PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32507787-5 2020 N-acetyl-aspartate (NAA), a substrate of ASPA, showed accumulation in all brain regions and in the spinal cord. N-acetylaspartate 0-18 aspartoacylase Rattus norvegicus 41-45 32507787-5 2020 N-acetyl-aspartate (NAA), a substrate of ASPA, showed accumulation in all brain regions and in the spinal cord. N-acetylaspartate 20-23 aspartoacylase Rattus norvegicus 41-45 24515258-2 2014 The reversible changes in NAA induced by mild TBI were due to a combination of transient mitochondrial malfunctioning with energy crisis (decrease in ATP and in the ATP/ADP ratio) and modulation in the gene and protein levels of N-acetyltransferase 8-like and increase of aspartoacylase levels. N-acetylaspartate 26-29 aspartoacylase Rattus norvegicus 272-286 24515258-3 2014 The irreversible decrease in NAA following severe TBI, was instead characterized by profound mitochondrial malfunctioning (constant 65% decrease of the ATP/ADP indicating permanent impairment of the mitochondrial phosphorylating capacity), dramatic repression of the N-acetyltransferase 8-like gene and concomitant remarkable increase in the aspartoacylase gene and protein levels. N-acetylaspartate 29-32 aspartoacylase Rattus norvegicus 342-356 21598311-1 2011 Aspartoacylase (ASPA) catalyzes deacetylation of N-acetylaspartate (NAA) to generate acetate and aspartate. N-acetylaspartate 49-66 aspartoacylase Rattus norvegicus 0-14 21598311-1 2011 Aspartoacylase (ASPA) catalyzes deacetylation of N-acetylaspartate (NAA) to generate acetate and aspartate. N-acetylaspartate 49-66 aspartoacylase Rattus norvegicus 16-20 21598311-1 2011 Aspartoacylase (ASPA) catalyzes deacetylation of N-acetylaspartate (NAA) to generate acetate and aspartate. N-acetylaspartate 68-71 aspartoacylase Rattus norvegicus 0-14 21598311-1 2011 Aspartoacylase (ASPA) catalyzes deacetylation of N-acetylaspartate (NAA) to generate acetate and aspartate. N-acetylaspartate 68-71 aspartoacylase Rattus norvegicus 16-20 21598311-12 2011 Strong ASPA expression in cell nuclei is consistent with a role for NAA-derived acetate in nuclear acetylation reactions, including histone acetylation. N-acetylaspartate 68-71 aspartoacylase Rattus norvegicus 7-11 21608034-1 2011 Aspartoacylase (ASPA) is an enzyme that functions to catabolize the neuronal amino acid derivative N-acetyl-L-aspartic acid (NAA). N-acetylaspartate 99-123 aspartoacylase Rattus norvegicus 16-20 21608034-1 2011 Aspartoacylase (ASPA) is an enzyme that functions to catabolize the neuronal amino acid derivative N-acetyl-L-aspartic acid (NAA). N-acetylaspartate 125-128 aspartoacylase Rattus norvegicus 16-20 21608034-3 2011 NAA synthesis and catabolism are tightly compartmentalized within neurons and oligodendrocytes, respectively, and there is evidence to suggest the developmental regulation of ASPA activity is transcriptional. N-acetylaspartate 0-3 aspartoacylase Rattus norvegicus 175-179 20464498-3 2010 ASPA produces free acetate from the concentrated brain metabolite, N-acetylaspartate (NAA). N-acetylaspartate 67-84 aspartoacylase Rattus norvegicus 0-4 20464498-3 2010 ASPA produces free acetate from the concentrated brain metabolite, N-acetylaspartate (NAA). N-acetylaspartate 86-89 aspartoacylase Rattus norvegicus 0-4 18478328-2 2009 The biomedical relevance of such inquiries is highlighted by the myelin-associated pathology of Canavan disease, an inherited childhood disorder resulting from mutation of aspartoacylase (ASPA), the NAA-hydrolyzing enzyme. N-acetylaspartate 199-202 aspartoacylase Rattus norvegicus 172-186 18478328-2 2009 The biomedical relevance of such inquiries is highlighted by the myelin-associated pathology of Canavan disease, an inherited childhood disorder resulting from mutation of aspartoacylase (ASPA), the NAA-hydrolyzing enzyme. N-acetylaspartate 199-202 aspartoacylase Rattus norvegicus 188-192 12147318-2 2002 A deletion of the aspartoacylase (ASPA) gene and resultant high levels of N-acetyl-aspartate (NAA) in the brain have been found in tremor rats. N-acetylaspartate 74-92 aspartoacylase Rattus norvegicus 18-32 15851013-3 2005 Normally, ASPA is enriched in oligodendrocytes and ASPA deficiency results in elevated levels of its substrate molecule, N-acetylaspartate (NAA), brain edema, and dysmyelination. N-acetylaspartate 121-138 aspartoacylase Rattus norvegicus 10-14 15851013-3 2005 Normally, ASPA is enriched in oligodendrocytes and ASPA deficiency results in elevated levels of its substrate molecule, N-acetylaspartate (NAA), brain edema, and dysmyelination. N-acetylaspartate 121-138 aspartoacylase Rattus norvegicus 51-55 15851013-3 2005 Normally, ASPA is enriched in oligodendrocytes and ASPA deficiency results in elevated levels of its substrate molecule, N-acetylaspartate (NAA), brain edema, and dysmyelination. N-acetylaspartate 140-143 aspartoacylase Rattus norvegicus 10-14 15851013-3 2005 Normally, ASPA is enriched in oligodendrocytes and ASPA deficiency results in elevated levels of its substrate molecule, N-acetylaspartate (NAA), brain edema, and dysmyelination. N-acetylaspartate 140-143 aspartoacylase Rattus norvegicus 51-55 15851013-9 2005 Our data suggest that NAA-mediated neuronal hyperexcitation but not oligodendrocyte dysfunction can be compensated for by neuronal ASPA expression. N-acetylaspartate 22-25 aspartoacylase Rattus norvegicus 131-135 15065127-1 2004 Aspartoacylase (ASPA; EC 3.5.1.15) catalyzes deacetylation of N-acetylaspartate (NAA) to generate free acetate in the central nervous system (CNS). N-acetylaspartate 62-79 aspartoacylase Rattus norvegicus 0-14 15065127-1 2004 Aspartoacylase (ASPA; EC 3.5.1.15) catalyzes deacetylation of N-acetylaspartate (NAA) to generate free acetate in the central nervous system (CNS). N-acetylaspartate 62-79 aspartoacylase Rattus norvegicus 16-20 15065127-1 2004 Aspartoacylase (ASPA; EC 3.5.1.15) catalyzes deacetylation of N-acetylaspartate (NAA) to generate free acetate in the central nervous system (CNS). N-acetylaspartate 81-84 aspartoacylase Rattus norvegicus 0-14 15065127-1 2004 Aspartoacylase (ASPA; EC 3.5.1.15) catalyzes deacetylation of N-acetylaspartate (NAA) to generate free acetate in the central nervous system (CNS). N-acetylaspartate 81-84 aspartoacylase Rattus norvegicus 16-20 16935940-1 2006 Mutations in the gene for aspartoacylase (ASPA), which catalyzes deacetylation of N-acetyl-L-aspartate in the central nervous system (CNS), result in Canavan Disease, a fatal dysmyelinating disease. N-acetylaspartate 82-102 aspartoacylase Rattus norvegicus 26-40 16935940-1 2006 Mutations in the gene for aspartoacylase (ASPA), which catalyzes deacetylation of N-acetyl-L-aspartate in the central nervous system (CNS), result in Canavan Disease, a fatal dysmyelinating disease. N-acetylaspartate 82-102 aspartoacylase Rattus norvegicus 42-46 15857674-2 2005 The absence of ASPA expression in these animals results in undetectable levels of enzyme activity and the accumulation of the substrate N-acetyl-aspartate (NAA) in brain, leading to generalized myelin vacuolation and severe motor and cognitive impairment. N-acetylaspartate 136-154 aspartoacylase Rattus norvegicus 15-19 15857674-2 2005 The absence of ASPA expression in these animals results in undetectable levels of enzyme activity and the accumulation of the substrate N-acetyl-aspartate (NAA) in brain, leading to generalized myelin vacuolation and severe motor and cognitive impairment. N-acetylaspartate 156-159 aspartoacylase Rattus norvegicus 15-19 15857674-4 2005 AAV-ASPA gene transfer resulted in elevated aspartoacylase bioactivity compared to untreated mutant animals and elicited a significant decrease in the pathologically elevated whole-brain NAA levels. N-acetylaspartate 187-190 aspartoacylase Rattus norvegicus 4-8 12147318-2 2002 A deletion of the aspartoacylase (ASPA) gene and resultant high levels of N-acetyl-aspartate (NAA) in the brain have been found in tremor rats. N-acetylaspartate 74-92 aspartoacylase Rattus norvegicus 34-38 12147318-2 2002 A deletion of the aspartoacylase (ASPA) gene and resultant high levels of N-acetyl-aspartate (NAA) in the brain have been found in tremor rats. N-acetylaspartate 94-97 aspartoacylase Rattus norvegicus 18-32 12147318-2 2002 A deletion of the aspartoacylase (ASPA) gene and resultant high levels of N-acetyl-aspartate (NAA) in the brain have been found in tremor rats. N-acetylaspartate 94-97 aspartoacylase Rattus norvegicus 34-38 12147318-8 2002 These results suggest that gene transfer of ASPA is effective in inhibiting the generation of absence-like seizures, probably by reducing the NAA level. N-acetylaspartate 142-145 aspartoacylase Rattus norvegicus 44-48