PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30972626-7 2019 These events were associated with a marked reduction of cocaine-induced internalization of D2R protomers in D2R-delta1R heteromer-containing cells vs D2R singly expressing cells as studied by means of confocal analysis of D2R-delta1R trafficking and internalization. Cocaine 56-63 dopamine receptor D2 Homo sapiens 91-94 30972626-0 2019 Acute Cocaine Enhances Dopamine D2R Recognition and Signaling and Counteracts D2R Internalization in Sigma1R-D2R Heteroreceptor Complexes. Cocaine 6-13 dopamine receptor D2 Homo sapiens 32-35 30972626-0 2019 Acute Cocaine Enhances Dopamine D2R Recognition and Signaling and Counteracts D2R Internalization in Sigma1R-D2R Heteroreceptor Complexes. Cocaine 6-13 dopamine receptor D2 Homo sapiens 78-81 30972626-1 2019 The current study was performed to establish the actions of nanomolar concentrations of cocaine, not blocking the dopamine transporter, on dopamine D2 receptor (D2R)-sigma 1 receptor (delta1R) heteroreceptor complexes and the D2R protomer recognition, signaling and internalization in cellular models. Cocaine 88-95 dopamine receptor D2 Homo sapiens 139-159 30972626-1 2019 The current study was performed to establish the actions of nanomolar concentrations of cocaine, not blocking the dopamine transporter, on dopamine D2 receptor (D2R)-sigma 1 receptor (delta1R) heteroreceptor complexes and the D2R protomer recognition, signaling and internalization in cellular models. Cocaine 88-95 dopamine receptor D2 Homo sapiens 161-164 30972626-4 2019 Furthermore, saturation binding assay demonstrated that in membrane preparations of HEK293 cells coexpressing D2R and delta1R, cocaine (1 nM) significantly increased the D2R Bmax values over cells singly expressing D2R. Cocaine 127-134 dopamine receptor D2 Homo sapiens 110-113 30972626-4 2019 Furthermore, saturation binding assay demonstrated that in membrane preparations of HEK293 cells coexpressing D2R and delta1R, cocaine (1 nM) significantly increased the D2R Bmax values over cells singly expressing D2R. Cocaine 127-134 dopamine receptor D2 Homo sapiens 170-173 30972626-4 2019 Furthermore, saturation binding assay demonstrated that in membrane preparations of HEK293 cells coexpressing D2R and delta1R, cocaine (1 nM) significantly increased the D2R Bmax values over cells singly expressing D2R. Cocaine 127-134 dopamine receptor D2 Homo sapiens 170-173 30972626-7 2019 These events were associated with a marked reduction of cocaine-induced internalization of D2R protomers in D2R-delta1R heteromer-containing cells vs D2R singly expressing cells as studied by means of confocal analysis of D2R-delta1R trafficking and internalization. Cocaine 56-63 dopamine receptor D2 Homo sapiens 108-111 30972626-7 2019 These events were associated with a marked reduction of cocaine-induced internalization of D2R protomers in D2R-delta1R heteromer-containing cells vs D2R singly expressing cells as studied by means of confocal analysis of D2R-delta1R trafficking and internalization. Cocaine 56-63 dopamine receptor D2 Homo sapiens 108-111 30972626-8 2019 Overall, the formation of D2R-delta1R heteromers enhanced the ability of cocaine to increase the D2R protomer function associated with a marked reduction of its internalization. Cocaine 73-80 dopamine receptor D2 Homo sapiens 26-29 30367264-5 2019 An association between the DRD2 T allele and crack cocaine addiction was found in women. Cocaine 51-58 dopamine receptor D2 Homo sapiens 27-31 23499958-5 2013 Treatment with resveratrol (50muM for 30min) enhanced cocaine-induced increases in the phosphorylation of DARPP-32 at Thr34 and GluA1 at Ser845, postsynaptic substrates for dopamine/D1 receptor/PKA signaling, and a cocaine-induced decrease in the phosphorylation of tyrosine hydroxylase at Ser40, a presynaptic substrate for dopamine/D2 receptor signaling. Cocaine 54-61 dopamine receptor D2 Homo sapiens 325-345 26572896-3 2016 OBJECTIVE: In this study, we aimed to establish the acute effects of administration of cannabis and cocaine on valence-dependent reversal learning as a function of DRD2 Taq1A (rs1800497) and COMT Val108/158Met (rs4680) genotype. Cocaine 100-107 dopamine receptor D2 Homo sapiens 164-168 26572896-7 2016 Effects of cocaine depended on the DRD2 genotype, as increases in proportion correct were seen only in the A1 carriers, and not in the A2/A2 homozygotes. Cocaine 11-18 dopamine receptor D2 Homo sapiens 35-39 26572896-10 2016 The effects of cocaine, but not cannabis, depend on interindividual genetic differences in the dopamine D2 receptor gene. Cocaine 15-22 dopamine receptor D2 Homo sapiens 95-115 26146874-10 2015 Polymorphisms of the DRD2, ANKK1, DAT1, DBH, and DRD4 genes have been found to moderate the effects of pharmacotherapy of alcohol, opioid, and cocaine use disorders. Cocaine 143-150 dopamine receptor D2 Homo sapiens 21-25 23999545-2 2014 The chronic use of drugs, including psychostimulants such as cocaine and amphetamine, has been associated with low D2/3 dopamine receptor availability, which in turn has been linked to poor clinical outcome. Cocaine 61-68 dopamine receptor D2 Homo sapiens 115-137 23670889-2 2013 Drug addiction polymorphisms such as the TaqI A1 allele of the dopamine D2 receptor (DRD2) are associated with cocaine, alcohol, and opioid use, but few studies have linked DRD2 to food craving. Cocaine 111-118 dopamine receptor D2 Homo sapiens 63-83 23670889-2 2013 Drug addiction polymorphisms such as the TaqI A1 allele of the dopamine D2 receptor (DRD2) are associated with cocaine, alcohol, and opioid use, but few studies have linked DRD2 to food craving. Cocaine 111-118 dopamine receptor D2 Homo sapiens 85-89 29066851-0 2017 Interaction Between the Trace Amine-Associated Receptor 1 and the Dopamine D2 Receptor Controls Cocaine"s Neurochemical Actions. Cocaine 96-103 dopamine receptor D2 Homo sapiens 66-86 23635803-8 2013 The GT/TT DRD2 genotype group showed a significant decrease in the number of cocaine-positive urine samples on disulfiram (N=9; 67-48%; P <= 0.0001), whereas the GG DRD2 genotype group showed only a marginal decrease (N=23; 84-63%; P=0.04). Cocaine 77-84 dopamine receptor D2 Homo sapiens 10-14 23760592-1 2013 Cocaine addiction is accompanied by a decrease in striatal dopamine signaling, measured as a decrease in dopamine D2 receptor binding as well as blunted dopamine release in the striatum. Cocaine 0-7 dopamine receptor D2 Homo sapiens 105-125 20034014-0 2010 Striatal dopamine D2 receptor availability predicts the thalamic and medial prefrontal responses to reward in cocaine abusers three years later. Cocaine 110-117 dopamine receptor D2 Homo sapiens 9-29 23340505-6 2013 DAT rs3836790 and DRD2 rs2283265 also interacted by modulating DAT protein activity in the ventral putamen of cocaine abusers. Cocaine 110-117 dopamine receptor D2 Homo sapiens 18-22 22110369-3 2011 We found that acute systemic injection of cocaine (20 mg/kg) increased NO efflux, which was reduced by the intrastriatal infusion of the dopamine D1 receptor antagonist, SCH23390 (7.5 nmol), and the dopamine D2 receptor agonist, quinpirole (5 nmol). Cocaine 42-49 dopamine receptor D2 Homo sapiens 199-219 20801583-5 2010 Several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes DRD2, COMT, SLC6A3 (coding for the dopamine transporter DAT) and DBH (coding for the dopamine beta hydroxylase) but unfortunately very few well established results. Cocaine 47-54 dopamine receptor D2 Homo sapiens 117-121 20336632-0 2010 Cocaine self-administration markedly increases dopamine D2 receptor negative cooperativity for dopamine binding: A receptor dimer-based analysis. Cocaine 0-7 dopamine receptor D2 Homo sapiens 47-67 22647301-7 2012 Decreased dopamine D2 receptor availability in the striatum has been found in animal models of binge eating, after cocaine self-administration in animals as well as in drug addiction and obesity in humans. Cocaine 115-122 dopamine receptor D2 Homo sapiens 10-30 20170711-6 2010 Cocaine-dependent individuals (n=347) and unaffected controls (n=257) of African descent were genotyped for the polymorphisms in the DRD2 and DAT1 genes. Cocaine 0-7 dopamine receptor D2 Homo sapiens 133-137 11256581-6 2000 Variants of the DRD2 gene have also been associated with cocaine, nicotine and opioid dependence, obesity and gambling. Cocaine 57-64 dopamine receptor D2 Homo sapiens 16-20 18418874-0 2008 D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats. Cocaine 55-62 dopamine receptor D2 Homo sapiens 0-3 18418874-1 2008 Dopamine (DA) D2 receptor (D2R) agonists and antagonists can modulate self-administration behavior, conditioned place preference, and locomotor responses to cocaine. Cocaine 157-164 dopamine receptor D2 Homo sapiens 27-30 18418874-2 2008 Low levels of D2R have also been observed in cocaine addicted subjects and in non human primates after chronic cocaine exposures. Cocaine 45-52 dopamine receptor D2 Homo sapiens 14-17 18418874-4 2008 Here we assess the effects of D2R upregulation in the NAc on cocaine intake in rats trained to self-administer cocaine. Cocaine 61-68 dopamine receptor D2 Homo sapiens 30-33 18418874-7 2008 D2R vector treatment resulted in a significant decrease (75%) in cocaine infusions and lever presses (70%) for cocaine. Cocaine 65-72 dopamine receptor D2 Homo sapiens 0-3 18418874-7 2008 D2R vector treatment resulted in a significant decrease (75%) in cocaine infusions and lever presses (70%) for cocaine. Cocaine 111-118 dopamine receptor D2 Homo sapiens 0-3 18418874-8 2008 This effect lasted 6 days before cocaine consumption returned to baseline levels, which corresponds roughly to the time it takes D2R to return to baseline levels. Cocaine 33-40 dopamine receptor D2 Homo sapiens 129-132 18418874-9 2008 These findings show that CSA and D2R in the NAc are negatively correlated and suggest that cocaine intake is modulated in part by D2R levels in NAc. Cocaine 91-98 dopamine receptor D2 Homo sapiens 33-36 18418874-9 2008 These findings show that CSA and D2R in the NAc are negatively correlated and suggest that cocaine intake is modulated in part by D2R levels in NAc. Cocaine 91-98 dopamine receptor D2 Homo sapiens 130-133 15328378-3 2005 The pressor response to intracisternal injection of cocaine was not mediated through central alpha-adrenergic receptors, but intracisternal pretreatment with D1 or D2 dopamine receptor antagonists shortened the duration of the response. Cocaine 52-59 dopamine receptor D2 Homo sapiens 164-184 12497624-4 2003 Variants of the DRD2 gene have also been associated with other addictive disorders including cocaine, nicotine and opioid dependence and obesity. Cocaine 93-100 dopamine receptor D2 Homo sapiens 16-20 10523822-7 1999 The DRD2 gene had an independent and additive effect on cocaine dependence. Cocaine 56-63 dopamine receptor D2 Homo sapiens 4-8 10881203-3 2000 The DRD2 gene has also been found to be involved in other substance use disorders including cocaine, nicotine and opioid dependence, and obesity. Cocaine 92-99 dopamine receptor D2 Homo sapiens 4-8 9650634-6 1998 Furthermore, the minor TaqI B (B1) allele of the DRD2 gene has been associated with alcoholism and psychostimulant (cocaine, amphetamine) abuse. Cocaine 116-123 dopamine receptor D2 Homo sapiens 49-53 1838199-1 1991 Involvement of D1 and D2 dopamine receptors in the effects of cocaine on schedule-controlled behavior was evaluated in squirrel monkeys responding under a multiple fixed-interval 5-min, fixed-ratio 10 schedule (mult FI FR) of food delivery. Cocaine 62-69 dopamine receptor D2 Homo sapiens 15-43 9631952-1 1998 Clinical evidence suggests that pergolide, a D1/D2 dopamine receptor agonist, may be useful in maintaining cocaine abstinence. Cocaine 107-114 dopamine receptor D2 Homo sapiens 45-68 8072432-4 1994 In as much as alcohol, cocaine, opiates, nicotine and food are known to increase brain dopamine levels and activate the mesocorticolimbic dopaminergic reward pathways of the brain, it is hypothesized that an inherited deficit of D2 dopamine receptor numbers in brain reward areas of A1 allelic subject predisposes them to substance abuse problems. Cocaine 23-30 dopamine receptor D2 Homo sapiens 229-249 8261891-1 1993 The objective of the present study was to examine allelic prevalence of the D2 dopamine receptor (DRD2) gene in male cocaine-dependent (CD) Caucasian (non-Hispanic) subjects and to determine the relationship of DRD2 alleles to family history and selected behavioral measures. Cocaine 117-124 dopamine receptor D2 Homo sapiens 76-96 8261891-1 1993 The objective of the present study was to examine allelic prevalence of the D2 dopamine receptor (DRD2) gene in male cocaine-dependent (CD) Caucasian (non-Hispanic) subjects and to determine the relationship of DRD2 alleles to family history and selected behavioral measures. Cocaine 117-124 dopamine receptor D2 Homo sapiens 98-102 2096297-6 1990 Inhibitory responses to either dopamine or cocaine were blocked by the specific D2 dopamine receptor antagonist sulpiride. Cocaine 43-50 dopamine receptor D2 Homo sapiens 80-100 8101394-3 1993 When compared to normal controls, cocaine abusers showed significant decreases in dopamine D2 receptor availability which persisted 3-4 months after detoxification. Cocaine 34-41 dopamine receptor D2 Homo sapiens 82-102 1604712-3 1992 An increase in CNS dopamine neurotransmission, resulting from a competitive blockade of high-affinity dopamine uptake mediated by both D1 and D2 dopamine receptors, is a primary determinant of the behavioral effects of cocaine. Cocaine 219-226 dopamine receptor D2 Homo sapiens 135-163 1365414-0 1992 Role of D1 and D2 dopamine receptors in the behavioral effects of cocaine. Cocaine 66-73 dopamine receptor D2 Homo sapiens 8-36 34506723-0 2021 Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors. Cocaine 0-7 dopamine receptor D2 Homo sapiens 15-35 34506723-2 2021 Although changes in the properties of D2-receptor-expressing medium spiny neurons (D2-MSNs) and connected striatal circuits following cocaine treatment are known, the contributions of altered D2-receptor (D2R) function in mediating the rewarding properties of cocaine remain unclear. Cocaine 134-141 dopamine receptor D2 Homo sapiens 38-49 34506723-2 2021 Although changes in the properties of D2-receptor-expressing medium spiny neurons (D2-MSNs) and connected striatal circuits following cocaine treatment are known, the contributions of altered D2-receptor (D2R) function in mediating the rewarding properties of cocaine remain unclear. Cocaine 260-267 dopamine receptor D2 Homo sapiens 192-203 34506723-2 2021 Although changes in the properties of D2-receptor-expressing medium spiny neurons (D2-MSNs) and connected striatal circuits following cocaine treatment are known, the contributions of altered D2-receptor (D2R) function in mediating the rewarding properties of cocaine remain unclear. Cocaine 260-267 dopamine receptor D2 Homo sapiens 205-208 34506723-4 2021 This cocaine-induced reduction of D2R sensitivity facilitated the development of the rewarding effects of cocaine as blocking the reduction in G protein expression was sufficient to prevent cocaine-induced behavioral adaptations. Cocaine 5-12 dopamine receptor D2 Homo sapiens 34-37 34506723-4 2021 This cocaine-induced reduction of D2R sensitivity facilitated the development of the rewarding effects of cocaine as blocking the reduction in G protein expression was sufficient to prevent cocaine-induced behavioral adaptations. Cocaine 106-113 dopamine receptor D2 Homo sapiens 34-37 34506723-4 2021 This cocaine-induced reduction of D2R sensitivity facilitated the development of the rewarding effects of cocaine as blocking the reduction in G protein expression was sufficient to prevent cocaine-induced behavioral adaptations. Cocaine 190-197 dopamine receptor D2 Homo sapiens 34-37 35390291-0 2022 Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors. Cocaine 0-7 dopamine receptor D2 Homo sapiens 15-35