PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16357950-3 2005 The dopamine D2 receptor agonist bromocriptine (1.25-20 mg/kg) and the dopamine D3 receptor agonist R(+)-7-OH-DPAT (0.0001-0.3 mg/kg) produced cocaine (10 mg/kg)-like discriminative stimulus effects. Cocaine 143-150 dopamine receptor D3 Rattus norvegicus 71-91 20142301-1 2011 Our previous studies have shown that the selective dopamine D(3) receptor antagonists SB-277011A or NGB 2904 significantly attenuate cocaine self-administration under a progressive-ratio reinforcement schedule and cocaine-, methamphetamine- or nicotine-enhanced brain stimulation reward. Cocaine 133-140 dopamine receptor D3 Rattus norvegicus 51-73 20142301-1 2011 Our previous studies have shown that the selective dopamine D(3) receptor antagonists SB-277011A or NGB 2904 significantly attenuate cocaine self-administration under a progressive-ratio reinforcement schedule and cocaine-, methamphetamine- or nicotine-enhanced brain stimulation reward. Cocaine 214-221 dopamine receptor D3 Rattus norvegicus 51-73 18298256-2 2008 It is demonstrated that responding by rats on the active lever for cocaine under a 2nd-order schedule of reinforcement, under which responding is maintained by response-contingent cocaine-paired conditioned reinforcers, is markedly attenuated by infusion of the dopamine D3 receptor antagonist SB-277011-A into the amygdala (2 and 4 microg/0.3 microl). Cocaine 67-74 dopamine receptor D3 Rattus norvegicus 262-282 18298256-2 2008 It is demonstrated that responding by rats on the active lever for cocaine under a 2nd-order schedule of reinforcement, under which responding is maintained by response-contingent cocaine-paired conditioned reinforcers, is markedly attenuated by infusion of the dopamine D3 receptor antagonist SB-277011-A into the amygdala (2 and 4 microg/0.3 microl). Cocaine 180-187 dopamine receptor D3 Rattus norvegicus 262-282 17303116-2 2007 Studies have shown that the selective dopamine D3 receptor antagonist SB-277011A reduces a variety of dependence-related behavioral effects of cocaine, alcohol and heroin. Cocaine 143-150 dopamine receptor D3 Rattus norvegicus 38-58 19136017-0 2009 The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in rats. Cocaine 65-72 dopamine receptor D3 Rattus norvegicus 17-37 16205781-0 2006 The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine"s rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Cocaine 60-67 dopamine receptor D3 Rattus norvegicus 10-30 16205781-1 2006 Accumulating evidence indicates that dopamine (DA) D(3) receptor antagonists appear highly promising in attenuating cocaine reward and relapse in preclinical models of addiction. Cocaine 116-123 dopamine receptor D3 Rattus norvegicus 37-64 16357950-4 2005 Both the dopamine D3 receptor antagonist GR103691 (1 mg/kg) and the dopamine D4 receptor antagonist L745870 (1 mg/kg) partially antagonized the discriminative stimulus effects of cocaine (10 mg/kg) and the cocaine (10 mg/kg)-like discriminative stimulus effects of R(+)-7-OH-DPAT (0.3 mg/kg). Cocaine 179-186 dopamine receptor D3 Rattus norvegicus 9-29 32851643-2 2020 Chronic cocaine use is associated with upregulated dopamine D3 receptor (D3 R) expression in the brain, and therefore, most D3 R-based medication development has focused on D3 R antagonists. Cocaine 8-15 dopamine receptor D3 Rattus norvegicus 51-71 16026480-0 2005 Selective dopamine D3 receptor antagonism by SB-277011A attenuates cocaine reinforcement as assessed by progressive-ratio and variable-cost-variable-payoff fixed-ratio cocaine self-administration in rats. Cocaine 67-74 dopamine receptor D3 Rattus norvegicus 10-30 16026480-0 2005 Selective dopamine D3 receptor antagonism by SB-277011A attenuates cocaine reinforcement as assessed by progressive-ratio and variable-cost-variable-payoff fixed-ratio cocaine self-administration in rats. Cocaine 168-175 dopamine receptor D3 Rattus norvegicus 10-30 16026480-1 2005 In rats, acute administration of SB-277011A, a highly selective dopamine (DA) D(3) receptor antagonist, blocks cocaine-enhanced brain stimulation reward, cocaine-seeking behaviour and reinstatement of cocaine-seeking behaviour. Cocaine 111-118 dopamine receptor D3 Rattus norvegicus 64-91 16026480-1 2005 In rats, acute administration of SB-277011A, a highly selective dopamine (DA) D(3) receptor antagonist, blocks cocaine-enhanced brain stimulation reward, cocaine-seeking behaviour and reinstatement of cocaine-seeking behaviour. Cocaine 154-161 dopamine receptor D3 Rattus norvegicus 64-91 15100700-0 2004 Increases in dopamine D3 receptor binding in rats receiving a cocaine challenge at various time points after cocaine self-administration: implications for cocaine-seeking behavior. Cocaine 62-69 dopamine receptor D3 Rattus norvegicus 13-33 15100700-0 2004 Increases in dopamine D3 receptor binding in rats receiving a cocaine challenge at various time points after cocaine self-administration: implications for cocaine-seeking behavior. Cocaine 109-116 dopamine receptor D3 Rattus norvegicus 13-33 15100700-0 2004 Increases in dopamine D3 receptor binding in rats receiving a cocaine challenge at various time points after cocaine self-administration: implications for cocaine-seeking behavior. Cocaine 109-116 dopamine receptor D3 Rattus norvegicus 13-33 15100700-2 2004 The present study examined the time course of changes in dopamine D3 receptor binding after terminating a cocaine self-administration regimen. Cocaine 106-113 dopamine receptor D3 Rattus norvegicus 57-77 12610655-6 2003 Such an approach has been validated for cocaine in animals, by using the dopamine D(3) receptor-selective partial agonist BP 897, which inhibits cocaine cue-induced drug-seeking behavior. Cocaine 40-47 dopamine receptor D3 Rattus norvegicus 73-95 12610655-6 2003 Such an approach has been validated for cocaine in animals, by using the dopamine D(3) receptor-selective partial agonist BP 897, which inhibits cocaine cue-induced drug-seeking behavior. Cocaine 145-152 dopamine receptor D3 Rattus norvegicus 73-95 8807743-1 1996 The dopamine D3 receptor has been implicated as a possible mediator in the reinforcement or abuse of psychostimulants such as cocaine. Cocaine 126-133 dopamine receptor D3 Rattus norvegicus 4-24 15671872-3 2005 Acute cocaine produced a transient increase in BDNF mRNA in the prefrontal cortex, associated with a long-lasting increase in drd3 mRNA, and a delayed and long-lasting increase in Drd3 protein in the nucleus accumbens. Cocaine 6-13 dopamine receptor D3 Rattus norvegicus 126-130 15671872-3 2005 Acute cocaine produced a transient increase in BDNF mRNA in the prefrontal cortex, associated with a long-lasting increase in drd3 mRNA, and a delayed and long-lasting increase in Drd3 protein in the nucleus accumbens. Cocaine 6-13 dopamine receptor D3 Rattus norvegicus 180-184 12798330-1 2003 The dopamine D(3) receptor subtype has been targeted as a potential neurochemical modulator of the behavioral actions of psychomotor stimulants, such as cocaine. Cocaine 153-160 dopamine receptor D3 Rattus norvegicus 4-26 12700684-0 2003 Cocaine-seeking behavior in response to drug-associated stimuli in rats: involvement of D3 and D2 dopamine receptors. Cocaine 0-7 dopamine receptor D3 Rattus norvegicus 88-116 11985331-0 2001 Does combined treatment with novel antidepressants and a dopamine D3 receptor agonist reproduce cocaine discrimination in rats? Cocaine 96-103 dopamine receptor D3 Rattus norvegicus 57-77 32708461-1 2020 The dopamine D3 receptor is a prime target for developing treatments for cocaine use disorders (CUDs). Cocaine 73-80 dopamine receptor D3 Rattus norvegicus 4-24 31562201-3 2019 Dopamine D3 receptor (D3R) antagonists have shown promise in attenuating opioid and cocaine reward and mitigating relapse in preclinical models. Cocaine 84-91 dopamine receptor D3 Rattus norvegicus 0-20 25851636-0 2015 The selective dopamine D3 receptor antagonist SB-277011A attenuates drug- or food-deprivation reactivation of expression of conditioned place preference for cocaine in male Sprague-Dawley rats. Cocaine 157-164 dopamine receptor D3 Rattus norvegicus 14-34 29313985-2 2018 Our previous work first confirmed that the inhibitory mechanism of the CART peptide on cocaine-induced locomotor activity is related to a reduction in cocaine-enhanced phosphorylated Ca2+ /calmodulin-dependent protein kinaseIIalpha (pCaMKIIalpha) and the enhancement of cocaine-induced D3R function. Cocaine 87-94 dopamine receptor D3 Rattus norvegicus 286-289 29313985-2 2018 Our previous work first confirmed that the inhibitory mechanism of the CART peptide on cocaine-induced locomotor activity is related to a reduction in cocaine-enhanced phosphorylated Ca2+ /calmodulin-dependent protein kinaseIIalpha (pCaMKIIalpha) and the enhancement of cocaine-induced D3R function. Cocaine 151-158 dopamine receptor D3 Rattus norvegicus 286-289 29313985-2 2018 Our previous work first confirmed that the inhibitory mechanism of the CART peptide on cocaine-induced locomotor activity is related to a reduction in cocaine-enhanced phosphorylated Ca2+ /calmodulin-dependent protein kinaseIIalpha (pCaMKIIalpha) and the enhancement of cocaine-induced D3R function. Cocaine 151-158 dopamine receptor D3 Rattus norvegicus 286-289 29313985-6 2018 CART peptide decreased the cocaine-enhanced phosphorylated cAMP response element binding protein (pCREB) expression via inhibition of the pCaMKIIalpha-D3R interaction, which may account for the prolonged locomotor sensitization induced by repeated cocaine treatment in lentivirus-transfected CaMKIIalpha-over-expressing cells. Cocaine 27-34 dopamine receptor D3 Rattus norvegicus 151-154 27582181-0 2016 Dopamine D1 and D3 receptor interactions in cocaine reward and seeking in rats. Cocaine 44-51 dopamine receptor D3 Rattus norvegicus 0-27 26710978-0 2016 The dopamine D3 receptor antagonist, SR 21502, facilitates extinction of cocaine conditioned place preference. Cocaine 73-80 dopamine receptor D3 Rattus norvegicus 4-24 26138517-0 2015 The selective dopamine D3 receptor antagonist SB-277011A significantly accelerates extinction to environmental cues associated with cocaine-induced place preference in male Sprague-Dawley rats. Cocaine 132-139 dopamine receptor D3 Rattus norvegicus 14-34 25261038-2 2014 We have previously reported a novel dopamine D3 receptor antagonist YQA14 with better pharmacokinetic behaviours and pharmacotherapeutic efficacy than other tested compounds in attenuating the reward and relapse of cocaine. Cocaine 215-222 dopamine receptor D3 Rattus norvegicus 36-56 24704326-0 2014 The novel dopamine D3 receptor antagonist, SR 21502, reduces cocaine conditioned place preference in rats. Cocaine 61-68 dopamine receptor D3 Rattus norvegicus 10-30 21507153-0 2012 YQA14: a novel dopamine D3 receptor antagonist that inhibits cocaine self-administration in rats and mice, but not in D3 receptor-knockout mice. Cocaine 61-68 dopamine receptor D3 Rattus norvegicus 15-35