PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35293760-1	2022	Inhibition of the S-adenosyl methionine (SAM)-producing metabolic enzyme, methionine adenosyltransferase 2A (MAT2A), has received significant interest in the field of medicinal chemistry due to its implication as a synthetic lethal target in cancers with the deletion of the methylthioadenosine phosphorylase (MTAP) gene.	S-Adenosylmethionine	41-44	methylthioadenosine phosphorylase	Homo sapiens	275-308	
17548352-2	2007	The sole function of MTAP is to recycle 5"-methylthioadenosine (MTA) to S-adenosylmethionine.	S-Adenosylmethionine	72-92	methylthioadenosine phosphorylase	Homo sapiens	21-25	
24148083-1	2013	Human 5"-methylthioadenosine phosphorylase (MTAP) is solely responsible for 5"-methylthioadenosine (MTA) metabolism to permit S-adenosylmethionine salvage.	S-Adenosylmethionine	126-146	methylthioadenosine phosphorylase	Homo sapiens	6-42	
24148083-1	2013	Human 5"-methylthioadenosine phosphorylase (MTAP) is solely responsible for 5"-methylthioadenosine (MTA) metabolism to permit S-adenosylmethionine salvage.	S-Adenosylmethionine	126-146	methylthioadenosine phosphorylase	Homo sapiens	44-48	
21985704-1	2011	Human 5"-methylthioadenosine phosphorylase (MTAP) links the polyamine biosynthetic and S-adenosyl-l-methionine salvage pathways and is a target for anticancer drugs.	S-Adenosylmethionine	87-110	methylthioadenosine phosphorylase	Homo sapiens	6-42	
21985704-1	2011	Human 5"-methylthioadenosine phosphorylase (MTAP) links the polyamine biosynthetic and S-adenosyl-l-methionine salvage pathways and is a target for anticancer drugs.	S-Adenosylmethionine	87-110	methylthioadenosine phosphorylase	Homo sapiens	44-48	
16000004-4	2005	Products of the MTAP reaction (adenine and 5-methylthio-alpha-D-ribose-1-phosphate) are recycled to S-adenosylmethionine, the precursor for polyamine synthesis.	S-Adenosylmethionine	100-120	methylthioadenosine phosphorylase	Homo sapiens	16-20	
16000004-5	2005	Potent inhibitors of MTAP might allow the build-up of sufficient levels of MTA to generate feedback inhibition of polyamine biosynthesis and/or reduce S-adenosylmethionine levels.	S-Adenosylmethionine	151-171	methylthioadenosine phosphorylase	Homo sapiens	21-25	
35293760-1	2022	Inhibition of the S-adenosyl methionine (SAM)-producing metabolic enzyme, methionine adenosyltransferase 2A (MAT2A), has received significant interest in the field of medicinal chemistry due to its implication as a synthetic lethal target in cancers with the deletion of the methylthioadenosine phosphorylase (MTAP) gene.	S-Adenosylmethionine	41-44	methylthioadenosine phosphorylase	Homo sapiens	310-314	
33893330-3	2021	5"-Methylthioadenosine (MTA), the substrate for MTAP, is formed in polyamine synthesis and is recycled by MTAP to S-adenosyl-L-methionine (SAM) via salvage pathways.	S-Adenosylmethionine	114-137	methylthioadenosine phosphorylase	Homo sapiens	48-52	
33893330-3	2021	5"-Methylthioadenosine (MTA), the substrate for MTAP, is formed in polyamine synthesis and is recycled by MTAP to S-adenosyl-L-methionine (SAM) via salvage pathways.	S-Adenosylmethionine	114-137	methylthioadenosine phosphorylase	Homo sapiens	106-110	
33893330-3	2021	5"-Methylthioadenosine (MTA), the substrate for MTAP, is formed in polyamine synthesis and is recycled by MTAP to S-adenosyl-L-methionine (SAM) via salvage pathways.	S-Adenosylmethionine	139-142	methylthioadenosine phosphorylase	Homo sapiens	48-52	
33893330-3	2021	5"-Methylthioadenosine (MTA), the substrate for MTAP, is formed in polyamine synthesis and is recycled by MTAP to S-adenosyl-L-methionine (SAM) via salvage pathways.	S-Adenosylmethionine	139-142	methylthioadenosine phosphorylase	Homo sapiens	106-110	
30860833-4	2019	Human 5"-methylthioadenosine phosphorylase (MTAP), a reported anticancer target, catalyzes phosphorolysis of 5"-methylthioadenosine to salvage S-adenosylmethionine.	S-Adenosylmethionine	143-163	methylthioadenosine phosphorylase	Homo sapiens	6-42	
30860833-4	2019	Human 5"-methylthioadenosine phosphorylase (MTAP), a reported anticancer target, catalyzes phosphorolysis of 5"-methylthioadenosine to salvage S-adenosylmethionine.	S-Adenosylmethionine	143-163	methylthioadenosine phosphorylase	Homo sapiens	44-48	
27068473-7	2016	MAT2A produces the PRMT5 substrate S-adenosylmethionine (SAM), and MAT2A depletion reduces growth and PRMT5 methylation activity selectively in MTAP-deleted cells.	S-Adenosylmethionine	35-55	methylthioadenosine phosphorylase	Homo sapiens	144-148	
27068473-7	2016	MAT2A produces the PRMT5 substrate S-adenosylmethionine (SAM), and MAT2A depletion reduces growth and PRMT5 methylation activity selectively in MTAP-deleted cells.	S-Adenosylmethionine	57-60	methylthioadenosine phosphorylase	Homo sapiens	144-148