vulnerability of associated cells to fetal drug exposure. Cocaine 91-98 solute carrier family 6 member 4 Rattus norvegicus 183-204 32721055-2 2020 Previous research showed that inherited serotonin transporter (SERT) down-regulation increases the motor response to cocaine, as well as moderate (as measured during daily 1-hr self-administration sessions) and compulsive (as measured during daily 6-hr self-administration sessions) intake of this psychostimulant. Cocaine 117-124 solute carrier family 6 member 4 Rattus norvegicus 40-61 9466725-0 1997 Convergent control of serotonin transporter expression by glucocorticoids and cocaine in fetal and neonatal rat brain. Cocaine 78-85 solute carrier family 6 member 4 Rattus norvegicus 22-43 34437872-10 2021 This dichotomy may be a function of cocaine having a greater affinity for the serotonin transporter than methamphetamine. Cocaine 36-43 solute carrier family 6 member 4 Rattus norvegicus 78-99 35605783-3 2022 Modafinil"s addictive potential is not yet clear, but one feature that differentiates it from potentially addictive drugs like cocaine revolves around affinity for SERT. Cocaine 127-134 solute carrier family 6 member 4 Rattus norvegicus 164-168 33880773-0 2021 Long-access to cocaine self-administration dysregulates the glutamate synapse in the nucleus accumbens core of serotonin transporter knockout rats. Cocaine 15-22 solute carrier family 6 member 4 Rattus norvegicus 111-132 33880773-2 2021 We have previously demonstrated that rats with ablation of the serotonin transporter (SERT-/- rats) show increased cocaine intake reminiscent of compulsivity. Cocaine 115-122 solute carrier family 6 member 4 Rattus norvegicus 63-84 33880773-2 2021 We have previously demonstrated that rats with ablation of the serotonin transporter (SERT-/- rats) show increased cocaine intake reminiscent of compulsivity. Cocaine 115-122 solute carrier family 6 member 4 Rattus norvegicus 86-90 33880773-9 2021 In cocaine-naive animals, SERT deletion evoked widespread abnormalities in markers of glutamatergic neurotransmission that, overall, indicate a reduction of glutamate signaling. Cocaine 3-10 solute carrier family 6 member 4 Rattus norvegicus 26-30 33880773-11 2021 We also found that SERT deletion altered glutamate homeostasis mainly after LgA, but not ShA, to cocaine. Cocaine 97-104 solute carrier family 6 member 4 Rattus norvegicus 19-23 33880773-12 2021 CONCLUSION AND IMPLICATIONS: Our findings reveal that SERT deletion may sensitize the glutamatergic synapses of the NAc core to the LgA, but not ShA, intake of cocaine. Cocaine 160-167 solute carrier family 6 member 4 Rattus norvegicus 54-58 32187792-0 2021 The role of the serotonin transporter in prefrontal cortex glutamatergic signaling following short- and long-access cocaine self-administration. Cocaine 116-123 solute carrier family 6 member 4 Rattus norvegicus 16-37 32187792-2 2021 We previously demonstrated that serotonin transporter knockout (SERT-/- ) rats show increased cocaine intake and develop signs of compulsivity. Cocaine 94-101 solute carrier family 6 member 4 Rattus norvegicus 32-53 32187792-2 2021 We previously demonstrated that serotonin transporter knockout (SERT-/- ) rats show increased cocaine intake and develop signs of compulsivity. Cocaine 94-101 solute carrier family 6 member 4 Rattus norvegicus 64-68 32187792-6 2021 SERT-/- rats, which compared to wild-type (SERT+/+ ) rats show increased ShA and LgA intake short-access (ShA) and long-access (LgA) cocaine intake, were sacrificed 24 h into withdrawal for ex vivo molecular analyses. Cocaine 133-140 solute carrier family 6 member 4 Rattus norvegicus 0-4 32187792-6 2021 SERT-/- rats, which compared to wild-type (SERT+/+ ) rats show increased ShA and LgA intake short-access (ShA) and long-access (LgA) cocaine intake, were sacrificed 24 h into withdrawal for ex vivo molecular analyses. Cocaine 133-140 solute carrier family 6 member 4 Rattus norvegicus 43-47 32187792-10 2021 These results point to SERT as a critical regulator of glutamate homeostasis in a way that differs between the subregions investigated, the duration of cocaine exposure as well as the cellular compartment analyzed. Cocaine 152-159 solute carrier family 6 member 4 Rattus norvegicus 23-27 9387868-6 1997 Cocaine significantly decreased the abundance of the SERT mRNA within the dlDR and DAT mRNA abundance within the SNc and the PBP, and increased the abundance of the NET mRNA within the LC. Cocaine 0-7 solute carrier family 6 member 4 Rattus norvegicus 53-57 9387868-7 1997 Finally, correlational analysis indicated that post-cocaine levels of DAT, SERT and NET mRNAs were not associated with cocaine-induced sensitization. Cocaine 52-59 solute carrier family 6 member 4 Rattus norvegicus 75-79 9037542-2 1996 In order to identify transporter sites on 5-HT neurons or on other 5-HT uptaking cells, three rabbit antisera against cocaine sensitive-serotonin transporter (5-HTT) were produced. Cocaine 118-125 solute carrier family 6 member 4 Rattus norvegicus 136-157 8880938-5 1996 Both ibogaine and 12-OH ibogamine demonstrated the highest potency values at the cocaine recognition site on the 5-HT transporter. Cocaine 81-88 solute carrier family 6 member 4 Rattus norvegicus 113-129 7714769-1 1995 V. Demonstration of two binding sites for the cocaine analog [125I]RTI-55 associated with the 5-HT transporter in rat brain membranes. Cocaine 46-53 solute carrier family 6 member 4 Rattus norvegicus 94-110 8429827-1 1993 The iodinated cocaine analog 2 beta-carbomethoxy-3 beta-(4- [125I]iodophenyl)tropane (beta-[125I]CIT) binds with high affinity to the platelet plasma membrane serotonin transporter, as previously reported for dopamine transporters from rat brain [Eur. Cocaine 14-21 solute carrier family 6 member 4 Rattus norvegicus 159-180 35174489-0 2022 Responsivity of serotonin transporter knockout rats to short and long access to cocaine: modulation of the glutamate signaling in the nucleus accumbens shell. Cocaine 80-87 solute carrier family 6 member 4 Rattus norvegicus 16-37 32721055-2 2020 Previous research showed that inherited serotonin transporter (SERT) down-regulation increases the motor response to cocaine, as well as moderate (as measured during daily 1-hr self-administration sessions) and compulsive (as measured during daily 6-hr self-administration sessions) intake of this psychostimulant. Cocaine 117-124 solute carrier family 6 member 4 Rattus norvegicus 63-67 30748070-0 2020 Ultrahigh-resolution MRI reveals structural brain differences in serotonin transporter knockout rats after sucrose and cocaine self-administration. Cocaine 119-126 solute carrier family 6 member 4 Rattus norvegicus 65-86 31606593-0 2019 Deletion of the serotonin transporter perturbs BDNF signaling in the central amygdala following long-access cocaine self-administration. Cocaine 108-115 solute carrier family 6 member 4 Rattus norvegicus 16-37 31606593-4 2019 Additionally, while BDNF is strongly regulated by serotonin levels and inherited serotonin transporter down-regulation is associated with increased vulnerability to cocaine addiction, the effects of serotonin transporter genotype on BDNF signaling in the amygdala under naive and cocaine exposure conditions are unknown. Cocaine 165-172 solute carrier family 6 member 4 Rattus norvegicus 81-102 31606593-7 2019 mBDNF protein expression and its signaling in cocaine-naive serotonin transporter knockout rats resembled that of wild-type rats with a history of long-access cocaine self-administration. Cocaine 46-53 solute carrier family 6 member 4 Rattus norvegicus 60-81 31606593-8 2019 Interestingly, cocaine-exposed serotonin transporter knockout rats showed increased BDNF levels, with no signs of phospho-TrkB receptor coupling to phospho-Akt and phospho-ERK1. Cocaine 15-22 solute carrier family 6 member 4 Rattus norvegicus 31-52 29357981-5 2018 RESULTS: SERT knockdown in the MRN increased cocaine intake selectively under ShA conditions and, like ShA cocaine self-administration, reduced corticotropin-releasing factor (CRF) immunodensity in the paraventricular nucleus of the hypothalamus. Cocaine 45-52 solute carrier family 6 member 4 Rattus norvegicus 9-13 29357981-6 2018 In contrast, SERT knockdown in the DRN increased cocaine intake selectively under LgA conditions and, like LgA cocaine self-administration, reduced CRF immunodensity in the central nucleus of the amygdala. Cocaine 49-56 solute carrier family 6 member 4 Rattus norvegicus 13-17 23706649-4 2013 We have therefore used this approach on the cocaine-sensitive rat serotonin transporter (SERT). Cocaine 44-51 solute carrier family 6 member 4 Rattus norvegicus 66-87 27140629-5 2016 Using membranes from HeLa cells expressing SERT and intact rat basophilic leukemia cells, we show that agents such as Na(+) and cocaine that stabilize outward-open conformations of SERT decreased phosphorylation and agents that stabilize inward-open conformations (e.g., 5-HT, ibogaine) increased phosphorylation. Cocaine 128-135 solute carrier family 6 member 4 Rattus norvegicus 181-185 23706649-4 2013 We have therefore used this approach on the cocaine-sensitive rat serotonin transporter (SERT). Cocaine 44-51 solute carrier family 6 member 4 Rattus norvegicus 89-93 21790908-10 2013 As 5-HTT(-/-) rodents model the low activity s-allele of the human serotonin transporter-linked polymorphic region, these findings may have heuristic value in the treatment of s-allele cocaine addicts. Cocaine 185-192 solute carrier family 6 member 4 Rattus norvegicus 67-88 21525301-1 2011 The serotonin transporter (SERT) is the principal mechanism for terminating serotonin (5-HT) signals in the nervous system and is a site of action for a variety of psychoactive drugs including antidepressants, amphetamines, and cocaine. Cocaine 228-235 solute carrier family 6 member 4 Rattus norvegicus 4-25 21525301-1 2011 The serotonin transporter (SERT) is the principal mechanism for terminating serotonin (5-HT) signals in the nervous system and is a site of action for a variety of psychoactive drugs including antidepressants, amphetamines, and cocaine. Cocaine 228-235 solute carrier family 6 member 4 Rattus norvegicus 27-31 21473034-7 2004 In a continuing effort to produce radiolabeled compounds that can be used for the non-invasive study of SERT, investigators developed some tropane analogs of cocaine and demonstrated that these compounds had a high selectivity for SERT and exhibited very low affinity for either the DAT or the NET (39, 40). Cocaine 158-165 solute carrier family 6 member 4 Rattus norvegicus 104-108 21108959-5 2011 Cocaine blocks reuptake of the serotonergic (5-HT) transporter and serotonin has been implicated in the modulation of anxiety. Cocaine 0-7 solute carrier family 6 member 4 Rattus norvegicus 45-62