PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10207609-5 1999 Calculation of steady-state AChE activity in the presence of inhibitor and oxime revealed that obidoxime was superior to pralidoxime. pralidoxime 121-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 9806430-4 1998 At oxime concentrations anticipated to be relevant in humans, obidoxime and pralidoxime were extremely weak reactivators of AChE. pralidoxime 76-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 1412499-5 1992 Based on 95% confidence limits the rank order of potentiation with eel AChE was TMB-4 = Toxogonin > HS-6 = HI-6 > 2-PAM Cl. pralidoxime 120-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 9587020-0 1998 Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds. pralidoxime 35-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 9587020-6 1998 Isolated human erythrocyte AChE was inhibited with soman, sarin, cyclosarin, tabun or VX for 30 min and reactivated in the absence of inhibitory activity over 5-60 min by obidoxime, pralidoxime, HI 6 or HLo 7 (10 and 30 microM). pralidoxime 182-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 9587020-10 1998 Obidoxime and pralidoxime were weak reactivators of cyclosarin-inhibited AChE. pralidoxime 14-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 8134223-5 1994 (2) Laboratory study: The direct effect of obidoxime and of pralidoxime on acetylcholinesterase activity in vitro was investigated in normal human packed red blood cells pretreated with an organophosphate (paraoxon) or a carbamate (aldicarb or methomyl). pralidoxime 60-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 5786978-5 1969 It has previously been demonstrated (Rogers et al., 1966) that one-third of the DFP-sensitive sites at the endplate can be reactivated by pyridine-2-aldoxime methiodide (2-PAM)-a compound which selectively reactivates phosphorylated acetylcholinesterase. pralidoxime 138-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-253 1909249-8 1991 However, the DFP-treated AChE biosensor recovered fully after a 10-min perfusion with pralidoxime (2-PAM). pralidoxime 86-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 2271146-3 1990 Reactivation of immobilized AChE after inhibition with reversible inhibitor, i.e. nicotine and fluoride ion is carried out using a mixture of working buffer and acetylcholine, whereas reactivation after inhibition with irreversible inhibitor, i.e. organophosphorus compounds is carried out using a mixture of acetylcholine and pyridine-2-aldoxime methiodide (PAM). pralidoxime 327-357 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 2271146-3 1990 Reactivation of immobilized AChE after inhibition with reversible inhibitor, i.e. nicotine and fluoride ion is carried out using a mixture of working buffer and acetylcholine, whereas reactivation after inhibition with irreversible inhibitor, i.e. organophosphorus compounds is carried out using a mixture of acetylcholine and pyridine-2-aldoxime methiodide (PAM). pralidoxime 359-362 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 35023196-6 2022 There is no doubt that obidoxime and pralidoxime are able to reactivate OP inhibited AChE activity in poisoned patients thereby increasing AChE activity and contributing substantially to terminate cholinergic crisis. pralidoxime 37-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 35023196-6 2022 There is no doubt that obidoxime and pralidoxime are able to reactivate OP inhibited AChE activity in poisoned patients thereby increasing AChE activity and contributing substantially to terminate cholinergic crisis. pralidoxime 37-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 34989015-2 2022 The AChE reactivating antidote pralidoxime was developed in the 1950s and soon noted to benefit patients occupationally poisoned with the highly potent OP insecticide parathion. pralidoxime 31-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 2804138-4 1989 The rank order in which ligands stabilized AChE was: edrophonium greater than decamethonium greater than pralidoxime chloride much greater than procainamide. pralidoxime 105-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 3421136-0 1988 Effects of pralidoxime applied locally into the midbrain reticular formation on the hippocampal theta rhythm induced by acetylcholinesterase inhibition. pralidoxime 11-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 3421136-1 1988 After local administration into the midbrain reticular formation of an acetylcholinesterase reactivator--Pralidoxime, a significant decrease of intensity of hippocampal theta rhythm induced by previous inhibition of acetylcholinesterase by DFP was observed already after 10 min. pralidoxime 105-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 3421136-1 1988 After local administration into the midbrain reticular formation of an acetylcholinesterase reactivator--Pralidoxime, a significant decrease of intensity of hippocampal theta rhythm induced by previous inhibition of acetylcholinesterase by DFP was observed already after 10 min. pralidoxime 105-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-236 3098245-2 1986 The present paper evaluates the interaction of aprophen with acetylcholinesterases, butyrylcholinesterases, and carboxylesterases with respect to protecting the enzyme from organophosphate and carbamate inhibition, accelerating pralidoxime iodide (2-PAM) regeneration of the diisopropylphospho-enzyme, and comparing the inhibition and regeneration kinetics of a soluble mammalian acetylcholinesterase with that of bovine erythrocyte acetylcholinesterase. pralidoxime 228-246 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 3746817-7 1986 The in vitro reactivation potency of the alpha-keto thiohydroximates approaches and even surpasses that of 2-PAM and toxogonin for GD-inhibited AChE. pralidoxime 107-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 5786978-5 1969 It has previously been demonstrated (Rogers et al., 1966) that one-third of the DFP-sensitive sites at the endplate can be reactivated by pyridine-2-aldoxime methiodide (2-PAM)-a compound which selectively reactivates phosphorylated acetylcholinesterase. pralidoxime 170-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-253 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. pralidoxime 12-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 33960866-10 2022 Five of six patients receiving pralidoxime chloride 2 g showed an initial increase in AChE and BuChE activity that was not sustained despite an infusion of pralidoxime. pralidoxime 31-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 33960866-10 2022 Five of six patients receiving pralidoxime chloride 2 g showed an initial increase in AChE and BuChE activity that was not sustained despite an infusion of pralidoxime. pralidoxime 31-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 32645360-6 2020 These compounds were evaluated for their in-vitro reactivation ability against pesticide (paraoxon-ethyl and paraoxon-methyl) inhibited-AChE and compared with standards antidote AChE reactivators pralidoxime and obidoxime. pralidoxime 196-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 32898602-9 2020 An increase in reactivation of POX-inhibited human brain acetylcholinesterase up to 36.08 +- 4.3% after intravenous administration of 2-PAM-DSPE-PEG2000-SLNs (dose of 2-PAM is 5 mg/kg) was achieved. pralidoxime 134-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. pralidoxime 12-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 29577198-1 2018 The efficiency of different reactivators of cholinesterase (toxogonin, dipiroxime, pralidoxime, carboxim, HI-6, and methoxime) at inhibition of butyrylcholinesterase and human acetylcholinesterase by organophosphate insecticide malathion was evaluated in in vitro experiments. pralidoxime 83-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 28328690-7 2018 There is reasonable theoretical science to suggest pralidoxime in case of acetylcholinesterase inhibitor toxicity. pralidoxime 51-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 31879781-5 2020 The primary therapeutic strategy employed in the U.S. to treat OP intoxication includes reactivation of inhibited AChE with the oxime pralidoxime (2-PAM) along with the muscarinic acetylcholine receptor antagonist atropine and the benzodiazepine, diazepam. pralidoxime 128-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 31100277-1 2019 Since the development in the 1950"s of 2-PAM (Pralidoxime), an antidote that reactivates organophosphate conjugated acetylcholinesterase in target tissues upon pesticide or nerve agent exposure, improvements in antidotal therapy have largely involved congeneric pyridinium aldoximes. pralidoxime 39-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 31100277-1 2019 Since the development in the 1950"s of 2-PAM (Pralidoxime), an antidote that reactivates organophosphate conjugated acetylcholinesterase in target tissues upon pesticide or nerve agent exposure, improvements in antidotal therapy have largely involved congeneric pyridinium aldoximes. pralidoxime 46-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 28106328-5 2017 QM/MM simulations of VX-inhibited AChE reactivation by pralidoxime (2-PAM), a classical reactivator, were performed. pralidoxime 55-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 29482737-10 2018 (2) 2-PAM Cl, showed limited effectiveness in reactivating PHO-inhibited AChE, suggesting that it may have limited usefulness in the clinical management of acute PHO intoxication. pralidoxime 4-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 28106328-5 2017 QM/MM simulations of VX-inhibited AChE reactivation by pralidoxime (2-PAM), a classical reactivator, were performed. pralidoxime 68-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 26558640-1 2016 Analogs of pralidoxime, which is a commercial antidote for intoxication from neurotoxic organophosphorus compounds, were designed, synthesized, characterized, and tested as potential inhibitors or reactivators of acetylcholinesterase (AChE) using the Ellman"s test, nuclear magnetic resonance, and molecular modeling. pralidoxime 11-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-233 26558640-1 2016 Analogs of pralidoxime, which is a commercial antidote for intoxication from neurotoxic organophosphorus compounds, were designed, synthesized, characterized, and tested as potential inhibitors or reactivators of acetylcholinesterase (AChE) using the Ellman"s test, nuclear magnetic resonance, and molecular modeling. pralidoxime 11-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-239 27102179-3 2016 As such, it is logical to assume that the currently accepted therapies for organophosphate poisoning (muscarinic antagonist atropine and the oxime acetylcholinesterase reactivator pralidoxime chloride [2-PAM Cl]) could afford therapeutic protection. pralidoxime 180-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 27062893-1 2016 Currently fielded treatments for nerve agent intoxication include atropine, an acetylcholine receptor antagonist, and pralidoxime (2PAM), a small molecule reactivator of acetylcholinesterase (AChE). pralidoxime 118-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 27062893-1 2016 Currently fielded treatments for nerve agent intoxication include atropine, an acetylcholine receptor antagonist, and pralidoxime (2PAM), a small molecule reactivator of acetylcholinesterase (AChE). pralidoxime 118-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 27179675-7 2016 Based on the full information provided by this method, the efficacy of reactivators, such as HI-6, obidoxime and pralidoxime, in the typical treatment of NAs poisoned AChE in in vitro was further evaluated. pralidoxime 113-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 21983245-8 2011 However, both newly developed oximes achieved similar reactivations rates that pralidoxime for chlorpyrifos and diazinon-inhibited AChE. pralidoxime 79-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 26210933-1 2016 The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP). pralidoxime 66-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 26165232-9 2015 Lastly, in addition to inhibition, AChE reactivation was measured in SH-SY5Y cells incubated with pralidoxime chloride (2-PAM). pralidoxime 98-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 23962483-5 2013 It became evident that pralidoxime and obidoxime in therapeutic concentrations aggravate the inhibition of AChE by carbaryl and propoxur, with obidoxime being substantially more potent compared to 2-PAM. pralidoxime 23-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 23461011-3 2013 Acetylcholinesterase reactivation peak (5-mins long) was found to take place upon introduction of dipyroxime (32.5%), pralidoxime (18%), carboxyme (16%) at a concentration of 2.5 x 10(-4) mol/l or toxogonine (26%) at a concentration of 5 x 10(-4) mol/l. pralidoxime 118-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 25712411-4 2015 Twenty four hours after administration of pralidoxime, RBC AChE activities had increased in patients in the dichlorvos and EPN groups, while RBC AChE activities had slightly decreased in the fenitrothion group. pralidoxime 42-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 25712411-4 2015 Twenty four hours after administration of pralidoxime, RBC AChE activities had increased in patients in the dichlorvos and EPN groups, while RBC AChE activities had slightly decreased in the fenitrothion group. pralidoxime 42-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 25672327-0 2014 Regional preparedness for mass acetylcholinesterase inhibitor poisoning through plans for stockpiling and interhospital sharing of pralidoxime. pralidoxime 131-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 25672327-2 2014 Little attention has been paid to how well regional preparedness efforts specifically affect availability of pralidoxime (2-PAM) if it were needed to treat a mass poisoning with acetylcholinesterase inhibitors (organophosphorus pesticides or nerve agents). pralidoxime 109-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 23527625-1 2014 The present work describes a simple integrated Quantum Mechanics/Molecular Mechanics method developed to study the reactivation steps by pralidoxime (2-PAM) of acetylcholinesterase (AChE) inhibited by the neurotoxic agent Tabun. pralidoxime 137-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-180 23527625-1 2014 The present work describes a simple integrated Quantum Mechanics/Molecular Mechanics method developed to study the reactivation steps by pralidoxime (2-PAM) of acetylcholinesterase (AChE) inhibited by the neurotoxic agent Tabun. pralidoxime 137-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 24157926-2 2013 Standard treatment by administration of atropine and oximes, e.g., obidoxime or pralidoxime, focuses on antagonism of mAChRs and reactivation of AChE, whereas nicotinic malfunction is not directly treated. pralidoxime 80-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 23735753-9 2013 On the other hand pralidoxime, an oxime, reactivating acetylcholinesterase (AChE) after organophosphate poisoning, induced population spike recovery after DFP exposure in the presence of bradykinin and Lys-des-Arg(9)-bradykinin. pralidoxime 18-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 23789829-6 2013 Furthermore, from virtual screening of two commercial databases, Maybridge and ChemNavigator using map-fitting of the model led us to identify two new non-oxime compounds showing reactivation efficacy within 10-fold range of 2-PAM for DFP-inhibited AChE. pralidoxime 225-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 249-253 22360473-7 2012 The current treatment for OPNA poisoning combines an antimuscarinic drug (e.g., atropine), an anticonvulsant drug (e.g., diazepam), and an AChE reactivator of the pyridinium aldoxime family (pralidoxime, trimedoxime, obidoxime, HI-6, HLo-7). pralidoxime 191-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 21569834-8 2011 Pralidoxime partially regenerated AChE activity and protected against POX inhibition of PSs. pralidoxime 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 20027669-5 2011 Commercial AChE reactivators (e.g. pralidoxime, HI-6, obidoxime, trimedoxime, methoxime) were originally developed for other members of the organophosphate family, such as nerve agents (e.g. sarin, soman, tabun, VX). pralidoxime 35-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 20027669-6 2011 Pralidoxime, HI-6, and methoxime were found to be weak reactivators of OPP-inhibited AChE. pralidoxime 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 20655881-6 2010 A homology model for wild-type Bo AChE was built using the recently published crystal structure of human AChE and used to generate models of 2-PAM and HI-6 bound to the active-sites of GF- and VR-inhibited Bo AChEs before nucleophilic attack. pralidoxime 141-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). pralidoxime 100-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 19651196-9 2009 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the recommended pyridinium oximes (pralidoxime, trimedoxime, obidoxime and HI-6) and diazepam are used for the treatment of OP poisoning in humans. pralidoxime 135-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 20227398-1 2010 The US Army utilizes pralidoxime (2-PAM) for the reactivation of OP-inhibited AChE. pralidoxime 21-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 20406208-2 2010 Human malathion poisoning has been treated with oximes (mainly pralidoxime) in an attempt to reactivate OP-inhibited acetylcholinesterase (AChE). pralidoxime 63-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 20370537-1 2010 Reactivation efficacy of three homologous and three isomeric series of pralidoxime-type reactivators with aldoxime group in position 2, 3 and 4 of the heterocycle was tested in reactivation of tabun-inhibited AChE. pralidoxime 71-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 19433070-11 2009 The effectiveness of pralidoxime in reactivating the inhibited acetylcholinesterase is strongly dependent on the CPO concentration. pralidoxime 21-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 18675298-5 2008 The results concerning the AChE inhibition by methyl-paraoxon and the subsequent reactivation by pyridine-2-aldoxime methochloride (2-PAM) are presented and discussed. pralidoxime 97-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 19564902-8 2009 Pralidoxime produced substantial and moderate red cell acetylcholinesterase reactivation in patients poisoned by diethyl and dimethyl compounds, respectively. pralidoxime 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 19564902-10 2009 Incorporating the baseline amount of acetylcholinesterase already aged and plasma OP concentration into the analysis increased the HR for patients receiving pralidoxime compared to placebo, further decreasing the likelihood that pralidoxime is beneficial. pralidoxime 157-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 19564902-10 2009 Incorporating the baseline amount of acetylcholinesterase already aged and plasma OP concentration into the analysis increased the HR for patients receiving pralidoxime compared to placebo, further decreasing the likelihood that pralidoxime is beneficial. pralidoxime 229-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 18617161-5 2008 In this study, we have tested potency of selected cholinesterase reactivators (pralidoxime, obidoxime, trimedoxime, methoxime and H-oxime HI-6) to reactivate human erythrocyte AChE and human plasma BuChE inhibited by pesticide paraoxon. pralidoxime 79-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 17503257-3 2007 In this article, we compared the reactivation potency of five structurally different AChE reactivators (pralidoxime, trimedoxime, methoxime, HS-6, and BI-6) to reactivate cyclosarin-inhibited cholinesterases of human brain. pralidoxime 104-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 18676153-2 2008 Eighteen monoquaternary reactivators of acetylcholinesterase with modified side chain were developed in an effort to extend the properties of pralidoxime. pralidoxime 142-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 17590326-6 2007 Ninety-five percent reactivation of the inhibited AChE could be regenerated using pralidoxime iodide within 8 min. pralidoxime 82-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 16904807-2 2007 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. pralidoxime 109-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 16904807-2 2007 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. pralidoxime 109-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 17096373-5 2007 Patient"s acetylcholinesterase (ACE) level was 3,319 IU/L in presentation and pralidoxim use was seen unnecessary for the treatment. pralidoxime 78-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-30 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. pralidoxime 53-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. pralidoxime 53-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. pralidoxime 373-387 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 16971069-1 2006 Pralidoxime iodide (2-PAM), an antidote approved for the reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning, dose-dependently hydrolyzed an acetylthiocholine iodide (ASCh). pralidoxime 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 16971069-1 2006 Pralidoxime iodide (2-PAM), an antidote approved for the reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning, dose-dependently hydrolyzed an acetylthiocholine iodide (ASCh). pralidoxime 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 16429518-1 2005 The aim of this work was the comparison of reactivation potency of four oxime acetylcholinesterase (AChE) reactivators (pralidoxime, HI-6, K027 and K033) on three resources of the enzyme (human, pig and rat brain homogenate) inhibited by nerve agent sarin. pralidoxime 120-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 16429518-1 2005 The aim of this work was the comparison of reactivation potency of four oxime acetylcholinesterase (AChE) reactivators (pralidoxime, HI-6, K027 and K033) on three resources of the enzyme (human, pig and rat brain homogenate) inhibited by nerve agent sarin. pralidoxime 120-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 15904945-2 2005 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. pralidoxime 109-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 15904945-2 2005 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. pralidoxime 109-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 16243090-9 2005 Acetylcholinesterase inhibited by fenthion or dimethoate responded poorly to pralidoxime treatment compared with chlorpyrifos-inhibited acetylcholinesterase. pralidoxime 77-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16119192-3 2005 Therefore, to better evaluate the efficacy of various oximes (pralidoxime, obidoxime, HI-6, K033) to reactivate brain acetylcholinesterase inhibited by sarin by in vitro methods, human, rat and pig brain acetylcholinesterase were used to calculate kinetic parameters for the reactivation. pralidoxime 62-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 16124202-3 2005 AChE reactivators (pralidoxime, obidoxime and HI-6) as causal antidotes are used for the cleavage of the bond between the enzyme and nerve agent. pralidoxime 19-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16119193-5 2005 Their cleaving potencies were compared with 4-PAM (4-hydroxyiminomethyl-1-methylpyridinium iodide), which is derived from the structure of the currently used AChE-reactivator 2-PAM (2-hydroxyiminomethyl-1-methylpyridinium iodide). pralidoxime 175-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 11180275-0 2001 Pralidoxime and l-lactate effects in vitro on the inhibition of acetylcholinesterase by paraoxon: pralidoxime does not confer superior protection. pralidoxime 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 12583698-3 2003 This implies that, while pralidoxime acts to reverse intoxication by organophosphate compounds due to the otherwise irreversible inhibition of acetylcholinesterase, it does not also supplement this detoxification by hydrolysis of the enzyme"s substrate, acetylcholine. pralidoxime 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 15181665-7 2003 In vitro studies with human erythrocyte AChE, which is derived from the same single gene as synaptic AChE, revealed marked differences in the potency and efficacy of pralidoxime, obidoxime, HI 6 and HLo 7, the latter two oximes being considered particularly effective in nerve agent poisoning. pralidoxime 166-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 15181665-7 2003 In vitro studies with human erythrocyte AChE, which is derived from the same single gene as synaptic AChE, revealed marked differences in the potency and efficacy of pralidoxime, obidoxime, HI 6 and HLo 7, the latter two oximes being considered particularly effective in nerve agent poisoning. pralidoxime 166-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105