PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23452061-0 2013 A single in vivo cocaine administration impairs 5-HT(1B) receptor-induced long-term depression in the nucleus accumbens. Cocaine 17-24 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 48-65 25514162-5 2014 Furthermore, DAT KO mice with reduced, but not eliminated, 5-HT1B receptor expression regained cocaine-stimulated locomotion, which was absent in DAT KO mice with normal levels of 5-HT1B receptor expression. Cocaine 95-102 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 59-74 29066957-0 2017 Effects of a 5-HT1B Receptor Agonist on Locomotion and Reinstatement of Cocaine-Conditioned Place Preference after Abstinence from Repeated Injections in Mice. Cocaine 72-79 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 13-28 29066957-1 2017 5-HT1B receptors (5-HT1BRs) modulate behavioral effects of cocaine. Cocaine 59-66 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 0-6 25514162-7 2014 These findings of complementation of the locomotor effects of DAT KO by reducing 5-HT1B receptor activity underscore roles for interactions between specific 5-HT receptors and dopamine (DA) systems in basal and cocaine-stimulated locomotion and support evaluation of 5-HT1B antagonists as potential, non-stimulant ADHD therapeutics. Cocaine 211-218 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 81-96 25514162-7 2014 These findings of complementation of the locomotor effects of DAT KO by reducing 5-HT1B receptor activity underscore roles for interactions between specific 5-HT receptors and dopamine (DA) systems in basal and cocaine-stimulated locomotion and support evaluation of 5-HT1B antagonists as potential, non-stimulant ADHD therapeutics. Cocaine 211-218 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 81-87 23452061-9 2013 Our results reveal a novel 5-HT1B receptor-mediated LTD in the NAc and suggest that cocaine exposure may result in elevated phosphorylation of presynaptic proteins involved in regulating glutamate release, which counteracts the presynaptic depressant effects of 5-HT1B receptors and thereby impairs the induction of LTD by 5-HT. Cocaine 84-91 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 27-42 23452061-9 2013 Our results reveal a novel 5-HT1B receptor-mediated LTD in the NAc and suggest that cocaine exposure may result in elevated phosphorylation of presynaptic proteins involved in regulating glutamate release, which counteracts the presynaptic depressant effects of 5-HT1B receptors and thereby impairs the induction of LTD by 5-HT. Cocaine 84-91 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 27-33 11374326-9 2001 The mice lacking the 5-HT1B receptor have also been reported to exhibit an increased vulnerability to cocaine. Cocaine 102-109 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 21-36 21886584-2 2011 Mice with a knock-out of the 5HT1b receptor gene (HTR1B) displayed increased locomotor response to cocaine and elevated motivation to self-administer cocaine and alcohol. Cocaine 99-106 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 29-43 21886584-2 2011 Mice with a knock-out of the 5HT1b receptor gene (HTR1B) displayed increased locomotor response to cocaine and elevated motivation to self-administer cocaine and alcohol. Cocaine 99-106 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 50-55 21886584-2 2011 Mice with a knock-out of the 5HT1b receptor gene (HTR1B) displayed increased locomotor response to cocaine and elevated motivation to self-administer cocaine and alcohol. Cocaine 150-157 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 29-43 21886584-2 2011 Mice with a knock-out of the 5HT1b receptor gene (HTR1B) displayed increased locomotor response to cocaine and elevated motivation to self-administer cocaine and alcohol. Cocaine 150-157 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 50-55 11080193-8 2000 These changes in 5-HT and DA metabolism were consistent with the increased aggressiveness and the supersensitivity to cocaine reported in 5-HT(1B) knockout mice. Cocaine 118-125 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 138-145 11093763-9 2000 Furthermore, this study underscores the role played by presynaptic 5-HT(1B) receptors in mediating the effects of cocaine on synaptic transmission. Cocaine 114-121 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 67-74 10432472-1 1999 Knockout of the 5-HT1B gene in mice results in increased aggression, as well as alcohol and cocaine consumption. Cocaine 92-99 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 16-22 10837864-5 2000 As other studies showed that 5-HT1B knock-out mice self-administer cocaine, these results suggest a dissociation between the psychologic state linked to self-administration and the one measured in conditioned place preference. Cocaine 67-74 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 29-35 11164086-0 2000 Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists. Cocaine 29-36 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 40-46 11164086-3 2000 To evaluate the role of the 5-HT1B receptor in mediating the actions of cocaine, we used two model systems: knockout (KO) mice lacking the 5-HT1B receptor and an acute treatment with the 5-HT1B/1D antagonist GR127935. Cocaine 72-79 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 28-43 11164086-3 2000 To evaluate the role of the 5-HT1B receptor in mediating the actions of cocaine, we used two model systems: knockout (KO) mice lacking the 5-HT1B receptor and an acute treatment with the 5-HT1B/1D antagonist GR127935. Cocaine 72-79 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 28-34 11164086-6 2000 In contrast, as demonstrated previously, the 5-HT1B receptor KO mice showed a heightened locomotor response to cocaine, as well as an increased propensity to self-administer cocaine. Cocaine 111-118 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 45-60 11164086-6 2000 In contrast, as demonstrated previously, the 5-HT1B receptor KO mice showed a heightened locomotor response to cocaine, as well as an increased propensity to self-administer cocaine. Cocaine 174-181 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 45-60 11164086-7 2000 Thus, an acute pharmacological blockade of the 5-HT1B receptor decreases some effects of cocaine, while a constitutive genetic KO of the same receptor has opposite effects. Cocaine 89-96 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 47-62 11164086-8 2000 These results suggest that compensatory changes have taken place during the development of the 5-HT1B KO mice, which may have rendered these mice more vulnerable to cocaine. Cocaine 165-172 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 95-101 10837864-2 2000 This study investigated the involvement of the serotonin 1B (5-HT1B) receptor in modulating cocaine-induced place conditioning by comparing the response of 5-HT1B receptor gene knock-out mice with wild type 129/Sv-ter mice. Cocaine 92-99 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 61-77 10414358-7 1999 However, pharmacological studies suggest that 5-HT1B stimulation enhances the effects of cocaine, while 5-HT1B blockade can attenuate some of the effects of cocaine. Cocaine 157-164 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 104-110 10414358-6 1999 The 5-HT1B receptor knockout mice show a phenotype of increased vulnerability to drugs of abuse such as cocaine. Cocaine 104-111 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 4-19 10414358-7 1999 However, pharmacological studies suggest that 5-HT1B stimulation enhances the effects of cocaine, while 5-HT1B blockade can attenuate some of the effects of cocaine. Cocaine 89-96 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 46-52 9603521-4 1998 We show that mice lacking 5-HT1B display increased locomotor responses to cocaine and that they are more motivated to self-administer cocaine. Cocaine 74-81 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 26-32 9822762-9 1998 Together, these findings indicate that 5-HT1B receptor stimulation facilitates the reinforcing properties of cocaine. Cocaine 109-116 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 39-54 9603521-4 1998 We show that mice lacking 5-HT1B display increased locomotor responses to cocaine and that they are more motivated to self-administer cocaine. Cocaine 134-141 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 26-32 9603521-5 1998 We propose that even drug-naive 5-HT1B-knockout mice are in a behavioural and biochemical state that resembles that of wild-type mice sensitized to cocaine by repeated exposure to the drug. Cocaine 148-155 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 32-38 9218264-0 1997 Intravenous cocaine self-administration in mice lacking 5-HT1B receptors. Cocaine 12-19 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 56-62 9218264-1 1997 The present experiment tested the hypothesis that 5-HT1B receptors are involved in the reinforcing effects of cocaine. Cocaine 110-117 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 50-56 9218264-7 1997 These results suggest that the 5-HT1B receptors may be implicated in the propensity to self-administer cocaine, but other mechanisms might be involved in the maintenance of cocaine self-administration. Cocaine 103-110 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 31-37 34564712-0 2022 Stress decreases serotonin tone in the nucleus accumbens in male mice to promote aversion and potentiate cocaine preference via decreased stimulation of 5-HT1B receptors. Cocaine 105-112 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 153-159 34564712-11 2022 Consistent with this hypothesis, a transient pharmacological blockade of mNAc 5-HT1B receptors potentiated subsequent cocaine CPP. Cocaine 118-125 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 78-84 32172944-0 2020 Dual Effect of 5-HT1B/1D Receptors on Dopamine Neurons in Ventral Tegmental Area: Implication for the Functional Switch After Chronic Cocaine Exposure. Cocaine 134-141 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 15-21 9145913-0 1997 5-Hydroxytryptamine1B receptors modulate the effect of cocaine on c-fos expression: converging evidence using 5-hydroxytryptamine1B knockout mice and the 5-hydroxytryptamine1B/1D antagonist GR127935. Cocaine 55-62 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 0-21 9145913-4 1997 5-HT1B knockout mice display a markedly reduced effect of cocaine on c-fos induction in different brain structures, most notably in the striatum. Cocaine 58-65 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 0-6 9145913-5 1997 In addition, the administration to wild-type mice of the 5-HT1B receptor agonist RU24969 results in a striatal induction of c-fos expression very similar to that induced by cocaine in its time course, cellular and anatomical distribution, and pharmacology. Cocaine 173-180 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 57-72 9145913-8 1997 These converging lines of evidence obtained with the knockout mice and 5-HT(1B/1D) antagonist indicate that cocaine acts as an indirect agonist of 5-HT1B receptors in vivo and demonstrate that activation of 5-HT1B receptors contributes to the cellular responses elicited by cocaine. Cocaine 108-115 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 147-153 9145913-8 1997 These converging lines of evidence obtained with the knockout mice and 5-HT(1B/1D) antagonist indicate that cocaine acts as an indirect agonist of 5-HT1B receptors in vivo and demonstrate that activation of 5-HT1B receptors contributes to the cellular responses elicited by cocaine. Cocaine 108-115 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 207-213 9145913-8 1997 These converging lines of evidence obtained with the knockout mice and 5-HT(1B/1D) antagonist indicate that cocaine acts as an indirect agonist of 5-HT1B receptors in vivo and demonstrate that activation of 5-HT1B receptors contributes to the cellular responses elicited by cocaine. Cocaine 274-281 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 207-213