PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10564376-1 1999 Intravenous cocaine self-administration in mice was studied to find correlates of the acquisition of cocaine-oriented operant behaviour in the expression of nerve growth factor-induced clone A (NGFI-A), c-fos and secretogranin II mRNAs. Cocaine 12-19 early growth response 1 Mus musculus 157-192 16672671-0 2006 Plasticity-associated gene Krox24/Zif268 is required for long-lasting behavioral effects of cocaine. Cocaine 92-99 early growth response 1 Mus musculus 27-33 16672671-0 2006 Plasticity-associated gene Krox24/Zif268 is required for long-lasting behavioral effects of cocaine. Cocaine 92-99 early growth response 1 Mus musculus 34-40 16672671-3 2006 We examined the role of Zif268, an immediate-early gene induced by drugs of abuse under the control of ERK, in behavioral responses to cocaine using knock-in mutant mice in which Zif268 was replaced by LacZ. Cocaine 135-142 early growth response 1 Mus musculus 24-30 16672671-5 2006 In contrast, locomotor sensitization to single or repeated cocaine injections was dramatically diminished in both heterozygous and homozygous Zif268 mutant mice. Cocaine 59-66 early growth response 1 Mus musculus 142-148 16672671-6 2006 Conditioned place preference in response to cocaine was prevented in Zif268-deficient mice. Cocaine 44-51 early growth response 1 Mus musculus 69-75 16672671-8 2006 Our results provide direct genetic evidence for the requirement of Zif268 for long-lasting association of environmental context with specific behavioral responses after short exposures to cocaine. Cocaine 188-195 early growth response 1 Mus musculus 67-73 16115217-3 2005 The patterns of cocaine-induced c-Fos, JunB and Zif268 protein expression were investigated, using an immunohistochemical approach, within distinct nuclei of the amygdala, either in the presence or absence of a selective inhibitor of the ERK pathway, SL327. Cocaine 16-23 early growth response 1 Mus musculus 48-54 10971643-7 2000 A low dose of cocaine, by itself essentially ineffective, produced an increase in c-fos and NGFI-A mRNA in the cerebral cortex in mice that had been drinking caffeine. Cocaine 14-21 early growth response 1 Mus musculus 92-98 10683479-7 2000 A single cocaine injection (2 mg kg(-)(1)) increased NGFI-A mRNA and decreased secretogranin II mRNA in the caudate putamen in C57 mice. Cocaine 9-16 early growth response 1 Mus musculus 53-59 10971643-9 2000 Cocaine and caffeine also synergistically increased NGFI-A expression in caudate-putamen. Cocaine 0-7 early growth response 1 Mus musculus 52-58 10564376-1 1999 Intravenous cocaine self-administration in mice was studied to find correlates of the acquisition of cocaine-oriented operant behaviour in the expression of nerve growth factor-induced clone A (NGFI-A), c-fos and secretogranin II mRNAs. Cocaine 12-19 early growth response 1 Mus musculus 194-200 10564376-1 1999 Intravenous cocaine self-administration in mice was studied to find correlates of the acquisition of cocaine-oriented operant behaviour in the expression of nerve growth factor-induced clone A (NGFI-A), c-fos and secretogranin II mRNAs. Cocaine 101-108 early growth response 1 Mus musculus 157-192 10564376-1 1999 Intravenous cocaine self-administration in mice was studied to find correlates of the acquisition of cocaine-oriented operant behaviour in the expression of nerve growth factor-induced clone A (NGFI-A), c-fos and secretogranin II mRNAs. Cocaine 101-108 early growth response 1 Mus musculus 194-200 10564376-7 1999 Non-contingent cocaine infusions increased NGFI-A mRNA expression in the core of nucleus accumbens, medial caudate putamen and frontal cortex, whereas self-administration eliminated these effects. Cocaine 15-22 early growth response 1 Mus musculus 43-49 33268547-0 2021 Cocaine-dependent acquisition of locomotor sensitization and conditioned place preference requires D1 dopaminergic signaling through a cyclic AMP, NCS-Rapgef2, ERK and Egr-1/Zif268 pathway. Cocaine 0-7 early growth response 1 Mus musculus 168-173 33226686-0 2021 Long-lasting tagging of neurons activated by seizures or cocaine administration in Egr1-CreERT2 transgenic mice. Cocaine 57-64 early growth response 1 Mus musculus 83-87 33268547-4 2021 NCS-Rapgef2 gene deletion in the nucleus accumbens (NAc) in adult mice, using AAV-mediated expression of cre recombinase, eliminated cocaine-induced ERK phosphorylation and Egr-1/Zif268 upregulation in D1-MSNs and cocaine-induced behaviors including locomotor sensitization and conditioned place preference (CPP). Cocaine 133-140 early growth response 1 Mus musculus 173-178 33268547-4 2021 NCS-Rapgef2 gene deletion in the nucleus accumbens (NAc) in adult mice, using AAV-mediated expression of cre recombinase, eliminated cocaine-induced ERK phosphorylation and Egr-1/Zif268 upregulation in D1-MSNs and cocaine-induced behaviors including locomotor sensitization and conditioned place preference (CPP). Cocaine 133-140 early growth response 1 Mus musculus 179-185 33268547-10 2021 NCS-Rapgef2 in the nucleus accumbens is required for activation of ERK and Egr-1/Zif268 in D1 dopaminoceptive neurons after acute cocaine administration, and subsequent enhanced locomotor response and drug seeking behavior after repeated cocaine administration. Cocaine 130-137 early growth response 1 Mus musculus 75-80 33268547-10 2021 NCS-Rapgef2 in the nucleus accumbens is required for activation of ERK and Egr-1/Zif268 in D1 dopaminoceptive neurons after acute cocaine administration, and subsequent enhanced locomotor response and drug seeking behavior after repeated cocaine administration. Cocaine 130-137 early growth response 1 Mus musculus 81-87 33268547-10 2021 NCS-Rapgef2 in the nucleus accumbens is required for activation of ERK and Egr-1/Zif268 in D1 dopaminoceptive neurons after acute cocaine administration, and subsequent enhanced locomotor response and drug seeking behavior after repeated cocaine administration. Cocaine 238-245 early growth response 1 Mus musculus 75-80 33268547-10 2021 NCS-Rapgef2 in the nucleus accumbens is required for activation of ERK and Egr-1/Zif268 in D1 dopaminoceptive neurons after acute cocaine administration, and subsequent enhanced locomotor response and drug seeking behavior after repeated cocaine administration. Cocaine 238-245 early growth response 1 Mus musculus 81-87 33268547-0 2021 Cocaine-dependent acquisition of locomotor sensitization and conditioned place preference requires D1 dopaminergic signaling through a cyclic AMP, NCS-Rapgef2, ERK and Egr-1/Zif268 pathway. Cocaine 0-7 early growth response 1 Mus musculus 174-180 25332000-5 2014 This study was designed to reveal neuronal c-Fos, Zif268 expression pattern in 10 brain regions following cocaine context-associated reward memory retrieval in mice, combining animal behavioral study and immunofluorescence method. Cocaine 106-113 early growth response 1 Mus musculus 50-56 31043484-8 2019 Further motif recognition analysis of the ChIP-seq data showed that cocaine-associated differential H3.3 accumulation correlated with the presence of several transcription factor binding motifs, including RBPJ1, EGR1, and SOX4, suggesting that these are potentially important regulators of molecular cascades associated with cocaine-induced neuronal plasticity. Cocaine 68-75 early growth response 1 Mus musculus 212-216 31043484-8 2019 Further motif recognition analysis of the ChIP-seq data showed that cocaine-associated differential H3.3 accumulation correlated with the presence of several transcription factor binding motifs, including RBPJ1, EGR1, and SOX4, suggesting that these are potentially important regulators of molecular cascades associated with cocaine-induced neuronal plasticity. Cocaine 325-332 early growth response 1 Mus musculus 212-216 27265728-6 2017 Three weeks after repeated tDCS, we investigated the induction of a gene expression marker (Zif268) by cocaine (25 mg/kg) in 26 cortical and 23 striatal regions using in situ hybridization histochemistry. Cocaine 103-110 early growth response 1 Mus musculus 92-98 27265728-8 2017 tDCS pretreatment increased basal expression and attenuated cocaine (25 mg/kg)-induced expression of Zif268 in specific corticostriatal circuits. Cocaine 60-67 early growth response 1 Mus musculus 101-107 26221832-6 2015 As the therapeutically most promising finding, only four 15 min episodes of dyadic social interaction were able to inhibit both the subsequent reacquisition/re-expression of preference for cocaine and the neural activation associated with this behavior, that is, an increase in the expression of the immediate early gene Early Growth Response protein 1 (EGR1, Zif268) in the nucleus accumbens, basolateral and central amygdala, and the ventral tegmental area. Cocaine 189-196 early growth response 1 Mus musculus 321-352 26221832-6 2015 As the therapeutically most promising finding, only four 15 min episodes of dyadic social interaction were able to inhibit both the subsequent reacquisition/re-expression of preference for cocaine and the neural activation associated with this behavior, that is, an increase in the expression of the immediate early gene Early Growth Response protein 1 (EGR1, Zif268) in the nucleus accumbens, basolateral and central amygdala, and the ventral tegmental area. Cocaine 189-196 early growth response 1 Mus musculus 354-358 26221832-6 2015 As the therapeutically most promising finding, only four 15 min episodes of dyadic social interaction were able to inhibit both the subsequent reacquisition/re-expression of preference for cocaine and the neural activation associated with this behavior, that is, an increase in the expression of the immediate early gene Early Growth Response protein 1 (EGR1, Zif268) in the nucleus accumbens, basolateral and central amygdala, and the ventral tegmental area. Cocaine 189-196 early growth response 1 Mus musculus 360-366 25592253-1 2015 Both cocaine and social interaction place preference conditioning lead to increased neuronal expression of the immediate early gene EGR1 in the nucleus accumbens, a central region of the reward pathway, suggesting that both drug and natural rewards may be processed in similar brain regions. Cocaine 5-12 early growth response 1 Mus musculus 132-136 25566008-10 2014 The cocaine CPP-induced EGR1 expression was only observed in D1- and D2-medium spiny neurons, whereas other types of neurons or glial cells were not involved. Cocaine 4-11 early growth response 1 Mus musculus 24-28 25332000-9 2014 The results showed that: Neuronal c-Fos, Zif268 protein expression levels in nucleus accumbens (NAc) core both were elevated in Cocaine retrieval group compared with those in Saline retrieval (Control) group during cocaine context-associated reward memory retrieval. Cocaine 128-135 early growth response 1 Mus musculus 41-47 25332000-10 2014 Zif268 protein expression level in basolateral amygdala (BLA) was also elevated in Cocaine retrieval group compared with that in control mice. Cocaine 83-90 early growth response 1 Mus musculus 0-6 21976515-9 2011 Consequently, TDE altered cocaine-induced regulation of genes bearing SRE site(s) in their promoters, including c-fos, zif268, DeltaFosB, and arc/arg3.1 (activity-regulated cytoskeleton-associated protein). Cocaine 26-33 early growth response 1 Mus musculus 119-125 21318636-0 2011 Regulation of the immediate-early genes arc and zif268 in a mouse operant model of cocaine seeking reinstatement. Cocaine 83-90 early growth response 1 Mus musculus 48-54 18463628-6 2009 On the other hand, they were associated with reduced cocaine-induced expression of the immediate early gene zif-268 in the nucleus accumbens (shell and core) of EE mice. Cocaine 53-60 early growth response 1 Mus musculus 108-115 19005643-2 2009 We have recently found that the behavioral effects of cocaine as well as its ability to increase expression of zif-268 are reduced in mice reared in enriched environments (EE). Cocaine 54-61 early growth response 1 Mus musculus 111-118 19181855-4 2009 Compared with WT mice, tPA-/- mice injected with cocaine displayed attenuated phosphorylation of ERK, cAMP response element binding protein (CREB), and dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and blunted induction of immediate early genes (IEGs) c-Fos, Egr-1, and Homer 1a in the amygdala and the nucleus accumbens (NAc). Cocaine 49-56 early growth response 1 Mus musculus 274-279 18509028-8 2008 Cocaine-induced expression of c-Fos and Zif268 predominated in D1R-expressing neurons but was also observed in D2R-expressing neurons. Cocaine 0-7 early growth response 1 Mus musculus 40-46