PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17635674-0	2007	Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons through TNF-alpha-mediated induction of Bax and phosphorylated c-Jun NH(2)-terminal kinase.	Cocaine	0-7	tumor necrosis factor	Rattus norvegicus	85-94	
17635674-10	2007	These simultaneous molecular events triggered by cocaine and TNF-alpha implicate a potential apoptotic signal transduction pathway via induction of phospho-c-Jun NH(2)-terminal kinase and Bax that may lead to caspase-3 activation and apoptosis in cocaine-exposed fetal LC neurons.	Cocaine	247-254	tumor necrosis factor	Rattus norvegicus	61-70	
14707577-16	2004	Serum interleukin-6 and interleukin-10 were elevated in rats treated with cocaine and lipopolysaccharide compared with rats treated with lipopolysaccharide alone, whereas serum tumor necrosis factor-alpha was reduced by cocaine pretreatment.	Cocaine	74-81	tumor necrosis factor	Rattus norvegicus	177-204	
14707577-16	2004	Serum interleukin-6 and interleukin-10 were elevated in rats treated with cocaine and lipopolysaccharide compared with rats treated with lipopolysaccharide alone, whereas serum tumor necrosis factor-alpha was reduced by cocaine pretreatment.	Cocaine	220-227	tumor necrosis factor	Rattus norvegicus	177-204	
35065197-10	2022	These alterations were strongly related to the CRS-induced reactive microglia and increased TNF-alpha mRNA and protein expression, since by administering minocycline, the impaired glutamate homeostasis and the facilitation of cocaine self-administration were prevented.	Cocaine	226-233	tumor necrosis factor	Rattus norvegicus	92-101	
10864098-4	2000	Chronic cocaine decreased serum levels of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6), but had no effect on interleukin-1 beta (IL-1beta).	Cocaine	8-15	tumor necrosis factor	Rattus norvegicus	42-69	
10864098-4	2000	Chronic cocaine decreased serum levels of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6), but had no effect on interleukin-1 beta (IL-1beta).	Cocaine	8-15	tumor necrosis factor	Rattus norvegicus	71-80	
34938803-9	2021	A nonsignificant increase in the level of TNF-alpha as a result of COC treatment was reversed by INI and INI+MET treatment.	Cocaine	67-70	tumor necrosis factor	Rattus norvegicus	42-51	
1320643-6	1992	The potentiating effect of cocaine could be reproduced by addition of rTNF-alpha or rTGF-beta to the cocultures of CMV-activated PBMC, although TGF-beta was substantially more potent than TNF-alpha.	Cocaine	27-34	tumor necrosis factor	Rattus norvegicus	70-80	
34014809-6	2021	HIV-1-infection of monocyte-derived macrophages in the presence of cocaine resulted in an increased number of TGF-beta1 high-EVs and; intravenous injection of these EVs in rats led to increased right ventricle systolic pressure accompanied by myocardial injury and increased levels of serum endothelin-1, TNF-alpha, and cardiac Troponin-I.	Cocaine	67-74	tumor necrosis factor	Rattus norvegicus	305-314	
28813640-11	2018	Cocaine self-administration increased the expression of mRNA for the proinflammatory cytokine interleukin-1ss, but not tumor necrosis factor alpha, in the VTA.	Cocaine	0-7	tumor necrosis factor	Rattus norvegicus	119-146