PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18393372-1	2008	UNLABELLED: We previously showed that S-adenosylmethionine (SAMe) and its metabolite methylthioadenosine (MTA) blocked lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNFalpha) expression in RAW (murine macrophage cell line) and Kupffer cells at the transcriptional level without affecting nuclear factor kappa B nuclear binding.	S-Adenosylmethionine	38-58	tumor necrosis factor	Mus musculus	152-179	
22159228-3	2012	S-adenosylmethionine (SAMe) and its metabolite methylthioadenosine (MTA) can inhibit lipopolysaccharide-induced TNF-alpha expression in macrophages.	S-Adenosylmethionine	0-20	tumor necrosis factor	Mus musculus	112-121	
19349371-6	2009	Interestingly, specific glutathione (GSH) up-regulation in hepatocytes by S-adenosylmethionine increased Mn-SOD expression and protected against I/R-mediated liver injury despite TNF/IL-1beta induction.	S-Adenosylmethionine	74-94	tumor necrosis factor	Mus musculus	179-182	
18393372-1	2008	UNLABELLED: We previously showed that S-adenosylmethionine (SAMe) and its metabolite methylthioadenosine (MTA) blocked lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNFalpha) expression in RAW (murine macrophage cell line) and Kupffer cells at the transcriptional level without affecting nuclear factor kappa B nuclear binding.	S-Adenosylmethionine	38-58	tumor necrosis factor	Mus musculus	181-189	
17446309-4	2007	Administration of SAM (50 mg/kg body wt ip every 12 h for 3 days) prevented the observed pathological changes as well as the increase of apoptotic hepatocytes, caspase 3 activity, and serum TNF-alpha levels.	S-Adenosylmethionine	18-21	tumor necrosis factor	Mus musculus	190-199	
17080400-6	2006	S-adenosylmethionine (SAM) and methylthioadenosine (MTA), an intermediate metabolite in SAM metabolism, are hepatoprotective by modulating TNFalpha expression and increasing reduced glutathione (GSH) levels.	S-Adenosylmethionine	0-20	tumor necrosis factor	Mus musculus	139-147	
17080400-6	2006	S-adenosylmethionine (SAM) and methylthioadenosine (MTA), an intermediate metabolite in SAM metabolism, are hepatoprotective by modulating TNFalpha expression and increasing reduced glutathione (GSH) levels.	S-Adenosylmethionine	22-25	tumor necrosis factor	Mus musculus	139-147	
31539805-8	2020	Furthermore, S-adenosylmethionine administration promoted enrichment of the euchromatin marker H3K4me3 in the promoters of Tnf-alpha, Il-6, and Nos2 and enhanced the mRNA up-regulation of these genes.	S-Adenosylmethionine	13-33	tumor necrosis factor	Mus musculus	123-132