PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32639720-0 2020 Structure of the Brain N-Acetylaspartate Biosynthetic Enzyme NAT8L Revealed by Computer Modeling. N-acetylaspartate 23-40 N-acetyltransferase 8 like Homo sapiens 61-66 32639720-1 2020 We report the results of computational modeling of a three-dimensional all-atom structure of the membrane-associated protein encoded by the NAT8L gene, aspartate N-acetyltransferase, which is essential for brain synthesis of N-acetyl-L-aspartate (NAA). N-acetylaspartate 225-245 N-acetyltransferase 8 like Homo sapiens 140-145 32639720-1 2020 We report the results of computational modeling of a three-dimensional all-atom structure of the membrane-associated protein encoded by the NAT8L gene, aspartate N-acetyltransferase, which is essential for brain synthesis of N-acetyl-L-aspartate (NAA). N-acetylaspartate 247-250 N-acetyltransferase 8 like Homo sapiens 140-145 32639720-2 2020 The lack of experimentally derived three-dimensional structures of NAT8L poses one of the obstacles in studies of the mechanism of NAA formation and understanding the precise role of NAA in neurological disorders. N-acetylaspartate 131-134 N-acetyltransferase 8 like Homo sapiens 67-72 32639720-2 2020 The lack of experimentally derived three-dimensional structures of NAT8L poses one of the obstacles in studies of the mechanism of NAA formation and understanding the precise role of NAA in neurological disorders. N-acetylaspartate 183-186 N-acetyltransferase 8 like Homo sapiens 67-72 31488434-0 2019 Correction: Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non-Small Cell Lung Cancer and Its Potential as a Circulating Biomarker. N-acetylaspartate 42-59 N-acetyltransferase 8 like Homo sapiens 64-69 20392701-1 2010 Our goal was to identify the reaction catalyzed by NAT8 (N-acetyltransferase 8), a putative N-acetyltransferase homologous to the enzyme (NAT8L) that produces N-acetylaspartate in brain. N-acetylaspartate 159-176 N-acetyltransferase 8 like Homo sapiens 138-143 30595160-3 2019 Aspartate N-acetyltransferase (Asp-NAT, encoded by Nat8l) synthesizes NAA from acetyl-CoA and aspartate and increases energy expenditure in brown adipocytes. N-acetylaspartate 70-73 N-acetyltransferase 8 like Homo sapiens 51-56 30595160-7 2019 Overexpression of Nat8l drains glucose-derived acetyl-CoA into the NAA pool at the expense of cellular lipids and certain amino acids. N-acetylaspartate 67-70 N-acetyltransferase 8 like Homo sapiens 18-23 27110360-7 2016 Starting without a priori knowledge, we detect metabolic flux changes, leading to an increased glutamine contribution to acetyl-CoA production, reveal biosynthesis of N-acetylaspartate by N-acetyltransferase 8-like (NAT8L) in lung cancer cells and show that NAT8L silencing inhibits proliferation of A549, JHH-4, PH5CH8, and BEAS-2B cells. N-acetylaspartate 167-184 N-acetyltransferase 8 like Homo sapiens 188-214 27110360-7 2016 Starting without a priori knowledge, we detect metabolic flux changes, leading to an increased glutamine contribution to acetyl-CoA production, reveal biosynthesis of N-acetylaspartate by N-acetyltransferase 8-like (NAT8L) in lung cancer cells and show that NAT8L silencing inhibits proliferation of A549, JHH-4, PH5CH8, and BEAS-2B cells. N-acetylaspartate 167-184 N-acetyltransferase 8 like Homo sapiens 216-221 27110360-7 2016 Starting without a priori knowledge, we detect metabolic flux changes, leading to an increased glutamine contribution to acetyl-CoA production, reveal biosynthesis of N-acetylaspartate by N-acetyltransferase 8-like (NAT8L) in lung cancer cells and show that NAT8L silencing inhibits proliferation of A549, JHH-4, PH5CH8, and BEAS-2B cells. N-acetylaspartate 167-184 N-acetyltransferase 8 like Homo sapiens 258-263 26819345-7 2016 RESULTS: Patients with high levels of tumoral NAA and its biosynthetic enzyme, aspartate N-acetyltransferase (NAT8L), had worse overall survival than patients with low levels of NAA and NAT8L. N-acetylaspartate 46-49 N-acetyltransferase 8 like Homo sapiens 110-115 26819345-7 2016 RESULTS: Patients with high levels of tumoral NAA and its biosynthetic enzyme, aspartate N-acetyltransferase (NAT8L), had worse overall survival than patients with low levels of NAA and NAT8L. N-acetylaspartate 46-49 N-acetyltransferase 8 like Homo sapiens 186-191 26511490-0 2016 Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non-Small Cell Lung Cancer and Its Potential as a Circulating Biomarker. N-acetylaspartate 30-47 N-acetyltransferase 8 like Homo sapiens 52-57 26511490-4 2016 NAA"s cancer specificity was further supported in our analysis of NAA synthetase (gene symbol: NAT8L) gene expression levels in The Cancer Genome Atlas: elevated NAT8L expression in approximately 40% of adenocarcinoma and squamous cell carcinoma cases (N = 577), with minimal expression in all nonmalignant lung tissues (N = 74). N-acetylaspartate 0-3 N-acetyltransferase 8 like Homo sapiens 66-80 26511490-4 2016 NAA"s cancer specificity was further supported in our analysis of NAA synthetase (gene symbol: NAT8L) gene expression levels in The Cancer Genome Atlas: elevated NAT8L expression in approximately 40% of adenocarcinoma and squamous cell carcinoma cases (N = 577), with minimal expression in all nonmalignant lung tissues (N = 74). N-acetylaspartate 0-3 N-acetyltransferase 8 like Homo sapiens 95-100 26511490-4 2016 NAA"s cancer specificity was further supported in our analysis of NAA synthetase (gene symbol: NAT8L) gene expression levels in The Cancer Genome Atlas: elevated NAT8L expression in approximately 40% of adenocarcinoma and squamous cell carcinoma cases (N = 577), with minimal expression in all nonmalignant lung tissues (N = 74). N-acetylaspartate 0-3 N-acetyltransferase 8 like Homo sapiens 162-167 26511490-5 2016 We then showed that NAT8L is functionally involved in NAA production of NSCLC cells through siRNA-mediated suppression of NAT8L, which caused selective reduction of intracellular and secreted NAA. N-acetylaspartate 54-57 N-acetyltransferase 8 like Homo sapiens 20-25 26511490-5 2016 We then showed that NAT8L is functionally involved in NAA production of NSCLC cells through siRNA-mediated suppression of NAT8L, which caused selective reduction of intracellular and secreted NAA. N-acetylaspartate 54-57 N-acetyltransferase 8 like Homo sapiens 122-127 26511490-5 2016 We then showed that NAT8L is functionally involved in NAA production of NSCLC cells through siRNA-mediated suppression of NAT8L, which caused selective reduction of intracellular and secreted NAA. N-acetylaspartate 192-195 N-acetyltransferase 8 like Homo sapiens 20-25 26511490-5 2016 We then showed that NAT8L is functionally involved in NAA production of NSCLC cells through siRNA-mediated suppression of NAT8L, which caused selective reduction of intracellular and secreted NAA. N-acetylaspartate 192-195 N-acetyltransferase 8 like Homo sapiens 122-127 26511490-8 2016 Taken together, these results indicate that NAA is produced specifically in NSCLC tumors through NAT8L overexpression, and its extracellular secretion can be detected in blood. N-acetylaspartate 44-47 N-acetyltransferase 8 like Homo sapiens 97-102 25069253-4 2013 Recently, it has been demonstrated that the substrate for shati/nat81 is aspaltate and shati/nat8l biosynthesizes N-acetylaspartate, which exists abundantly in the mammalian brain. N-acetylaspartate 114-131 N-acetyltransferase 8 like Homo sapiens 93-98 21936773-1 2012 Aspartate N-acetyltransferase (NAT8L, N-acetyltransferase 8-like), the enzyme that synthesizes N-acetylaspartate, is membrane-bound and is at least partially associated with the ER (endoplasmic reticulum). N-acetylaspartate 95-112 N-acetyltransferase 8 like Homo sapiens 31-36 21936773-1 2012 Aspartate N-acetyltransferase (NAT8L, N-acetyltransferase 8-like), the enzyme that synthesizes N-acetylaspartate, is membrane-bound and is at least partially associated with the ER (endoplasmic reticulum). N-acetylaspartate 95-112 N-acetyltransferase 8 like Homo sapiens 38-65 20385109-0 2010 Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS. N-acetylaspartate 54-57 N-acetyltransferase 8 like Homo sapiens 41-46 20385109-5 2010 A very recent report has identified Nat8l as the gene encoding Asp-NAT and confirmed that the only child diagnosed with a lack of NAA on brain magnetic resonance spectrograms has a 19-bp deletion in this gene. N-acetylaspartate 130-133 N-acetyltransferase 8 like Homo sapiens 36-41 20385109-7 2010 In studies done concurrently in our laboratory we have demonstrated via cloning, expression, specificity for acetylation of aspartate, responsiveness to methamphetamine treatment, molecular modeling and comparative immunolocalization that NAT8L is the NAA biosynthetic enzyme Asp-NAT. N-acetylaspartate 252-255 N-acetyltransferase 8 like Homo sapiens 239-244 19807691-6 2009 Transfection studies in HEK-293T [human embryonic kidney-293 cells expressing the large T-antigen of SV40 (simian virus 40)] indicated that NAT8L, but not NAT14, catalysed the synthesis of NAA from L-aspartate and acetyl-CoA. N-acetylaspartate 189-192 N-acetyltransferase 8 like Homo sapiens 140-145 19807691-9 2009 A mutation search in the NAT8L gene of the only patient known to be deficient in NAA disclosed the presence of a homozygous 19 bp deletion, resulting in a change in reading frame and the absence of production of a functional protein. N-acetylaspartate 81-84 N-acetyltransferase 8 like Homo sapiens 25-30 19807691-10 2009 We conclude that NAT8L, a neuron-specific protein, is responsible for NAA synthesis and is mutated in primary NAA deficiency (hypoacetylaspartia). N-acetylaspartate 70-73 N-acetyltransferase 8 like Homo sapiens 17-22