PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16626650-0 2006 Prenatal cocaine exposure accelerates morphological changes and transient expression of tyrosine hydroxylase in the cochlea of developing rats. Cocaine 9-16 tyrosine hydroxylase Rattus norvegicus 88-108 25653355-10 2015 Within the subpopulation of TH-positive neurons, 36% were excited by cocaine and 64% were inhibited. Cocaine 69-76 tyrosine hydroxylase Rattus norvegicus 28-30 18955248-2 2009 Repeated injections of cocaine produce an increase in locomotor activity and the expression of tyrosine hydroxylase (TH) in the main dopaminergic areas. Cocaine 23-30 tyrosine hydroxylase Rattus norvegicus 95-115 18955248-2 2009 Repeated injections of cocaine produce an increase in locomotor activity and the expression of tyrosine hydroxylase (TH) in the main dopaminergic areas. Cocaine 23-30 tyrosine hydroxylase Rattus norvegicus 117-119 18955248-8 2009 Cocaine challenge (15 mg/kg, i.p) produced a larger increase in locomotor activity and expression of TH in the central dopaminergic areas. Cocaine 0-7 tyrosine hydroxylase Rattus norvegicus 101-103 18955248-11 2009 30 min before the daily injections of cocaine significantly inhibited the cocaine-induced locomotor activity as well as TH expression in the central dopaminergic areas. Cocaine 38-45 tyrosine hydroxylase Rattus norvegicus 120-122 18992788-2 2009 Many studies have suggested that behavioral sensitization by repeated injections of cocaine produce an increase in locomotor activity and an increase in the expression of tyrosine hydroxylase (TH), in the central dopaminergic system. Cocaine 84-91 tyrosine hydroxylase Rattus norvegicus 171-191 18992788-2 2009 Many studies have suggested that behavioral sensitization by repeated injections of cocaine produce an increase in locomotor activity and an increase in the expression of tyrosine hydroxylase (TH), in the central dopaminergic system. Cocaine 84-91 tyrosine hydroxylase Rattus norvegicus 193-195 18992788-6 2009 Cocaine challenge produced a large increase in the locomotor activity and the expression of TH in the ventral tegmental area (VTA). Cocaine 0-7 tyrosine hydroxylase Rattus norvegicus 92-94 12787079-6 2003 In the accumbens of cocaine-trained rats, GluR1 and NMDAR1 levels were increased on days 1 and 90, while GluR2 levels were increased on days 1 and 30, but not day 90; PKA activity levels were increased on days 1 and 30, but not day 90, while AC activity, TH and cdk5 levels were unaltered. Cocaine 20-27 tyrosine hydroxylase Rattus norvegicus 255-257 15447670-8 2004 Finally, phospho-Ser31 TH levels were increased in dopaminergic neurons of rats trained to chronically self-administer cocaine. Cocaine 119-126 tyrosine hydroxylase Rattus norvegicus 23-25 15447670-9 2004 These results demonstrate direct and indirect regulation of the phosphorylation state of a Cdk5/ERK1/2 site on TH and suggest a role for these pathways in the neuroadaptive changes associated with chronic cocaine exposure. Cocaine 205-212 tyrosine hydroxylase Rattus norvegicus 111-113 12787079-7 2003 In the VTA of cocaine-trained rats, NMDAR1 levels were increased for up to 90 days, while GluR2 levels were increased only on day 1; TH and Cdk5 levels were increased only on day 1, while PKA and AC activity levels were unaltered. Cocaine 14-21 tyrosine hydroxylase Rattus norvegicus 133-135 11284443-0 2001 Sensitization to the behavioural effects of cocaine: alterations in tyrosine hydroxylase or endogenous opioid mRNAs are not necessarily involved. Cocaine 44-51 tyrosine hydroxylase Rattus norvegicus 68-88 12394414-3 2002 We also examined whether the time-dependent changes in cocaine seeking correlate with the levels of the dopamine transporter (DAT) and tyrosine hydroxylase (TH) proteins in the amygdala, nucleus accumbens, prefrontal cortex and orbitofrontal cortex. Cocaine 55-62 tyrosine hydroxylase Rattus norvegicus 135-155 12394414-3 2002 We also examined whether the time-dependent changes in cocaine seeking correlate with the levels of the dopamine transporter (DAT) and tyrosine hydroxylase (TH) proteins in the amygdala, nucleus accumbens, prefrontal cortex and orbitofrontal cortex. Cocaine 55-62 tyrosine hydroxylase Rattus norvegicus 157-159 11284443-10 2001 The mRNA for tyrosine hydroxylase (TH) in substantia nigra + ventral tegmental area was significantly elevated to about 140% of saline controls both in the "repeated cocaine" and the "acute cocaine" group as compared with the "saline group". Cocaine 166-173 tyrosine hydroxylase Rattus norvegicus 13-33 11085341-2 2000 This study aims to evaluate, in an experimental model of neonatal exposure to cocaine in the rat, the immunocytochemical expression of tyrosine hydroxylase in the retina and the levels of different neurotransmitters and its metabolites. Cocaine 78-85 tyrosine hydroxylase Rattus norvegicus 135-155 10922520-0 2000 Repeated cocaine treatment alters tyrosine hydroxylase in the rat nucleus accumbens. Cocaine 9-16 tyrosine hydroxylase Rattus norvegicus 34-54 7902421-0 1993 Chronic cocaine administration increases CNS tyrosine hydroxylase enzyme activity and mRNA levels and tryptophan hydroxylase enzyme activity levels. Cocaine 8-15 tyrosine hydroxylase Rattus norvegicus 45-65 7902421-2 1993 Tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) catalyze the rate-limiting steps in dopamine and serotonin biosynthesis, respectively, and are the subject of dynamic regulatory mechanisms that could be sensitive to the actions of cocaine. Cocaine 241-248 tyrosine hydroxylase Rattus norvegicus 0-20 7902421-2 1993 Tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) catalyze the rate-limiting steps in dopamine and serotonin biosynthesis, respectively, and are the subject of dynamic regulatory mechanisms that could be sensitive to the actions of cocaine. Cocaine 241-248 tyrosine hydroxylase Rattus norvegicus 22-24 7902421-3 1993 This study assessed the effects of chronic cocaine on brain TH and TPH activities. Cocaine 43-50 tyrosine hydroxylase Rattus norvegicus 60-62 7902421-11 1993 In summary, the chronic response-independent administration of cocaine produces increases in the expression of TH mRNA and activity in both the cell bodies of motor (nigrostriatal) and reinforcement (mesolimbic) dopamine pathways. Cocaine 63-70 tyrosine hydroxylase Rattus norvegicus 111-113 19912951-1 1993 We have demonstrated previously that chronic morphine and cocaine treatments increase levels of tyrosine hydroxylase (TH), and decrease levels of neurofilament (NF) proteins, in the ventral tegmental area (VTA), a major dopaminergic brain reward region, of outbred Sprague-Dawley rats. Cocaine 58-65 tyrosine hydroxylase Rattus norvegicus 96-116 19912951-1 1993 We have demonstrated previously that chronic morphine and cocaine treatments increase levels of tyrosine hydroxylase (TH), and decrease levels of neurofilament (NF) proteins, in the ventral tegmental area (VTA), a major dopaminergic brain reward region, of outbred Sprague-Dawley rats. Cocaine 58-65 tyrosine hydroxylase Rattus norvegicus 118-120 8518951-1 1993 In previous studies, we demonstrated that tyrosine hydroxylase and neurofilament proteins are regulated by chronic morphine and chronic cocaine treatments in the ventral tegmental area in Sprague-Dawley rats and that the inbred Lewis and Fischer 344 rat strains, under drug-naive conditions, show different levels of these proteins specifically in this brain region. Cocaine 136-143 tyrosine hydroxylase Rattus norvegicus 42-62