PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34318655-0 2021 Blockade of corticotropin-releasing factor receptor 1 in the central amygdala prevents cocaine-seeking behaviour induced by orexin-A administered to the posterior paraventricular nucleus of the thalamus in male rats. Cocaine 87-94 hypocretin neuropeptide precursor Rattus norvegicus 124-132 32798290-2 2021 Cocaine self-administration with the intermittent access (IntA) procedure produces a robust addiction-like state that is orexin-dependent. Cocaine 0-7 hypocretin neuropeptide precursor Rattus norvegicus 121-127 34318655-1 2021 Background: Orexin-A (OrxA) administration in the posterior paraventricular nucleus of the thalamus (pPVT) reinstates extinguished cocaine-seeking behaviour following extended access to the drug (a model of dependence). Cocaine 131-138 hypocretin neuropeptide precursor Rattus norvegicus 12-20 30219208-7 2019 This increase in orexin cell number and activity persisted during protracted withdrawal from cocaine for at least 150 days and was accompanied by enhanced incubation of craving in the same rats. Cocaine 93-100 hypocretin neuropeptide precursor Rattus norvegicus 17-23 33091458-8 2021 We also report that cocaine intake and motivation are reduced by a selective orexin-1 receptor antagonist when rats have a history of cocaine + alcohol, but not a limited history of cocaine alone. Cocaine 20-27 hypocretin neuropeptide precursor Rattus norvegicus 77-83 33091458-8 2021 We also report that cocaine intake and motivation are reduced by a selective orexin-1 receptor antagonist when rats have a history of cocaine + alcohol, but not a limited history of cocaine alone. Cocaine 134-141 hypocretin neuropeptide precursor Rattus norvegicus 77-83 33091458-8 2021 We also report that cocaine intake and motivation are reduced by a selective orexin-1 receptor antagonist when rats have a history of cocaine + alcohol, but not a limited history of cocaine alone. Cocaine 134-141 hypocretin neuropeptide precursor Rattus norvegicus 77-83 31112988-2 2019 Orexin-1 receptor (OxR1) antagonism reduces demand for cocaine and remifentanil, indicating that orexin-based therapies may reduce demand for many classes of abused drugs. Cocaine 55-62 hypocretin neuropeptide precursor Rattus norvegicus 0-6 31112988-2 2019 Orexin-1 receptor (OxR1) antagonism reduces demand for cocaine and remifentanil, indicating that orexin-based therapies may reduce demand for many classes of abused drugs. Cocaine 55-62 hypocretin neuropeptide precursor Rattus norvegicus 97-103 33708078-0 2021 Cocaine-Seeking Behavior Induced by Orexin A Administration in the Posterior Paraventricular Nucleus of the Thalamus Is Not Long-Lasting: Neuroadaptation of the Orexin System During Cocaine Abstinence. Cocaine 0-7 hypocretin neuropeptide precursor Rattus norvegicus 36-44 33708078-0 2021 Cocaine-Seeking Behavior Induced by Orexin A Administration in the Posterior Paraventricular Nucleus of the Thalamus Is Not Long-Lasting: Neuroadaptation of the Orexin System During Cocaine Abstinence. Cocaine 0-7 hypocretin neuropeptide precursor Rattus norvegicus 36-42 33708078-5 2021 Orexin A administration in the pPVT induced cocaine-seeking behavior after intermediate abstinence, as reported previously. Cocaine 44-51 hypocretin neuropeptide precursor Rattus norvegicus 0-8 30219208-10 2019 Thus, the orexin system is a potential novel target for pharmacotherapies designed to treat cocaine addiction. Cocaine 92-99 hypocretin neuropeptide precursor Rattus norvegicus 10-16 30219208-8 2019 Selective knockdown of lateral hypothalamic orexin neurons reduced motivation for cocaine, and orexin-1 receptor signaling played a larger role in drug seeking after IntA. Cocaine 82-89 hypocretin neuropeptide precursor Rattus norvegicus 44-50 29703996-4 2018 Chronic Hcrt silencing did not impact cocaine self-administration under short-access conditions, but robustly attenuated cocaine intake under extended access conditions, a model that mimics key features of compulsive cocaine taking. Cocaine 121-128 hypocretin neuropeptide precursor Rattus norvegicus 8-12 29703996-4 2018 Chronic Hcrt silencing did not impact cocaine self-administration under short-access conditions, but robustly attenuated cocaine intake under extended access conditions, a model that mimics key features of compulsive cocaine taking. Cocaine 121-128 hypocretin neuropeptide precursor Rattus norvegicus 8-12 29703996-5 2018 In addition, Hcrt silencing decreased motivation for both cocaine and a highly palatable food reward (i.e., sweetened condensed milk; SCM) under a progressive ratio schedule of reinforcement, but did not alter responding for SCM under a fixed ratio schedule. Cocaine 58-65 hypocretin neuropeptide precursor Rattus norvegicus 13-17 27558790-0 2018 Differential role of hypothalamic orexin/hypocretin neurons in reward seeking motivated by cocaine versus palatable food. Cocaine 91-98 hypocretin neuropeptide precursor Rattus norvegicus 34-40 29888304-11 2018 In contrast, hypothalamic orexin neuron activation after cocaine was significantly attenuated in LBN rats. Cocaine 57-64 hypocretin neuropeptide precursor Rattus norvegicus 26-32 28419646-0 2018 Suvorexant, an orexin/hypocretin receptor antagonist, attenuates motivational and hedonic properties of cocaine. Cocaine 104-111 hypocretin neuropeptide precursor Rattus norvegicus 15-21 26055195-2 2016 We showed that activation of the neuropeptide S (NPS) system exacerbates reinstatement vulnerability to cocaine and alcohol via stimulation of the hypocretin-1/orexin-A (Hcrt-1/Ox-A) system. Cocaine 104-111 hypocretin neuropeptide precursor Rattus norvegicus 160-168 27567312-12 2017 CONCLUSIONS: These findings suggest that HCRT neurotransmission within the CeA is implicated in compulsive-like cocaine-seeking. Cocaine 112-119 hypocretin neuropeptide precursor Rattus norvegicus 41-45 27540003-0 2016 Orexin-A/Hypocretin-1 Mediates Cocaine-Seeking Behavior in the Posterior Paraventricular Nucleus of the Thalamus via Orexin/Hypocretin Receptor-2. Cocaine 31-38 hypocretin neuropeptide precursor Rattus norvegicus 0-8 27540003-0 2016 Orexin-A/Hypocretin-1 Mediates Cocaine-Seeking Behavior in the Posterior Paraventricular Nucleus of the Thalamus via Orexin/Hypocretin Receptor-2. Cocaine 31-38 hypocretin neuropeptide precursor Rattus norvegicus 0-6 27540003-8 2016 Orx-A/Hcrt-1 alone reinstated (primed) cocaine seeking. Cocaine 39-46 hypocretin neuropeptide precursor Rattus norvegicus 6-10 22411428-2 2013 OBJECTIVES: Here, we asked whether orexin and glutamate interact within ventral tegmental area (VTA) to promote reinstatement of extinguished cocaine seeking in a rat self-administration paradigm. Cocaine 142-149 hypocretin neuropeptide precursor Rattus norvegicus 35-41 25754681-0 2015 Orexin-1 receptor signaling increases motivation for cocaine-associated cues. Cocaine 53-60 hypocretin neuropeptide precursor Rattus norvegicus 0-6 25754681-1 2015 The orexin/hypocretin system is involved in multiple cocaine addiction processes that involve drug-associated environmental cues, including cue-induced reinstatement of extinguished cocaine seeking and expression of conditioned place preference. Cocaine 53-60 hypocretin neuropeptide precursor Rattus norvegicus 4-10 25754681-3 2015 We hypothesized that cocaine-associated cues, but not cocaine alone, engage signaling at orexin-1 receptors (OX1Rs), and this cue-engaged OX1R signaling increases motivation for cocaine. Cocaine 21-28 hypocretin neuropeptide precursor Rattus norvegicus 89-95 25926444-5 2015 Cocaine binding to the sigma1R-CRF1R-OX1R complex promotes a long-term disruption of the orexin-A-CRF negative crosstalk. Cocaine 0-7 hypocretin neuropeptide precursor Rattus norvegicus 89-97 25926444-6 2015 Through this mechanism, cocaine sensitizes VTA cells to the excitatory effects of both CRF and orexin-A, thus providing a mechanism by which stress induces cocaine seeking. Cocaine 24-31 hypocretin neuropeptide precursor Rattus norvegicus 95-103 25926444-6 2015 Through this mechanism, cocaine sensitizes VTA cells to the excitatory effects of both CRF and orexin-A, thus providing a mechanism by which stress induces cocaine seeking. Cocaine 156-163 hypocretin neuropeptide precursor Rattus norvegicus 95-103 22971541-0 2012 Repeated orexin 1 receptor antagonism effects on cocaine seeking in rats. Cocaine 49-56 hypocretin neuropeptide precursor Rattus norvegicus 9-15 22971541-2 2012 Acute orexin receptor blockade with the orexin-1 receptor (OX1R) antagonist, SB-334867, has been found to reduce cocaine seeking after cocaine self-administration. Cocaine 113-120 hypocretin neuropeptide precursor Rattus norvegicus 6-12 22971541-2 2012 Acute orexin receptor blockade with the orexin-1 receptor (OX1R) antagonist, SB-334867, has been found to reduce cocaine seeking after cocaine self-administration. Cocaine 135-142 hypocretin neuropeptide precursor Rattus norvegicus 6-12 21285875-0 2011 Orexin-1 receptor antagonist SB-334867 reduces the acquisition and expression of cocaine-conditioned reinforcement and the expression of amphetamine-conditioned reward. Cocaine 81-88 hypocretin neuropeptide precursor Rattus norvegicus 0-6 22457508-0 2012 A septal-hypothalamic pathway drives orexin neurons, which is necessary for conditioned cocaine preference. Cocaine 88-95 hypocretin neuropeptide precursor Rattus norvegicus 37-43 22457508-4 2012 In addition, using local inactivation in LS and orexin antisense morpholinos in LH, we found that LSr influences on LH orexin neurons are critical for the expression of cocaine preference. Cocaine 169-176 hypocretin neuropeptide precursor Rattus norvegicus 48-54 22457508-4 2012 In addition, using local inactivation in LS and orexin antisense morpholinos in LH, we found that LSr influences on LH orexin neurons are critical for the expression of cocaine preference. Cocaine 169-176 hypocretin neuropeptide precursor Rattus norvegicus 119-125 19815001-3 2010 Fos expression in LH orexin neurons varied in proportion to conditioned place preference (CPP) for morphine, cocaine, or food. Cocaine 109-116 hypocretin neuropeptide precursor Rattus norvegicus 21-27 19815001-9 2010 In self-administration studies, the orexin 1 receptor antagonist SB-334867 (SB) blocked cocaine-seeking induced by discrete or contextual cues previously associated with cocaine, but not by a priming injection of cocaine. Cocaine 88-95 hypocretin neuropeptide precursor Rattus norvegicus 36-42 19815001-9 2010 In self-administration studies, the orexin 1 receptor antagonist SB-334867 (SB) blocked cocaine-seeking induced by discrete or contextual cues previously associated with cocaine, but not by a priming injection of cocaine. Cocaine 170-177 hypocretin neuropeptide precursor Rattus norvegicus 36-42 19815001-9 2010 In self-administration studies, the orexin 1 receptor antagonist SB-334867 (SB) blocked cocaine-seeking induced by discrete or contextual cues previously associated with cocaine, but not by a priming injection of cocaine. Cocaine 170-177 hypocretin neuropeptide precursor Rattus norvegicus 36-42 19591850-2 2010 We examined the role of the orexin system in cocaine-seeking elicited by a drug-associated context following abstinence or extinction from chronic cocaine self-administration. Cocaine 45-52 hypocretin neuropeptide precursor Rattus norvegicus 28-34 19591850-2 2010 We examined the role of the orexin system in cocaine-seeking elicited by a drug-associated context following abstinence or extinction from chronic cocaine self-administration. Cocaine 147-154 hypocretin neuropeptide precursor Rattus norvegicus 28-34 19591850-7 2010 These results indicate that orexin signaling at OX(1)R is critical for conditioned cocaine-seeking elicited by a drug-associated context, following either extinction or abstinence. Cocaine 83-90 hypocretin neuropeptide precursor Rattus norvegicus 28-34 19671464-1 2009 Work from our laboratory has shown that orexin (ORX; or hypocretin) neurons in the lateral hypothalamus are involved in preference for morphine, cocaine, and food. Cocaine 145-152 hypocretin neuropeptide precursor Rattus norvegicus 40-46 19656173-0 2009 Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking. Cocaine 76-83 hypocretin neuropeptide precursor Rattus norvegicus 0-6 19656173-0 2009 Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking. Cocaine 76-83 hypocretin neuropeptide precursor Rattus norvegicus 35-41 19656173-2 2009 We examined the involvement of the orexin system in cue-induced reinstatement of extinguished cocaine-seeking by administering the orexin 1 receptor antagonist SB-334867 (SB) or the orexin 2 receptor antagonist 4-pyridylmethyl (S)-tert-leucyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (4PT) prior to reinstatement testing. Cocaine 94-101 hypocretin neuropeptide precursor Rattus norvegicus 35-41 19656173-11 2009 These results show that orexin transmission at the orexin 1 receptor, but not the orexin 2 receptor, is necessary for the reinstatement of cocaine-seeking elicited by drug-paired cues and that orexin signaling is not critical for cocaine reinforcement or cocaine-stimulus conditioning. Cocaine 139-146 hypocretin neuropeptide precursor Rattus norvegicus 24-30 19251246-0 2009 Reinstatement of cocaine seeking by hypocretin (orexin) in the ventral tegmental area: independence from the local corticotropin-releasing factor network. Cocaine 17-24 hypocretin neuropeptide precursor Rattus norvegicus 36-46 19251246-7 2009 RESULTS: Ventral tegmental area perfusion of Hcrt-1 or footshock stress reinstated cocaine seeking and caused release of VTA glutamate and dopamine. Cocaine 83-90 hypocretin neuropeptide precursor Rattus norvegicus 45-49 18436386-5 2008 We found that orexin mRNA levels were decreased after cocaine place conditioning in the LH of SD rats. Cocaine 54-61 hypocretin neuropeptide precursor Rattus norvegicus 14-20 18436386-6 2008 A decreased LH orexin mRNA level was also observed after chronic escalating-dose cocaine (but not CPP pattern regimen without conditioning, or steady-dose regimen) in both strains. Cocaine 81-88 hypocretin neuropeptide precursor Rattus norvegicus 15-21 18436386-7 2008 In F344 rats only, acute withdrawal from chronic escalating-dose cocaine administration resulted in increases in both LH orexin and ppDyn mRNA levels, which were unaltered by naloxone or after chronic withdrawal. Cocaine 65-72 hypocretin neuropeptide precursor Rattus norvegicus 121-127 18655797-3 2009 We found that Fos expression in LH orexin neurons varied in proportion to preference for morphine, cocaine or food. Cocaine 99-106 hypocretin neuropeptide precursor Rattus norvegicus 35-41