PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31182637-6 2019 This effect in RasGRF2 mice is likely mediated by the Ras-ERK signaling pathway, as pERK1/2 upregulation following cocaine SA was absent in RasGRF2 KO mice. Cocaine 115-122 RAS protein-specific guanine nucleotide-releasing factor 2 Mus musculus 15-22 31182637-11 2019 Here we show, using a combination of molecular, pharmacological, and lentiviral techniques, that the guanine nucleotide exchange factor RasGRF2 mediates cocaine self-administration via an ERK-dependent mechanism, whereas RasGRF1 has no effect on responding for cocaine. Cocaine 153-160 RAS protein-specific guanine nucleotide-releasing factor 2 Mus musculus 136-143 31182637-11 2019 Here we show, using a combination of molecular, pharmacological, and lentiviral techniques, that the guanine nucleotide exchange factor RasGRF2 mediates cocaine self-administration via an ERK-dependent mechanism, whereas RasGRF1 has no effect on responding for cocaine. Cocaine 261-268 RAS protein-specific guanine nucleotide-releasing factor 2 Mus musculus 136-143