PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27375565-9	2016	Importantly, our results show that inhibition of p38 MAPK/MSK1 signaling by specific pharmacological inhibitors abrogated the positive effect of cocaine on HIV-1 transcription.	Cocaine	145-152	ribosomal protein S6 kinase A5	Homo sapiens	58-62	
19183268-6	2009	In response to cocaine, MSK1 controls an early phase of histone H3 phosphorylation at the c-fos promoter in striatal neurons.	Cocaine	15-22	ribosomal protein S6 kinase A5	Homo sapiens	24-28	
19183268-8	2009	H3 phosphorylation by MSK1 is critically involved in c-fos transcription, and cocaine-induced locomotor sensitization.	Cocaine	78-85	ribosomal protein S6 kinase A5	Homo sapiens	22-26	
27375565-10	2016	These results validate the functional link between cocaine and p38 MAPK/MSK1 pathways.	Cocaine	51-58	ribosomal protein S6 kinase A5	Homo sapiens	72-76	
27375565-11	2016	Together, our results demonstrate for the first time that the p38 MAPK/MSK1 signaling pathway plays a critical role in the cocaine-induced potentiating effects on HIV-1 infection, thus providing new insights into the interplay between cocaine abuse and HIV-1 neuro-pathogenesis.	Cocaine	123-130	ribosomal protein S6 kinase A5	Homo sapiens	71-75	
25980739-0	2015	Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-kappaB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR.	Cocaine	0-7	ribosomal protein S6 kinase A5	Homo sapiens	105-109	
25980739-3	2015	We demonstrate that cocaine treatment promotes HIV-1 gene expression by activating both nuclear factor-kappa B (NF-kB) and mitogen- and stress-activated kinase 1 (MSK1).	Cocaine	20-27	ribosomal protein S6 kinase A5	Homo sapiens	163-167