PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27553823-0 2016 Sex differences in behavioral and PKA cascade responses to repeated cocaine administration. Cocaine 68-75 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 34-37 27553823-7 2016 In addition, cocaine induced a sexual dimorphic pattern in the progression of neuronal adaptations on the PKA cascade signaling in region (NAc vs. CPu) and time (days of cocaine administration)-dependent manners. Cocaine 13-20 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 106-109 27553823-7 2016 In addition, cocaine induced a sexual dimorphic pattern in the progression of neuronal adaptations on the PKA cascade signaling in region (NAc vs. CPu) and time (days of cocaine administration)-dependent manners. Cocaine 170-177 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 106-109 27553823-8 2016 In general, more PKA signaling cascade changes were found in the NAc of males on day 5 and in the CPu of females with repeated cocaine injection. Cocaine 127-134 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 17-20 27553823-10 2016 Our studies suggest that repeated cocaine administration induced different patterns of behavioral and molecular responses in the PKA cascade in male and female rats. Cocaine 34-41 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 129-132 26740398-3 2016 Moreover, in the same study we showed similar induction of adenylyl cyclase and PKA activity in nucleus accumbens (NAc) in response to chronic administration of cocaine, but not of several non-abused psychoactive drugs. Cocaine 161-168 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 80-83 26740398-7 2016 Specifically, opiates in several CNS regions including NAc, and cocaine more selectively in NAc, induce expression of certain adenylyl cyclase isoforms and PKA subunits via the transcription factor, CREB, and these transcriptional adaptations serve a homeostatic function to oppose drug action. Cocaine 64-71 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 156-159 19457111-0 2009 Signaling pathway adaptations and novel protein kinase A substrates related to behavioral sensitization to cocaine. Cocaine 107-114 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 40-56 23873418-0 2014 Involvement of amygdalar protein kinase A, but not calcium/calmodulin-dependent protein kinase II, in the reconsolidation of cocaine-related contextual memories in rats. Cocaine 125-132 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 25-41 23873418-9 2014 CONCLUSIONS: PKA, but not CaMKII, activation in the BLA is critical for cocaine memory re-stabilization processes that facilitate subsequent drug context-induced instrumental cocaine-seeking behavior. Cocaine 72-79 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 13-16 19457111-9 2009 Using proteomics, novel sensitization-related PKA substrates were identified, including two structural proteins (CRMP-2 and alpha-tubulin) that we speculate may link PKA signaling to previously reported dendritic remodeling in NAc neurons of cocaine-sensitized rats. Cocaine 242-249 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 46-49 19457111-9 2009 Using proteomics, novel sensitization-related PKA substrates were identified, including two structural proteins (CRMP-2 and alpha-tubulin) that we speculate may link PKA signaling to previously reported dendritic remodeling in NAc neurons of cocaine-sensitized rats. Cocaine 242-249 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 166-169 15659224-5 2005 Only protein kinase A activity levels were altered by cocaine treatment, but this alteration persisted for only 7 days, whereas a sensitized locomotor response was still evident at 21 days. Cocaine 54-61 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 5-21 14696012-0 2004 Changes in PKA activity and Gs alpha and Golf alpha levels after amphetamine- and cocaine-induced behavioral sensitization. Cocaine 82-89 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 11-14 14696012-2 2004 Studies relevant to this hypothesis have provided conflicting evidence, however, because repeated cocaine and amphetamine treatment has been alternately reported to either increase or decrease protein kinase A (PKA) activity in the nucleus accumbens and dorsal striatum. Cocaine 98-105 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 193-209 14696012-2 2004 Studies relevant to this hypothesis have provided conflicting evidence, however, because repeated cocaine and amphetamine treatment has been alternately reported to either increase or decrease protein kinase A (PKA) activity in the nucleus accumbens and dorsal striatum. Cocaine 98-105 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 211-214 14696012-4 2004 Results showed that seven consecutive daily injections of amphetamine or cocaine produced locomotor sensitization and caused a reduction in accumbal PKA activity. Cocaine 73-80 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 149-152 14696012-7 2004 Because repeated amphetamine and cocaine treatment both induced behavioral sensitization and decreased accumbal PKA activity, it appears that psychostimulant-induced increases in PKA activity are not necessary for the ultimate expression of behavioral sensitization. Cocaine 33-40 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 112-115 9439825-0 1997 Protein kinases A and C are involved in the mechanisms underlying consolidation of cocaine place conditioning. Cocaine 83-90 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 0-23