PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30817127-5 2019 To elucidate the contribution of SERT antagonism to the actions of cocaine, we engineered a mouse model that significantly reduces cocaine potency at SERT without disrupting the expression or function of SERT in vivo. Cocaine 131-138 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 150-154 30817127-0 2019 The SERT Met172 Mouse: An Engineered Model To Elucidate the Contributions of Serotonin Signaling to Cocaine Action. Cocaine 100-107 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 4-8 30817127-4 2019 In particular, a significant body of work points to altered serotonin (5-HT) signaling as one such component, not surprising given that, relative to DAT, cocaine acts as potently to block the 5-HT transporter (SERT) as to block DAT, and thereby elevates extracellular 5-HT levels throughout the brain when reward-eliciting DA elevations occur. Cocaine 154-161 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 192-208 30817127-4 2019 In particular, a significant body of work points to altered serotonin (5-HT) signaling as one such component, not surprising given that, relative to DAT, cocaine acts as potently to block the 5-HT transporter (SERT) as to block DAT, and thereby elevates extracellular 5-HT levels throughout the brain when reward-eliciting DA elevations occur. Cocaine 154-161 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 210-214 30817127-5 2019 To elucidate the contribution of SERT antagonism to the actions of cocaine, we engineered a mouse model that significantly reduces cocaine potency at SERT without disrupting the expression or function of SERT in vivo. Cocaine 131-138 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 150-154 11320258-1 2001 Cocaine blocks uptake by neuronal plasma membrane transporters for dopamine (DAT), serotonin (SERT), and norepinephrine (NET). Cocaine 0-7 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 94-98 11320258-2 2001 Cocaine reward/reinforcement has been linked to actions at DAT or to blockade of SERT. Cocaine 0-7 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 81-85 11320258-4 2001 Conceivably, the molecular bases of cocaine reward might display sufficient redundancy that either DAT or SERT might be able to mediate cocaine reward in the other"s absence. Cocaine 136-143 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 106-110 11320258-9 2001 The serotonin dependence of cocaine reward in DAT knockout mice is thus confirmed by the elimination of cocaine place preference in DAT/SERT double knockout mice. Cocaine 28-35 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 136-140 11320258-9 2001 The serotonin dependence of cocaine reward in DAT knockout mice is thus confirmed by the elimination of cocaine place preference in DAT/SERT double knockout mice. Cocaine 104-111 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 136-140 34564712-2 2022 In male mice, we found that conditional deletion of KOR from Slc6a4 (SERT)-expressing neurons blocked stress-induced potentiation of cocaine conditioned place preference (CPP). Cocaine 133-140 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 61-67 28585320-3 2017 EXPERIMENTAL APPROACH: We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. Cocaine 65-72 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 50-54 30578419-5 2019 Given that amphetamine and methylphenidate, unlike cocaine, lack high-affinity interactions with the serotonin (5-HT) transporter (SERT), we hypothesized that the lack of cocaine-induced hyperlocomotion in DAT Val559 mice arises from SERT blockade and augmented 5-HT signaling relative to cocaine actions on wildtype animals. Cocaine 171-178 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 131-135 30578419-6 2019 Consistent with this idea, the SERT blocker fluoxetine abolished methylphenidate-induced locomotor activity in DAT Val559 mice, mimicking the effects seen with cocaine. Cocaine 160-167 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 31-35 30578419-7 2019 Additionally, a cocaine analog (RTI-113) with greater selectivity for DAT over SERT retains locomotor activation in DAT Val559 mice. Cocaine 16-23 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 79-83 30578419-8 2019 Furthermore, genetic elimination of high-affinity cocaine interactions at SERT in DAT Val559 mice, or specific inhibition of 5-HT2C receptors in these animals, restored cocaine-induced locomotion, but did not restore cocaine-induced elevations of extracellular DA. Cocaine 50-57 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 74-78 28585320-0 2017 Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine. Cocaine 99-106 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 16-32 28585320-4 2017 We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption. Cocaine 31-38 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 12-16 28585320-4 2017 We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption. Cocaine 168-175 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 12-16 28585320-10 2017 Distinct SERT-dependent gene expression networks triggered by acute and chronic cocaine administration were identified, including PrL Akt and nucleus accumbens ERK1/2 signalling. Cocaine 80-87 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 9-13 28585320-11 2017 CONCLUSION AND IMPLICATIONS: Our studies reveal distinct SERT contributions to cocaine action, reinforcing the possibility of targeting specific aspects of cocaine addiction by modulation of 5-HT signalling. Cocaine 79-86 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 57-61 28585320-11 2017 CONCLUSION AND IMPLICATIONS: Our studies reveal distinct SERT contributions to cocaine action, reinforcing the possibility of targeting specific aspects of cocaine addiction by modulation of 5-HT signalling. Cocaine 156-163 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 57-61 26019340-3 2015 In addition, SERT is a major molecular target for psychostimulants such as cocaine and amphetamines. Cocaine 75-82 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 13-17 26019340-0 2015 Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by alphaCaMKII. Cocaine 26-33 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 64-85 24950119-7 2014 Here we investigate this issue using transgenic mice expressing a SERT that exhibits normal 5-HT recognition and transport but significantly reduced cocaine potency (SERT Met172). Cocaine 149-156 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 66-70 24871545-3 2014 Cocaine acts as a blocker at the transporters for dopamine (DAT), serotonin (SERT), and norepinephrine (NET), but amphetamines are substrates that do not only block the uptake of monoamines but also induce substrate efflux by promoting reverse transport. Cocaine 0-7 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 77-81 24950119-10 2014 We conclude that SERT antagonism is required for the phase shifting of the SCN circadian clock induced by cocaine. Cocaine 106-113 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 17-21 19482066-1 2009 The behavioral effects of cocaine are affected by gene knockout (KO) of the dopamine transporter (DAT), the serotonin transporter (SERT) and the norepinephrine transporter (NET). Cocaine 26-33 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 108-129 21185387-3 2011 Cocaine acts to block the dopamine, norepinephrine, and serotonin transporters (DAT, NET, and SERT) that clear their respective neurotransmitters from the synapses, helping to terminate cognate neurotransmission. Cocaine 0-7 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 94-98 21075611-3 2011 Expression of the gene encoding cocaine-and-amphetamine-related-peptide, which colocalizes with urocortin 1, was also increased in 5-HTT TG mutants. Cocaine 32-39 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 131-136 19969013-6 2010 When compared to their respective WT controls, dopamine transporter deletion slightly attenuated cocaine-induced aversion while deletion of SERT or NET resulted in a more significant delay in the onset and strength of cocaine-induced taste aversions. Cocaine 218-225 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 140-144 19969013-7 2010 The data lead us to conclude that the action of cocaine to inhibit NET contributes most substantially to its aversive effects, with some involvement of SERT and minimal contribution of DAT. Cocaine 48-55 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 152-156 19482066-1 2009 The behavioral effects of cocaine are affected by gene knockout (KO) of the dopamine transporter (DAT), the serotonin transporter (SERT) and the norepinephrine transporter (NET). Cocaine 26-33 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 131-135 19482066-5 2009 Cocaine increased locomotor activity acutely during the initial conditioning session in SERT KO and NET KO, but not DAT KO, mice. Cocaine 0-7 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 88-92 19482066-6 2009 Surprisingly, locomotor responses in the cocaine-paired subjects diminished over the five conditioning sessions in SERT KO mice, while locomotor responses increased in DAT KO mice, despite the fact that they did not demonstrate any initial locomotor responses to cocaine. Cocaine 41-48 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 115-119 18003826-6 2007 These findings are consistent with the hypothesis that, in the absence of dopamine, cocaine-mediated SERT blockade activates dopamine neurons, which then release some other neurotransmitter that contributes to cocaine reward in DD mice. Cocaine 84-91 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 101-105 17712549-7 2007 SERT -/- mice also exhibit altered behavioral responses to cocaine and ethanol, related to abnormal serotonin, and possibly dopamine and norepinephrine, homeostasis. Cocaine 59-66 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 0-4 18003826-6 2007 These findings are consistent with the hypothesis that, in the absence of dopamine, cocaine-mediated SERT blockade activates dopamine neurons, which then release some other neurotransmitter that contributes to cocaine reward in DD mice. Cocaine 210-217 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 101-105 16407898-3 2006 Treatments with High dose psychostimulants that block DAT as well as the norepinephrine (NET) and serotonin (SERT) transporters (60 mg/kg cocaine or methylphenidate) significantly impaired PPI in wild-type mice. Cocaine 138-145 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 98-107 16908151-1 2006 A series of novel piperidine based analogs of cocaine was synthesized and evaluated in vitro against the three monoamine transporters to develop new potential selective SERT radiotracers. Cocaine 46-53 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 169-173 16407898-3 2006 Treatments with High dose psychostimulants that block DAT as well as the norepinephrine (NET) and serotonin (SERT) transporters (60 mg/kg cocaine or methylphenidate) significantly impaired PPI in wild-type mice. Cocaine 138-145 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 109-113 15542699-4 2004 We have also identified evidence that, in the absence of DAT, there is greater participation in cocaine reward by serotonin (SERT) and norepinephrine (NET) transporters. Cocaine 96-103 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 114-123 15542699-4 2004 We have also identified evidence that, in the absence of DAT, there is greater participation in cocaine reward by serotonin (SERT) and norepinephrine (NET) transporters. Cocaine 96-103 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 125-129 15542699-6 2004 The striking elimination of cocaine CPP in combined DAT/SERT KO mice contrasts with effects that we have identified in combined NET/SERT knockout mice, which display increases in cocaine reward, and with recent reports that suggest that DAT/NET combined KOs retain substantial cocaine CPP. Cocaine 28-35 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 56-60 15542699-7 2004 Overall, these studies indicate important requirements for several monoaminergic system genes to fully explain cocaine reward, in particular those expressed by dopamine and serotonin systems. Cocaine 111-118 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 173-182 15226739-9 2004 Cocaine-induced alterations in CPu DA levels in DAT-, SERT-, and DAT/SERT double-KO mice appear to provide better correlations with cocaine CPP than cocaine-induced DA level alterations in NAc or PFc. Cocaine 0-7 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 54-58 15226739-9 2004 Cocaine-induced alterations in CPu DA levels in DAT-, SERT-, and DAT/SERT double-KO mice appear to provide better correlations with cocaine CPP than cocaine-induced DA level alterations in NAc or PFc. Cocaine 0-7 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 69-73 14612139-9 2003 Third, most are also conserved in the serotonin transporter (SERT), a transporter that is now strongly implicated in cocaine reward based on data from knockout mice. Cocaine 117-124 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 38-59 14612139-9 2003 Third, most are also conserved in the serotonin transporter (SERT), a transporter that is now strongly implicated in cocaine reward based on data from knockout mice. Cocaine 117-124 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 61-65 14612139-12 2003 These studies provide a strong basis for redirected studies aimed at producing dopamine- and serotonin-sparing cocaine antagonists that would represent combined DAT/SERT disinhibitors. Cocaine 111-118 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 165-169 14612142-2 2003 However, the fact that cocaine similarly binds to the serotonin and norepinephrine transporters (SERT and NET, respectively), raises the possibility that modulation of mesocorticolimbic dopaminergic transmission might be achieved through alternate pathways. Cocaine 23-30 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 97-101 14612142-3 2003 The successful disruption of the genes coding for the DAT, the SERT and the NET offered ideal tools to determine the extent of the participation of these transporters and respective monoaminergic systems in the reinforcing effects of cocaine. Cocaine 234-241 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 63-67 16754872-1 2006 There are three known high-affinity targets for cocaine: the dopamine transporter (DAT), the serotonin transporter (SERT), and the norepinephrine transporter (NET). Cocaine 48-55 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 93-114 16754872-1 2006 There are three known high-affinity targets for cocaine: the dopamine transporter (DAT), the serotonin transporter (SERT), and the norepinephrine transporter (NET). Cocaine 48-55 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 116-120 16754872-7 2006 This mouse model is unique in that it is specifically designed to differentiate the role of DAT from the roles of NET and SERT in cocaine-induced biochemical and behavioral effects. Cocaine 130-137 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 122-126 16125150-1 2005 The present study examined whether the inhibition of serotonin transporters (SERT) contributes to cocaine- and other local anesthetics-induced convulsions, and which subtypes of 5-HT receptor are involved in the convulsions. Cocaine 98-105 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 77-81 15476748-4 2004 In contrast, 5-HT transporter (SERT) or 5-HT(1A) receptor antagonists potentiated cocaine-stimulated activity in ISS, but not in ILS, mice; this potentiation in ISS mice was abolished by dopamine D1 receptor blockade. Cocaine 82-89 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 13-29 15476748-4 2004 In contrast, 5-HT transporter (SERT) or 5-HT(1A) receptor antagonists potentiated cocaine-stimulated activity in ISS, but not in ILS, mice; this potentiation in ISS mice was abolished by dopamine D1 receptor blockade. Cocaine 82-89 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 31-35 15226739-1 2004 Cocaine conditioned place preference (CPP) is intact in dopamine transporter (DAT) knockout (KO) mice and enhanced in serotonin transporter (SERT) KO mice. Cocaine 0-7 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 118-139 15226739-1 2004 Cocaine conditioned place preference (CPP) is intact in dopamine transporter (DAT) knockout (KO) mice and enhanced in serotonin transporter (SERT) KO mice. Cocaine 0-7 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 141-145 15226739-6 2004 Adding SERT to DAT deletion attenuates the cocaine-induced DAex increases found in CPu, but not those found in PFc. Cocaine 43-50 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 7-11 12626658-1 2003 Termination of serotonergic transmission is the function of the plasma membrane 5-hydroxytryptamine (serotonin, 5-HT) transporter (SERT), which is also a high-affinity target in vivo for antidepressants, amphetamines, and cocaine. Cocaine 222-229 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 112-129 12626658-1 2003 Termination of serotonergic transmission is the function of the plasma membrane 5-hydroxytryptamine (serotonin, 5-HT) transporter (SERT), which is also a high-affinity target in vivo for antidepressants, amphetamines, and cocaine. Cocaine 222-229 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 131-135