PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18987553-3 2009 It has been also shown that an acetylcholinesterase inhibitor, the short-acting drug edrophonium administered intravenously caused a greater increase in the esophageal contraction amplitude and duration than bethanechol. Edrophonium 85-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 10619655-4 1999 The action of AChE was not affected by edrophonium and tacrine both active site inhibitors, but it was abolished by propidium and gallamine, two peripheral anionic binding site (PAS) ligands. Edrophonium 39-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 18585045-0 2008 Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors. Edrophonium 26-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 12195322-8 2002 The edrophonium test (short acting inhibitor of acetylcholinesterase) was positive (elevation of the ptotic lid after injection of edrophonium). Edrophonium 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 12195322-8 2002 The edrophonium test (short acting inhibitor of acetylcholinesterase) was positive (elevation of the ptotic lid after injection of edrophonium). Edrophonium 131-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 11313335-7 2001 Furthermore, when the acylation site ligands edrophonium or m-(N, N,N-trimethylammonio)trifluoroacetophenone form ternary complexes with AChE and thioflavin T, the fluorescence is quenched by factors of 2.7-4.2. Edrophonium 45-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 8506114-5 1993 Finally, AChE purified by affinity chromatography on edrophonium chloride was shown to be antigenic by Western blotting, and in ELISA, against post-infection sera, although a degree of re-activity was also seen with normal human sera. Edrophonium 53-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 9398183-2 1997 The Y337 (F330) in mammalian acetylcholinesterase, which is replaced by A328 in human butyrylcholinesterase, is implicated in the binding of ligands such as huperzine A, edrophonium, and acridines and one end of bisquaternary compounds such as BW284C51 and decamethonium. Edrophonium 170-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 8306998-6 1994 AChE in all three extracts was affected by the AChE inhibitors eserine, bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide and edrophonium chloride, but was resistant to the effects of tetramonoisopropylpyrophosphortetramide, a butyrylcholinesterase inhibitor. Edrophonium 133-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 10433700-0 1999 Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium. Edrophonium 94-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 10433700-2 1999 This study with native, wild-type, and mutant recombinant DNA-expressed AChEs, each inhibited by representative OP compounds, establishes a relationship between edrophonium acceleration of oxime-induced reactivation of OP-AChE conjugates and phosphoryl oxime inhibition of the reactivated enzyme that occurs during reactivation by pyridinium oximes LuH6 and TMB4. Edrophonium 161-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 8900891-8 1996 After injection of edrophonium-chloride (Tensilon) inhibition of AChE activity can be demonstrated as well. Edrophonium 19-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 8900891-8 1996 After injection of edrophonium-chloride (Tensilon) inhibition of AChE activity can be demonstrated as well. Edrophonium 41-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 1986786-4 1991 Kinetic analysis of the inactivation of AcChE (i) by various concentrations of 1 indicated that it behaves as an affinity label, (ii) at three different pH levels suggested that the pKa of the labelled residue was higher than 7 and (iii) in the presence of different selective ligands for either the active site (edrophonium) or the peripheral site (propidium) indicated that 1 alkylated the active site rather than the peripheral one. Edrophonium 313-324 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-45 1547059-0 1992 Effects of neostigmine and edrophonium on human erythrocyte acetylcholinesterase activity. Edrophonium 27-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 1547059-1 1992 Erythrocyte acetylcholinesterase (AChE) activities in vivo were measured over 60 min using a spectrophotometric method after administration of neostigmine or edrophonium for antagonism of pancuronium-induced neuromuscular block in 31 patients. Edrophonium 158-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 1547059-1 1992 Erythrocyte acetylcholinesterase (AChE) activities in vivo were measured over 60 min using a spectrophotometric method after administration of neostigmine or edrophonium for antagonism of pancuronium-induced neuromuscular block in 31 patients. Edrophonium 158-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 1547059-4 1992 The results suggest that mechanisms other than AChE inhibition may be responsible for the anti-curare effect of edrophonium. Edrophonium 112-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 1909249-4 1991 The reversible inhibitor edrophonium (0.1 mM) inhibited AChE and consequently reduced fluorescence quenching. Edrophonium 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 2804138-4 1989 The rank order in which ligands stabilized AChE was: edrophonium greater than decamethonium greater than pralidoxime chloride much greater than procainamide. Edrophonium 53-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 4005268-5 1985 Binding of edrophonium to the active site of 11 S acetylcholinesterase increases alpha-helix, while binding of propidium to the peripheral site increases beta-sheet. Edrophonium 11-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 2666960-4 1989 Because no improvement was seen for 2 weeks, the acetylcholinesterase inhibitors edrophonium and pyridostigmine were instituted. Edrophonium 81-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 2913485-4 1989 With this band as a probe, the bound tacrine could be displaced by edrophonium or decamethonium, both of which are known to bind to the anionic site at the active center of AChE, but not by propidium, which binds to the peripheral site of the enzyme. Edrophonium 67-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 3166338-8 1988 In our experience, the inhibitor constant (Kl) for edrophonium, which is highly specific for AChE, is approximately 5 x 10(-5) M against adult human erythrocytes that contain significantly more total cholinesterase activity than do erythrocytes from umbilical cord blood. Edrophonium 51-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 1125207-13 1975 Although propidium and edrophonium associate at separate sites on acetylcholinesterase, bis-quaternary ligands where the quaternary nitrogens are separated by 14 A displace both ligands from the enzyme with equal effectiveness. Edrophonium 23-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 7315401-4 1981 The dissociation constant of the crude enzyme-edrophonium complex determined in the affinity chromatographic experiments was 1.5 X 10(-5) M and in enzymatic experiments 1.8 X 10(-7) M. It is proposed that there is present in mammalian neuronal tissue a factor that increases the affinity of certain cholinergic ligands to a site other than the catalytic site on AChE. Edrophonium 46-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 362-366 7402075-1 1980 Endogenous cholinergic stimulation, produced by the intravenous injection of edrophonium (10 mg), an acetylcholinesterase inhibitor, into 8 normal human subjects, resulted in an increase in the mean (+/- SE) serum growth hormone (GH) concentration from 0.6 +/- 0.1 ng/ml to 5.6 +/- 1.4 ng/ml (p < 0.01) at 40 min with no changes in serum prolactin. Edrophonium 77-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 6371009-3 1984 Nonspecific proteolytic degradation was reduced both by the inclusion of edrophonium chloride, which protected acetylcholinesterase from inactivation, and by covalent attachment of papain to Sepharose CL-4B. Edrophonium 73-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 21397501-3 2011 One novel compound was found to be a promising inhibitor of hAChE (in nM range) and was better than edrophonium chloride or BW284c51, but was worse than ambenonium chloride. Edrophonium 100-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-65 4274701-0 1973 Effect of diisopropylfluorophosphate, edrophonium and a stabilizing agent on the conformation of acetylcholinesterase. Edrophonium 38-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 29635172-2 2018 In the present study, a surface plasmon resonance (SPR)-based assay was developed and employed to investigate interactions between human recombinant AChE (hAChE) and four known ligands: galantamine, tacrine, donepezil and edrophonium. Edrophonium 222-233 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 28852920-5 2018 Inhibition of both the catalytic activities of AChE with edrophonium significantly reduced the amount of mineralization by decreasing the alkaline phosphatase (ALP) activity and expression of differentiation-related genes such as RUNX-2, COL1A, ALP, OC, and OP significantly (p < 0.05). Edrophonium 57-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 13314695-0 1955 The interaction of tensilon and neostigmine with acetylcholinesterase. Edrophonium 19-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 26799963-1 2016 INTRODUCTION: Acetylcholinesterase inhibitors (neostigmine, edrophonium) and encapsulating agents (sugammadex and calabadion) can be used to reverse residual neuromuscular blockade (NMB). Edrophonium 60-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34