PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17898233-4 2007 Glutamate receptor 1 (GluR1) and GluR2 surface/intracellular (S/I) ratios were increased after 14 d of withdrawal in sensitized rats but were decreased 24 h after challenge with cocaine (which elicited a sensitized locomotor response) or saline (which elicited conditioned locomotion). Cocaine 178-185 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 0-20 18160635-7 2007 To mimic the longer elevation in extracellular DA levels produced by systemic cocaine, cocultures were incubated with DA for 1 h. Synaptic GluR1 was increased 24 h later, reminiscent of the increased AMPA/NMDA ratio at excitatory synapses onto VTA DA neurons 24 h after cocaine injection (Ungless et al., 2001). Cocaine 78-85 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 139-144 18160635-7 2007 To mimic the longer elevation in extracellular DA levels produced by systemic cocaine, cocultures were incubated with DA for 1 h. Synaptic GluR1 was increased 24 h later, reminiscent of the increased AMPA/NMDA ratio at excitatory synapses onto VTA DA neurons 24 h after cocaine injection (Ungless et al., 2001). Cocaine 270-277 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 139-144 17680995-4 2007 Moreover, in sensitized rats acute cocaine administration modified phosphorylation levels of Thr75- and Thr34-DARPP-32, GluR1, and NR1 subunits in the nucleus accumbens only at a dose double the efficacious dose in control rats. Cocaine 35-42 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 120-125 17898233-4 2007 Glutamate receptor 1 (GluR1) and GluR2 surface/intracellular (S/I) ratios were increased after 14 d of withdrawal in sensitized rats but were decreased 24 h after challenge with cocaine (which elicited a sensitized locomotor response) or saline (which elicited conditioned locomotion). Cocaine 178-185 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 22-27 17898233-7 2007 JNK phosphorylation also increased after withdrawal, but after cocaine challenge, it was inversely related to GluR1 and GluR2 S/I ratios. Cocaine 63-70 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 110-115 17898233-11 2007 Although JNK results were complex, JNK and p38 may be involved in AMPAR internalization after cocaine or saline challenge, respectively. Cocaine 94-101 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 66-71 17439498-5 2007 Chronic cocaine produced region- and substrate-specific tolerance to cAMP-dependent protein phosphorylation, including GluR1(S845) phosphorylation in striatal and amygdala subregions and NR1(S897) phosphorylation in the CA1 subregion of the hippocampus. Cocaine 8-15 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 119-124 15548228-3 2004 The present study investigated whether in Sprague-Dawley rats a single, behavioural sensitizing dose of cocaine is sufficient to induce changes in the mRNA levels of growth-associated protein 43 (GAP-43), an important protein in mediating experience-dependent plasticity and synaptic reorganization, and of glutamate receptor 1 (GluR1), a subunit of AMPA glutamate receptors, a protein that is up-regulated with repeated cocaine. Cocaine 104-111 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 307-327 16794574-0 2007 Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors. Cocaine 12-19 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 100-105 16207873-4 2005 Surface/intracellular (S/I) ratios for glutamate receptor 1 (GluR1) and GluR2/3 subunits were increased 21 d after the last injection in cocaine-sensitized rats but not rats that failed to sensitize, and the magnitude of the S/I ratio for cocaine-sensitized rats was positively correlated with the magnitude of behavioral sensitization. Cocaine 137-144 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 39-59 16207873-4 2005 Surface/intracellular (S/I) ratios for glutamate receptor 1 (GluR1) and GluR2/3 subunits were increased 21 d after the last injection in cocaine-sensitized rats but not rats that failed to sensitize, and the magnitude of the S/I ratio for cocaine-sensitized rats was positively correlated with the magnitude of behavioral sensitization. Cocaine 137-144 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 61-66 15548228-0 2004 A single high dose of cocaine induces behavioural sensitization and modifies mRNA encoding GluR1 and GAP-43 in rats. Cocaine 22-29 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 91-96 15548228-3 2004 The present study investigated whether in Sprague-Dawley rats a single, behavioural sensitizing dose of cocaine is sufficient to induce changes in the mRNA levels of growth-associated protein 43 (GAP-43), an important protein in mediating experience-dependent plasticity and synaptic reorganization, and of glutamate receptor 1 (GluR1), a subunit of AMPA glutamate receptors, a protein that is up-regulated with repeated cocaine. Cocaine 104-111 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 329-334 12787079-6 2003 In the accumbens of cocaine-trained rats, GluR1 and NMDAR1 levels were increased on days 1 and 90, while GluR2 levels were increased on days 1 and 30, but not day 90; PKA activity levels were increased on days 1 and 30, but not day 90, while AC activity, TH and cdk5 levels were unaltered. Cocaine 20-27 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 42-47 26384129-10 2017 Cocaine self-administration alone decreased total GluA1 and/or pSer845GluA1 expression in basolateral amygdala and nucleus accumbens. Cocaine 0-7 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 50-55 8613793-3 1996 By immunoblotting procedures using subunit-specific antibodies, we found that repeated, but not acute, cocaine treatment increased the levels of immunoreactivity of GluR1 (an AMPA receptor subunit) and NMDAR1 (an NMDA receptor subunit) in the ventral tegmental area (VTA), a nucleus containing mesolimbic DA neurons. Cocaine 103-110 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 165-170 33361540-4 2021 Interestingly, compared to saline exposure, cocaine significantly increased the immunofluorescence intensity of GluA1 in two sub-regions, the core and the shell, of the NAcc on withdrawal day 21 following cocaine exposure, which led to locomotor sensitization. Cocaine 44-51 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 112-117 33361540-4 2021 Interestingly, compared to saline exposure, cocaine significantly increased the immunofluorescence intensity of GluA1 in two sub-regions, the core and the shell, of the NAcc on withdrawal day 21 following cocaine exposure, which led to locomotor sensitization. Cocaine 205-212 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 112-117 30104957-0 2018 Activation of Protein Kinase G After Repeated Cocaine Administration Is Necessary for the Phosphorylation of alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor GluA1 at Serine 831 in the Rat Nucleus Accumbens. Cocaine 46-53 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 175-180 30104957-2 2018 The present study determined if activation of protein kinase G (PKG) contributes to the phosphorylation of AMPA receptor GluA1 subunit at the position of serine 831 (GluA1-S831) in the rat nucleus accumbens (NAc) after repeated cocaine administration. Cocaine 228-235 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 121-126 30104957-2 2018 The present study determined if activation of protein kinase G (PKG) contributes to the phosphorylation of AMPA receptor GluA1 subunit at the position of serine 831 (GluA1-S831) in the rat nucleus accumbens (NAc) after repeated cocaine administration. Cocaine 228-235 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 166-171 30104957-4 2018 injections of cocaine (20 mg/kg) once a day for seven consecutive days significantly increased the level of phosphorylated (p)GluA1-S831. Cocaine 14-21 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 126-131 30104957-6 2018 Repeated cocaine administration increased PKG binding activity to GluA1. Cocaine 9-16 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 66-71 30104957-7 2018 This increase in GluA1-S831 phosphorylation after repeated cocaine administration was decreased by the intra-NAc infusion of the synthetic peptide (Tat-tagged interfering peptide (Tat-GluA1-i)), that interferes with the binding of PKG to GluA1. Cocaine 59-66 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 17-22 30104957-7 2018 This increase in GluA1-S831 phosphorylation after repeated cocaine administration was decreased by the intra-NAc infusion of the synthetic peptide (Tat-tagged interfering peptide (Tat-GluA1-i)), that interferes with the binding of PKG to GluA1. Cocaine 59-66 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 184-189 30104957-7 2018 This increase in GluA1-S831 phosphorylation after repeated cocaine administration was decreased by the intra-NAc infusion of the synthetic peptide (Tat-tagged interfering peptide (Tat-GluA1-i)), that interferes with the binding of PKG to GluA1. Cocaine 59-66 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 184-189 30104957-9 2018 These findings suggest that activated PKG, after repeated exposure to cocaine, binds to AMPA receptor GluA1 and is required for the phosphorylation of S831, contributing to behavioral changes. Cocaine 70-77 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 102-107 29521680-0 2018 Leptin in the nucleus accumbens blocks the increase of GluA1 phosphorylation induced by acute cocaine administration. Cocaine 94-101 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 55-60 29521680-2 2018 In the present study, we further measured the phosphorylation levels of GluA1 after bilateral microinjections of leptin in this site followed by acute administration of cocaine. Cocaine 169-176 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 72-77 29521680-3 2018 Interestingly, leptin in the NAcc core significantly blocks the increase of GluA1 phosphorylation levels at serine 845 induced by acute administration of cocaine. Cocaine 154-161 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 76-81 29196318-0 2018 Inactivation of NMDA Receptors in the Ventral Tegmental Area during Cocaine Self-Administration Prevents GluA1 Upregulation but with Paradoxical Increases in Cocaine-Seeking Behavior. Cocaine 68-75 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 105-110 29196318-1 2018 Cocaine self-administration increases expression of GluA1 subunits in ventral tegmental area (VTA) dopamine neurons, which subsequently enhance the motivation for cocaine. Cocaine 0-7 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 52-57 29196318-1 2018 Cocaine self-administration increases expression of GluA1 subunits in ventral tegmental area (VTA) dopamine neurons, which subsequently enhance the motivation for cocaine. Cocaine 163-170 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 52-57 29196318-3 2018 In this study, we used viral-mediated expression of a dominant-negative GluN1 subunit (HSV-dnGluN1) in VTA neurons to study the effect of transient NMDAR inactivation on the GluA1 increases induced by chronic cocaine self-administration in male rats. Cocaine 209-216 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 174-179 29196318-4 2018 We found that dnGluN1 expression in the VTA limited to the 3 weeks of cocaine self-administration prevents the subsequent increase in tissue GluA1 levels when compared with control infusions of HSV-LacZ. Cocaine 70-77 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 141-146 29196318-7 2018 Together, these data suggest that NMDARs mediate cocaine-induced increases in VTA GluA1 expression, but such transient NMDAR inactivation also leads to compensatory scaling of synaptic AMPA receptors that enhance the motivational for cocaine.SIGNIFICANCE STATEMENT Dopamine neurons in the ventral tegmental area (VTA) are critical substrates of drug rewards. Cocaine 49-56 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 82-87 11801363-7 2002 Moreover, we observed that rats sensitized to cocaine presented a significant increase in the levels of GLUR1, NR1 and NR2B, in the nucleus accumbens, and of NR2B in the hippocampus compared to control animals. Cocaine 46-53 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 104-109 30092246-5 2018 In the postsynaptic density, cocaine reduced the expression of the NMDA receptor subunits GluN1, GluN2A and GluN2B as well as of the AMPA GluA1 and GluA2 subunits. Cocaine 29-36 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 138-143 29317777-1 2018 Previous work indicated that activation of D1-like dopamine receptors (D1DRs) in the nucleus accumbens shell promoted cocaine seeking through a process involving the activation of PKA and GluA1-containing AMPA receptors (AMPARs). Cocaine 118-125 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 188-193 29317777-1 2018 Previous work indicated that activation of D1-like dopamine receptors (D1DRs) in the nucleus accumbens shell promoted cocaine seeking through a process involving the activation of PKA and GluA1-containing AMPA receptors (AMPARs). Cocaine 118-125 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 221-227 29317777-8 2018 This viral-mediated attenuation of cocaine reinstatement was accompanied by decreased phosphorylation of GluA1-containing AMPARs and attenuated AMPAR eEPSCs. Cocaine 35-42 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 105-110 29317777-8 2018 This viral-mediated attenuation of cocaine reinstatement was accompanied by decreased phosphorylation of GluA1-containing AMPARs and attenuated AMPAR eEPSCs. Cocaine 35-42 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 122-128 26384129-10 2017 Cocaine self-administration alone decreased total GluA1 and/or pSer845GluA1 expression in basolateral amygdala and nucleus accumbens. Cocaine 0-7 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 70-75 24345425-6 2014 These changes were associated with increased activation of the trkB-Akt pathway resulting in enhanced pmTOR and pS6 kinase, which ultimately produced an up-regulation of Arc and a consequent reduction of GluA1 expression in the mPFC of PD 90 cocaine-treated rats. Cocaine 242-249 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 204-209 25589145-11 2015 CONCLUSIONS: Results support a scheme in which pSer845-GluA1 in NAc core underlies expression of cocaine CPP and does so by stabilizing or trafficking Ca(2+)-permeable AMPARs to the synaptic membrane. Cocaine 97-104 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 55-60 25589145-11 2015 CONCLUSIONS: Results support a scheme in which pSer845-GluA1 in NAc core underlies expression of cocaine CPP and does so by stabilizing or trafficking Ca(2+)-permeable AMPARs to the synaptic membrane. Cocaine 97-104 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 168-174 22882295-4 2012 In the NAc from the stress plus cocaine group we observed a decrease in the phosphorylation of two ABPs, cofilin and cortactin, and an increase in the PSD size and the surface expression of GluR1, consistent with a more highly branched actin cytoskeleton. Cocaine 32-39 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 190-195 23583340-0 2013 Protein kinase G increases AMPA receptor GluR1 phosphorylation at serine 845 after repeated cocaine administration in the rat nucleus accumbens. Cocaine 92-99 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 41-46 23583340-1 2013 The regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluR1 subunit phosphorylation at serine 845 (GluR1-Ser845) by protein kinase G (PKG) activation was investigated in the nucleus accumbens (NAc) after repeated cocaine administration. Cocaine 250-257 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 91-96 23583340-1 2013 The regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluR1 subunit phosphorylation at serine 845 (GluR1-Ser845) by protein kinase G (PKG) activation was investigated in the nucleus accumbens (NAc) after repeated cocaine administration. Cocaine 250-257 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 136-141 23583340-5 2013 These findings suggest that the AMPA receptor provides a PKG-sensitive phosphorylation site on GluR1-Ser845 in the NAc after repeated cocaine, thus contributing to behavioral alterations. Cocaine 134-141 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 95-100 23334104-0 2013 Activation of protein kinase C is required for AMPA receptor GluR1 phosphorylation at serine 845 in the dorsal striatum following repeated cocaine administration. Cocaine 139-146 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 61-66 23334104-3 2013 This study was performed to determine whether GluR1-S845 phosphorylation in the rat dorsal striatum is altered by repeated cocaine via a signaling mechanism involving glutamate receptor-associated and Ca(2+)-dependent protein kinases. Cocaine 123-130 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 46-51 23334104-4 2013 RESULTS: Systemic administration of cocaine (20 mg/kg, once a day for 7 days) upregulated GluR1-S845 phosphorylation. Cocaine 36-43 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 90-95 23334104-8 2013 CONCLUSIONS: These findings suggest that phosphorylation of AMPA receptors at GluR1-S845 is upregulated by interactions of glutamate receptor-coupled Ca(2+)-dependent protein kinases following repeated cocaine administration in the dorsal striatum. Cocaine 202-209 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 78-83 24201449-2 2014 Adaptations in glutamate receptor 1 (GluR1) phosphorylation in limbic brain regions have been shown to occur during withdrawal from addictive drugs, such as cocaine, methamphetamine, and heroin. Cocaine 157-164 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 15-35 24201449-2 2014 Adaptations in glutamate receptor 1 (GluR1) phosphorylation in limbic brain regions have been shown to occur during withdrawal from addictive drugs, such as cocaine, methamphetamine, and heroin. Cocaine 157-164 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 37-42 24079996-0 2013 Different locomotor sensitization responses to repeated cocaine injections are associated with differential phosphorylation of GluA1 in the dorsomedial striatum of adult rats. Cocaine 56-63 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 127-132 23352852-0 2013 Acute cocaine increases phosphorylation of CaMKII and GluA1 in the dorsolateral striatum of drug naive rats, but not cocaine-experienced rats. Cocaine 6-13 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 54-59 23352852-1 2013 Transport of GluA1-containing AMPA glutamate receptors to synapses in the nucleus accumbens, a process that involves phosphorylation of key serine residues by CaMKII, is associated with the reinstatement of cocaine-seeking behavior. Cocaine 207-214 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 13-18 23352852-11 2013 These results indicate that acute exposure to cocaine in drug naive rats increased CaMKII-mediated phosphorylation of GluA1-containing AMPA receptors in the DL striatum, an effect that was not observed during cocaine priming-induced reinstatement of drug seeking. Cocaine 46-53 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 118-123 23352852-12 2013 It is possible; therefore, that increased phosphorylation of CaMKII and GluA1 following acute cocaine is a compensatory mechanism in the DL striatum. Cocaine 94-101 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 72-77 22882295-9 2012 Furthermore, by regulating GluR1 expression in the NAc, elevated actin cycling contributes to the expression of cross-sensitization between stress and cocaine, while stress-induced changes in the Pfc were not associated with cross-sensitization. Cocaine 151-158 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 27-32 21613507-2 2011 Here we show that daily intravenous cocaine self-administration, but not passive cocaine administration, induces dynamic upregulation of the AMPA glutamate receptor subunits GluR1 and GluR2 in the ventral tegmental area (VTA) of rats. Cocaine 36-43 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 174-179 22655064-9 2012 The acute cocaine-induced increases in NMDARs in dSTR of LCRs may help to explain the more ready development of locomotor sensitization and susceptibility to addiction-like behaviors in rats that initially exhibit little or no cocaine-induced activation, whereas the AMPAR increases after repeated cocaine may relate to recruitment of more dorsal striatal circuits and maintenance of the marked cocaine-induced locomotor activation observed in all of the rats. Cocaine 10-17 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 267-272 21640333-0 2011 Enhanced cocaine-conditioned place preference and associated brain regional levels of BDNF, p-ERK1/2 and p-Ser845-GluA1 in food-restricted rats. Cocaine 9-16 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 114-119 21640333-8 2011 On the other hand, FR rats, whether injected with cocaine or vehicle, displayed elevated p-ERK1/2 and p-Ser845-GluA1 in dorsal hippocampus. Cocaine 50-57 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 111-116 21309958-0 2011 Emergence of context-associated GluR(1) and ERK phosphorylation in the nucleus accumbens core during withdrawal from cocaine self-administration. Cocaine 117-124 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 32-39 21309958-8 2011 These results suggest that time-dependent emergence of context-associated GluR(1) (S845) phosphorylation in the nucleus accumbens core may contribute to the persistence of cocaine-seeking behavior, whereas ERK phosphorylation may be a consequence of this behavior. Cocaine 172-179 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 74-81 20942997-8 2011 Following re-exposure to a cocaine-paired context, surface expression of the AMPA-type glutamate receptor GluR1 was significantly reduced whereas GluR2 was significantly increased in the dlCPu, independent of Arc antisense ODN infusion. Cocaine 27-34 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 106-111 21216391-6 2011 Among them, GluA1 and GluA3 are preferentially upregulated in their palmitoylation levels by a systemic injection of cocaine. Cocaine 117-124 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 12-17 21692887-3 2011 The latter could reflect enhancement of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) transmission, because AMPARs in the NAc mediate some cocaine-induced behaviors. Cocaine 167-174 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 136-142 21613507-4 2011 We investigated the functional significance of GluR1 upregulation in the VTA on cocaine self-administration using localized viral-mediated gene transfer. Cocaine 80-87 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 47-52 21613507-7 2011 In cocaine self-administering animals, overexpression of GluR1(WT) in the VTA markedly increased the motivation for cocaine injections on a progressive ratio schedule of cocaine reinforcement. Cocaine 3-10 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 57-62 21613507-7 2011 In cocaine self-administering animals, overexpression of GluR1(WT) in the VTA markedly increased the motivation for cocaine injections on a progressive ratio schedule of cocaine reinforcement. Cocaine 116-123 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 57-62 21613507-7 2011 In cocaine self-administering animals, overexpression of GluR1(WT) in the VTA markedly increased the motivation for cocaine injections on a progressive ratio schedule of cocaine reinforcement. Cocaine 116-123 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 57-62 21613507-8 2011 In contrast, overexpression of protein kinase A-resistant GluR1(S845A) in the VTA reduced peak rates of cocaine self-administration on a fixed ratio reinforcement schedule. Cocaine 104-111 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 58-63 19629758-0 2010 Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation. Cocaine 38-45 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 111-116 20600170-9 2010 In the ventral tegmental area, cocaine self-administration elevated glutamatergic receptor subunits NR1 and GluR1 and scaffolding protein PSD95, but not GABA(A)beta, protein levels. Cocaine 31-38 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 108-113 19629758-5 2010 Under both paradigms, established cocaine sensitization under non-silenced conditions was associated with enhanced PSD-95 and synapsin I protein expression as well as enhanced Ser(845) phosphorylation of the GluR1 subunit on withdrawal day. Cocaine 34-41 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 208-213 19559763-2 2009 In this study, we investigated the regulation of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor GluR1 subunit phosphorylation by cocaine exposure in the rat dorsal striatum in vivo. Cocaine 155-162 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 122-127 19812341-5 2009 Biochemical assays of isolated mPFC tissue from postnatal rats further showed that cocaine exposure in utero caused a marked reduction in the surface expression of GABA(A) receptor subunits alpha1, beta2, and beta3, but had no effect on glutamate receptor subunit GluR1. Cocaine 83-90 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 264-269 19559763-3 2009 We found that acute cocaine challenge followed by 6 days of repeated systemic injections of cocaine (20 mg/kg once daily) enhanced the sensitivity of the GluR1 subunit in its phosphorylation at serine 831 (Ser831) in the dorsal striatum. Cocaine 20-27 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 154-159 19559763-3 2009 We found that acute cocaine challenge followed by 6 days of repeated systemic injections of cocaine (20 mg/kg once daily) enhanced the sensitivity of the GluR1 subunit in its phosphorylation at serine 831 (Ser831) in the dorsal striatum. Cocaine 92-99 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 154-159 19559763-6 2009 In addition, inhibition of protein phosphatase 1/2A or calcineurin increased GluR1-Ser831 phosphorylation in the dorsal striatum of normal rats, whereas inhibition of these phosphatases did not further enhance the Ser831 phosphorylation in rats pretreated with 7 daily injections of cocaine. Cocaine 283-290 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 77-82 19559763-7 2009 These data suggest that the phosphorylation of AMPA receptor GluR1 subunits at Ser831 is subject to upregulation by acute and repeated cocaine administration. Cocaine 135-142 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 61-66 18640148-9 2008 In cocaine sensitized rats GluR1 protein was increased in the mPFC on PND37 but not in other ages. Cocaine 3-10 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 27-32 18640148-11 2008 However, cocaine pretreatment during adolescence induced a transient increase of GluR1 in the mPFC only when animals were challenged in the same age. Cocaine 9-16 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 81-86 18486119-0 2008 Contributions of nucleus accumbens core and shell GluR1 containing AMPA receptors in AMPA- and cocaine-primed reinstatement of cocaine-seeking behavior. Cocaine 95-102 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 50-55 18486119-0 2008 Contributions of nucleus accumbens core and shell GluR1 containing AMPA receptors in AMPA- and cocaine-primed reinstatement of cocaine-seeking behavior. Cocaine 127-134 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 50-55 18486119-4 2008 We also tested the hypothesis that GluR1 subunit (GluR1) containing alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) receptors in the nucleus accumbens core and not the shell regulate reinstatement of previously extinguished cocaine-seeking behavior. Cocaine 241-248 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 35-40 18486119-4 2008 We also tested the hypothesis that GluR1 subunit (GluR1) containing alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) receptors in the nucleus accumbens core and not the shell regulate reinstatement of previously extinguished cocaine-seeking behavior. Cocaine 241-248 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 50-55 19368820-9 2009 These data suggest that extinguished cocaine seeking is associated with changes in GluR1 and NMDAR1 expression and subcellular distribution that are region-specific and consist of both a reversal of cocaine-induced adaptations and emergent extinction-related alterations that include receptor subunit redistribution and may involve alterations in scaffolding proteins. Cocaine 37-44 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 83-88 19368820-9 2009 These data suggest that extinguished cocaine seeking is associated with changes in GluR1 and NMDAR1 expression and subcellular distribution that are region-specific and consist of both a reversal of cocaine-induced adaptations and emergent extinction-related alterations that include receptor subunit redistribution and may involve alterations in scaffolding proteins. Cocaine 199-206 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 83-88 18278040-4 2008 Cocaine reinstatement is associated with D1-like dopamine receptor-dependent increases in accumbens shell CaMKII phosphorylated on Thr286 and glutamate receptor 1 (GluR1) phosphorylated on Ser831 (a known CaMKII phosphorylation site), in addition to increases in cell-surface expression of GluR1-containing AMPA receptors in the shell. Cocaine 0-7 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 142-162 18278040-4 2008 Cocaine reinstatement is associated with D1-like dopamine receptor-dependent increases in accumbens shell CaMKII phosphorylated on Thr286 and glutamate receptor 1 (GluR1) phosphorylated on Ser831 (a known CaMKII phosphorylation site), in addition to increases in cell-surface expression of GluR1-containing AMPA receptors in the shell. Cocaine 0-7 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 164-169 18278040-4 2008 Cocaine reinstatement is associated with D1-like dopamine receptor-dependent increases in accumbens shell CaMKII phosphorylated on Thr286 and glutamate receptor 1 (GluR1) phosphorylated on Ser831 (a known CaMKII phosphorylation site), in addition to increases in cell-surface expression of GluR1-containing AMPA receptors in the shell. Cocaine 0-7 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 290-295 18278040-5 2008 Consistent with these findings, cocaine reinstatement is attenuated by intra-shell administration of AAV10-GluR1-C99, a vector that impairs the transport of GluR1-containing AMPA receptors. Cocaine 32-39 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 107-112 18278040-5 2008 Consistent with these findings, cocaine reinstatement is attenuated by intra-shell administration of AAV10-GluR1-C99, a vector that impairs the transport of GluR1-containing AMPA receptors. Cocaine 32-39 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 157-162