PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9337154-1 1997 Liver methionine adenosyltransferase (MAT) plays a critical role in the metabolism of methionine converting this amino acid, in the presence of ATP, into S-adenosylmethionine. S-Adenosylmethionine 154-174 methionine adenosyltransferase 1A Homo sapiens 38-41 33175851-1 2020 S-adenosyl methionine synthetase (SAMS) catalyzes the biosynthesis of S-adenosyl methionine (SAM), which serves as a universal methyl group donor for numerous biochemical reactions. S-Adenosylmethionine 0-21 methionine adenosyltransferase 1A Homo sapiens 34-38 8903381-1 1996 S-adenosylmethionine synthetase (SAMS) catalyzes the formation of S-adenosylmethionine (SAM) and is essential to normal cell function. S-Adenosylmethionine 0-20 methionine adenosyltransferase 1A Homo sapiens 33-37 8903381-1 1996 S-adenosylmethionine synthetase (SAMS) catalyzes the formation of S-adenosylmethionine (SAM) and is essential to normal cell function. S-Adenosylmethionine 33-36 methionine adenosyltransferase 1A Homo sapiens 0-31 8278461-1 1993 Methionine adenosyltransferase (MAT), a key enzyme in metabolism, catalyzes the synthesis of one of the most important and pivotal biological molecules, S-adenosyl-methionine. S-Adenosylmethionine 153-174 methionine adenosyltransferase 1A Homo sapiens 0-30 34647332-8 2022 LINC00662 can reduce the promoter methylation level of s-adenosylmethionine (SAM)-dependent hepatocellular carcinoma (HCC)-promoting genes by regulating the MAT1A/SAM and AHCY/SAH axes, thereby promoting the activation of oncogenes. S-Adenosylmethionine 55-75 methionine adenosyltransferase 1A Homo sapiens 157-166 34647332-8 2022 LINC00662 can reduce the promoter methylation level of s-adenosylmethionine (SAM)-dependent hepatocellular carcinoma (HCC)-promoting genes by regulating the MAT1A/SAM and AHCY/SAH axes, thereby promoting the activation of oncogenes. S-Adenosylmethionine 77-80 methionine adenosyltransferase 1A Homo sapiens 157-166 34065390-2 2021 Hepatic and extrahepatic tissues methionine adenosyltransferases (MATs) are products of two genes, MAT1A and MAT2A that catalyze the formation of S-adenosylmethionine (SAM), the principal biological methyl donor. S-Adenosylmethionine 146-166 methionine adenosyltransferase 1A Homo sapiens 99-104 34065390-2 2021 Hepatic and extrahepatic tissues methionine adenosyltransferases (MATs) are products of two genes, MAT1A and MAT2A that catalyze the formation of S-adenosylmethionine (SAM), the principal biological methyl donor. S-Adenosylmethionine 168-171 methionine adenosyltransferase 1A Homo sapiens 99-104 35091576-1 2022 MATalpha1 catalyzes the synthesis of S-adenosylmethionine, the principal biological methyl donor. S-Adenosylmethionine 37-57 methionine adenosyltransferase 1A Homo sapiens 0-9 30657139-6 2019 As a result, SAMS from cell lysate achieved about 95% activity recovery in the biosynthesis of S-adenosylmethionine (SAM) under high temperature conditions (70 C) with a simple mixing step. S-Adenosylmethionine 95-115 methionine adenosyltransferase 1A Homo sapiens 13-17 31959915-7 2020 Mechanistically, LINC00662 was determined to regulate the key enzymes influencing SAM and SAH levels, namely, methionine adenosyltransferase 1A (MAT1A) and S-adenosylhomocysteine hydrolase (AHCY), by RNA-RNA and RNA-protein interactions. S-Adenosylmethionine 82-85 methionine adenosyltransferase 1A Homo sapiens 110-143 31959915-7 2020 Mechanistically, LINC00662 was determined to regulate the key enzymes influencing SAM and SAH levels, namely, methionine adenosyltransferase 1A (MAT1A) and S-adenosylhomocysteine hydrolase (AHCY), by RNA-RNA and RNA-protein interactions. S-Adenosylmethionine 82-85 methionine adenosyltransferase 1A Homo sapiens 145-150 31552788-1 2020 S-adenosylmethionine (SAM), biosynthesis from methionine and ATP, is markedly decreased in hepatocellularular carcinoma (HCC) for a diminution in ATP levels, and the down regulation of the liver specific MAT1a enzyme. S-Adenosylmethionine 0-20 methionine adenosyltransferase 1A Homo sapiens 204-209 31552788-1 2020 S-adenosylmethionine (SAM), biosynthesis from methionine and ATP, is markedly decreased in hepatocellularular carcinoma (HCC) for a diminution in ATP levels, and the down regulation of the liver specific MAT1a enzyme. S-Adenosylmethionine 22-25 methionine adenosyltransferase 1A Homo sapiens 204-209 31959915-8 2020 In addition, we demonstrated that some SAM-dependent HCC-promoting genes could be regulated by LINC00662 by altering the methylation status of their promoters via the LINC00662-coupled axes of MAT1A/SAM and AHCY/SAH. S-Adenosylmethionine 39-42 methionine adenosyltransferase 1A Homo sapiens 193-198 31077594-1 2019 Methionine adenosyltransferase alpha1 (MATalpha1, encoded by MAT1A) is responsible for hepatic biosynthesis of S-adenosyl methionine, the principal methyl donor. S-Adenosylmethionine 111-132 methionine adenosyltransferase 1A Homo sapiens 61-66 23665184-1 2013 Downregulation of liver-specific MAT1A gene, encoding S-adenosylmethionine (SAM) synthesizing isozymes MATI/III, and upregulation of widely expressed MAT2A, encoding MATII isozyme, known as MAT1A:MAT2A switch, occurs in hepatocellular carcinoma (HCC). S-Adenosylmethionine 54-74 methionine adenosyltransferase 1A Homo sapiens 33-38 30050996-1 2018 The under-regulation of liver-specific MAT1A gene codifying for S-adenosylmethionine (SAM) synthesizing isozymes MATI/III, and the up-regulation of widely expressed MAT2A, MATII isozyme occurs in hepatocellular carcinoma (HCC). S-Adenosylmethionine 64-84 methionine adenosyltransferase 1A Homo sapiens 39-44 30050996-1 2018 The under-regulation of liver-specific MAT1A gene codifying for S-adenosylmethionine (SAM) synthesizing isozymes MATI/III, and the up-regulation of widely expressed MAT2A, MATII isozyme occurs in hepatocellular carcinoma (HCC). S-Adenosylmethionine 86-89 methionine adenosyltransferase 1A Homo sapiens 39-44 28748147-1 2017 Methionine adenosyltransferase (MAT) I/III deficiency is an inborn error of metabolism caused by mutations in MAT1A, encoding the catalytic subunit of MAT responsible for the synthesis of S-adenosylmethionine, and is characterized by persistent hypermethioninemia. S-Adenosylmethionine 188-208 methionine adenosyltransferase 1A Homo sapiens 110-115 27548429-1 2016 Methionine adenosyltransferases MAT I and MAT III (encoded by Mat1a) catalyze S-adenosylmethionine synthesis in normal liver. S-Adenosylmethionine 78-98 methionine adenosyltransferase 1A Homo sapiens 62-67 25559387-1 2015 S-adenosyl-L-methionine (SAM) synthase (SAMS) catalyze the biosynthesis of SAM, which is a precursor for ethylene and polyamines, and a methyl donor for a number of biomolecules. S-Adenosylmethionine 25-28 methionine adenosyltransferase 1A Homo sapiens 40-44 27474977-8 2016 Expression of Met adenosyltransferase 1A (MAT1A), which catalyzes the first step of Met metabolism to generate S-adenosylmethionine (SAM), a primary methyl donor, was decreased with increasing dl-Met or HMB concentration. S-Adenosylmethionine 111-131 methionine adenosyltransferase 1A Homo sapiens 14-40 27474977-8 2016 Expression of Met adenosyltransferase 1A (MAT1A), which catalyzes the first step of Met metabolism to generate S-adenosylmethionine (SAM), a primary methyl donor, was decreased with increasing dl-Met or HMB concentration. S-Adenosylmethionine 111-131 methionine adenosyltransferase 1A Homo sapiens 42-47 27474977-8 2016 Expression of Met adenosyltransferase 1A (MAT1A), which catalyzes the first step of Met metabolism to generate S-adenosylmethionine (SAM), a primary methyl donor, was decreased with increasing dl-Met or HMB concentration. S-Adenosylmethionine 133-136 methionine adenosyltransferase 1A Homo sapiens 14-40 27474977-8 2016 Expression of Met adenosyltransferase 1A (MAT1A), which catalyzes the first step of Met metabolism to generate S-adenosylmethionine (SAM), a primary methyl donor, was decreased with increasing dl-Met or HMB concentration. S-Adenosylmethionine 133-136 methionine adenosyltransferase 1A Homo sapiens 42-47 26289392-2 2015 MAT1A encodes the subunit that forms two methionine adenosyltransferase isoenzymes, tetrameric MAT I and dimeric MAT III, that catalyze the conversion of methionine and ATP to S-adenosylmethionine (AdoMet). S-Adenosylmethionine 176-196 methionine adenosyltransferase 1A Homo sapiens 0-5 26289392-2 2015 MAT1A encodes the subunit that forms two methionine adenosyltransferase isoenzymes, tetrameric MAT I and dimeric MAT III, that catalyze the conversion of methionine and ATP to S-adenosylmethionine (AdoMet). S-Adenosylmethionine 176-196 methionine adenosyltransferase 1A Homo sapiens 95-100 26289392-2 2015 MAT1A encodes the subunit that forms two methionine adenosyltransferase isoenzymes, tetrameric MAT I and dimeric MAT III, that catalyze the conversion of methionine and ATP to S-adenosylmethionine (AdoMet). S-Adenosylmethionine 176-196 methionine adenosyltransferase 1A Homo sapiens 117-120 26289392-2 2015 MAT1A encodes the subunit that forms two methionine adenosyltransferase isoenzymes, tetrameric MAT I and dimeric MAT III, that catalyze the conversion of methionine and ATP to S-adenosylmethionine (AdoMet). S-Adenosylmethionine 198-204 methionine adenosyltransferase 1A Homo sapiens 0-5 26289392-2 2015 MAT1A encodes the subunit that forms two methionine adenosyltransferase isoenzymes, tetrameric MAT I and dimeric MAT III, that catalyze the conversion of methionine and ATP to S-adenosylmethionine (AdoMet). S-Adenosylmethionine 198-204 methionine adenosyltransferase 1A Homo sapiens 95-100 26289392-2 2015 MAT1A encodes the subunit that forms two methionine adenosyltransferase isoenzymes, tetrameric MAT I and dimeric MAT III, that catalyze the conversion of methionine and ATP to S-adenosylmethionine (AdoMet). S-Adenosylmethionine 198-204 methionine adenosyltransferase 1A Homo sapiens 117-120 26461333-5 2014 Pioneer works showed how oxidized GSH inhibits the activity of S-adenosyl methionine synthetase, MAT1A, a key enzyme involved in the synthesis of S-adenosyl methionine (SAM), which is used by DNA methyltransferases (DNMTs) and histone methyltransferases (HMTs). S-Adenosylmethionine 63-84 methionine adenosyltransferase 1A Homo sapiens 97-102 26461333-5 2014 Pioneer works showed how oxidized GSH inhibits the activity of S-adenosyl methionine synthetase, MAT1A, a key enzyme involved in the synthesis of S-adenosyl methionine (SAM), which is used by DNA methyltransferases (DNMTs) and histone methyltransferases (HMTs). S-Adenosylmethionine 169-172 methionine adenosyltransferase 1A Homo sapiens 97-102 24649856-1 2014 UNLABELLED: Methionine adenosyltransferase (MAT) is a family of enzymes that utilizes ATP and methionine to produce S-adenosylmethionine (AdoMet), the most crucial methyl donor in the biological methylation of biomolecules and bioactive natural products. S-Adenosylmethionine 116-136 methionine adenosyltransferase 1A Homo sapiens 12-42 24649856-1 2014 UNLABELLED: Methionine adenosyltransferase (MAT) is a family of enzymes that utilizes ATP and methionine to produce S-adenosylmethionine (AdoMet), the most crucial methyl donor in the biological methylation of biomolecules and bioactive natural products. S-Adenosylmethionine 116-136 methionine adenosyltransferase 1A Homo sapiens 44-47 24649856-1 2014 UNLABELLED: Methionine adenosyltransferase (MAT) is a family of enzymes that utilizes ATP and methionine to produce S-adenosylmethionine (AdoMet), the most crucial methyl donor in the biological methylation of biomolecules and bioactive natural products. S-Adenosylmethionine 138-144 methionine adenosyltransferase 1A Homo sapiens 12-42 24649856-1 2014 UNLABELLED: Methionine adenosyltransferase (MAT) is a family of enzymes that utilizes ATP and methionine to produce S-adenosylmethionine (AdoMet), the most crucial methyl donor in the biological methylation of biomolecules and bioactive natural products. S-Adenosylmethionine 138-144 methionine adenosyltransferase 1A Homo sapiens 44-47 27508177-4 2014 Alterations in the methylation of the promoter of methyl adenosyltransferase MAT1A and MAT2A genes in HCC result in decreased S-adenosylmethionine levels, global DNA hypomethylation, and deregulation of signal transduction pathways linked to methionine metabolism and methyl adenosyltransferases activity. S-Adenosylmethionine 126-146 methionine adenosyltransferase 1A Homo sapiens 77-82 27508177-5 2014 Changes in S-adenosylmethionine levels may also depend on MAT1A mRNA destabilization associated with MAT2A mRNA stabilization by specific proteins. S-Adenosylmethionine 11-31 methionine adenosyltransferase 1A Homo sapiens 58-63 23665184-1 2013 Downregulation of liver-specific MAT1A gene, encoding S-adenosylmethionine (SAM) synthesizing isozymes MATI/III, and upregulation of widely expressed MAT2A, encoding MATII isozyme, known as MAT1A:MAT2A switch, occurs in hepatocellular carcinoma (HCC). S-Adenosylmethionine 76-79 methionine adenosyltransferase 1A Homo sapiens 33-38 21185701-2 2012 The S-adenosylmethionine synthetase type-1 (MAT1A), an essential enzyme in the conversion of methionine to S-adenosylmethionine, plays a key role in homocysteine metabolism. S-Adenosylmethionine 4-24 methionine adenosyltransferase 1A Homo sapiens 44-49 23425511-0 2013 Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits. S-Adenosylmethionine 15-33 methionine adenosyltransferase 1A Homo sapiens 88-118 23425511-1 2013 MAT (methionine adenosyltransferase) utilizes L-methionine and ATP to form SAM (S-adenosylmethionine), the principal methyl donor in biological methylation. S-Adenosylmethionine 75-78 methionine adenosyltransferase 1A Homo sapiens 5-35 23425511-1 2013 MAT (methionine adenosyltransferase) utilizes L-methionine and ATP to form SAM (S-adenosylmethionine), the principal methyl donor in biological methylation. S-Adenosylmethionine 80-100 methionine adenosyltransferase 1A Homo sapiens 5-35 22318685-1 2012 UNLABELLED: Down-regulation of the liver-specific MAT1A gene, encoding S-adenosylmethionine (SAM) synthesizing isozymes MATI/III, and up-regulation of widely expressed MAT2A, encoding MATII isozyme, known as MAT1A:MAT2A switch, occurs in hepatocellular carcinoma (HCC). S-Adenosylmethionine 71-91 methionine adenosyltransferase 1A Homo sapiens 50-55 22270009-0 2012 Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethionine. S-Adenosylmethionine 133-153 methionine adenosyltransferase 1A Homo sapiens 54-90 22270009-1 2012 Methionine adenosyltransferase I/III (MATI/III) synthesizes S-adenosylmethionine (SAM) in quiescent hepatocytes. S-Adenosylmethionine 60-80 methionine adenosyltransferase 1A Homo sapiens 0-36 22270009-1 2012 Methionine adenosyltransferase I/III (MATI/III) synthesizes S-adenosylmethionine (SAM) in quiescent hepatocytes. S-Adenosylmethionine 60-80 methionine adenosyltransferase 1A Homo sapiens 38-46 22270009-1 2012 Methionine adenosyltransferase I/III (MATI/III) synthesizes S-adenosylmethionine (SAM) in quiescent hepatocytes. S-Adenosylmethionine 82-85 methionine adenosyltransferase 1A Homo sapiens 0-36 22270009-1 2012 Methionine adenosyltransferase I/III (MATI/III) synthesizes S-adenosylmethionine (SAM) in quiescent hepatocytes. S-Adenosylmethionine 82-85 methionine adenosyltransferase 1A Homo sapiens 38-46 20363925-1 2010 Methionine adenosyltransferase (MAT) catalyzes the synthesis of S-adenosylmethionine, the principal methyl donor, and is encoded by MAT1A and MAT2A in mammals. S-Adenosylmethionine 64-84 methionine adenosyltransferase 1A Homo sapiens 132-137 24212770-4 2011 Methionine adenosyltransferase (MAT) is an essential enzyme required for the biosynthesis of S-adenosylmethionine (AdoMet), an important methyl donor in the cell. S-Adenosylmethionine 93-113 methionine adenosyltransferase 1A Homo sapiens 0-30 24212770-4 2011 Methionine adenosyltransferase (MAT) is an essential enzyme required for the biosynthesis of S-adenosylmethionine (AdoMet), an important methyl donor in the cell. S-Adenosylmethionine 93-113 methionine adenosyltransferase 1A Homo sapiens 32-35 24212770-4 2011 Methionine adenosyltransferase (MAT) is an essential enzyme required for the biosynthesis of S-adenosylmethionine (AdoMet), an important methyl donor in the cell. S-Adenosylmethionine 115-121 methionine adenosyltransferase 1A Homo sapiens 0-30 24212770-4 2011 Methionine adenosyltransferase (MAT) is an essential enzyme required for the biosynthesis of S-adenosylmethionine (AdoMet), an important methyl donor in the cell. S-Adenosylmethionine 115-121 methionine adenosyltransferase 1A Homo sapiens 32-35 20675163-2 2010 In the liver, MAT I and III, tetrameric and dimeric isoforms of the same catalytic subunit encoded by the gene MAT1A, account for the predominant portion of total body synthesis of S-adenosylmethionine (SAM), a versatile sulfonium ion-containing molecule involved in a variety of vital metabolic reactions and in the control of hepatocyte proliferation and differentiation. S-Adenosylmethionine 181-201 methionine adenosyltransferase 1A Homo sapiens 111-116 20675163-2 2010 In the liver, MAT I and III, tetrameric and dimeric isoforms of the same catalytic subunit encoded by the gene MAT1A, account for the predominant portion of total body synthesis of S-adenosylmethionine (SAM), a versatile sulfonium ion-containing molecule involved in a variety of vital metabolic reactions and in the control of hepatocyte proliferation and differentiation. S-Adenosylmethionine 203-206 methionine adenosyltransferase 1A Homo sapiens 111-116 20363925-7 2010 Huh7 cells overexpressing MAT1A had higher S-adenosylmethionine levels but lower bromodeoxyuridine incorporation than control cells. S-Adenosylmethionine 43-63 methionine adenosyltransferase 1A Homo sapiens 26-31 19497982-8 2009 Nuclear accumulation of the active enzyme only correlated with histone H3K27 trimethylation among the epigenetic modifications evaluated, therefore pointing to the necessity of methionine adenosyltransferase I/III to guarantee the supply of S-adenosylmethionine for specific methylations. S-Adenosylmethionine 241-261 methionine adenosyltransferase 1A Homo sapiens 177-213 20102719-1 2010 BACKGROUND & AIMS: Hepatic de-differentiation, liver development, and malignant transformation are processes in which the levels of hepatic S-adenosylmethionine are tightly regulated by 2 genes: methionine adenosyltransferase 1A (MAT1A) and methionine adenosyltransferase 2A (MAT2A). S-Adenosylmethionine 144-164 methionine adenosyltransferase 1A Homo sapiens 199-232 20102719-1 2010 BACKGROUND & AIMS: Hepatic de-differentiation, liver development, and malignant transformation are processes in which the levels of hepatic S-adenosylmethionine are tightly regulated by 2 genes: methionine adenosyltransferase 1A (MAT1A) and methionine adenosyltransferase 2A (MAT2A). S-Adenosylmethionine 144-164 methionine adenosyltransferase 1A Homo sapiens 234-239 20043323-2 2010 Methionine adenosyltransferase (MAT) catalyzes biosynthesis of S-adenosylmethionine (SAMe), the principle methyl donor. S-Adenosylmethionine 63-83 methionine adenosyltransferase 1A Homo sapiens 0-30 20356199-1 2010 In this paper, we report on n-alkyl phosphonic acid (PA) self-assembled monolayer (SAM)/hafnium oxide (HfO(2)) hybrid dielectrics utilizing the advantages of SAMs for control over the dielectric/semiconductor interface with those of high-k metal oxides for low-voltage organic thin film transistors (OTFTs). S-Adenosylmethionine 83-86 methionine adenosyltransferase 1A Homo sapiens 158-162 17631143-1 2007 BACKGROUND & AIMS: Two genes (MAT1A and MAT2A) encode for methionine adenosyltransferase, an essential enzyme responsible for S-adenosylmethionine (SAMe) biosynthesis. S-Adenosylmethionine 130-150 methionine adenosyltransferase 1A Homo sapiens 34-39 19017057-1 2008 S-adenosylmethionine is one of the most important metabolites in living cells and is synthesized in a single reaction catalyzed by methionine adenosyltransferase (MAT). S-Adenosylmethionine 0-20 methionine adenosyltransferase 1A Homo sapiens 131-161 19017057-1 2008 S-adenosylmethionine is one of the most important metabolites in living cells and is synthesized in a single reaction catalyzed by methionine adenosyltransferase (MAT). S-Adenosylmethionine 0-20 methionine adenosyltransferase 1A Homo sapiens 163-166 18041713-4 2008 Methionine adenosyltransferase (MAT) is an essential enzyme that catalyzes the formation of S-adenosylmethionine (SAMe), the principal methyl donor and precursor of polyamines. S-Adenosylmethionine 92-112 methionine adenosyltransferase 1A Homo sapiens 0-30 18041713-4 2008 Methionine adenosyltransferase (MAT) is an essential enzyme that catalyzes the formation of S-adenosylmethionine (SAMe), the principal methyl donor and precursor of polyamines. S-Adenosylmethionine 92-112 methionine adenosyltransferase 1A Homo sapiens 32-35 16054984-1 2005 Two genes (MAT1A and MAT2A) encode for the essential enzyme methionine adenosyltransferase (MAT), which catalyzes the biosynthesis of S-adenosylmethionine (SAMe), the principal methyl donor and, in the liver, a precursor of glutathione. S-Adenosylmethionine 134-154 methionine adenosyltransferase 1A Homo sapiens 11-16 16958675-1 2006 Methionine adenosyltransferase (MAT) is an essential enzyme that catalyzes the formation of the principal methyl donor S-adenosylmethionine (SAMe). S-Adenosylmethionine 119-139 methionine adenosyltransferase 1A Homo sapiens 0-30 16958675-1 2006 Methionine adenosyltransferase (MAT) is an essential enzyme that catalyzes the formation of the principal methyl donor S-adenosylmethionine (SAMe). S-Adenosylmethionine 119-139 methionine adenosyltransferase 1A Homo sapiens 32-35 15670956-3 2005 Methionine S-adenosyltransferase (MAT) is an enzyme involved in the synthesis of S-adenosylmethionine (SAM), a methyl donor essential for mycolipid biosynthesis. S-Adenosylmethionine 81-101 methionine adenosyltransferase 1A Homo sapiens 0-32 15670956-3 2005 Methionine S-adenosyltransferase (MAT) is an enzyme involved in the synthesis of S-adenosylmethionine (SAM), a methyl donor essential for mycolipid biosynthesis. S-Adenosylmethionine 81-101 methionine adenosyltransferase 1A Homo sapiens 34-37 15670956-3 2005 Methionine S-adenosyltransferase (MAT) is an enzyme involved in the synthesis of S-adenosylmethionine (SAM), a methyl donor essential for mycolipid biosynthesis. S-Adenosylmethionine 103-106 methionine adenosyltransferase 1A Homo sapiens 0-32 15670956-3 2005 Methionine S-adenosyltransferase (MAT) is an enzyme involved in the synthesis of S-adenosylmethionine (SAM), a methyl donor essential for mycolipid biosynthesis. S-Adenosylmethionine 103-106 methionine adenosyltransferase 1A Homo sapiens 34-37 14709722-1 2004 The expression of genes for S-adenosylmethionine synthetase (SAMS), which catalyzes the synthesis of S-adenosylmethionine (AdoMet), a major methyl donor in cells, was studied in symbiont-free (D) and symbiont-bearing (xD) amoeba strains to determine the effect of bacterial endosymbionts. S-Adenosylmethionine 28-48 methionine adenosyltransferase 1A Homo sapiens 61-65 15033934-1 2004 Methionine adenosyltransferase (MAT) is an essential enzyme because it catalyzes the formation of S-adenosylmethionine (SAMe), the principal biological methyl donor. S-Adenosylmethionine 98-118 methionine adenosyltransferase 1A Homo sapiens 32-35 14709722-1 2004 The expression of genes for S-adenosylmethionine synthetase (SAMS), which catalyzes the synthesis of S-adenosylmethionine (AdoMet), a major methyl donor in cells, was studied in symbiont-free (D) and symbiont-bearing (xD) amoeba strains to determine the effect of bacterial endosymbionts. S-Adenosylmethionine 123-129 methionine adenosyltransferase 1A Homo sapiens 28-59 14709722-1 2004 The expression of genes for S-adenosylmethionine synthetase (SAMS), which catalyzes the synthesis of S-adenosylmethionine (AdoMet), a major methyl donor in cells, was studied in symbiont-free (D) and symbiont-bearing (xD) amoeba strains to determine the effect of bacterial endosymbionts. S-Adenosylmethionine 123-129 methionine adenosyltransferase 1A Homo sapiens 61-65 12660248-1 2003 In mammals, methionine adenosyltransferase (MAT), the enzyme responsible for S-adenosylmethionine (AdoMet) synthesis, is encoded by two genes, MAT1A and MAT2A. S-Adenosylmethionine 77-97 methionine adenosyltransferase 1A Homo sapiens 12-42 14530285-2 2003 Two genes (MAT1A and MAT2A) encode for methionine adenosyltransferase (MAT), an essential cellular enzyme responsible for S-adenosylmethionine biosynthesis. S-Adenosylmethionine 122-142 methionine adenosyltransferase 1A Homo sapiens 11-16 12660248-1 2003 In mammals, methionine adenosyltransferase (MAT), the enzyme responsible for S-adenosylmethionine (AdoMet) synthesis, is encoded by two genes, MAT1A and MAT2A. S-Adenosylmethionine 77-97 methionine adenosyltransferase 1A Homo sapiens 44-47 12660248-1 2003 In mammals, methionine adenosyltransferase (MAT), the enzyme responsible for S-adenosylmethionine (AdoMet) synthesis, is encoded by two genes, MAT1A and MAT2A. S-Adenosylmethionine 77-97 methionine adenosyltransferase 1A Homo sapiens 143-148 12660248-1 2003 In mammals, methionine adenosyltransferase (MAT), the enzyme responsible for S-adenosylmethionine (AdoMet) synthesis, is encoded by two genes, MAT1A and MAT2A. S-Adenosylmethionine 99-105 methionine adenosyltransferase 1A Homo sapiens 12-42 12660248-1 2003 In mammals, methionine adenosyltransferase (MAT), the enzyme responsible for S-adenosylmethionine (AdoMet) synthesis, is encoded by two genes, MAT1A and MAT2A. S-Adenosylmethionine 99-105 methionine adenosyltransferase 1A Homo sapiens 44-47 12660248-1 2003 In mammals, methionine adenosyltransferase (MAT), the enzyme responsible for S-adenosylmethionine (AdoMet) synthesis, is encoded by two genes, MAT1A and MAT2A. S-Adenosylmethionine 99-105 methionine adenosyltransferase 1A Homo sapiens 143-148 11320206-1 2001 Liver-specific and nonliver-specific methionine adenosyltransferases (MATs) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (AdoMet), the principal biological methyl donor. S-Adenosylmethionine 165-185 methionine adenosyltransferase 1A Homo sapiens 103-108 12671891-1 2003 BACKGROUND & AIMS: Of the 2 genes (MAT1A, MAT2A) encoding methionine adenosyltransferase, the enzyme that synthesizes S-adenosylmethionine, MAT1A, is expressed in liver, whereas MAT2A is expressed in extrahepatic tissues. S-Adenosylmethionine 122-142 methionine adenosyltransferase 1A Homo sapiens 39-44 12671891-1 2003 BACKGROUND & AIMS: Of the 2 genes (MAT1A, MAT2A) encoding methionine adenosyltransferase, the enzyme that synthesizes S-adenosylmethionine, MAT1A, is expressed in liver, whereas MAT2A is expressed in extrahepatic tissues. S-Adenosylmethionine 122-142 methionine adenosyltransferase 1A Homo sapiens 144-149 11520127-4 2001 In this study we investigated whether L-dopa increases the transmethylation process by inducing methionine adenosyl transferase (MAT), the enzyme that produces SAM, and catechol-O-methyl transferase (COMT), the enzyme that transfers the methyl group from SAM to L-dopa and DA. S-Adenosylmethionine 160-163 methionine adenosyltransferase 1A Homo sapiens 129-132 9755242-2 1998 Hepatic MAT plays an essential role in the metabolism of methionine, converting this amino acid into S-adenosylmethionine. S-Adenosylmethionine 101-121 methionine adenosyltransferase 1A Homo sapiens 8-11 10674710-1 2000 Hepatic methionine adenosyltransferase (MAT) deficiency is caused by mutations in the human MAT1A gene that abolish or reduce hepatic MAT activity that catalyzes the synthesis of S-adenosylmethionine from methionine and ATP. S-Adenosylmethionine 179-199 methionine adenosyltransferase 1A Homo sapiens 92-97 11208539-1 2001 Methionine adenosyltransferase (MAT), an essential enzyme that catalyzes the formation of S-adenosylmethionine (SAM), is encoded by two genes, MAT1A (liver-specific) and MAT2A (non-liver-specific). S-Adenosylmethionine 90-110 methionine adenosyltransferase 1A Homo sapiens 143-148 10955733-1 2000 Methionine adenosyltransferase (MAT) catalyzes the synthesis of S-adenosylmethionine (AdoMet) from ATP and L-methionine. S-Adenosylmethionine 64-84 methionine adenosyltransferase 1A Homo sapiens 0-30 10955733-1 2000 Methionine adenosyltransferase (MAT) catalyzes the synthesis of S-adenosylmethionine (AdoMet) from ATP and L-methionine. S-Adenosylmethionine 64-84 methionine adenosyltransferase 1A Homo sapiens 32-35 10955733-1 2000 Methionine adenosyltransferase (MAT) catalyzes the synthesis of S-adenosylmethionine (AdoMet) from ATP and L-methionine. S-Adenosylmethionine 86-92 methionine adenosyltransferase 1A Homo sapiens 0-30 10955733-1 2000 Methionine adenosyltransferase (MAT) catalyzes the synthesis of S-adenosylmethionine (AdoMet) from ATP and L-methionine. S-Adenosylmethionine 86-92 methionine adenosyltransferase 1A Homo sapiens 32-35 10567242-1 1999 S-Adenosylmethionine (AdoMet) synthetase (SAMS: EC 2.5.1.6) catalyses the formation of AdoMet from methionine and ATP. S-Adenosylmethionine 22-28 methionine adenosyltransferase 1A Homo sapiens 42-46 10415148-2 1999 The activity of L-methionine S-adenosyltransferase (MAT), a regulatory enzyme of S-adenosylmethionine biosynthesis, was investigated in erythrocytes of 21 patients with ALS, spinal cord specimens of 7 ALS patients, and matched controls. S-Adenosylmethionine 81-101 methionine adenosyltransferase 1A Homo sapiens 16-50 10415148-2 1999 The activity of L-methionine S-adenosyltransferase (MAT), a regulatory enzyme of S-adenosylmethionine biosynthesis, was investigated in erythrocytes of 21 patients with ALS, spinal cord specimens of 7 ALS patients, and matched controls. S-Adenosylmethionine 81-101 methionine adenosyltransferase 1A Homo sapiens 52-55 10216131-1 1999 Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (SAM), the principal methyl donor. S-Adenosylmethionine 164-184 methionine adenosyltransferase 1A Homo sapiens 38-68 10216131-1 1999 Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (SAM), the principal methyl donor. S-Adenosylmethionine 164-184 methionine adenosyltransferase 1A Homo sapiens 70-73 10216131-1 1999 Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (SAM), the principal methyl donor. S-Adenosylmethionine 164-184 methionine adenosyltransferase 1A Homo sapiens 102-107 10216131-1 1999 Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (SAM), the principal methyl donor. S-Adenosylmethionine 186-189 methionine adenosyltransferase 1A Homo sapiens 38-68 10216131-1 1999 Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (SAM), the principal methyl donor. S-Adenosylmethionine 186-189 methionine adenosyltransferase 1A Homo sapiens 70-73 10216131-1 1999 Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (SAM), the principal methyl donor. S-Adenosylmethionine 186-189 methionine adenosyltransferase 1A Homo sapiens 102-107 9537246-8 1998 SAM level and SAM:S-adenosylhomocysteine (SAH) ratio increased by 50-75% after MAT1A transfection and by an additional 60-80% after MAT2A antisense treatment. S-Adenosylmethionine 0-3 methionine adenosyltransferase 1A Homo sapiens 79-84 9655679-1 1998 Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes (MAT1A and MAT2A, respectively) that catalyze the formation of S-adenosylmethionine (SAM), the principal methyl donor. S-Adenosylmethionine 164-184 methionine adenosyltransferase 1A Homo sapiens 102-107 9655679-1 1998 Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes (MAT1A and MAT2A, respectively) that catalyze the formation of S-adenosylmethionine (SAM), the principal methyl donor. S-Adenosylmethionine 186-189 methionine adenosyltransferase 1A Homo sapiens 102-107