PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26930476-7	2016	These losartan-mediated protective effects were inhibited by the phosphatidyl-inositol-3-kinase (PI3K) inhibitor LY294002, indicating that losartan provides significant protection from cocaine-induced renal toxicity through PI3K/Akt signaling.	Cocaine	185-192	thymoma viral proto-oncogene 1	Mus musculus	229-232	
26930476-8	2016	Our results suggest that genetic inhibition of GPx-1 potentiates cocaine-induced renal damage via activation of AT1R by inhibition of PI3K-Akt signaling, and that AT1R can be a therapeutic target against renal toxicity induced by cocaine.	Cocaine	65-72	thymoma viral proto-oncogene 1	Mus musculus	139-142	
24505362-6	2014	Acute administration of cocaine significantly decreased the phosphorylation of Akt-Thr308 (pAkt-Thr308) and GSK3beta in the caudate putamen and nucleus accumbens core, without altering pAkt-Ser473 and pGSK3alpha.	Cocaine	24-31	thymoma viral proto-oncogene 1	Mus musculus	79-82	
24505362-7	2014	To investigate the role of dopamine and NMDA receptors in the regulation of Akt and GSK3 by cocaine, specific receptor antagonists were administered prior to cocaine.	Cocaine	92-99	thymoma viral proto-oncogene 1	Mus musculus	76-79	
22145570-0	2012	Pre-synaptic dopamine D(3)  receptor mediates cocaine-induced structural plasticity in mesencephalic dopaminergic neurons via ERK and Akt pathways.	Cocaine	46-53	thymoma viral proto-oncogene 1	Mus musculus	134-137	
22145570-3	2012	In this work, we showed that cocaine significantly increased dendritic arborization and soma area of dopaminergic neurons from E12.5 mouse embryos by activating phosphorylation of extracellular signal-regulated kinase (ERK) and thymoma viral proto-oncogene (Akt).	Cocaine	29-36	thymoma viral proto-oncogene 1	Mus musculus	258-261	
22145570-5	2012	Cocaine effects on morphology and ERK/Akt phosphorylation were inhibited by pre-incubation with the phosphatidylinositol 3-kinase inhibitor LY294002.	Cocaine	0-7	thymoma viral proto-oncogene 1	Mus musculus	38-41	
22145570-8	2012	These findings indicate a direct involvement of D3R and ERK/Akt pathways as critical mediators of cocaine-induced structural plasticity, suggesting their involvement in psychostimulant addiction.	Cocaine	98-105	thymoma viral proto-oncogene 1	Mus musculus	60-63	
17164407-5	2007	This effect was blocked by the DAT inhibitor cocaine, suggesting that AMPH must interact with DAT to inhibit Akt.	Cocaine	45-52	thymoma viral proto-oncogene 1	Mus musculus	109-112	
24505362-2	2014	Here, the ability of cocaine to regulate the activity of Akt and GSK3 was investigated by measuring the phosphorylation states of the two kinases.	Cocaine	21-28	thymoma viral proto-oncogene 1	Mus musculus	57-60	
34522005-6	2022	The behavioural effect of cocaine was attenuated by intra-NAc administration of LY294002, an AKT-specific inhibitor, suggesting that PIPs may contribute to mTOR activation in response to cocaine.	Cocaine	26-33	thymoma viral proto-oncogene 1	Mus musculus	93-96	
34522005-6	2022	The behavioural effect of cocaine was attenuated by intra-NAc administration of LY294002, an AKT-specific inhibitor, suggesting that PIPs may contribute to mTOR activation in response to cocaine.	Cocaine	187-194	thymoma viral proto-oncogene 1	Mus musculus	93-96