PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27375565-9 2016 Importantly, our results show that inhibition of p38 MAPK/MSK1 signaling by specific pharmacological inhibitors abrogated the positive effect of cocaine on HIV-1 transcription. Cocaine 145-152 ribosomal protein S6 kinase A5 Homo sapiens 58-62 27375565-10 2016 These results validate the functional link between cocaine and p38 MAPK/MSK1 pathways. Cocaine 51-58 ribosomal protein S6 kinase A5 Homo sapiens 72-76 27375565-11 2016 Together, our results demonstrate for the first time that the p38 MAPK/MSK1 signaling pathway plays a critical role in the cocaine-induced potentiating effects on HIV-1 infection, thus providing new insights into the interplay between cocaine abuse and HIV-1 neuro-pathogenesis. Cocaine 123-130 ribosomal protein S6 kinase A5 Homo sapiens 71-75 25980739-0 2015 Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-kappaB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR. Cocaine 0-7 ribosomal protein S6 kinase A5 Homo sapiens 105-109 25980739-3 2015 We demonstrate that cocaine treatment promotes HIV-1 gene expression by activating both nuclear factor-kappa B (NF-kB) and mitogen- and stress-activated kinase 1 (MSK1). Cocaine 20-27 ribosomal protein S6 kinase A5 Homo sapiens 163-167 19183268-6 2009 In response to cocaine, MSK1 controls an early phase of histone H3 phosphorylation at the c-fos promoter in striatal neurons. Cocaine 15-22 ribosomal protein S6 kinase A5 Homo sapiens 24-28 19183268-8 2009 H3 phosphorylation by MSK1 is critically involved in c-fos transcription, and cocaine-induced locomotor sensitization. Cocaine 78-85 ribosomal protein S6 kinase A5 Homo sapiens 22-26