PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35144664-8 2022 We then showed that cocaine and amphetamine regulated transcript prepropeptide (CARTPT) and breast cancer-associated transcript 54 (BRCAT54) mRNA-previously shown by microarray analysis to be highly expressed in DCIS-were detectable in these samples. Cocaine 20-27 CART prepropeptide Homo sapiens 80-86 33705816-1 2021 The existence of the peptide encoded by the cocaine- and amphetamine-regulated transcript (Cartpt) has been recognized since 1981, but it was not until 1995, that the gene encoding CART peptide (CART) was identified. Cocaine 44-51 CART prepropeptide Homo sapiens 181-185 35488751-0 2022 (Cocaine-amphetamine regulated transcript (CART) - promising omics breakthrough in the endocrinology). Cocaine 1-8 CART prepropeptide Homo sapiens 43-47 34043767-1 2021 Cocaine- and Amphetamine-Regulated Transcript encodes an eponymous peptide, CARTp, which exerts diverse pharmacologic actions in the central and peripheral nervous systems, as well as in several endocrine organs, including pancreas. Cocaine 0-7 CART prepropeptide Homo sapiens 76-81 33705816-1 2021 The existence of the peptide encoded by the cocaine- and amphetamine-regulated transcript (Cartpt) has been recognized since 1981, but it was not until 1995, that the gene encoding CART peptide (CART) was identified. Cocaine 44-51 CART prepropeptide Homo sapiens 195-199 31999650-5 2020 We also identified cocaine- and amphetamine-regulated transcript peptide (CARTp) as a GPR160 ligand. Cocaine 19-26 CART prepropeptide Homo sapiens 74-79 32005500-1 2020 Cocaine-regulated and amphetamine-regulated transcript (CART) is a neuropeptide with reported neuroprotective effects in ischemic cerebral injury. Cocaine 0-7 CART prepropeptide Homo sapiens 56-60 28860971-0 2017 A New Insight into the Role of CART in Cocaine Reward: Involvement of CaMKII and Inhibitory G-Protein Coupled Receptor Signaling. Cocaine 39-46 CART prepropeptide Homo sapiens 31-35 29652077-0 2018 The implications of cocaine use and associated behaviors on adverse cardiovascular outcomes among veterans: Insights from the VA Clinical Assessment, Reporting, and Tracking (CART) Program. Cocaine 20-27 CART prepropeptide Homo sapiens 129-173 29983247-0 2018 Cocaine- and amphetamine-regulated transcript (CART) peptide in the enteric nervous system of the porcine esophagus. Cocaine 0-7 CART prepropeptide Homo sapiens 47-51 29080905-2 2018 CART is activated by high levels of dopamine and might be of interested in understanding the changes in the REDOX system associated with crack/cocaine intake. Cocaine 137-142 CART prepropeptide Homo sapiens 0-4 29080905-2 2018 CART is activated by high levels of dopamine and might be of interested in understanding the changes in the REDOX system associated with crack/cocaine intake. Cocaine 143-150 CART prepropeptide Homo sapiens 0-4 29080905-3 2018 The goal of this study was to determine whether exposure to crack in utero is associated with increased CART levels. Cocaine 60-65 CART prepropeptide Homo sapiens 104-108 29080905-10 2018 CONCLUSION: The increase in CART levels in EN UBC suggests a response to crack/cocaine-induced oxidative stress during gestational period, as a potential attempt of neuroprotection. Cocaine 73-78 CART prepropeptide Homo sapiens 28-32 29080905-10 2018 CONCLUSION: The increase in CART levels in EN UBC suggests a response to crack/cocaine-induced oxidative stress during gestational period, as a potential attempt of neuroprotection. Cocaine 79-86 CART prepropeptide Homo sapiens 28-32 31918705-0 2020 Cocaine and amphetamine-regulated transcript prepropeptide gene (CARTPT) polymorphism interacts with Diet Quality Index-International (DQI-I) and Healthy Eating Index (HEI) to affect hypothalamic hormones and cardio-metabolic risk factors among obese individuals. Cocaine 0-7 CART prepropeptide Homo sapiens 65-71 28860971-2 2017 Injection of CART into the NAc can inhibit the behavioral effects of cocaine, and injecting CART into the ventral tegmental area (VTA) reduces cocaine-seeking behavior. Cocaine 69-76 CART prepropeptide Homo sapiens 13-17 28860971-5 2017 Hence, we review the role of CaMKII and inhibitory GPCR signaling in the effect of CART on cocaine reward and provide a new insight into the mechanism of that effect. Cocaine 91-98 CART prepropeptide Homo sapiens 83-87 28860971-8 2017 Furthermore, we will discuss how CaMKII and inhibitory GPCR signaling are involved in the mechanistic action of CART in cocaine reward. Cocaine 120-127 CART prepropeptide Homo sapiens 112-116 28860971-9 2017 Finally, we will provide our opinions regarding the future directions of research on the role of CaMKII and inhibitory GPCR signaling in the effect of CART on cocaine reward. Cocaine 159-166 CART prepropeptide Homo sapiens 151-155 26730935-0 2016 Leptin-Induced CART (Cocaine- and Amphetamine-Regulated Transcript) Is a Novel Intraovarian Mediator of Obesity-Related Infertility in Females. Cocaine 21-28 CART prepropeptide Homo sapiens 15-19 27121571-0 2016 Immunohistochemical localization of cocaine- and amphetamine-regulated transcript peptide (CARTp) in the brain of the pigeon (Columba livia) and zebra finch (Taeniopygia guttata). Cocaine 36-43 CART prepropeptide Homo sapiens 91-96 27121571-1 2016 Cocaine- and amphetamine-regulated transcript peptides (CARTp) are neuropeptides that act as neurotransmitters in the brain of vertebrates. Cocaine 0-7 CART prepropeptide Homo sapiens 56-61 26730935-6 2016 Importantly, we show that leptin induces expression of the neuropeptide cocaine- and amphetamine-regulated transcript (CART) in the granulosa cells (GCs) of ovarian follicles both in vitro and in vivo. Cocaine 72-79 CART prepropeptide Homo sapiens 119-123 25309361-3 2014 Consistent with this proposition, we previously found that inactivation of the PVT or infusions of CART into the PVT suppressed drug-seeking behavior in an animal model of contingent cocaine self-administration. Cocaine 183-190 CART prepropeptide Homo sapiens 99-103 26188033-3 2015 The results showed that DEX significantly inhibited gene expression of cocaine- and amphetamine-regulated transcripts (CART), melanocortin receptor 4 (MC4R), and corticotropin-releasing hormone (CRH), and inhibited the protein level of the phospho-TOR compared with the control in HFD-fed chicks (P<0.05) but not in LFD-fed chicks (P>0.05). Cocaine 71-78 CART prepropeptide Homo sapiens 119-123 25309361-5 2014 Further, our previous work did not assess how infusions of CART, which we found to decrease cocaine-seeking, altered the activity of PVT neurons. Cocaine 92-99 CART prepropeptide Homo sapiens 59-63 25309361-12 2014 Application of CART significantly suppressed excitatory synaptic drive to PVT neurons in both cocaine-treated and control recordings. Cocaine 94-101 CART prepropeptide Homo sapiens 15-19 22186082-2 2012 We hypothesized that the neuropeptide cocaine- and amphetamine-regulated transcript (CART) is involved in the natural reward action mediated by the circuitry. Cocaine 38-45 CART prepropeptide Homo sapiens 85-89 22903082-0 2012 Characterisation of cocaine- and amphetamine- regulated transcript-like immunoreactive (CART-LI) enteric neurons in the porcine small intestine. Cocaine 20-27 CART prepropeptide Homo sapiens 88-92 22030409-0 2011 Comparative distribution of cocaine- and amphetamine-regulated transcript (CART) in the hypothalamus of the capuchin monkey (Cebus apella) and the common marmoset (Callithrix jacchus). Cocaine 28-35 CART prepropeptide Homo sapiens 75-79 22030409-1 2011 Cocaine- and amphetamine-regulated transcript (CART) is widely distributed in the brain of many species. Cocaine 0-7 CART prepropeptide Homo sapiens 47-51 17854774-6 2008 These and other data suggest that CART in the accumbens blunts the effects of cocaine. Cocaine 78-85 CART prepropeptide Homo sapiens 34-38 18572320-0 2008 Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence. Cocaine 24-31 CART prepropeptide Homo sapiens 76-82 18572320-4 2008 Genotypes of three HapMap tagging SNPs (rs6894758; rs11575893; rs17358300) across the CARTPT gene region were obtained in cocaine dependent individuals (n=348) and normal controls (n=256). Cocaine 122-129 CART prepropeptide Homo sapiens 86-92 21886553-2 2011 Injection of CART 55-102 into the nucleus accumbens produces no effect, but when co-administered with cocaine, it reduces the locomotor and rewarding properties of cocaine. Cocaine 164-171 CART prepropeptide Homo sapiens 13-17 17631364-7 2007 However, in the monkey sublenticular extended amygdala, low dose cocaine self-administration resulted in increased CART transcript levels after both 5 and 100 days of self-administration, whereas no difference was found after high dose self-administration. Cocaine 65-72 CART prepropeptide Homo sapiens 115-119 16765484-2 2006 The neuropeptide CART was discovered in 1995 in a search for cocaine and amphetamine regulated transcripts in the striatum, but subsequently found to be expressed at much higher levels in the hypothalamus. Cocaine 61-68 CART prepropeptide Homo sapiens 17-21 17088012-1 2006 Synthetic derivative of C-terminal fragment of CART (55-102) with reduced thiol groups, [Abu(86,94)]CART (85-102)(red), given together with amphetamine (5 mg/kg, s.c.) or cocaine (15 mg/kg, s.c.), reversed hyperlocomotion induced by these drugs at a dose of 0.1 microg but not at a higher dose. Cocaine 171-178 CART prepropeptide Homo sapiens 47-51 16766084-2 2006 There is extensive anatomical, pharmacological, and behavioral evidence supporting the importance of CART peptides in psychostimulant, namely cocaine and amphetamine, abuse. Cocaine 142-149 CART prepropeptide Homo sapiens 101-105 16146347-5 2005 Second, CART 55 to 102 blunts some of the behavioral effects of cocaine and dopamine (DA). Cocaine 64-71 CART prepropeptide Homo sapiens 8-12 16146347-11 2005 Fifth, in humans, CART is altered in the ventral tegmental area of cocaine overdose victims, and a mutation in the CART gene associates with alcoholism. Cocaine 67-74 CART prepropeptide Homo sapiens 18-22 11713200-0 2001 Characterization of two forms of cocaine- and amphetamine-regulated transcript (CART) peptide precursors in goldfish: molecular cloning and distribution, modulation of expression by nutritional status, and interactions with leptin. Cocaine 33-40 CART prepropeptide Homo sapiens 80-84 11713200-1 2001 Complementary DNAs encoding two forms of cocaine- and amphetamine-regulated transcript (CART) peptide precursors were identified from goldfish brain and named CART I and CART II. Cocaine 41-48 CART prepropeptide Homo sapiens 88-92 11713200-1 2001 Complementary DNAs encoding two forms of cocaine- and amphetamine-regulated transcript (CART) peptide precursors were identified from goldfish brain and named CART I and CART II. Cocaine 41-48 CART prepropeptide Homo sapiens 159-163 11713200-1 2001 Complementary DNAs encoding two forms of cocaine- and amphetamine-regulated transcript (CART) peptide precursors were identified from goldfish brain and named CART I and CART II. Cocaine 41-48 CART prepropeptide Homo sapiens 159-163 15051141-10 2004 The specific location of CART peptide in the dentate granule cells of rodents and in the mossy cells of the human hippocampus may indicate involvement of neuronal circuitry of the dentate gyrus in the memory-related effects of cocaine and amphetamine. Cocaine 227-234 CART prepropeptide Homo sapiens 25-29 12801595-4 2003 But in the nucleus accumbens, CART peptide reduces the locomotor-increasing effects of cocaine. Cocaine 87-94 CART prepropeptide Homo sapiens 30-34 12609760-1 2003 Cocaine- and amphetamine-regulated transcript (CART) mRNA is expressed in a number of hypothalamic nuclei including the arcuate nucleus (ARC). Cocaine 0-7 CART prepropeptide Homo sapiens 47-51 12007533-9 2002 Cocaine amphetamine regulated transcript (CART) peptides and pre-proglucagon derived peptides, glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) are catabolic neurotransmitters synthesised in neurones of the arcuate nucleus and the nucleus of the solitary tract, respectively. Cocaine 0-7 CART prepropeptide Homo sapiens 42-46