PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28935766-5 2017 To answer these questions, we investigated the contribution of 5-HT2B receptors to cocaine-dependent behavioral responses. Cocaine 83-90 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 63-69 28935766-6 2017 Male mice permanently lacking 5-HT2B receptors, even restricted to dopamine neurons, developed heightened cocaine-induced locomotor responses. Cocaine 106-113 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 30-36 28935766-10 2017 These data identify the 5-HT2B receptor as a pharmacological intermediate and provide mechanistic insight into attenuated dopamine tone following exposure to drugs of abuse.SIGNIFICANCE STATEMENT Here we report that mice lacking 5-HT2B receptors totally or exclusively in dopamine neurons exhibit heightened cocaine-induced locomotor responses. Cocaine 308-315 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 24-30 28935766-10 2017 These data identify the 5-HT2B receptor as a pharmacological intermediate and provide mechanistic insight into attenuated dopamine tone following exposure to drugs of abuse.SIGNIFICANCE STATEMENT Here we report that mice lacking 5-HT2B receptors totally or exclusively in dopamine neurons exhibit heightened cocaine-induced locomotor responses. Cocaine 308-315 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 229-235 28935766-14 2017 These data support the idea that the chronic 5-HT2B-receptor inhibition makes mice behave like animals already exposed to cocaine with higher cocaine-induced locomotion associated with changes in dopamine neuron reactivity. Cocaine 122-129 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 45-51 28935766-14 2017 These data support the idea that the chronic 5-HT2B-receptor inhibition makes mice behave like animals already exposed to cocaine with higher cocaine-induced locomotion associated with changes in dopamine neuron reactivity. Cocaine 142-149 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 45-51