PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16205775-0 2006 Administration of the D2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking. Cocaine 134-141 dopamine receptor D2 Rattus norvegicus 22-42 16835769-0 2007 Differential ability of D1 and D2 dopamine receptor agonists to induce and modulate expression and reinstatement of cocaine place preference in rats. Cocaine 116-123 dopamine receptor D2 Rattus norvegicus 24-51 16541082-0 2007 Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration. Cocaine 100-107 dopamine receptor D2 Rattus norvegicus 40-60 16844308-9 2006 Microinfusion of the D2/3 dopamine receptor antagonist sulpiride ((S)-5-aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide) (1.0 microg) into the nucleus accumbens shell 10 minutes prior to SKF-81297 (1.0 microg) blocked the ability of this D1-like dopamine receptor agonist to reinstate cocaine seeking. Cocaine 305-312 dopamine receptor D2 Rattus norvegicus 21-43 16005579-8 2006 These results confirm the importance of the D3 as well as the D2 dopamine receptor in modulating the cue-induced cocaine relapse and the possible usefulness of the D3 dopamine receptor ligands as potential medication in cocaine addicts. Cocaine 113-120 dopamine receptor D2 Rattus norvegicus 62-82 16111825-0 2005 D1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement. Cocaine 121-128 dopamine receptor D2 Rattus norvegicus 0-32 16111825-6 2005 Collectively, these results indicate that D1-like and D2 dopamine receptors in the nucleus accumbens shell selectively modulate the reinforcing efficacy of cocaine, whereas D1-like and D2 dopamine receptors in the accumbens core have a more general influence on reinforced behaviors. Cocaine 156-163 dopamine receptor D2 Rattus norvegicus 42-75 10082221-0 1999 Effects of D1 and D2 dopamine receptor antagonists on cocaine-induced self-stimulation and locomotor activity in rats. Cocaine 54-61 dopamine receptor D2 Rattus norvegicus 18-38 10516962-1 1999 The effects of acute and repeated gamma-hydroxybutyrate (GHB) and cocaine administration on D1 and D2 dopamine receptor mRNA expression were examined using in situ hybridization histochemistry in different rat brain structures rich in GHB receptors. Cocaine 66-73 dopamine receptor D2 Rattus norvegicus 99-119 10082221-6 1999 We therefore suspect that cocaine"s augmentative effect on those behaviors, especially ICSS, requires activation of both D1 and D2 dopamine receptors. Cocaine 26-33 dopamine receptor D2 Rattus norvegicus 121-149 8998398-0 1995 Adaptive changes in the proenkephalin and D2 dopamine receptor mRNA expression after chronic cocaine in the nucleus accumbens and striatum of the rat. Cocaine 93-100 dopamine receptor D2 Rattus norvegicus 42-62 8205476-0 1994 Increased occupation of D1 and D2 dopamine receptors accompanies cocaine-induced behavioral sensitization. Cocaine 65-72 dopamine receptor D2 Rattus norvegicus 24-52 7855736-0 1994 Amphetamine- and cocaine-induced fos in the rat striatum depends on D2 dopamine receptor activation. Cocaine 17-24 dopamine receptor D2 Rattus norvegicus 68-88 8058056-0 1994 Intranigral administration of D2 dopamine receptor antisense oligodeoxynucleotides establishes a role for nigrostriatal D2 autoreceptors in the motor actions of cocaine. Cocaine 161-168 dopamine receptor D2 Rattus norvegicus 30-50 8205476-2 1994 injections, the occupation of D1 and D2 dopamine receptors by dopamine, measured as protection from N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) receptor denaturation, was increased by about 100% compared to animals receiving cocaine in a treatment regimen that produced behavioural tolerance. Cocaine 235-242 dopamine receptor D2 Rattus norvegicus 30-58 11224206-0 1993 The role of D1 and D2 dopamine receptors in the acquisition and expression of cocaine-induced conditioned increases in locomotor behavior. Cocaine 78-85 dopamine receptor D2 Rattus norvegicus 12-40 7838914-9 1994 These results suggest that behavioral sensitization to cocaine may develop through either D1 or D2 dopamine receptor stimulation or possibly through stimulation of some non-dopaminergic receptor. Cocaine 55-62 dopamine receptor D2 Rattus norvegicus 96-116 8097045-9 1993 These data suggest that both D1 and D2 dopamine receptors contribute to the discriminative stimulus effects of cocaine. Cocaine 111-118 dopamine receptor D2 Rattus norvegicus 29-57 2150444-2 1990 This study found an increase in D2 dopamine receptor binding, associated with an increase in ligand affinity, in striatum of weanling rats exposed prenatally to cocaine. Cocaine 161-168 dopamine receptor D2 Rattus norvegicus 32-52 2149299-0 1990 Effects of repeated injections of cocaine on D1 and D2 dopamine receptors in rat brain. Cocaine 34-41 dopamine receptor D2 Rattus norvegicus 45-73 29454035-2 2018 Here, we compared the effect of decreased mRNA level of Drd2 in each region on cocaine self-administration in a dose-response function. Cocaine 79-86 dopamine receptor D2 Rattus norvegicus 56-60 2647210-7 1989 ; a D2 dopamine receptor antagonist) each attenuate cocaine analgesia in both tests at doses that alone do not affect performance in either test. Cocaine 52-59 dopamine receptor D2 Rattus norvegicus 4-24 30952156-8 2019 Eight-day withdrawal from high cocaine escalation was associated, respectively, with increased and decreased dopamine receptor D2 (DRD2) and serotonin receptor 2C (HTR2C) expression in the ventral striatum compared with controls. Cocaine 31-38 dopamine receptor D2 Rattus norvegicus 109-129 30952156-8 2019 Eight-day withdrawal from high cocaine escalation was associated, respectively, with increased and decreased dopamine receptor D2 (DRD2) and serotonin receptor 2C (HTR2C) expression in the ventral striatum compared with controls. Cocaine 31-38 dopamine receptor D2 Rattus norvegicus 131-135 29454035-6 2018 Compared to scrambled shRNA treated rats, Drd2 knockdown in the VTA increased cocaine self-administration at all tested doses (0.02-0.56 mg/kg/infusion) producing an upward shift (both the ascending and descending limb) in the dose-response curve of cocaine self-administration. Cocaine 78-85 dopamine receptor D2 Rattus norvegicus 42-46 29454035-6 2018 Compared to scrambled shRNA treated rats, Drd2 knockdown in the VTA increased cocaine self-administration at all tested doses (0.02-0.56 mg/kg/infusion) producing an upward shift (both the ascending and descending limb) in the dose-response curve of cocaine self-administration. Cocaine 250-257 dopamine receptor D2 Rattus norvegicus 42-46 25596492-0 2015 Cocaine-seeking is associated with PKC-dependent reduction of excitatory signaling in accumbens shell D2 dopamine receptor-expressing neurons. Cocaine 0-7 dopamine receptor D2 Rattus norvegicus 102-122 24223783-4 2013 Therefore, we exploited individual differences in behavioral responses to D2 dopamine receptor stimulation to test its relationship with cocaine-mediated behaviors. Cocaine 137-144 dopamine receptor D2 Rattus norvegicus 74-94 24223783-0 2013 Initial d2 dopamine receptor sensitivity predicts cocaine sensitivity and reward in rats. Cocaine 50-57 dopamine receptor D2 Rattus norvegicus 8-28 24223783-2 2013 Expression of the D2 dopamine receptor subtype has been implicated as both a predisposing factor and consequence of chronic cocaine use. Cocaine 124-131 dopamine receptor D2 Rattus norvegicus 18-38 24223783-11 2013 These findings suggest that individual differences in D2 dopamine receptor sensitivity may be predictive of cocaine sensitivity and reward. Cocaine 108-115 dopamine receptor D2 Rattus norvegicus 54-74